Phosphorylation: a molecular switch in opioid tolerance.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Life Science

• Publication date

  2006-09-27

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.LFS.2006.05.023PMID 16831450
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Failures and successes of NMDA receptor antagonists: Molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults

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• Morphine Promotes Rapid, Arrestin-Dependent Endocytosis of μ-Opioid Receptors in Striatal Neurons

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• Neuronal nitric oxide modulates morphine antinociceptive tolerance by enhancing constitutive activity of the μ-opioid receptor

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• Morphine promotes phosphorylation of the human δ-opioid receptor at serine 363

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• Morphine promotes phosphorylation of the human delta-opioid receptor at serine 363.

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• Comment On

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• The effects of FK506 on the development and expression of morphine tolerance and dependence in mice

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• The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA.

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• Converging Protein Kinase Pathways Mediate Adenylyl Cyclase Superactivation upon Chronic δ-Opioid Agonist Treatment

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• Morphine Acutely Regulates Opioid Receptor Trafficking Selectively in Dendrites of Nucleus Accumbens Neurons

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• Inhibition by immunophilin ligands of morphine-induced tolerance and dependence in guinea pig ileum.

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• Identification of two C-terminal amino acids, Ser(355) and Thr(357), required for short-term homologous desensitization of mu-opioid receptors.

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• Inhibition of spinal protein kinase Cα expression by an antisense oligonucleotide attenuates morphine infusion-induced tolerance

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• Involvement of Spinal Protein Kinase Cγ in the Attenuation of Opioid μ-Receptor-Mediated G-Protein Activation after Chronic Intrathecal Administration of [d-Ala2,N-MePhe4,Gly-Ol5]Enkephalin

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• Constitutively Active μ-Opioid Receptors Inhibit Adenylyl Cyclase Activity in Intact Cells and Activate G-proteins Differently than the Agonist [d-Ala2,N-MePhe4,Gly-ol5]Enkephalin

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• Constitutively Active (cid:1) -Opioid Receptors Inhibit Adenylyl Cyclase Activity in Intact Cells and Activate G-proteins Differently than the Agonist [ D -Ala 2 , N -MePhe 4 ,Gly-ol 5 ]Enkephalin*

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• Expression of α-Transducin in Chinese Hamster Ovary Cells Stably Transfected with the Human δ-Opioid Receptor Attenuates Chronic Opioid Agonist-Induced Adenylyl Cyclase Superactivation

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• Protein Kinase C-Mediated Inhibition of μ-Opioid Receptor Internalization and Its Involvement in the Development of Acute Tolerance to Peripheral μ-Agonist Analgesia

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• Heterologous Activation of Protein Kinase C Stimulates Phosphorylation of δ-Opioid Receptor at Serine 344, Resulting in β-Arrestin- and Clathrin-mediated Receptor Internalization*

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• Threonine 180 Is Required for G-protein-coupled Receptor Kinase 3- and β-Arrestin 2-mediated Desensitization of the μ-Opioid Receptor in Xenopus Oocytes*

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• Chronic morphine induces the concomitant phosphorylation and altered association of multiple signaling proteins: A novel mechanism for modulating cell signaling

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• Expression of alpha-transducin in Chinese hamster ovary cells stably transfected with the human delta-opioid receptor attenuates chronic opioid agonist-induced adenylyl cyclase superactivation.

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• Phosphorylation of Ser363, Thr370, and Ser375 Residues within the Carboxyl Tail Differentially Regulates μ-Opioid Receptor Internalization*

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• Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC&ggr; mutant mice

  2001cited by this paper
• Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization.

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• Regulation of opioid receptor function by chronic agonist exposure: constitutive activity and desensitization.

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• Protein kinase C-mediated inhibition of mu-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral mu-agonist analgesia.

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• Changes in the expression of G protein‐coupled receptor kinases and β‐arrestin 2 in rat brain during opioid tolerance and supersensitivity

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• Molecular neurobiology of addiction.

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• Role for C-Tail Residues in Delta Opioid Receptor Downregulation

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• Colocalization of the mu-opioid receptor and calcium/calmodulin-dependent kinase II in distinct pain-processing brain regions.

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• Protein kinase C-mediated acute tolerance to peripheral mu-opioid analgesia in the bradykinin-nociception test in mice.

  2000cited by this paper
• Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.

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• μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

  2000cited by this paper
• Allelic Variation S268P of the Human μ-Opioid Receptor Affects Both Desensitization and G Protein Coupling

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• Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusion

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