Parkin in Parkinson’s Disease and Cancer: a Double-Edged Sword

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Molecular Neurobiology

• Publication date

  2018-01-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12035-018-0879-1PMID 29349575
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2017influential reference
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• Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

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• PARK2 orchestrates cyclins to avoid cancer

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• Differential risks of cancer types in people with Parkinson's disease: a national record-linkage study.

  2014cited by this paper
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• The hallmarks of Parkinson's disease

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• Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease.

  2013cited by this paper
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  2012cited by this paper
• Cancer genetics and epigenetics: two sides of the same coin?

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• Common fragile sites: mechanisms of instability revisited.

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• Regulation of cell migration by dynamic microtubules.

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• Allelic loss of 6q25-27, the PARKIN tumor suppressor gene locus, in cervical carcinoma

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• Restriction of trophic factors and nutrients induces PARKIN expression

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• Hallmarks of cancer: the next generation.

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• Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

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• Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

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• Otto Warburg's contributions to current concepts of cancer metabolism

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• Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells.

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• Autoregulation of Parkin activity through its ubiquitin‐like domain

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• Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria.

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• The familial Parkinson Disease gene PARK2 is a multisite tumor suppressor on chromosome 6q25.2-27 that regulates cyclin E

  2010cited by this paper
• Replication dynamics at common fragile site FRA6E

  2010cited by this paper
• Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

  2010influential reference
• Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy*

  2010cited by this paper
• Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

  2010cited by this paper
• PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

  2010cited by this paper
• Parkin Enhances the Expression of Cyclin-dependent Kinase 6 and Negatively Regulates the Proliferation of Breast Cancer Cells*

  2010influential reference
• Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

  2010cited by this paper
• Cancer risk in association with Parkinson disease: a population-based study.

  2010cited by this paper
• Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling

  2009cited by this paper
• Impaired dopamine release and synaptic plasticity in the striatum of Parkin−/− mice

  2009cited by this paper
• Attenuation of proteolysis‐mediated cyclin E regulation by alternatively spliced Parkin in human colorectal cancers

  2009cited by this paper
• Neuroinflammation in Parkinson’s Disease

  2009cited by this paper
• Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule‐dependent mechanism

  2009cited by this paper
• Parkin Protects Dopaminergic Neurons against Microtubule-depolymerizing Toxins by Attenuating Microtubule-associated Protein Kinase Activation*

  2009cited by this paper
• Mice Expressing Mutant Parkin Exhibit Hallmark Features of Parkinson's Disease

  2009cited by this paper
• Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair.

  2009cited by this paper
• Attenuation of proteolysis-mediated cyclin E regulation by alternatively spliced Parkin in human colorectal cancers

  2009cited by this paper
• Protein degradation in Parkinson disease revisited: it's complex.

  2009cited by this paper
• Regulation of DNA repair by parkin.

  2009cited by this paper
• Molecular basis of Parkinson's disease.

  2009cited by this paper
• Glial Dysfunction in Parkin Null Mice: Effects of Aging

  2008cited by this paper
• Combined kinase inhibition modulates parkin inactivation

  2008cited by this paper
• Cell Type-Specific Upregulation of Parkin in Response to ER Stress

  2007cited by this paper
• Mortality, oxidative stress and tau accumulation during ageing in parkin null mice

  2007cited by this paper
• Calcium, ageing, and neuronal vulnerability in Parkinson's disease.

  2007cited by this paper
• A Prospective Cohort Study of Cancer Incidence Following the Diagnosis of Parkinson's Disease

  2007cited by this paper
• Phosphorylation of Parkin by the Cyclin-dependent Kinase 5 at the Linker Region Modulates Its Ubiquitin-Ligase Activity and Aggregation*

  2007cited by this paper
• Chromosome fragile sites.

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• Inflammation and cancer: An ancient link with novel potentials

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• Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia

  2006cited by this paper
• Parkin enhances mitochondrial biogenesis in proliferating cells.

  2006cited by this paper
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• Parkin-mediated lysine 63-linked polyubiquitination: a link to protein inclusions formation in Parkinson's and other conformational diseases?

  2006cited by this paper
• Accumulation of the Authentic Parkin Substrate Aminoacyl-tRNA Synthetase Cofactor, p38/JTV-1, Leads to Catecholaminergic Cell Death

  2005cited by this paper
• Molecular pathophysiology of Parkinson's disease.

  2005cited by this paper
• Differential effects of l‐DOPA on monoamine metabolism, cell survival and glutathione production in midbrain neuronal‐enriched cultures from parkin knockout and wild‐type mice

  2005cited by this paper
• Parkin Stabilizes Microtubules through Strong Binding Mediated by Three Independent Domains*

  2005cited by this paper
• Parkin Phosphorylation and Modulation of Its E3 Ubiquitin Ligase Activity*

  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
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  2004cited by this paper
• S-Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function

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• N-myc Regulates Parkin Expression*

  2004cited by this paper
• Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis.

  2004cited by this paper
• The anti-angiogenic basis of metronomic chemotherapy

  2004cited by this paper
• Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice*

  2004cited by this paper
• Parkin attenuates manganese‐induced dopaminergic cell death

  2004cited by this paper
• Alterations of the Tumor Suppressor Gene Parkin in Non-Small Cell Lung Cancer

  2004cited by this paper
• Parkin gene alterations in hepatocellular carcinoma

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• Integrity of actin fibers and microtubules influences metastatic tumor cell adhesion.

  2004cited by this paper
• Atypical cancer pattern in patients with Parkinson's disease

  2004cited by this paper
• Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons*

  2003cited by this paper
• Parkin Facilitates the Elimination of Expanded Polyglutamine Proteins and Leads to Preservation of Proteasome Function*

  2003cited by this paper
• ReviewMitochondria : Releasing Power for Life and Unleashing the Machineries of Death

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• Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity.

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• Parkin and Endoplasmic Reticulum Stress

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• Metastasis suppressors alter the signal transduction of cancer cells

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• Parkinson's Disease and Mitotherapy-Based Approaches towards α-Synucleinopathies.

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