Contaminants in Atlantic walruses in Svalbard Part 2: Relationships with endocrine and immune systems.

Marine mammals in the Barents Sea region have among the highest levels of contaminants recorded in the Arctic and the Atlantic walrus (Odobenus rosmarus rosmarus) is one of the most contaminated species within this region. We therefore investigated the relationships bewteen blubber concentrations of lipophilic persistent organic pollutants (POPs) and plasma concentrations of perfluoroalkyl substances (PFASs) and markers of endocrine and immune functions in adult male Atlantic walruses (n = 38) from Svalbard, Norway. To do so, we assessed plasma concentrations of five forms of thyroid hormones and transcript levels of genes related to the endocrine and immune systems as endpoints; transcript levels of seven genes in blubber and 23 genes in blood cells were studied. Results indicated that plasma total thyroxine (TT4) concentrations and ratio of TT4 and reverse triiodothyronine decreased with increasing blubber concentrations of lipophilic POPs. Blood cell transcript levels of genes involved in the function of T and B cells (FC like receptors 2 and 5, cytotoxic T-lymphocyte associated protein 4 and protein tyrosine phosphatase non-receptor type 22) were increased with plasma PFAS concentrations. These results suggest that changes in thyroid and immune systems in adult male walruses are linked to current levels of contaminant exposure.

• Publication year

  2019

• Venue

  Environmental Pollution

• Publication date

  2019-03-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.envpol.2018.11.097PMID 30611942
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Contaminants in Atlantic walruses in Svalbard part 1: Relationships between exposure, diet and pathogen prevalence.

  2019cited by this paper
• Brucella Antibodies in Alaskan True Seals and Eared Seals—Two Different Stories

  2018cited by this paper
• Ecotoxicologic Stress in Arctic Marine Mammals, With Particular Focus on Polar Bears

  2018cited by this paper
• Chlorinated Polyfluoroalkylether Sulfonates Exhibit Similar Binding Potency and Activity to Thyroid Hormone Transport Proteins and Nuclear Receptors as Perfluorooctanesulfonate.

  2018cited by this paper
• The classic pathways of thyroid hormone metabolism.

  2017cited by this paper
• Spatial Distributions of DDTs in the Water Masses of the Arctic Ocean.

  2017cited by this paper
• SHORT DURATION IMMOBILIZATION OF ATLANTIC WALRUS (ODOBENUS ROSMARUS ROSMARUS) WITH ETORPHINE, AND REVERSAL WITH NALTREXONE

  2017cited by this paper
• Protein tyrosine phosphatase PTPN22 has dual roles in promoting pathogen versus homeostatic‐driven CD8 T‐cell responses

  2017cited by this paper
• Environmental perfluorooctane sulfonate exposure drives T cell activation in bottlenose dolphins

  2017cited by this paper
• Possible mechanism for the polychlorinated bipheny-linduced liver-selective accumulation of thyroxine in rats.

  2017cited by this paper
• Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study (GoDARTS)

  2017cited by this paper
• Variation in adrenal and thyroid hormones with life-history stage in juvenile northern elephant seals (Mirounga angustirostris).

  2017cited by this paper
• Circulating thyroid hormones and associated metabolites in white whales (Delphinapterus leucas) determined using isotope‐dilution mass spectrometry

  2017cited by this paper
• Potentiation of ecological factors on the disruption of thyroid hormones by organo‐halogenated contaminants in female polar bears (Ursus maritimus) from the Barents Sea

  2017cited by this paper
• Immunomodulatory effects of exposure to polychlorinated biphenyls and perfluoroalkyl acids in East Greenland ringed seals (Pusa hispida).

  2016cited by this paper
• Fc Receptor-Like Proteins in Pathophysiology of B-cell Disorder

  2016cited by this paper
• Enhanced susceptibility of obese mice to glycidamide‐induced sperm chromatin damage without increased oxidative stress

  2016cited by this paper
• Environmental Chemicals Modulate Polar Bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and Adipogenesis in Vitro.

  2016cited by this paper
• Immunotoxic effects of environmental pollutants in marine mammals.

  2016cited by this paper
• Anthropogenic flank attack on polar bears: interacting consequences of climate warming and pollutant exposure

  2015cited by this paper
• Brucella CβG induces a dual pro- and anti-inflammatory response leading to a transient neutrophil recruitment

  2015cited by this paper
• Uridine Diphosphate-Glucuronosyltransferase (UGT) Xenobiotic Metabolizing Activity and Genetic Evolution in Pinniped Species.

  2015cited by this paper
• Transport of volume, heat, and salt towards the Arctic in the Faroe Current 1993–2013

  2015cited by this paper
• Arctic marine mammal population status, sea ice habitat loss, and conservation recommendations for the 21st century

  2015cited by this paper
• EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.

  2015cited by this paper
• Reporter Cell Lines for the Characterization of the Interactions between Human Nuclear Receptors and Endocrine Disruptors

  2015cited by this paper
• Nuclear Receptors, RXR, and the Big Bang.

  2014cited by this paper
• Biological Impact of the TSHβ Splice Variant in Health and Disease

  2014cited by this paper
• Thyroid hormone regulation of metabolism.

  2014cited by this paper
• Proportion of higher trophic-level prey in the diet of Pacific walruses (Odobenus rosmarus divergens)

  2014cited by this paper
• Deep water masses and sediments are main compartments for polychlorinated biphenyls in the Arctic Ocean.

  2014cited by this paper
• PCB related effects thresholds as derived through gene transcript profiles in locally contaminated ringed seals (Pusa hispida).

  2014cited by this paper
• Walruses recovering after 60+ years of protection in Svalbard, Norway

  2014cited by this paper
• In vitro PFOS exposure on immune endpoints in bottlenose dolphins (Tursiops truncatus) and mice

  2014cited by this paper
• MRNA expression of genes regulating lipid metabolism in ringed seals (Pusa hispida) from differently polluted areas.

  2014cited by this paper
• Inter-annual variability in the proportional contribution of higher trophic levels to the diet of Pacific walruses

  2014cited by this paper
• Development of a thyroperoxidase inhibition assay for high-throughput screening.

  2014cited by this paper
• A protein A/G indirect enzyme-linked immunosorbent assay for the detection of anti-Brucella antibodies in Arctic wildlife

  2013cited by this paper
• Structure-activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity.

  2013cited by this paper
• No Control Genes Required: Bayesian Analysis of qRT-PCR Data

  2013cited by this paper
• Associations between perfluoroalkyl compounds and immune and clinical chemistry parameters in highly exposed bottlenose dolphins (Tursiops truncatus)

  2013cited by this paper
• Effects of perfluoroalkyl acids on the function of the thyroid hormone and the aryl hydrocarbon receptor

  2013cited by this paper
• Health status, infection and disease in California sea lions (Zalophus californianus) studied using a canine microarray platform and machine-learning approaches.

  2012cited by this paper
• What have we learned from brucellosis in the mouse model?

  2012cited by this paper
• Primer3—new capabilities and interfaces

  2012cited by this paper
• Human blood RNA stabilization in samples collected and transported for a large biobank

  2012cited by this paper
• Changes in thyroid peroxidase activity in response to various chemicals.

  2012cited by this paper
• Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues

  2012cited by this paper
• Quantifying the Influence of Atlantic Heat on Barents Sea Ice Variability and Retreat

  2012cited by this paper
• A review of Brucella infection in marine mammals, with special emphasis on Brucella pinnipedialis in the hooded seal (Cystophora cristata)

  2011cited by this paper
• Impacts of changing sea-ice conditions on Arctic marine mammals

  2011cited by this paper
• Blood plasma sample preparation method for the assessment of thyroid hormone-disrupting potency in effect-directed analysis.

  2011cited by this paper
• In vitro evaluation of the immunotoxic potential of perfluorinated compounds (PFCs).

  2011cited by this paper
• New B-cell CD molecules.

  2011cited by this paper
• Analysis of thyroid hormones in serum of Baikal seals and humans by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and immunoassay methods: application of the LC-MS/MS method to wildlife tissues.

  2011cited by this paper
• Disruptive effects of persistent organohalogen contaminants on thyroid function in white whales (Delphinapterus leucas) from Svalbard.

  2011cited by this paper
• Levels and patterns of hydroxylated polychlorinated biphenyls (OH-PCBs) and their associations with thyroid hormones in hooded seal (Cystophora cristata) mother-pup pairs.

  2011cited by this paper
• Forming functional fat: a growing understanding of adipocyte differentiation

  2011cited by this paper
• The human glucocorticoid receptor: molecular basis of biologic function.

  2010cited by this paper
• Interleukin-2 receptor signaling: at the interface between tolerance and immunity.

  2010cited by this paper
• Comparative endocrine disruptive effects of contaminants in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea.

  2010cited by this paper
• Polychlorinated Biphenyl-Mediated Decrease in Serum Thyroxine Level in Rodents

  2010cited by this paper
• New insights into regulation of lipid metabolism by thyroid hormone.

  2010cited by this paper
• EFFECTOR MECHANISMS OF CELL-MEDIATED IMMUNITY

  2010cited by this paper
• Exposure and effects assessment of persistent organohalogen contaminants in arctic wildlife and fish.

  2010cited by this paper
• Fatty acid composition of the blubber and dermis of adult male Atlantic walruses (Odobenus rosmarus rosmarus) in Svalbard, and their potential prey

  2010cited by this paper
• A locus on chromosome 1p36 is associated with thyrotropin and thyroid function as identified by genome-wide association study.

  2010cited by this paper
• Molecular mechanism and function of CD40/CD40L engagement in the immune system

  2009cited by this paper
• Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype*

  2009cited by this paper
• Thyroid-Disrupting Chemicals: Interpreting Upstream Biomarkers of Adverse Outcomes

  2009cited by this paper
• Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism.

  2009cited by this paper
• Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

  2009cited by this paper
• Effects of climate change on Arctic marine mammal health.

  2008cited by this paper
• Mercury immune toxicity in harbour seals: links to in vitro toxicity

  2008cited by this paper
• Quantifying the sensitivity of Arctic marine mammals to climate-induced habitat change.

  2008cited by this paper
• Biotransformation of PCBs in relation to phase I and II xenobiotic-metabolizing enzyme activities in ringed seals (Phoca hispida) from Svalbard and the Baltic Sea.

  2008cited by this paper
• Suppression of humoral immunity in mice following exposure to perfluorooctane sulfonate.

  2008cited by this paper
• Bone‐related effects of contaminants in seals may be associated with vitamin D and thyroid hormones

  2008cited by this paper
• Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function.

  2008cited by this paper
• Immunotoxicity: the risk is real.

  2007cited by this paper
• Small self-RNA generated by RNase L amplifies antiviral innate immunity

  2007cited by this paper
• Contaminant-associated disruption of vitamin A and its receptor (retinoic acid receptor alpha) in free-ranging harbour seals (Phoca vitulina).

  2007cited by this paper
• Enhancements and modifications of primer design program Primer3

  2007cited by this paper
• A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats

  2007cited by this paper
• PCB-Related Alteration of Thyroid Hormones and Thyroid Hormone Receptor Gene Expression in Free-Ranging Harbor Seals (Phoca vitulina)

  2006cited by this paper
• A molecular perspective of CTLA-4 function.

  2006cited by this paper
• Congener-specific accumulation and patterns of chlorinated and brominated contaminants in adult male walruses from Svalbard, Norway: indications for individual-specific prey selection.

  2006cited by this paper
• New nomenclature for Fc receptor–like molecules

  2006cited by this paper
• Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia.

  2006cited by this paper
• Bmc Molecular Biology Selection of Reference Genes for Quantitative Rt-pcr Studies in Striped Dolphin (stenella Coeruleoalba) Skin Biopsies

  2006cited by this paper
• Transcriptional regulation of metabolism.

  2006cited by this paper
• Comparison of relative mRNA quantification models and the impact of RNA integrity in quantitative real-time RT-PCR

  2006cited by this paper
• Notch promotes survival of pre–T cells at the β-selection checkpoint by regulating cellular metabolism

  2005cited by this paper
• The Fatty Acid-binding Protein, aP2, Coordinates Macrophage Cholesterol Trafficking and Inflammatory Activity

  2005cited by this paper
• Alternate Pathways of Thyroid Hormone Metabolism

  2005cited by this paper
• UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects.

  2005cited by this paper
• The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.

  2005cited by this paper
• Thyroid Hormone Transporters in Health and Disease

  2005cited by this paper
• Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses.

  2004cited by this paper
• Relationships between PCBs and thyroid hormones and retinol in female and male polar bears.

  2004cited by this paper

• Differential associations between synthetic endocrine disruptors and renal function impairment across varying degrees in middle-aged and older adult populations

  2025cites this paper
• Fin Whale as a Sink of Legacy and Emerging Contaminants: First Integrated Chemical Exposomics and Gene Expression Analysis in Cetaceans

  2025cites this paper
• A Review of Circumpolar Arctic Marine Mammal Health—A Call to Action in a Time of Rapid Environmental Change

  2023cites this paper
• Ecotoxicological Characterization of Type C Killer Whales From Terra Nova Bay (Ross Sea, Antarctica): Molecular Biomarkers, Legacy, and Emerging Persistent Organic Contaminants

  2022cites this paper
• The adverse health effects of increasing microplastic pollution on aquatic mammals

  2022cites this paper
• A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure

  2022cites this paper
• Associations of exposure to perfluoroalkyl substances individually and in mixtures with persistent infections: Recent findings from NHANES 1999-2016.

  2021cites this paper
• Anthropogenic impacts on the Atlantic walrus

  2021cites this paper
• Per- and polyfluoroalkyl substances (PFAS), trace elements and life history parameters of mass-stranded common dolphins (Delphinus delphis) in New Zealand.

  2021cites this paper
• Perfluoroalkyl substances (PFASs) in white whales (Delphinapterus leucas) from Svalbard - A comparison of concentrations in plasma sampled 15 years apart.

  2020cites this paper
• Toward an integrated framework for assessing micropollutants in marine mammals: Challenges, progress, and opportunities

  2020cites this paper
• Persistent organic pollutant exposure and celiac disease: A pilot study.

  2020cites this paper