Splanchnic lipolysis in human obesity.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Clinical Investigation

• Publication date

  2004-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI21047PMID 15173884PMCID PMC419492
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Splanchnic free fatty acid kinetics.

  2003influential reference
• Energy expenditure, sex, and endogenous fuel availability in humans.

  2003influential reference
• Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus.

  2002cited by this paper
• Systemic and regional free fatty acid metabolism in type 2 diabetes.

  2001cited by this paper
• Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity.

  2001cited by this paper
• Measuring leg muscle and fat mass in humans: comparison of CT and dual-energy X-ray absorptiometry.

  2000influential reference
• Insulin regulation of regional free fatty acid metabolism.

  1999cited by this paper
• Glycerol and nonesterified fatty acid metabolism in human muscle and adipose tissue in vivo.

  1999cited by this paper
• Regional postprandial fatty acid metabolism in different obesity phenotypes.

  1999cited by this paper
• Regional lipolytic responses to isoproterenol in women.

  1997cited by this paper
• Purinergic agonists, but not cAMP, stimulate coupled granule fusion and Cl- conductance in HT29-Cl.16E.

  1997cited by this paper
• Contribution of leg and splanchnic free fatty acid (FFA) kinetics to postabsorptive FFA flux in men and women.

  1996cited by this paper
• Measurement of abdominal and visceral fat with computed tomography and dual-energy x-ray absorptiometry.

  1995cited by this paper
• Skeletal muscle utilization of free fatty acids in women with visceral obesity.

  1995influential reference
• Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans.

  1995cited by this paper
• Gender differences in regional fatty acid metabolism before and after meal ingestion.

  1995cited by this paper
• Free Fatty Acid as a Link in the Regulation of Hepatic Glucose Output by Peripheral Insulin

  1995cited by this paper
• Interaction between glucose and free fatty acid metabolism in human skeletal muscle.

  1993cited by this paper
• Assessment of body composition with use of dual-energy x-ray absorptiometry: evaluation and comparison with other methods.

  1993cited by this paper
• How valid are isotopic measurements of fatty acid oxidation?

  1991cited by this paper
• Saturation kinetics of palmitate uptake in perfused skeletal muscle

  1991cited by this paper
• Effects of body fat distribution on regional lipolysis in obesity.

  1991influential reference
• Regulation of forearm lipolysis in different types of obesity. In vivo evidence for adipocyte heterogeneity.

  1991cited by this paper
• Micro-Method for Measurement of Sub-Nanomole Amounts of Triacylglycerol

  1990cited by this paper
• "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes.

  1990cited by this paper
• Metabolism of adipose tissue in intraabdominal depots of nonobese men and women.

  1989cited by this paper
• Biology of regional body fat distribution: relationship to non-insulin-dependent diabetes mellitus.

  1989cited by this paper
• Heterogeneous distribution of beta and alpha‐2 adrenoceptor binding sites in human fat cells from various fat deposits: functional consequences

  1987cited by this paper
• Validation of a new method for determination of free fatty acid turnover.

  1987cited by this paper
• Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity.

  1987cited by this paper
• Effect of fatty acids on glucose production and utilization in man.

  1983cited by this paper
• Relation of body fat distribution to metabolic complications of obesity.

  1982cited by this paper
• Role of insulin resistance in adipose tissue and liver in the pathogenesis of endogenous hypertriglyceridaemia in man

  1976cited by this paper
• Leg blood flow during exercise in man.

  1971cited by this paper
• Hepatic metabolism of free fatty acids in normal and diabetic dogs.

  1970cited by this paper
• Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans.

  1970influential reference
• FREE FATTY ACID METABOLISM BY SKELETAL MUSCLE.

  1964cited by this paper
• THE ESTIMATION OF HEPATIC BLOOD FLOW IN MAN.

  1945cited by this paper

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