Effects of hyperoxia on VEGF, its receptors, and HIF-2alpha in the newborn rat lung.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  American Journal of Physiology - Lung cellular and Molecular Physiology

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Environmental Science

• Identifiers
  PMID 12626331
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons.

  2002cited by this paper
• Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

  2002cited by this paper
• Bronchopulmonary dysplasia.

  2001cited by this paper
• A new mathematical model for relative quantification in real-time RT-PCR.

  2001cited by this paper
• Hypoxia induces vascular endothelial growth factor gene transcription in human osteoblast-like cells through the hypoxia-inducible factor-2alpha.

  2001cited by this paper
• VEGF induces airway epithelial cell proliferation in human fetal lung in vitro.

  2001cited by this paper
• Role of vascular endothelial growth factor in regulation of physiological angiogenesis.

  2001cited by this paper
• Timing of hyperoxic exposure during alveolarization influences damage mediated by leukotrienes.

  2001cited by this paper
• Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia.

  2001cited by this paper
• Differential regulation of diverse physiological responses to VEGF in pulmonary endothelial cells.

  2001cited by this paper
• Inhibition of angiogenesis decreases alveolarization in the developing rat lung.

  2000cited by this paper
• Stretch-induced upregulation of VEGF gene expression in murine pulmonary culture: a role for angiogenesis in lung development.

  2000cited by this paper
• Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice.

  1999cited by this paper
• Differential expression of VEGF mRNA splice variants in newborn and adult hyperoxic lung injury.

  1999cited by this paper
• Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal‐induced interaction with CBP/p300

  1999cited by this paper
• Exposure to hyperoxia decreases the expression of vascular endothelial growth factor and its receptors in adult rat lungs.

  1999cited by this paper
• VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo

  1998cited by this paper
• A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.

  1997cited by this paper
• Mechanisms of angiogenesis

  1997cited by this paper
• Extracellular Cleavage of the Vascular Endothelial Growth Factor 189-Amino Acid Form by Urokinase Is Required for Its Mitogenic Effect*

  1997cited by this paper
• Hyperoxic injury decreases alveolar epithelial cell expression of vascular endothelial growth factor (VEGF) in neonatal rabbit lung.

  1997cited by this paper
• Leukotrienes are indicated as mediators of hyperoxia-inhibited alveolarization in newborn rats.

  1997cited by this paper
• Vascular endothelial growth factor, a specific regulator of angiogenesis

  1996cited by this paper
• Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats.

  1996cited by this paper
• Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

  1995cited by this paper
• Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

  1995cited by this paper
• Neonatal pulmonary oxygen toxicity in the rat and lung changes with aging

  1990cited by this paper
• Postnatal development of alveoli. Regulation and evidence for a critical period in rats.

  1985cited by this paper
• Oxygen-Induced Alterations in Lung Vascular Development in the Newborn Rat

  1983cited by this paper
• The postnatal growth of the rat lung II. Autoradiography

  1974cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Longitudinal transcriptomic analysis of the hyperoxia-exposed preterm rabbit as a model of BPD

  2025cites this paper
• Hypoxia as a medicine

  2025cites this paper
• Caffeine Protects Against Hyperoxia-Induced Structural Lung Injury and Restores Alveolar Development in Neonatal Rats

  2025cites this paper
• Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease

  2025cites this paper
• Interplay of hypoxia-inducible factors and oxygen therapy in cardiovascular medicine

  2023cites this paper
• Endothelial-Specific Loss of IKKβ Disrupts Pulmonary Endothelial Angiogenesis and Impairs Postnatal Lung Growth.

  2023cites this paper
• Effects of Hyperoxia on Aging Biomarkers: A Systematic Review

  2022cites this paper
• Decreased plasma levels of PDGF-BB, VEGF-A, and HIF-2α in preterm infants after ibuprofen treatment

  2022cites this paper
• Hyperoxia and Lungs: What We Have Learned From Animal Models

  2021cites this paper
• Role of vitamin D–vitamin D receptor signaling on hyperoxia‐induced bronchopulmonary dysplasia in neonatal rats

  2021cites this paper
• Prolonged oxygen exposure causes the mobilization and functional damage of stem or progenitor cells and exacerbates cardiac ischemia or reperfusion injury in healthy mice

  2021cites this paper
• Hyperoxia-induced S1P1 signaling reduced angiogenesis by suppression of TIE-2 leading to experimental bronchopulmonary dysplasia

  2021cites this paper
• Systemic Factors Associated with a Thinner Choroid in Preterm Infants

  2021cites this paper
• New Pharmacologic Approaches to Bronchopulmonary Dysplasia

  2021cites this paper
• Maternal Vitamin D Deficiency Causes Sustained Impairment of Lung Structure and Function and Increases Susceptibility to Hyperoxia-Induced Lung Injury in Infant Rats.

  2020cites this paper
• Preterm birth impairs postnatal lung development in the neonatal rabbit model

  2020influential citation
• Lung development and emerging roles for type 2 immunity

  2019cites this paper
• Caspase-1 Inhibition Attenuates Hyperoxia-Induced Lung and Brain Injury in Neonatal Mice.

  2019cites this paper
• Intra-tracheal administration of a naked plasmid expressing stromal derived factor-1 improves lung structure in rodents with experimental bronchopulmonary dysplasia

  2019cites this paper
• Bronchopulmonary Dysplasia: Crosstalk Between PPARγ, WNT/β-Catenin and TGF-β Pathways; The Potential Therapeutic Role of PPARγ Agonists

  2019cites this paper
• Effect of intermittent hypoxia or hyperoxia on lung development in preterm rat neonates during constant oxygen therapy

  2019cites this paper
• Caffeine is associated with improved alveolarization and angiogenesis in male mice following hyperoxia induced lung injury

  2019cites this paper
• Antioxidants & bronchopulmonary dysplasia: Beating the system or beating a dead horse?

  2019cites this paper
• Role of the HIF-1 signaling pathway in chronic obstructive pulmonary disease

  2018cites this paper
• Maternal omega-3 PUFA supplementation prevents hyperoxia-induced pulmonary hypertension in the offspring.

  2018cites this paper
• Distinct roles for IκB kinases alpha and beta in regulating pulmonary endothelial angiogenic function during late lung development

  2018cites this paper
• Sex‐specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro: Role of Hif‐1&agr;

  2017cites this paper
• The angiogenic response of human dental pulp to orthodontic force application

  2017cites this paper
• Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway.

  2017cites this paper
• Effects of Hyperoxia on the Developing Airway and Pulmonary Vasculature.

  2017cites this paper
• Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome

  2017cites this paper
• Influence of prenatal hypoxia and postnatal hyperoxia on morphologic lung maturation in mice

  2017cites this paper
• Can We Understand the Pathobiology of Bronchopulmonary Dysplasia?

  2017cites this paper
• Disruption of Essential Developmental Pathways Impaired and Dysmorphic Pulmonary Vascular Growth

  2017cites this paper
• Differential sex-specific effects of oxygen toxicity in human umbilical vein endothelial cells.

  2017cites this paper
• Protective effects of BMSCs in combination with erythropoietin in bronchopulmonary dysplasia-induced lung injury.

  2016cites this paper
• Effects of intermittent hypoxia and hyperoxia on angiogenesis and lung development in newborn mice

  2016cites this paper
• Aberrant Pulmonary Vascular Growth and Remodeling in Bronchopulmonary Dysplasia

  2016cites this paper
• Mesenchymal stem cells in combination with erythropoietin repair hyperoxia-induced alveoli dysplasia injury in neonatal mice via inhibition of TGF-β1 signaling

  2016cites this paper
• Bridging Lung Development with Chronic Obstructive Pulmonary Disease. Relevance of Developmental Pathways in Chronic Obstructive Pulmonary Disease Pathogenesis.

  2016cites this paper
• Sphingolipids in Congenital Diaphragmatic Hernia; Results from an International Multicenter Study

  2016cites this paper
• Sex-specific differences in neonatal hyperoxic lung injury.

  2016cites this paper
• Postnatal growth restriction augments oxygen-induced pulmonary hypertension in a neonatal rat model of bronchopulmonary dysplasia

  2016cites this paper
• Sphingolipids as cell fate regulators in lung development and disease

  2015influential citation
• Intestinal Vascular Endothelial Growth Factor Is Decreased in Necrotizing Enterocolitis

  2015cites this paper
• Activation of the nuclear factor-κB pathway during postnatal lung inflammation preserves alveolarization by suppressing macrophage inflammatory protein-2.

  2015cites this paper
• Hypoxia-inducible factor-1 stimulates postnatal lung development but does not prevent O2-induced alveolar injury.

  2015cites this paper
• Adapted approach to profile genes while reconciling Vegf-a mRNA expression in the developing and injured lung.

  2015cites this paper
• Omeprazole Attenuates Pulmonary Aryl Hydrocarbon Receptor Activation and Potentiates Hyperoxia-Induced Developmental Lung Injury in Newborn Mice.

  2015cites this paper
• Effects of hyperoxic exposure on signal transduction pathways in the lung.

  2015cites this paper
• Bone marrow-derived mesenchymal stem cells protect against lung injury in a mouse model of bronchopulmonary dysplasia.

  2015cites this paper
• Bridging lung development with COPD : relevance of developmental pathways in COPD pathogenesis

  2015cites this paper
• Sphingolipids in lung growth and repair.

  2014cites this paper
• Nuclear Factor-Kappa-B Signaling in Lung Development and Disease: One Pathway, Numerous Functions

  2014cites this paper
• Alveolar type II cells maintain bioenergetic homeostasis in hypoxia through metabolic and molecular adaptation.

  2014cites this paper
• Diabetic macular edema.

  2014cites this paper
• Role of Reactive Oxygen Species in Neonatal Pulmonary Vascular Disease

  2014cites this paper
• Perinatal and Prenatal Disorders

  2014cites this paper
• Animal models of bronchopulmonary dysplasia. The preterm and term rabbit models.

  2014cites this paper
• Effects of a superoxide dismutase mimetic on biomarkers of lung angiogenesis and alveolarization during hyperoxia with intermittent hypoxia.

  2013cites this paper
• The role of hyperoxia in the pathogenesis of experimental BPD.

  2013cites this paper
• Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-γ Agonist, Restores Alveolar and Pulmonary Vascular Development in a Rat Model of Bronchopulmonary Dysplasia

  2013cites this paper
• HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression.

  2013cites this paper
• Beyond pulmonary hypertension: sildenafil for chronic lung disease of prematurity.

  2013cites this paper
• Chronic lung disease in the preterm infant. Lessons learned from animal models.

  2013cites this paper
• AMBIENT OXYGEN AVAILABILITY MODULATES EXPRESSION OF VASCULAR ANGIOGENIC FACTORS AND CAPILLARY REMODELING (ANGIOPLASTICITY) IN THE MOUSE BRAIN

  2013cites this paper
• Lung Injury and Repair

  2013cites this paper
• Mesenchymal stem cells protect against neonatal rat hyperoxic lung injury

  2013cites this paper
• Fluoxetine may worsen hyperoxia-induced lung damage in neonatal rats.

  2012cites this paper
• Decreased VEGF expression and microvascular density, but increased HIF-1 and 2α accumulation and EPO expression in chronic moderate hyperoxia in the mouse brain.

  2012cites this paper
• Role of EC-SOD Overexpression in Preserving Pulmonary Angiogenesis Inhibited by Oxidative Stress

  2012cites this paper
• VEGF levels in humans and animal models with RDS and BPD: Temporal relationships

  2012cites this paper
• The Role of Semaphorin-Neuropilin-1 Signalling in Pulmonary Vascular Development

  2012cites this paper
• Effects of Oxidative Stress and Antenatal Corticosteroids on the Pulmonary Expression of Vascular Endothelial Growth Factor (VEGF) and Alveolarization

  2012cites this paper
• Hypoxia up-regulates expression of hemoglobin in alveolar epithelial cells.

  2011cites this paper
• Vitamin A and Retinoic Acid Act Synergistically to Increase Lung Retinyl Esters During Normoxia and Reduce Hyperoxic Lung Injury in Newborn Mice

  2010cites this paper
• 26S Proteasome Activity Is Down-Regulated in Lung Cancer Stem-Like Cells Propagated In Vitro

  2010cites this paper
• Effects of Antenatal Betamethasone and Dexamethasone on the Lung Expression of Vascular Endothelial Growth Factor and Alveolarization in Newborn Rats Exposed to Acute Hypoxia and Recovered in Normoxia or Hyperoxia

  2010cites this paper
• Angiostatins decrease in the kidney of newborn piglets after hypoxia-reoxygenation.

  2010cites this paper
• Moderate postnatal hyperoxia accelerates lung growth and attenuates pulmonary hypertension in infant rats after exposure to intra-amniotic endotoxin.

  2010cites this paper
• Association of Increased Pulmonary Interleukin-6 with the Priming Effect of Intra-Amniotic Lipopolysaccharide on Hyperoxic Lung Injury in a Rat Model of Bronchopulmonary Dysplasia

  2009cites this paper
• Pulmonary effects of keratinocyte growth factor in newborn rats exposed to hyperoxia.

  2009cites this paper
• Time course of alterations in pre- and post-synaptic chemoreceptor function during developmental hyperoxia.

  2009cites this paper
• Balance of growth factors in the human perinatal lung : Implications for physiological lung development and link to bronchopulmonary dysplasia

  2009cites this paper
• Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis

  2009cites this paper
• Bronchopulmonary dysplasia and emphysema: in search of common therapeutic targets.

  2009cites this paper
• Pulmonary Vascular Endothelial Growth Factor Expression and Disaturated Phospholipid Content in a Chicken Model of Hypoxia-Induced Fetal Growth Restriction

  2009cites this paper
• Placental Growth Factor and Vascular Endothelial Growth Factor Receptor-2 in Human Lung Development

  2008cites this paper
• Developmental regulation of NO-mediated VEGF-induced effects in the lung.

  2008cites this paper
• Cord compression may rapidly influence the expression of placental angiogenic genes in pre-eclampsia.

  2008cites this paper
• Recombinant Human Clara Cell Secretory Protein Treatment Increases Lung mRNA Expression of Surfactant Proteins and Vascular Endothelial Growth Factor in a Premature Lamb Model of Respiratory Distress Syndrome

  2008cites this paper
• Bronchopulmonary dysplasia and early prophylactic inhaled nitric oxide in preterm infants: current concepts and future research strategies in animal models

  2008cites this paper
• VEGF Attenuates Hyperoxic Injury through Decreased Apoptosis in Explanted Rat Embryonic Lung

  2008cites this paper
• The cellular basis for diverse responses to oxygen.

  2007cites this paper
• Hypoxia-inducible factors HIF-1α and HIF-2α are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs

  2007cites this paper
• Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs.

  2007cites this paper
• Intrauterine pulmonary hypertension impairs angiogenesis in vitro: role of vascular endothelial growth factor nitric oxide signaling.

  2007cites this paper
• Molecular Mechanisms of Pulmonary Vascular Development

  2007cites this paper
• Retinal growth hormone in perinatal and adult rats

  2007cites this paper
• Altered Expressions of Fibroblast Growth Factor Receptors and Alveolarization in Neonatal Mice Exposed to 85% Oxygen

  2007cites this paper