Interactions of microbicide nanoparticles with a simulated vaginal fluid.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Molecular Pharmaceutics

• Publication date

  2012-10-08

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/mp300408mPMID 23003680
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chitosan nanoparticles: a survey of preparation methods

  2012cited by this paper
• Polymeric Nanoparticles Affect the Intracellular Delivery, Antiretroviral Activity and Cytotoxicity of the Microbicide Drug Candidate Dapivirine

  2012cited by this paper
• Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus

  2012cited by this paper
• Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.

  2012cited by this paper
• Mucoadhesive nanomedicines: characterization and modulation of mucoadhesion at the nanoscale

  2011cited by this paper
• Biological hydrogels as selective diffusion barriers.

  2011cited by this paper
• Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus.

  2011cited by this paper
• HIV sexual transmission and microbicides

  2011cited by this paper
• An adsorption chromatography assay to probe bulk particle transport through hydrogels.

  2011cited by this paper
• Mucoadhesive nanosystems for vaginal microbicide development: friend or foe?

  2011cited by this paper
• Disruption of the mucus barrier by topically applied exogenous particles.

  2010cited by this paper
• Barrier properties of gastrointestinal mucus to nanoparticle transport.

  2010cited by this paper
• Nanotechnology-based systems for the treatment and prevention of HIV/AIDS.

  2010cited by this paper
• The Impact of Vehicles on the Mucoadhesive Properties of Orally Administrated Nanoparticles: a Case Study with Chitosan-4-Thiobutylamidine Conjugate

  2010cited by this paper
• Characterization of particle translocation through mucin hydrogels.

  2010cited by this paper
• Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

  2010cited by this paper
• Development and validation of a rapid reversed-phase HPLC method for the determination of the non-nucleoside reverse transcriptase inhibitor dapivirine from polymeric nanoparticles.

  2010cited by this paper
• Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

  2009cited by this paper
• The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles.

  2009cited by this paper
• Altering Mucus Rheology to “Solidify” Human Mucus at the Nanoscale

  2009cited by this paper
• Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses

  2009cited by this paper
• Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.

  2009cited by this paper
• Introduction: Back to basics: mucosal immunity and novel HIV vaccine concepts

  2009cited by this paper
• Movements of HIV-virions in human cervical mucus.

  2009cited by this paper
• Rheological properties of vaginal hydrophilic polymer gels.

  2009cited by this paper
• Human Immunodeficiency Virus Type 1 Is Trapped by Acidic but Not by Neutralized Human Cervicovaginal Mucus

  2009cited by this paper
• Controlled surface modification with poly(ethylene)glycol enhances diffusion of PLGA nanoparticles in human cervical mucus.

  2009cited by this paper
• Vaginal Drug Delivery Systems for HIV Prevention

  2009cited by this paper
• Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery.

  2009cited by this paper
• Barrier properties of mucus.

  2009cited by this paper
• Rheological synergy in aqueous mixtures of pectin and mucin

  2008cited by this paper
• Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier.

  2008cited by this paper
• Performance of an in vitro mucoadhesion testing method for vaginal semisolids: influence of different testing conditions and instrumental parameters.

  2008cited by this paper
• Effect of pH on the association behavior in aqueous solutions of pig gastric mucin.

  2008cited by this paper
• Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

  2008cited by this paper
• Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles.

  2007cited by this paper
• Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus

  2007cited by this paper
• Rheology of gastric mucin exhibits a pH-dependent sol-gel transition.

  2007cited by this paper
• Intracellular Delivery of Saquinavir in Biodegradable Polymeric Nanoparticles for HIV/AIDS

  2006cited by this paper
• Mucin structure, aggregation, physiological functions and biomedical applications

  2006cited by this paper
• Macrophage uptake of core-shell nanoparticles surface modified with poly(ethylene glycol).

  2006cited by this paper
• Poly(ethylene oxide)-modified poly(ɛ-caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer

  2005cited by this paper
• Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems.

  2005cited by this paper
• Real-time multiple-particle tracking: applications to drug and gene delivery.

  2005cited by this paper
• Atomic force microscopy reveals aggregation of gastric mucin at low pH.

  2005cited by this paper
• Viscoelastic properties and dynamics of porcine gastric mucin.

  2005cited by this paper
• Poly(ethylene oxide)-modified poly(epsilon-caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer.

  2005cited by this paper
• Feature point tracking and trajectory analysis for video imaging in cell biology.

  2005cited by this paper
• Chapter 4 – Mucus

  2005cited by this paper
• Transport of Polymeric Nanoparticle Gene Carriers in Gastric Mucus

  2004cited by this paper
• Efficient active transport of gene nanocarriers to the cell nucleus

  2003cited by this paper
• Assemblies for In Vitro Measurement of Bioadhesive Strength and Retention Characteristics in Simulated Vaginal Environment

  2002cited by this paper
• Effects of chelating agents on the rheological property of cervical mucus.

  2002cited by this paper
• Entanglement Coupling in Porcine Stomach Mucin

  2002cited by this paper
• Characterization of chitosan hydrochloride--mucin rheological interaction: influence of polymer concentration and polymer:mucin weight ratio.

  2001cited by this paper
• Estimating the viscoelastic moduli of complex fluids using the generalized Stokes–Einstein equation

  2000cited by this paper
• A vaginal fluid simulant.

  1999cited by this paper
• Acid Production by Vaginal Flora In Vitro Is Consistent with the Rate and Extent of Vaginal Acidification

  1999cited by this paper
• A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration.

  1998cited by this paper
• Particle Tracking Microrheology of Complex Fluids

  1997cited by this paper
• Comparative rheological investigation of crude gastric mucin and natural gastric mucus.

  1997cited by this paper
• Mucoadhesion of colloidal particulate systems in the gastro-intestinal tract

  1997cited by this paper
• Single-particle tracking: applications to membrane dynamics.

  1997cited by this paper
• [Cervical mucus].

  1993cited by this paper
• Human cervical mucus: Research update

  1991cited by this paper

• Mucosal administration of lipid nanoparticles containing self-amplifying mRNA induces local uptake and expression in a pig model as a potential vaccination platform against STIs

  2025cites this paper
• Recent advances in in vitro models simulating the female genital tract toward more effective intravaginal therapeutic delivery

  2024cites this paper
• Nanomedicines for intranasal delivery: understanding the nano-bio interactions at the nasal mucus-mucosal barrier

  2024cites this paper
• Ex Vivo and In Vivo Retention Time Evaluation of Fucoidan Isolated from Macrocystis pyrifera Through a Thermosensitive Gel System in The Vaginal Route

  2024cites this paper
• Cotton Fibers with a Lactic Acid‐Like Surface for Re‐establishment of Protective Lactobacillus Microbiota by Selectively Inhibiting Vaginal Pathogens

  2023cites this paper
• Mucus-Permeable Sonodynamic Therapy Mediated Amphotericin B-Loaded PEGylated PLGA Nanoparticles Enable Eradication of Candida albicans Biofilm

  2023cites this paper
• Passive and Active Microrheology for Biomedical Systems

  2022cites this paper
• In vitro and ex vivo models for evaluating vaginal drug delivery systems.

  2022cites this paper
• Simulated vaginal fluid: Candida resistant strains' biofilm characterization and vapor phase of essential oil effect.

  2022cites this paper
• Vaginal epithelial drug delivery.

  2022cites this paper
• Nanomedicine for vaginal drug delivery

  2021cites this paper
• Characterization of Bioadhesion, Mucin‐interactions and Mucosal Permeability of Pharmaceutical Nano‐ and Microsystems

  2021cites this paper
• Validation of spectrophotometric method to quantify cabotegravir in simulated vaginal fluid and porcine vaginal tissue in ex vivo permeation and retention studies from thermosensitive and mucoadhesive gels.

  2021cites this paper
• Development of thermosensitive and mucoadhesive gels of cabotegravir for enhanced permeation and retention profiles in vaginal tissue: A proof of concept study.

  2021cites this paper
• MPTHub: An Open-Source Software for Characterizing the Transport of Particles in Biorelevant Media

  2021cites this paper
• Nanomedicines for the topical treatment of vulvovaginal infections: addressing the challenges of antimicrobial resistance.

  2021cites this paper
• Lipo-PEG nano-ocular formulation successfully encapsulates hydrophilic fluconazole and traverses corneal and non-corneal path to reach posterior eye segment

  2021cites this paper
• Novel and revisited approaches in nanoparticle systems for buccal drug delivery.

  2020cites this paper
• The Vaginal-PVPA: A Vaginal Mucosa-Mimicking In Vitro Permeation Tool for Evaluation of Mucoadhesive Formulations

  2020influential citation
• Molecular and cellular cues governing nanomaterial-mucosae interactions: from nanomedicine to nanotoxicology.

  2020cites this paper
• Prediction of the enhanced insulin absorption across a triple co-cultured intestinal model using mucus penetrating PLGA nanoparticles.

  2020cites this paper
• Pharmaceutical Vehicles for Vaginal and Rectal Administration of Anti-HIV Microbicide Nanosystems

  2019cites this paper
• Rational Development of Liposomal Hydrogels: A Strategy for Topical Vaginal Antiretroviral Drug Delivery in the Context of HIV Prevention

  2019cites this paper
• Nanocrystal Formulation Improves Vaginal Delivery of CSIC for HIV Prevention

  2019cites this paper
• Establishment of a Mucin Secreting Cell Line Cx-03 from an Uterine Carcino Sarcoma

  2018cites this paper
• Nanoparticle-mediated drug delivery to treat infections in the female reproductive tract: evaluation of experimental systems and the potential for mathematical modeling

  2018cites this paper
• Revisiting the role of sucrose in PLGA-PEG nanocarrier for potential intranasal delivery

  2018cites this paper
• Lyophilized tablets for focal delivery of fluconazole and itraconazole through vaginal mucosa, rational design and in vitro evaluation

  2018cites this paper
• Design, Characterization, and Biopharmaceutical Behavior of Nanoparticles Loaded with an HIV-1 Fusion Inhibitor Peptide.

  2018cites this paper
• Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief associated with gynecological surgery.

  2018cites this paper
• Activated micromotor propulsion by enzyme catalysis in a biofluid medium

  2018cites this paper
• PLGA-modified nanoparticles for the treatment of hypo-vascularized HPV-related cervical cancers.

  2018cites this paper
• Application of nanotechnology for the development of microbicides

  2017cites this paper
• The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles.

  2017cites this paper
• Mucus models to evaluate the diffusion of drugs and particles.

  2017cites this paper
• The role of mucus in cell‐based models used to screen mucosal drug delivery☆

  2017cites this paper
• Controlled‐release biodegradable nanoparticles: From preparation to vaginal applications

  2017cites this paper
• Nanotechnologies for early diagnosis, in situ disease monitoring, and prevention

  2017cites this paper
• Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes

  2017cites this paper
• Tissue-based in vitro and ex vivo models for vaginal permeability studies

  2016cites this paper
• Freeze-dried mucoadhesive polymeric system containing pegylated lipoplexes: Towards a vaginal sustained released system for siRNA.

  2016cites this paper
• Drug Transport across Skin

  2016cites this paper
• Stimuli-sensitive thiolated hyaluronic acid based nanofibers: synthesis, preclinical safety and in vitro anti-HIV activity.

  2016cites this paper
• Nanoparticles-in-film for the combined vaginal delivery of anti-HIV microbicide drugs.

  2016cites this paper
• Nanotechnology for vaginal drug delivery and targeting

  2016cites this paper
• Nanoencapsulation of psoralidin via chitosan and Eudragit S100 for enhancement of oral bioavailability.

  2016cites this paper
• PEGylation of lipoplexes: The right balance between cytotoxicity and siRNA effectiveness.

  2016cites this paper
• Buccal delivery of low molecular weight heparin by cationic polymethacrylate nanoparticles.

  2016cites this paper
• Nanomedicine in the development of anti-HIV microbicides.

  2016cites this paper
• Mucus-penetrating drug carriers for vaginal drug delivery

  2015cites this paper
• Predicting first traversal times for virions and nanoparticles in mucus with slowed diffusion.

  2015influential citation
• Maximum likelihood estimation for single particle, passive microrheology data with drift

  2015cites this paper
• Chitosan-g-oligo(epsilon-caprolactone) polymeric micelles: microwave-assisted synthesis and physicochemical and cytocompatibility characterization.

  2015cites this paper
• Formulation of Hyaluronidase Enzyme Sensitive Topical Nanomicrobicides for HIV Virus Transmission Prevention

  2015cites this paper
• VAGINAL DELIVERY OF A HYDROPHOBIC ANTIRETROVIRAL DRUG CSIC FOR HIV PREVENTION: NOVEL FORMULATION STRATEGIES FOR IMPROVED DRUG SOLUBILIZATION AND LYMPHATIC TARGETING

  2015cites this paper
• Étude toxicologique de nanoparticules polymériques véhicules de S-nitrosoglutathion

  2015cites this paper
• Microrheology and Heterogeneity in Biological Fluids: Approaches, Models and Applications

  2015cites this paper
• Profiles and technological requirements of urogenital probiotics.

  2015cites this paper
• Mucin-controlled drug release from mucoadhesive phenylboronic acid-rich nanoparticles.

  2015cites this paper
• Nano-sized platforms for vaginal drug delivery.

  2015cites this paper
• Precise engineering of dapivirine-loaded nanoparticles for the development of anti-HIV vaginal microbicides.

  2015cites this paper
• Polymer-based nanocarriers for vaginal drug delivery.

  2015cites this paper
• Nanotech-derived topical microbicides for HIV prevention: the road to clinical development.

  2015cites this paper
• The potential of HIV-1 nanotherapeutics: from in vitro studies to clinical trials.

  2015cites this paper
• Safety Aspects of Topical Anti-HIV Microbicides

  2014cites this paper
• Biodistribution and Pharmacokinetics of Dapivirine-Loaded Nanoparticles after Vaginal Delivery in Mice

  2014cites this paper
• Vaginal Microbicide Films

  2014cites this paper
• Nanotherapeutics--product development along the "nanomaterial" discussion.

  2014cites this paper
• Nanotechnology-Based Systems for Microbicide Development

  2014cites this paper
• Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review

  2014cites this paper
• Vaginal Drug Delivery

  2014cites this paper
• Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects.

  2014cites this paper
• Chitosan-coated liposomes for topical vaginal therapy: assuring localized drug effect.

  2014cites this paper
• Assessing the physical-chemical properties and stability of dapivirine-loaded polymeric nanoparticles.

  2013cites this paper
• A review of nanotechnological approaches for the prophylaxis of HIV/AIDS.

  2013cites this paper
• In vitro and ex vivo evaluation of polymeric nanoparticles for vaginal and rectal delivery of the anti-HIV drug dapivirine.

  2013cites this paper
• Mucus barrier components, challenges for nanoscale drug delivery

  2013cites this paper
• Vaginal polymeric film containing combination of antiretrovirals for prevention of HIV-1 sexual transmission: Impact of co-delivery

  2013cites this paper