Biodegradability engineering of biodegradable Mg alloys: Tailoring the electrochemical properties and microstructure of constituent phases

Crystalline Mg-based alloys with a distinct reduction in hydrogen evolution were prepared through both electrochemical and microstructural engineering of the constituent phases. The addition of Zn to Mg-Ca alloy modified the corrosion potentials of two constituent phases (Mg + Mg2Ca), which prevented the formation of a galvanic circuit and achieved a comparable corrosion rate to high purity Mg. Furthermore, effective grain refinement induced by the extrusion allowed the achievement of much lower corrosion rate than high purity Mg. Animal studies confirmed the large reduction in hydrogen evolution and revealed good tissue compatibility with increased bone deposition around the newly developed Mg alloy implants. Thus, high strength Mg-Ca-Zn alloys with medically acceptable corrosion rate were developed and showed great potential for use in a new generation of biodegradable implants.

• Publication year

  2013

• Venue

  Scientific Reports

• Publication date

  2013-08-06

• Fields of study

  Medicine, Materials Science, Engineering, Environmental Science

• Identifiers
  DOI 10.1038/srep02367PMID 23917705PMCID 3734439
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization and Corrosion Behavior of Biodegradable Mg-Ca and Mg-Ca-Zn Implant Alloys

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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
• Research on an Mg-Zn alloy as a degradable biomaterial.

  2010cited by this paper
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  2010cited by this paper
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  2009cited by this paper
• Biodegradable alloys: The glass window of opportunities.

  2009cited by this paper
• In vitro corrosion and biocompatibility of binary magnesium alloys.

  2009cited by this paper
• A Review on

  2008cited by this paper
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  2008cited by this paper
• The development of binary Mg-Ca alloys for use as biodegradable materials within bone.

  2008cited by this paper
• Microstructure, mechanical properties and bio-corrosion properties of Mg–Zn–Mn–Ca alloy for biomedical application

  2008cited by this paper
• Degradable biomaterials based on magnesium corrosion

  2008cited by this paper
• Control of biodegradation of biocompatable magnesium alloys

  2007cited by this paper
• Magnesium and its alloys as orthopedic biomaterials: a review.

  2006cited by this paper
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  2005cited by this paper
• In vivo corrosion of four magnesium alloys and the associated bone response.

  2005cited by this paper
• Nutrition and metabolism.

  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  1996cited by this paper
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  1994cited by this paper
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  1967cited by this paper

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