Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.Brain cancer encompasses a diverse range of complex malignancies, many of which are associated with a poor prognosis and require more effective treatments. In this Position Paper, an international panel of clinicians and laboratory-based scientists convened by Cancer Research UK identify and discuss seven challenges that must be overcome if we are to cure all patients with a brain tumour.
Challenges to curing primary brain tumours
K. Aldape,K. Brindle,L. Chesler,R. Chopra,A. Gajjar,M. Gilbert,N. Gottardo,D. Gutmann,D. Hargrave,E. Holland,David T. W. Jones,J. Joyce,P. Kearns,M. Kieran,I. Mellinghoff,M. Merchant,S. Pfister,S. Pollard,V. Ramaswamy,J. Rich,G. Robinson,D. Rowitch,J. Sampson,Michael D. Taylor,P. Workman,R. Gilbertson
Published 2019 in Nature Reviews Clinical Oncology
ABSTRACT
PUBLICATION RECORD
- Publication year
2019
- Venue
Nature Reviews Clinical Oncology
- Publication date
2019-02-07
- Fields of study
Medicine
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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