Inhibition of T Helper Cell Type 2 Cell Differentiation and Immunoglobulin E Response by Ligand-Activated Vα14 Natural Killer T Cells

Murine Vα14 natural killer T (NKT) cells are thought to play a crucial role in various immune responses, including infectious, allergic, and autoimmune diseases. Because Vα14 NKT cells produce large amounts of both interleukin (IL)-4 and interferon (IFN)-γ upon in vivo stimulation with a specific ligand, α-galactosylceramide (α-GalCer), or after treatment with anti-CD3 antibody, a regulatory role on helper T (Th) cell differentiation has been proposed for these cells. However, the identity of the cytokine produced by Vα14 NKT cells that play a dominant role on the Th cell differentiation still remains controversial. Here, we demonstrate by using Vα14 NKT-deficient mice that Vα14 NKT cells are dispensable for the induction of antigen-specific immunoglobulin (Ig)E responses induced by ovalbumin immunization or Nippostrongylus brasiliensis infection. However, upon in vivo activation with α-GalCer, Vα14 NKT cells are found to suppress antigen-specific IgE production. The suppression appeared to be IgE specific, and was not detected in either Vα14 NKT– or IFN-γ–deficient mice. Consistent with these results, we also found that ligand-activated Vα14 NKT cells inhibited Th2 cell differentiation in an in vitro induction culture system. Thus, it is likely that activated Vα14 NKT cells exert a potent inhibitory effect on Th2 cell differentiation and subsequent IgE production by producing a large amount of IFN-γ. In marked contrast, our studies have revealed that IL-4 produced by Vα14 NKT cells has only a minor effect on Th2 cell differentiation.

• Publication year

  1999

• Venue

  Journal of Experimental Medicine

• Publication date

  1999-09-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.190.6.783PMID 10499917PMCID 2195639
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CD1d-restricted and TCR-mediated activation of V α14 NKT cells by glycosylceramides

  2000influential reference
• T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation.

  1999cited by this paper
• CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells.

  1999cited by this paper
• The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells

  1999cited by this paper
• Requirement for gammadelta T cells in allergic airway inflammation.

  1998cited by this paper
• Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol.

  1998cited by this paper
• Cytokines induce the development of functionally heterogeneous T helper cell subsets.

  1998cited by this paper
• Requirement for p56(lck) tyrosine kinase activation in Th subset differentiation.

  1998cited by this paper
• Requirement for γδ T Cells in Allergic Airway Inflammation

  1998cited by this paper
• Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches.

  1997cited by this paper
• Requirement for Vα14 NKT Cells in IL-12-Mediated Rejection of Tumors

  1997influential reference
• Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes.

  1997cited by this paper
• CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.

  1997cited by this paper
• Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice.

  1997cited by this paper
• Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors.

  1997cited by this paper
• CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.

  1997cited by this paper
• Immunoglobulin E Production in the Absence of Interleukin-4-Secreting CD1-Dependent Cells

  1997cited by this paper
• Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1.

  1997cited by this paper
• Phenotypes and invariant alpha beta TCR expression of peripheral V alpha 14+ NK T cells.

  1997cited by this paper
• Essential requirement of an invariant V alpha 14 T cell antigen receptor expression in the development of natural killer T cells.

  1996cited by this paper
• IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses.

  1996cited by this paper
• gd T Cells from Tolerized ab T Cell Receptor ( TCR ) – deficient Mice Inhibit Contact Sensitivity-Effector T Cells In Vivo , and Their Interferon-g Production In Vitro

  1996cited by this paper
• Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)- microglobulin-deficient BALB/c mice

  1996cited by this paper
• Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

  1996cited by this paper
• Functional diversity of helper T lymphocytes

  1996cited by this paper
• Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

  1996cited by this paper
• Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

  1996cited by this paper
• Essential role of Stat6 in IL-4 signalling

  1996cited by this paper
• Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses

  1996cited by this paper
• Enhancing effects of (2S,3S,4R)-1-O-(alpha-D-galactopyranosyl)-2-(N-hexacosanoylamino) -1,3,4-octadecanetriol (KRN7000) on antigen-presenting function of antigen-presenting cells and antimetastatic activity of KRN7000-pretreated antigen-presenting cells.

  1996cited by this paper
• Beta 2-microglobulin-dependent T cells are dispensable for allergen- induced T helper 2 responses

  1996cited by this paper
• γδ T Cells from Tolerized αβ T Cell Receptor (TCR)–deficient Mice Inhibit Contact Sensitivity-Effector T Cells In Vivo, and Their Interferon-γ Production In Vitro

  1996cited by this paper
• IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

  1996cited by this paper
• Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

  1996cited by this paper
• Development of Valpha4+ NK T cells in the early stages of embryogenesis.

  1996cited by this paper
• Genetic Susceptibility to Leishmania: IL-12 Responsiveness in TH1 Cell Development

  1996cited by this paper
• Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.

  1995cited by this paper
• Role of NK1.1+ T Cells in a TH2 Response and in Immunoglobulin E Production

  1995cited by this paper
• Predominant expression of invariant Vα14+ TCR α chain in NK1.1+ T cell populations

  1995cited by this paper
• Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

  1995cited by this paper
• Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo.

  1995cited by this paper
• In susceptible mice, Leishmania major induce very rapid interleukin‐4 production by CD4+ T cells which are NK1.1−

  1995cited by this paper
• Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product.

  1995cited by this paper
• Positive selection of invariant V alpha 14+ T cells by non-major histocompatibility complex-encoded class I-like molecules expressed on bone marrow-derived cells.

  1995cited by this paper
• Early IL-4 production by non-CD4+ cells at the site of antigen deposition predicts the development of a T helper 2 cell response to Schistosoma mansoni eggs.

  1995cited by this paper
• Predominant expression of invariant V alpha 14+ TCR alpha chain in NK1.1+ T cell populations.

  1995cited by this paper
• Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4.

  1995cited by this paper
• Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha

  1995cited by this paper
• Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection.

  1994cited by this paper
• CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3

  1994cited by this paper
• Acquisition of lymphokine-producing phenotype by CD4+ T cells.

  1994cited by this paper
• Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells.

  1994cited by this paper
• A subset of CD4+ thymocytes selected by MHC class I molecules.

  1994cited by this paper
• An Invariant T Cell Receptor ~x Chain Is Used by a Unique Subset of Major Histocompatibility Complex Class I-specific Cd4 + and Cd4-8-t Cells in Mice and Humans

  1994cited by this paper
• Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice

  1994cited by this paper
• Acquisition of lymphokine-producing phenotype by CD4+ T cells.

  1994cited by this paper
• An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans

  1994cited by this paper
• Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

  1993cited by this paper
• Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.

  1993cited by this paper
• Mechanism and regulation of immunoglobulin isotype switching.

  1993cited by this paper
• Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice

  1993cited by this paper
• Fc epsilon receptor-positive cells are a major source of antigen-induced interleukin-4 in spleens of mice infected with Schistosoma mansoni.

  1993cited by this paper
• Disruption of the murine IL-4 gene blocks Th2 cytokine responses

  1993cited by this paper
• Differential regulation of murine T lymphocyte subsets.

  1993cited by this paper
• Fcϵ receptor‐positive cells are a major source of antigen‐induced interIeukin‐4 in spleens of mice infected with Schistosoma mansoni

  1993cited by this paper
• Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

  1992cited by this paper
• Induction of TH1 and TH2 responses: a key role for the 'natural' immune response?

  1992cited by this paper
• The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice

  1992cited by this paper
• An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor V beta family.

  1992cited by this paper
• The fate of CD4-8- T cell receptor-alpha beta+ thymocytes.

  1991cited by this paper
• Generation and analysis of interleukin-4 deficient mice.

  1991cited by this paper
• Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils.

  1991cited by this paper
• Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4- producing cells

  1990cited by this paper
• IL-4 directs the development of Th2-like helper effectors.

  1990cited by this paper
• Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells

  1990cited by this paper
• Unusual T cell populations in adult murine bone marrow. Prevalence of CD3+CD4-CD8- and alpha beta TCR+NK1.1+ cells.

  1990cited by this paper
• NK1.1+ thymocytes. Adult murine CD4-, CD8- thymocytes contain an NK1.1+, CD3+, CD5hi, CD44hi, TCR-V beta 8+ subset.

  1990cited by this paper
• Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

  1989cited by this paper
• Protective immunity and eosinophilia in IgE-deficient SJA/9 mice infected with Nippostrongylus brasiliensis and Trichinella spiralis.

  1988cited by this paper
• Studies on murine IgE with monoclonal antibodies. I. Characterization of rat monoclonal anti-IgE antibodies and the use of these antibodies for determinations of serum IgE levels and for anaphylactic reactions.

  1988cited by this paper
• Studies on Murine IgE with Monoclonal Antibodies

  1988cited by this paper
• Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes

  1987cited by this paper
• A novel population of T-cell receptor αβ-bearing thymocytes which predominantly expresses a single Vβ gene family

  1987cited by this paper
• A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family.

  1987cited by this paper
• Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

  1986cited by this paper
• A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

  1986cited by this paper
• Differential regulation of T helper phenotype development by interleukins 4 and 10 in an c43 T-cell-receptor transgenic system

  year unknowncited by this paper

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