Plasmin-Sensitive Dibasic Sequences in the Third Fibronectin-like Domain of L1–Cell Adhesion Molecule (CAM) Facilitate Homomultimerization and Concomitant Integrin Recruitment

L1 is a multidomain transmembrane neural recognition molecule essential for neurohistogenesis. While moieties in the immunoglobulin-like domains of L1 have been implicated in both heterophilic and homophilic binding, the function of the fibronectin (FN)-like repeats remains largely unresolved. Here, we demonstrate that the third FN-like repeat of L1 (FN3) spontaneously homomultimerizes to form trimeric and higher order complexes. Remarkably, these complexes support direct RGD-independent interactions with several integrins, including αvβ3 and α5β1. A pep- tide derived from the putative C-C′ loop of FN3 (GSQRKHSKRHIHKDHV852) also forms trimeric complexes and supports αvβ3 and α5β1 binding. Substitution of the dibasic RK841 and KR845 sequences within this peptide or the FN3 domain limited multimerization and abrogated integrin binding. Evidence is presented that the multimerization of, and integrin binding to, the FN3 domain is regulated both by conformational constraints imposed by other domains and by plasmin- mediated cleavage within the sequence RK↓HSK↓RH846. The integrin α9β1, which also recognizes the FN3 domain, colocalizes with L1 in a manner restricted to sites of cell–cell contact. We propose that distal receptor ligation events at the cell–cell interface may induce a conformational change within the L1 ectodomain that culminates in receptor multimerization and integrin recruitment via interaction with the FN3 domain.

• Publication year

  2000

• Venue

  Journal of Cell Biology

• Publication date

  2000-06-26

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1083/JCB.149.7.1485PMID 10871287PMCID 2175144
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997influential reference
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  1997cited by this paper
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• Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3

  1996cited by this paper
• Possible involvement of plasmin in long-term potentiation of rat hippocampal slices.

  1996cited by this paper
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  1996cited by this paper
• Outline structure of the human L1 cell adhesion molecule and the sites where mutations cause neurological disorders.

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• Structural Analysis of the Murine Cell Adhesion Molecule L1 by Electron Microscopy and Computer‐assisted Modelling

  1996influential reference
• L1 adhesion molecule on human lymphocytes and monocytes: expression and involvement in binding to alpha v beta 3 integrin.

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  1995cited by this paper
• Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

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  1995influential reference
• Adhesive hierarchy involving the cell adhesion molecules L1, CD24, and alpha 6 integrin in murine neuroblastoma N2A cells.

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  1995influential reference
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  1994influential reference
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• Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle [published erratum appears in J Cell Biol 1994 Feb;124(3):395]

  1993cited by this paper
• A developmental study of soluble L1

  1990influential reference
• A plasminogen activator is induced during goldfish optic nerve regeneration.

  1990cited by this paper
• Drosophila neuroglian: a member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1.

  1989cited by this paper
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  1988cited by this paper
• Biochemical Characterization of Different Molecular Forms of the Neural Cell Adhesion Molecule L1

  1988influential reference
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• Plasminogen activator release at the neuronal growth cone.

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  2008cites this paper
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