The efficacy of combined use of intraarticular and intravenous tranexamic acid on reducing blood loss and transfusion rate in total knee arthroplasty.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Arthroplasty

• Publication date

  2015-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.arth.2014.12.001PMID 25534864
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013influential reference
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  2013cited by this paper
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  2013cited by this paper
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  2013influential reference
• The effect of tranexamic acid on blood loss and use of blood products in total knee arthroplasty: a meta-analysis

  2012influential reference
• Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty

  2012influential reference
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  2012influential reference
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  2010influential reference
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  2009cited by this paper
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  2009cited by this paper
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  1999cited by this paper
• The effect of tranexamic acid on local and plasma fibrinolysis during total knee arthroplasty.

  1997cited by this paper
• Tranexamic Acid Radically Decreases Blood Loss and Transfusions Associated with Total Knee Arthroplasty

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  1995cited by this paper
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  1995cited by this paper
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  1977cited by this paper
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  1976cited by this paper
• Prediction of blood volume in normal human adults.

  1962cited by this paper

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