Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34(+) cells by hematopoietic growth factors: implication of survivin expression in normal hematopoiesis.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Blood

• Publication date

  2001-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V98.7.2091PMID 11567995
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cytokine-regulated expression of survivin in myeloid leukemia.

  2001cited by this paper
• Transcriptional and ERK1/2-dependent synergistic upregulation of p21(cip1/waf1) associated with steel factor synergy in MO7e.

  2001cited by this paper
• Expression and prognostic significance of survivin in de novo acute myeloid leukaemia

  2000cited by this paper
• A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy.

  2000cited by this paper
• Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death

  2000cited by this paper
• Survivin promotes cell proliferation in human hepatocellular carcinoma

  2000cited by this paper
• Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions.

  2000cited by this paper
• Expression of survivin and its relationship to loss of apoptosis in breast carcinomas.

  2000cited by this paper
• Expression of the antiapoptosis gene,Survivin, predicts death from recurrent colorectal carcinoma

  2000cited by this paper
• Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway*

  2000cited by this paper
• Control of apoptosis during angiogenesis by survivin expression in endothelial cells.

  2000cited by this paper
• Expression and activation of caspase-3/CPP32 in CD34(+) cord blood cells is linked to apoptosis after growth factor withdrawal.

  2000cited by this paper
• Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16INK4a and Cdk2/Cyclin E complex activation

  2000cited by this paper
• High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma

  2000cited by this paper
• Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth.

  2000cited by this paper
• Prognostic significance of survivin expression in diffuse large B-cell lymphomas.

  2000cited by this paper
• Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma.

  1999cited by this paper
• Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation.

  1999cited by this paper
• Transcriptional analysis of human survivin gene expression.

  1999cited by this paper
• The cancer antiapoptosis mouse survivin gene: characterization of locus and transcriptional requirements of basal and cell cycle-dependent expression.

  1999cited by this paper
• Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

  1999cited by this paper
• A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers.

  1999cited by this paper
• Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells.

  1999cited by this paper
• Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia.

  1999cited by this paper
• Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line.

  1999cited by this paper
• Tumor content of the antiapoptosis molecule survivin and recurrence of bladder cancer.

  1999cited by this paper
• Novel anticancer drug discovery.

  1999cited by this paper
• Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer.

  1998cited by this paper
• Control of apoptosis and mitotic spindle checkpoint by survivin

  1998cited by this paper
• IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

  1998cited by this paper
• Induction of Apoptosis and Inhibition of Cell Proliferation bysurvivin Gene Targeting*

  1998cited by this paper
• Anti-apoptosis gene, survivin, and prognosis of neuroblastoma.

  1998cited by this paper
• Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation.

  1998cited by this paper
• The c‐IAP‐1 and c‐IAP‐2 proteins are direct inhibitors of specific caspases

  1997cited by this paper
• Functional heterogeneity of human CD34(+) cells isolated in subcompartments of the G0 /G1 phase of the cell cycle.

  1997cited by this paper
• X-linked IAP is a direct inhibitor of cell-death proteases

  1997cited by this paper
• Functional Heterogeneity of Human CD34+ Cells Isolated in Subcompartments of the G0 /G1 Phase of the Cell Cycle

  1997cited by this paper
• The Unexpected G 0 / G 1 Cell Cycle Status of Mobilized Hematopoietic Stem Cells From Peripheral Blood

  1997cited by this paper
• A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

  1997cited by this paper
• The unexpected G0/G1 cell cycle status of mobilized hematopoietic stem cells from peripheral blood.

  1997cited by this paper
• Establishment and characterization of a unique human cell line that proliferates dependently on GM‐CSF, IL‐3, or erythropoietin

  1989cited by this paper

• Survivin as a Therapeutic Target for the Treatment of Human Cancer

  2024cites this paper
• Estimation of Salivary Levels of an Inhibitory Apoptotic Protein Survivin in Oral Leukoplakia and Squamous Cell Carcinoma.

  2024cites this paper
• Survivin (BIRC5): Implications in cancer therapy.

  2024cites this paper
• Survivin Small Molecules Inhibitors: Recent Advances and Challenges

  2023cites this paper
• A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors

  2021cites this paper
• Survivin as a biological biomarker for diagnosis and therapy

  2021cites this paper
• A Novel Recombinant Fcγ Receptor-Targeted Survivin Combines with Chemotherapy for Efficient Cancer Treatment

  2021cites this paper
• Prognostic Significance of Survivin Expression in Patients with Ovarian Carcinoma: A Meta-Analysis

  2021cites this paper
• Bacteriophage Therapy of Bacterial Infections: The Rediscovered Frontier

  2021cites this paper
• The Role of Src-Phosphorylation at the α1-Na/K-ATPase at Caveola in the Pathogenesis and Treatment of NASH Related Hepatocellular Carcinoma: Overview of Published Literature

  2020cites this paper
• The effect of Mesenchymal Stem Cells of Amniotic Membrane on the Proliferation and Differentiation of Umbilical Cord Blood CD34+ cells

  2020cites this paper
• Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment

  2020cites this paper
• The survivin molecule as a double‐edged sword in cellular physiologic and pathologic conditions and its role as a potential biomarker and therapeutic target in cancer

  2020influential citation
• Emerging Importance of Survivin in Stem Cells and Cancer: the Development of New Cancer Therapeutics

  2020cites this paper
• DNA damage response and preleukemic fusion genes induced by ionizing radiation in umbilical cord blood hematopoietic stem cells

  2020cites this paper
• Unraveling survivin expression in chronic myeloid leukemia: Molecular interactions and clinical implications.

  2020cites this paper
• A survivin-responsive, conditionally replicating adenovirus induces potent cytocidal effects in adult T-cell leukemia/lymphoma

  2019cites this paper
• Survivin -31G/C promoter polymorphism and P53 antibodies in breast cancer

  2019cites this paper
• MUC1‐C drives myeloid leukaemogenesis and resistance to treatment by a survivin‐mediated mechanism

  2018cites this paper
• AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel

  2018cites this paper
• Survivin Measurement improves Clinical Prediction of Transition From Arthralgia to RA—Biomarkers to Improve Clinical Sensitivity of Transition From Arthralgia to RA

  2018cites this paper
• Survivin Is Required for Mouse and Human Bone Marrow Mesenchymal Stromal Cell Function

  2018cites this paper
• Survivin in autoimmune diseases.

  2017cites this paper
• Molecular Interaction Between the Microenvironment and FLT3/ITD+ AML Cells Leading to the Refractory Phenotype

  2017cites this paper
• 9 Survivin :

  2017cites this paper
• Nuclear survivin promoted by acetylation is associated with the aggressive phenotype of oral squamous cell carcinoma

  2017cites this paper
• Identification and Characterization of Novel Survivin Splice Variants with Anti-Apoptotic Activities

  2017cites this paper
• Hematopoietic stem/progenitor cells are less prone to undergo apoptosis than lymphocytes despite similar DNA damage response

  2017influential citation
• Transarterial chemoembolization of hepatocellular carcinoma in a rat model: the effect of additional injection of survivin siRNA to the treatment protocol

  2016cites this paper
• SELF-AMPLIFYING RNA VECTORS ENCODING SURVIVIN AS ANTI-TUMORAL VACCINE CANDIDATES Relatore: Prof. Diego Maria Michele FORNASARI Correlatore: Prof. Antonio SICCARDI Coordinatore del Dottorato: Prof. Massimo LOCATI

  2016cites this paper
• Does Different Doses of Malachite Green Affect Hepatic Tissue in AdultAlbino Rats (Histological, Biochemical And Immunohistochemical)

  2016cites this paper
• TAT-IL-24-KDEL-induced apoptosis is inhibited by survivin but restored by the small molecular survivin inhibitor, YM155, in cancer cells

  2016cites this paper
• Inhibition of Survivin Is Associated with Zoledronic Acid-induced Apoptosis of Prostate Cancer Cells.

  2016cites this paper
• Cardioprotection by combination of three compounds from ShengMai preparations in mice with myocardial ischemia/reperfusion injury through AMPK activation-mediated mitochondrial fission

  2016cites this paper
• Prognostic significance of intracellular survivin in myeloid blast cells as an inhibitor of apoptosis in Egyptian adult acute myeloid leukemia patients

  2015cites this paper
• Wnt Signaling in Stem Cells and Tumor Stem Cells

  2015cites this paper
• The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: Implications in targeted cancer therapies

  2015cites this paper
• Silibinin induces apoptosis and inhibits proliferation of SKOV-3 human ovarian cancer cells through suppressing survivin and HLA-G expression

  2015cites this paper
• Influence of survivin-targeted therapy on chemosensitivity in the treatment of acute myeloid leukemia.

  2015cites this paper
• Examination of survivin expression in 50 chordoma specimens—A histological and in vitro study

  2015cites this paper
• Survivin for chemotherapy efficacy in gastric cancer

  2015cites this paper
• Linking fms-like tyrosine kinase 3 and urokinase signalling to survivin expression in experimental arthritis

  2014cites this paper
• The role of the wnt signaling pathway in cancer stem cells: prospects for drug development

  2014cites this paper
• Survivin Modulates Genes with Divergent Molecular Functions and Regulates Proliferation of Hematopoietic Stem Cells through Evi-1

  2014cites this paper
• Physiological functions of TNF family receptor/ligand interactions in hematopoiesis and transplantation.

  2014cites this paper
• Survivin as a Preferential Target for Cancer Therapy

  2014cites this paper
• Wnt/Catenin Signaling in Adult Stem Cell Physiology and Disease

  2014cites this paper
• Molecular Regulators of Stem Cell Fate and Tumor Development in the Cerebellum

  2014cites this paper
• The role of the Wnt signaling pathway in cancer stem cells: prospects for drug development

  2014cites this paper
• Resistance of Hematopoietic Progenitors to Fas-Mediated Apoptosis Is Actively Sustained by NFκB with a Characteristic Transcriptional Signature

  2014cites this paper
• Apoptotic signaling through Fas and TNF receptors ameliorates GVHD in mobilized peripheral blood grafts

  2014cites this paper
• Prognostic Value and Targeted Inhibition of Survivin Expression in Esophageal Adenocarcinoma and Cancer-Adjacent Squamous Epithelium

  2013cites this paper
• Lack of differences in the pharmacokinetics of sepantronium bromide (YM155) between US and Japanese patients with advanced solid tumors or non-Hodgkin lymphoma.

  2013cites this paper
• (-)-Epigallocatechin-3-gallate Modulates the Differential Expression of Survivin Splice Variants and Protects Spermatogenesis During Testicular Torsion

  2013cites this paper
• Survivin-3B potentiates immune escape in cancer but also inhibits the toxicity of cancer chemotherapy.

  2013cites this paper
• Silencing of survivin using YM155 induces apoptosis and chemosensitization in neuroblastomas cells.

  2013cites this paper
• The Process of Apoptosis in a Holocrine Gland as Shown by the Avian Uropygial Gland

  2013cites this paper
• Depletion of PAK1 enhances Ubiquitin-mediated Survivin degradation in pancreatic β-cells

  2013cites this paper
• Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2.

  2013cites this paper
• Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease

  2013cites this paper
• Molecular and Cellular Pathobiology Survivin-3 B Potentiates Immune Escape in Cancer but Also Inhibits the Toxicity of Cancer Chemotherapy

  2013cites this paper
• Transcriptional regulation of the survivin gene

  2013cites this paper
• TNF‐α Has Tropic Rather than Apoptotic Activity in Human Hematopoietic Progenitors: Involvement of TNF Receptor‐1 and Caspase‐8

  2013cites this paper
• Interleukin Enhancer-binding Factor 3/NF110 Is a Target of YM155, a Suppressant of Survivin

  2012cites this paper
• Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease.

  2012cites this paper
• Role of the apoptotic and mitotic regulator survivin in melanoma.

  2012cites this paper
• The role of FLT3 kinase as an AML therapy target.

  2012cites this paper
• Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer.

  2012cites this paper
• Population pharmacokinetic modeling of Sepantronium bromide (YM155), a small molecule survivin suppressant, in patients with non-small cell lung cancer, hormone refractory prostate cancer, or unresectable stage III or IV melanoma

  2012cites this paper
• The Interface between BCR-ABL-Dependent and -Independent Resistance Signaling Pathways in Chronic Myeloid Leukemia

  2012cites this paper
• Calcium upregulated survivin expression and associated osteogenesis of normal human osteoblasts.

  2012cites this paper
• Activation of Fms-Like Tyrosine Kinase 3 Signaling Enhances Survivin Expression in a Mouse Model of Rheumatoid Arthritis

  2012cites this paper
• Differentiation and Cell Survival of Myeloid Leukemia Cells

  2012cites this paper
• Survivin in Solid Tumors: Rationale for Development of Inhibitors

  2012cites this paper
• Colorectal Cancer Stem Cells and Cell Death

  2011cites this paper
• Antitumor effects of YM155, a novel survivin suppressant, against human aggressive non-Hodgkin lymphoma.

  2011cites this paper
• Silencing Survivin Splice Variant 2B Leads to Antitumor Activity in Taxane-Resistant Ovarian Cancer

  2011cites this paper
• Survivin in skin pathologies

  2011cites this paper
• Is survivin the potential Achilles' heel of cancer?

  2011cites this paper
• Potential molecular targeting of splice variants for cancer treatment.

  2011cites this paper
• Carbenoxolone induces apoptosis and inhibits survivin and survivin-ΔEx3 genes expression in human leukemia K562 cells

  2011cites this paper
• Pulse exposure of haematopoietic grafts to prostaglandin E2in vitro facilitates engraftment and recovery

  2011cites this paper
• Pleiotropic effects of prostaglandin E2 in hematopoiesis; prostaglandin E2 and other eicosanoids regulate hematopoietic stem and progenitor cell function.

  2011cites this paper
• Eicosanoid Regulation of Hematopoietic Stem and Progenitor Cell Function

  2011influential citation
• Targeting survivin in leukemia

  2011cites this paper
• Anàlisi “ex vivo” de mecanismes d’inducció d’apoptosi i resistència al tractament en gliomes malignes

  2011cites this paper
• Survivin isoform expression patterns in CML patients correlate with resistance to imatinib and progression, but do not trigger cytolytic responses.

  2011cites this paper
• Survivin: Identification of Selective Functional Signaling Pathways inTransformed Cells and Identification of a New Splice Variant with Growth Survival Activity

  2011cites this paper
• Predictive markers for treatment sensitivity in head and neck squamous cell carcinoma

  2010cites this paper
• Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markers.

  2010cites this paper
• Small molecules and stem cells. Potency and lineage commitment: the new quest for the fountain of youth.

  2010cites this paper
• Survivin is a critical regulator of spindle organization and chromosome segregation during rat oocyte meiotic maturation

  2010cites this paper
• Biomarkers , Genomics , Proteomics , and Gene Regulation Generation of a Novel Transgenic Mouse Model for Bioluminescent Monitoring of Survivin Gene Activity in Vivo at Various Pathophysiological Processes Survivin Expression Overlaps with Stem Cell Markers

  2010cites this paper
• Overexpression of Survivin Initiates Hematologic Malignancies In Vivo

  2010cites this paper
• Down-Modulation of Survivin Expression and Inhibition of Tumor Growth In Vivo by EZN-3042, A Locked Nucleic Acid Antisense Oligonucleotide

  2010cites this paper
• Hsp70 est un nouveau régulateur majeur de l'érythropoïèse empêchant le clivage du facteur de transcription GATA-1 par la caspase-3 au cours de la différenciation.

  2010cites this paper
• Expression, purification and characterization of the extracellular domain of human Flt3 ligand in Escherichia coli

  2010cites this paper
• Survivin Selectively Modulates Genes Deregulated in Human Leukemia Stem Cells

  2010cites this paper
• Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?

  2010cites this paper
• Targeting of tumor radioiodine therapy by expression of the sodium iodide symporter under control of the survivin promoter

  2010cites this paper