Operational tolerance in kidney transplantation and associated biomarkers

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Clinical and Experimental Immunology

• Publication date

  2017-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/cei.12981PMID 28449211PMCID PMC5508347
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of Ex Vivo–Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques

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• Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial

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• Erosion of Transplantation Tolerance After Infection

  2017cited by this paper
• IL-10-produced by human transitional B-cells down-regulates CD86 expression on B-cells leading to inhibition of CD4+T-cell responses

  2016cited by this paper
• Fingerprints of transplant tolerance suggest opportunities for immunosuppression minimization.

  2016cited by this paper
• Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?

  2016cited by this paper
• Acquisition of C3d‐Binding Activity by De Novo Donor‐Specific HLA Antibodies Correlates With Graft Loss in Nonsensitized Pediatric Kidney Recipients

  2016cited by this paper
• Application of Operational Tolerance Signatures Are Limited by Variability and Type of Immunosuppression in Renal Transplant Recipients: A Cross-Sectional Study

  2016cited by this paper
• Failure of Calcineurin Inhibitor (Tacrolimus) Weaning Randomized Trial in Long‐Term Stable Kidney Transplant Recipients

  2016cited by this paper
• Immune monitoring in renal transplantation: The search for biomarkers

  2016cited by this paper
• Effect of tolerance versus chronic immunosuppression protocols on the quality of life of kidney transplant recipients.

  2016cited by this paper
• The DESCARTES-Nantes survey of kidney transplant recipients displaying clinical operational tolerance identifies 35 new tolerant patients and 34 almost tolerant patients.

  2016cited by this paper
• Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss.

  2015cited by this paper
• B Cell Markers of Operational Tolerance Can Discriminate Acute Kidney Allograft Rejection From Stable Graft Function

  2015cited by this paper
• Central Role of CD45RA-Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance

  2015cited by this paper
• Tolerant Kidney Transplant Patients Produce B Cells with Regulatory Properties.

  2015cited by this paper
• B-lymphocytes support and regulate indirect T-cell alloreactivity in individual patients with chronic antibody-mediated rejection.

  2015cited by this paper
• Circulating biomarkers of tolerance.

  2015cited by this paper
• A Three-Gene Assay for Monitoring Immune Quiescence in Kidney Transplantation.

  2015influential reference
• Central Role of CD45RA- Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance.

  2015cited by this paper
• Chimerism, Graft Survival, and Withdrawal of Immunosuppressive Drugs in HLA Matched and Mismatched Patients After Living Donor Kidney and Hematopoietic Cell Transplantation

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• Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients

  2015cited by this paper
• Longitudinal Studies of a B Cell–Derived Signature of Tolerance in Renal Transplant Recipients

  2015influential reference
• Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance

  2015cited by this paper
• Adverse Outcomes of Tacrolimus Withdrawal in Immune-Quiescent Kidney Transplant Recipients.

  2015cited by this paper
• Immune Reconstitution/Immunocompetence in Recipients of Kidney Plus Hematopoietic Stem/Facilitating Cell Transplants

  2015cited by this paper
• Unexplained post-renal transplant tolerance: a case report

  2015cited by this paper
• A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft

  2015cited by this paper
• Graft Failure Due to Noncompliance Among 628 Kidney Transplant Recipients With Long-term Follow-up: A Single-Center Observational Study

  2014cited by this paper
• Unique B Cell Differentiation Profile in Tolerant Kidney Transplant Patients

  2014influential reference
• Gene expression signature of tolerance and lymphocyte subsets in stable renal transplants: results of a cross-sectional study.

  2014cited by this paper
• B cells with immune-regulating function in transplantation

  2014cited by this paper
• Long‐Term Results in Recipients of Combined HLA‐Mismatched Kidney and Bone Marrow Transplantation Without Maintenance Immunosuppression

  2014cited by this paper
• 15-Year Follow-up of a Multicenter, Randomized, Calcineurin Inhibitor Withdrawal Study in Kidney Transplantation

  2014cited by this paper
• HCV-Induced Immune Responses Influence the Development of Operational Tolerance After Liver Transplantation in Humans

  2014cited by this paper
• Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients

  2013cited by this paper
• B-Cell-Related Biomarkers of Tolerance are Up-Regulated in Rejection-Free Kidney Transplant Recipients

  2013cited by this paper
• Expansion of Memory-Type CD8+ T Cells Correlates With the Failure of Early Immunosuppression Withdrawal After Cadaver Liver Transplantation Using High-Dose ATG Induction and Rapamycin

  2013cited by this paper
• HLA-mismatched renal transplantation without maintenance immunosuppression.

  2013cited by this paper
• Prospective assessment of antidonor cellular alloreactivity is a tool for guidance of immunosuppression in kidney transplantation.

  2013cited by this paper
• Operational tolerance in kidney transplantation-improved terminology may enable more precise investigation.

  2013cited by this paper
• Transplantation tolerance

  2013cited by this paper
• Molecular markers of rejection and tolerance: lessons from clinical research.

  2013cited by this paper
• GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation.

  2012cited by this paper
• The Natural History of Clinical Operational Tolerance After Kidney Transplantation Through Twenty‐Seven Cases

  2012cited by this paper
• Combined introduction of anti-IL2 receptor antibodies, mycophenolic acid and tacrolimus: effect on malignancies after renal transplantation in a single-centre retrospective cohort study.

  2012cited by this paper
• Chimerism and Tolerance Without GVHD or Engraftment Syndrome in HLA-Mismatched Combined Kidney and Hematopoietic Stem Cell Transplantation

  2012cited by this paper
• Transplantation: Is donor T-cell engraftment a biomarker for tolerance?

  2012cited by this paper
• Preserving the B-Cell Compartment Favors Operational Tolerance in Human Renal Transplantation

  2012cited by this paper
• Tolerogenic therapies in transplantation

  2012cited by this paper
• Spontaneous Operational Tolerance in Kidney Transplant Recipients: Response

  2012cited by this paper
• Donor‐Specific Indirect Pathway Analysis Reveals a B‐Cell‐Independent Signature which Reflects Outcomes in Kidney Transplant Recipients

  2012cited by this paper
• Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation.

  2012cited by this paper
• Cellular Infiltrates and NF&kgr;B Subunit c-Rel Signaling in Kidney Allografts of Patients With Clinical Operational Tolerance

  2012cited by this paper
• Spontaneous Operational Tolerance in Kidney Transplant Recipients

  2012cited by this paper
• Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant.

  2012cited by this paper
• Identification of a gene expression profile associated with operational tolerance among a selected group of stable kidney transplant patients

  2011cited by this paper
• Intragraft Regulatory T Cells in Protocol Biopsies Retain Foxp3 Demethylation and Are Protective Biomarkers for Kidney Graft Outcome

  2011cited by this paper
• Clinical transplantation tolerance

  2011cited by this paper
• Donor-Specific Indirect Pathway Analysis Reveals a B-Cell-Independent Signature which Reflects Outcomes in Kidney Transplant Recipients

  2011influential reference
• Long‐Term Allograft Tolerance Is Characterized by the Accumulation of B Cells Exhibiting an Inhibited Profile

  2011cited by this paper
• Liver antigen-presenting cells.

  2011cited by this paper
• New-Onset Diabetes After Renal Transplantation

  2011cited by this paper
• Comparison of Transcriptional and Blood Cell‐Phenotypic Markers Between Operationally Tolerant Liver and Kidney Recipients

  2011influential reference
• Histological findings in two renal transplants accomplishing operational tolerance criteria

  2011cited by this paper
• Operational tolerance after immunosuppressive withdrawal in a case with renal transplantation.

  2011cited by this paper
• Identification of a B cell signature associated with renal transplant tolerance in humans.

  2010influential reference
• Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans.

  2010influential reference
• Differential monocyte STAT6 activation and CD4(+)CD25(+)Foxp3(+) T cells in kidney operational tolerance transplanted individuals.

  2010cited by this paper
• Clinical Operational Tolerance After Renal Transplantation: Current Status and Future Challenges

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• Is calculating the standard deviation of tacrolimus blood levels the new gold standard for evaluating non‐adherence to medications in transplant recipients?

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• Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype.

  2010influential reference
• Early and Limited Use of Tacrolimus to Avoid Rejection in an Alemtuzumab and Sirolimus Regimen for Kidney Transplantation: Clinical Results and Immune Monitoring

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• Successful Reduction of Immunosuppression in Older Renal Transplant Recipients Who Exhibit Donor-Specific Regulation

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• Clinical transplantation tolerance: a myth no more, but...

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• HLA-mismatched renal transplantation without maintenance immunosuppression.

  2008cited by this paper
• Immunosuppressive drug‐free operational immune tolerance in human kidney transplant recipients: Part I. blood gene expression statistical analysis

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• Differential gene expression profiles are dependent upon method of peripheral blood collection and RNA isolation

  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• A HaemAtlas: characterizing gene expression in differentiated human blood cells

  2008cited by this paper
• Immunosuppressive therapy and tolerance of organ allografts.

  2008cited by this paper
• The renal cortical interstitium: morphological and functional aspects

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• Effect on Kidney Graft Survival of Reducing or Discontinuing Maintenance Immunosuppression After the First Year Posttransplant

  2008cited by this paper
• The 'short' history of regulatory B cells.

  2008cited by this paper
• Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance

  2007cited by this paper
• Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance

  2007influential reference
• A Retrospective Analysis of Immunosuppression Compliance, Dose Reduction and Discontinuation in Kidney Transplant Recipients

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• DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells

  2007cited by this paper
• TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation

  2007cited by this paper
• Cutting Edge: Transplant Tolerance Induced by Anti-CD45RB Requires B Lymphocytes1

  2007cited by this paper
• Multiparameter Immune Profiling of Operational Tolerance in Liver Transplantation

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• Human CD4+CD25low Adaptive T Regulatory Cells Suppress Delayed-Type Hypersensitivity during Transplant Tolerance1

  2007influential reference
• Humoral and Cellular Responses to Influenza Vaccination in Human Recipients Naturally Tolerant to a Kidney Allograft

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• Clinical Operational Tolerance after Kidney Transplantation

  2006influential reference
• Contrasting CD25hiCD4+T Cells/FOXP3 Patterns in Chronic Rejection and Operational Drug-Free Tolerance

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• How can we measure immunologic tolerance in humans?

  2006influential reference
• Transplant Tolerance: Converging on a Moving Target

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• An Appraisal of Tolerance in Liver Transplantation

  2006cited by this paper
• Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.

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• Single-cell transcriptomics reveals targeted modulation of inflammatory repertoire by SOCE blockers.

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• Tolerogenic Therapies in Cardiac Transplantation

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• Plasma immune signatures can predict rejection-free survival in the first year after pediatric liver transplantation.

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• Discovery of cellular and genetic signatures of immune tolerance in kidney transplant recipients through single cell RNA sequencing analysis.

  2023influential citation
• An exome-wide study of renal operational tolerance

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• More than four decades of graft survival in pediatric kidney transplant recipients

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• Incidental detection of operational tolerance in a deceased donor kidney transplant recipient lost to follow-up for more than 10 years: A case report and literature review

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• A Lesson of Immunosuppression in Renal Transplant: Retreat or Hold?

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• The gray area between operational tolerance and overt rejection in kidney transplantation

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• Emerging local immunomodulatory strategies to circumvent systemic immunosuppression in cell transplantation

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• Revisiting transplant immunology through the lens of single-cell technologies

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• Clinical and Basic Research Progress on Treg-Induced Immune Tolerance in Liver Transplantation

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• Myeloid and Mesenchymal Stem Cell Therapies for Solid Organ Transplant Tolerance

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• Self-Centered Function of Adaptive Immunity in Regulation of Immune Responses and in Tolerance

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• Indicators of monocyte-derived component of the immune system in patients with satisfactory renal graft function

  2020cites this paper
• Long-term Prognosis of Kidney Allograft Function

  2020cites this paper
• Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy

  2020cites this paper
• The dynamics of CD3+ CD4+ CD8+ T-lymphocytes in kidney transplant recipients in the early and late post-transplantation period

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• Recent Advances on Biomarkers of Early and Late Kidney Graft Dysfunction

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• Progress in Translational Regulatory T Cell Therapies for Type 1 Diabetes and Islet Transplantation.

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• Research of subpopulation CD3+ CD4- CD8- double-negative T lymphocytes in kidney transplant recipients

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• АКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ТРАНСПЛАНТОЛОГИИ ACTUAL ISSUES OF TRANSPLANTATION

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• CD3+CD4+CD25+ activated T cells and CD3+CD4+CD25+highCD127+low T-regulatory lymphocytes in patients after kidney transplantation with various types of post-transplantation period

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• Clinical Operational Tolerance and Immunosuppression Minimization in Kidney Transplantation: Where Do We Stand?

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