Nanoparticles for two-photon photodynamic therapy in living cells.

We describe here a nontoxic two-photon photodynamic nanoparticle platform and its cellular application. We demonstrate that the dye's potential toxicity can be circumvented by its permanent encapsulation into a biocompatible nanoparticle polymer matrix; this was examined by dye leaching experiments and confirmed by cell uptake experiments. Infrared two-photon nanoplatform phototoxicity was demonstrated for rat C6 glioma cells, while the controls showed no dark toxicity for these living cells.

• Publication year

  2006

• Venue

  Nano letters (Print)

• Publication date

  2006-10-24

• Fields of study

  Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.1021/NL0617179PMID 17090062PMCID PMC2577608
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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