EWS-FLI1 and Ewing’s Sarcoma: Recent Molecular Data and New Insights

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Cancer Biology & Therapy

• Publication date

  2002-05-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cbt.1.4.2900PMID 12432241
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Supplemental Information for

  2002cited by this paper
• A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.

  2002cited by this paper
• The EWS/NOR1 Fusion Gene Product Gains a Novel Activity Affecting Pre-mRNA Splicing*

  2002cited by this paper
• Direct regulation of BCL‐2 by FLI‐1 is involved in the survival of FLI‐1‐transformed erythroblasts

  2002cited by this paper
• Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines

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• The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts.

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• Alternative Spliced Transcripts as Cancer Markers

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• Basic fibroblast growth factor (bFGF)-induced cell death is mediated through a caspase-dependent and p53-independent cell death receptor pathway

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• Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in Ewing tumors

  2002cited by this paper
• Expression analysis of pediatric solid tumor cell lines using oligonucleotide microarrays.

  2002cited by this paper
• Molecular Analysis of the 9p21 Locus and p53 Genes in Ewing Family Tumors

  2001cited by this paper
• Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation

  2001cited by this paper
• Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts.

  2001cited by this paper
• PRCC, the commonest TFE3 fusion partner in papillary renal carcinoma is associated with pre-mRNA splicing factors

  2001cited by this paper
• Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia

  2001cited by this paper
• The ETS-domain transcription factor family

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• Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

  2001cited by this paper
• Downregulation and forced expression of EWS-Fli1 fusion gene results in changes in the expression of G 1 regulatory genes

  2001cited by this paper
• WWOX, the FRA16D gene, behaves as a suppressor of tumor growth.

  2001cited by this paper
• Oncogenic TLS/ERG and EWS/Fli-1 fusion proteins inhibit RNA splicing mediated by YB-1 protein.

  2001cited by this paper
• PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors

  2001cited by this paper
• Phosphorylation of the EWS IQ domain regulates transcriptional activity of the EWS/ATF1 and EWS/FLI1 fusion proteins

  2001cited by this paper
• EWS/FLI Alters 5′-Splice Site Selection*

  2001cited by this paper
• Identification of interaction partners for two closely-related members of the ETS protein family, FLI and ERG.

  2001cited by this paper
• Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5.

  2001cited by this paper
• Splicing factor SRP20 is a novel partner of BCL6 in a t(3;6)(q27;p21) translocation in transformed follicular lymphoma

  2001cited by this paper
• Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents.

  2001cited by this paper
• Aberrant expression of tumor suppressor proteins in the Ewing family of tumors.

  2001cited by this paper
• Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2 and c-Myc expression

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• The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25

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• Alternative mRNA splicing in colon cancer causes loss of expression of neural cell adhesion molecule.

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• Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia

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• Characterization of distinct consecutive phases in non-genotoxic p53-induced apoptosis of Ewing tumor cells and the rate-limiting role of caspase 8

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• Prognostic impact of P53 status in Ewing sarcoma

  2000cited by this paper
• Alternative pre-mRNA splicing: the logic of combinatorial control.

  2000cited by this paper
• EWS·Fli-1 Fusion Protein Interacts with Hyperphosphorylated RNA Polymerase II and Interferes with Serine-Arginine Protein-mediated RNA Splicing*

  2000cited by this paper
• Induction of cell death by basic fibroblast growth factor in Ewing's sarcoma.

  2000cited by this paper
• Modification of alternative splicing pathways as a potential approach to chemotherapy.

  2000cited by this paper
• EWS fli-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice.

  2000cited by this paper
• EWS-FLI1, EWS-ERG, and EWS-ETV1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type II receptor gene.

  2000cited by this paper
• The Ets family member Erg gene is expressed in mesodermal tissues and neural crests at fundamental steps during mouse embryogenesis.

  2000cited by this paper
• Molecular biology of the Ewing's sarcoma/primitive neuroectodermal tumor family.

  2000cited by this paper
• The role of Fli-1 in normal cell function and malignant transformation

  2000cited by this paper
• Suppression of the Ewing’s sarcoma phenotype by FLI1/ERF repressor hybrids

  2000cited by this paper
• Variability in Gene Expression Patterns of Ewing Tumor Cell Lines Differing in EWS-FLI1 Fusion Type

  2000cited by this paper
• Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint

  2000cited by this paper
• The Acute Myeloid Leukemia-Associated Protein, Dek, Forms a Splicing-Dependent Interaction with Exon-Product Complexes

  2000cited by this paper
• Association of EWS-FLI1 type 1 fusion with lower proliferative rate in Ewing's sarcoma.

  2000cited by this paper
• Prognostic impact of INK4A deletion in Ewing sarcoma

  2000cited by this paper
• Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation

  2000cited by this paper
• TLS-ERG Leukemia Fusion Protein Inhibits RNA Splicing Mediated by Serine-Arginine Proteins

  2000cited by this paper
• The Splicing Factor U1C Represses EWS/FLI-mediated Transactivation*

  2000cited by this paper
• Structure and assembly of the spliceosomal small nuclear ribonucleoprotein particles.

  1999cited by this paper
• Regulation of the human stress response gene GADD153 expression: role of ETS1 and FLI-1 gene products

  1999cited by this paper
• Fli-1, an Ets-Related Transcription Factor, Regulates Erythropoietin-Induced Erythroid Proliferation and Differentiation: Evidence for Direct Transcriptional Repression of the Rb Gene during Differentiation

  1999cited by this paper
• Overexpression of p53 protein in primary Ewing's sarcoma of bone: relationship to tumour stage, response and prognosis

  1999cited by this paper
• Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis.

  1999cited by this paper
• Activation of p53 by oncogenes.

  1999cited by this paper
• The Ewing family of tumors and the search for the Achilles' heel.

  1999cited by this paper
• INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

  1999cited by this paper
• Molecular phylogeny of the ETS gene family

  1999cited by this paper
• FLI-1 inhibits differentiation and induces proliferation of primary erythroblasts

  1999cited by this paper
• Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma.

  1999cited by this paper
• Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein

  1999cited by this paper
• Molecular genetics of chromosome translocations involving EWS and related family members.

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  1999cited by this paper
• Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity

  1999cited by this paper
• Peripheral primitive neuroectodermal tumors in adults: documentation by molecular analysis.

  1998cited by this paper
• EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction

  1998cited by this paper
• Homozygous deletions at chromosome 9p21 involving p16 and p15 are associated with histologic progression in follicle center lymphoma.

  1998cited by this paper
• Abnormalities of the FHIT Transcripts in Osteosarcoma and Ewing Sarcoma

  1998cited by this paper
• The Transcription Factor Spi-1/PU.1 Interacts with the Potential Splicing Factor TLS*

  1998cited by this paper
• EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma.

  1998cited by this paper
• The Transcriptional Repressor ZFM1 Interacts with and Modulates the Ability of EWS to Activate Transcription*

  1998cited by this paper
• Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.

  1998cited by this paper
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  1997cited by this paper
• The Insulin-like Growth Factor-I Receptor Is Required for EWS/FLI-1 Transformation of Fibroblasts*

  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors

  1997cited by this paper
• A new member of the ETS family fused to EWS in Ewing tumors

  1997cited by this paper
• EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells.

  1997cited by this paper
• Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?

  1996cited by this paper
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• Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma.

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• Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.

  1996cited by this paper
• EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro.

  1996cited by this paper
• A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma.

  1996cited by this paper
• Gene fusions encoding chimaeric transcription factors in solid tumours.

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• Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target.

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• The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene.

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• Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins.

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• Fusion of an ETS‐family gene, EIAF, to EWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy

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• Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas.

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