Incidence and time course of everolimus-related adverse events in postmenopausal women with hormone receptor-positive advanced breast cancer: insights from BOLERO-2

H. Rugo,K. Pritchard,M. Gnant,S. Noguchi,M. Piccart,G. Hortobagyi,J. Baselga,Alejandra T. Perez,M. Geberth,T. Csőszi,E. Chouinard,V. Srimuninnimit,P. Puttawibul,J. Eakle,W. Feng,H. Bauly,M. El-Hashimy,T. Taran,H. Burris

Published 2014 in Annals of Oncology

ABSTRACT

The BOLERO-2 trial demonstrated that adding everolimus to exemestane substantially improved clinical benefit with acceptable safety in postmenopausal women with HR+ breast cancer relapsing/progressing on a nonsteroidal aromatase inhibitor. Incidences and severities of everolimus-related toxicity were consistent with other oncology settings, and were manageable using established strategies.

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