Metalloproteinase MT1-MMP islets act as memory devices for podosome reemergence

Karim El azzouzi,Christiane Wiesner,S. Linder

Published 2016 in Journal of Cell Biology

ABSTRACT

The authors find that matrix metalloproteinase MT1-MMP is enriched at the plasma membrane of macrophage podosomes, where it persists beyond podosome lifetime and, through binding to the subcortical actin cytoskeleton, forms subcellular signposts that facilitate podosome reformation.

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