Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Nature Genetics

• Publication date

  1993-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/NG0693-175PMID 7503811
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Four restriction fragment length polymorphisms revealed by probes from a single cosmid map to human chromosome 12q

  2004cited by this paper
• Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

  1993cited by this paper
• The last shall be first

  1993cited by this paper
• The t(8;21) translocation in acute myeloid leukemia results in production of an AML1‐MTG8 fusion transcript.

  1993cited by this paper
• The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA

  1992cited by this paper
• CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

  1992cited by this paper
• Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)

  1992cited by this paper
• Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

  1992cited by this paper
• Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt.

  1992cited by this paper
• Isolation, characterization and chromosomal localization of the human GADD153 gene.

  1992cited by this paper
• A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)

  1991cited by this paper
• Oncogenic conversion of transcription factors by chromosomal translocations.

  1991cited by this paper
• A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14).

  1991cited by this paper
• Confirmation of the assignment of the vitronectin (VNRA) and fibronectin (FNRA) receptor α‐subunits

  1991cited by this paper
• HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

  1991cited by this paper
• Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia.

  1991cited by this paper
• The tcl‐3 proto‐oncogene altered by chromosomal translocation in T‐cell leukemia codes for a homeobox protein.

  1991cited by this paper
• Structural and functional chimerism results from chromosomal translocation in lymphoid tumors.

  1991cited by this paper
• Translocations, master genes, and differences between the origins of acute and chronic leukemias.

  1991cited by this paper
• Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.

  1991cited by this paper
• Confirmation of the assignment of the vitronectin (VNRA) and fibronectin (FNRA) receptor alpha-subunits.

  1991cited by this paper
• A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.

  1990cited by this paper
• Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.

  1990cited by this paper
• The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

  1990cited by this paper
• Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17.

  1990cited by this paper
• Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2.

  1990cited by this paper
• Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.

  1989cited by this paper
• Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10.

  1988cited by this paper
• A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) Burkitt lymphoma.

  1984cited by this paper
• Chromosome translocation can occur on either side of the c-myc oncogene in Burkitt lymphoma cells

  1984cited by this paper
• Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22.

  1984cited by this paper
• Catalogue of Chromosome Aberrations in Cancer

  1984cited by this paper
• Translocation joins c-myc and immunoglobulin γ1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene

  1983cited by this paper
• A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

  1983cited by this paper
• Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

  1983cited by this paper
• Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt.

  1983cited by this paper
• A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

  1982cited by this paper
• Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

  1982cited by this paper
• Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

  1982cited by this paper
• Assignment of the human locus determining phosphoglycolate phosphatase (PGP) to chromosome 16

  1980cited by this paper
• Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

  1980cited by this paper
• Detection of specific sequences among DNA fragments separated by gel electrophoresis.

  1975cited by this paper
• A minute chromosome in human chronic granulocytic leukemia

  1960cited by this paper
• Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor a locus (leukemogenesis/rearrangements)

  year unknowncited by this paper

• Targeting fused in sarcoma (FUS): a novel antisense strategy for treating idiopathic pulmonary fibrosis

  2026cites this paper
• Dynamic properties of transcriptional condensates modulate CRISPRa-mediated gene activation

  2025cites this paper
• G-quadruplex structural motifs modulate protein–RNA interactions within the transcriptome

  2025cites this paper
• Updates on Disease Mechanisms and Therapeutics for Amyotrophic Lateral Sclerosis

  2024cites this paper
• Circular RNA in cancer

  2024cites this paper
• Homologous Peptide Foldamer Promotes FUS Aggregation and Triggers Cancer Cell Death.

  2024cites this paper
• Biomolecular condensates: A new lens on cancer biology.

  2024cites this paper
• Back to the future! Selected bone and soft tissue neoplasms with shared genetic alterations but differing morphological and immunohistochemical phenotypes.

  2024cites this paper
• Gene of the month: DDIT3

  2023cites this paper
• Laparoscopic resection of a metastatic myxoid liposarcoma in the mesentery of the small intestine: a case report

  2023cites this paper
• Novel EWSR1::GFI1B gene fusion in angiofibroma of soft tissue

  2023cites this paper
• Combination of Genomic Landsscape and 3D Culture Functional Assays Bridges Sarcoma Phenotype to Target and Immunotherapy

  2023cites this paper
• Saccharomyces cerevisiae as a research tool for RNA‐mediated human disease

  2023cites this paper
• Potential roles of the endoplasmic reticulum stress pathway in amyotrophic lateral sclerosis

  2023cites this paper
• Myxoid Pleomorphic Liposarcoma.

  2023cites this paper
• The spectrum and significance of secondary (co‐occurring) genetic alterations in sarcomas: the hallmarks of sarcomagenesis

  2023cites this paper
• Patterns of Metastatic Recurrence of Genetically Confirmed Myxoid Liposarcoma

  2023cites this paper
• Fusion genes aiding the diagnosis of soft tissue tumours of the oral cavity: from bench to bedside.

  2023cites this paper
• FUS-mediated HypEVs: Neuroprotective effects against ischemic stroke

  2023cites this paper
• CRISPR-assisted transcription activation by phase-separation proteins

  2023cites this paper
• Targeting epigenetic aberrations of sarcoma in CRISPR era

  2023cites this paper
• FUS Facilitates Gene Body Export from Nuclear Condensates

  2023influential citation
• FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons

  2023cites this paper
• ALS-causing hPFN1 mutants differentially disrupt LLPS of FUS prion-like domain.

  2023cites this paper
• Suppression of antitumor cytokine IL‑24 by PRG4 and PAI‑1 may promote myxoid liposarcoma cell survival.

  2023cites this paper
• The transformation of isolated gastric myeloid sarcoma into acute myeloid leukemia presenting with a complex karyotype and TLS-ERG gene fusion

  2022cites this paper
• The Role of CDK Pathway Dysregulation and Its Therapeutic Potential in Soft Tissue Sarcoma

  2022cites this paper
• Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty

  2022cites this paper
• Phase separation of low-complexity domains in cellular function and disease

  2022cites this paper
• The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma.

  2022cites this paper
• First‐line chemotherapy in advanced intra‐abdominal well‐differentiated/dedifferentiated liposarcoma: An EORTC Soft Tissue and Bone Sarcoma Group retrospective analysis

  2022cites this paper
• Generation of a heterozygous FUS-Q290X knock in human embryonic stem cell line (WAe009-A-83) using CRISPR/Cas9 system.

  2022cites this paper
• Stress granules in the spinal muscular atrophy and amyotrophic lateral sclerosis: The correlation and promising therapy.

  2022cites this paper
• Molecular aspects of Ewing's sarcomas

  2022cites this paper
• Adrenal myelolipomas.

  2021cites this paper
• Establishment of multiplex RT-PCR to detect fusion genes for the diagnosis of Ewing sarcoma

  2021cites this paper
• Pediatric liposarcoma: A case series and literature review

  2021cites this paper
• Blood-derived lncRNAs as potential biomarkers for early cancer diagnosis: The Good, the Bad and the Beauty

  2021cites this paper
• Aberrant Stress Granule Dynamics and Aggrephagy in ALS Pathogenesis

  2021cites this paper
• Fused in sarcoma regulates DNA replication timing and kinetics

  2021cites this paper
• Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment

  2021cites this paper
• Wild-Type and Mutant FUS Expression Reduce Proliferation and Neuronal Differentiation Properties of Neural Stem Progenitor Cells

  2021cites this paper
• Prognostic value of FUS immunoexpression for Gleason patterns and prostatic adenocarcinoma progression.

  2021cites this paper
• FUS Oncofusion Protein Condensates Recruit mSWI/SNF Chromatin Remodelers via Heterotypic Interactions Between Prion-like Domains

  2021cites this paper
• Cellular Radiosensitivity of Soft Tissue Sarcoma

  2021cites this paper
• The atypical RNA-binding protein TAF15 regulates dorsoanterior neural development through diverse mechanisms in Xenopus tropicalis

  2021cites this paper
• Genetic drivers and cells of origin in sarcomagenesis

  2021cites this paper
• Aberrant phase separation and cancer

  2021cites this paper
• Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology

  2021cites this paper
• Redox-mediated regulation of low complexity domain self-association.

  2021cites this paper
• miR-4478 sensitizes ovarian cancer cells to irradiation by inhibiting Fus and attenuating autophagy

  2020cites this paper
• Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations.

  2020cites this paper
• Unmanipulated haploidentical peripheral blood stem cell transplantation for patients with Philadelphia-negative acute lymphoblastic leukaemia in first complete remission

  2020cites this paper
• Liposarcomas of the mediastinum

  2020cites this paper
• Implications of androgen receptor and FUS expression on tumor progression in urothelial carcinoma.

  2020cites this paper
• Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA

  2020cites this paper
• HLA-Matched and HLA-Haploidentical Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia with t (16;21) (p11.2;q22)

  2020cites this paper
• A multidisciplinary approach to soft-tissue sarcoma of the extremities

  2020cites this paper
• Biochemical timekeeping via reentrant phase transitions.

  2020cites this paper
• DDIT3 Immunohistochemistry Is a Useful Tool for the Diagnosis of Myxoid Liposarcoma

  2020cites this paper
• FUS-dependent loading of SUV39H1 to OCT4 pseudogene-lncRNA programs a silencing complex with OCT4 promoter specificity

  2020cites this paper
• The role of DNA damage response in amyotrophic lateral sclerosis

  2020cites this paper
• Investigation of the Involvement of Parkin in Parkinson's Disease and Cancer by Monitoring the Changes in SH-SY5Y Cells at the Nuclear Proteome Level

  2020cites this paper
• Natural selection has preserved and enhanced the phase-separation properties of FUS during 160 million years of mammalian evolution

  2020cites this paper
• Fused in sarcoma regulates DNA replication timing and progression

  2020cites this paper
• Multifaceted Genes in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia

  2020cites this paper
• FUS-dependent loading of SUV39H1 to OCT4 pseudogene-lncRNA programs a silencing complex with OCT4 promoter specificity

  2020cites this paper
• Soft Tissue Tumour Pathology

  2020cites this paper
• IGF2/IGF1R Signaling as a Therapeutic Target in MYB-Positive Adenoid Cystic Carcinomas and Other Fusion Gene-Driven Tumors

  2019cites this paper
• Diagnostic classification of soft tissue malignancies: A review and update from a surgical pathology perspective.

  2019cites this paper
• A Low-Grade Myxoid Liposarcoma Arising in a Deep-Seated Conventional Lipoma

  2019cites this paper
• The immune microenvironment of sarcomas : a comprehensive evaluation of infiltrating immune cells and checkpoint biomarkers in musculoskeletal tumors

  2019cites this paper
• MiR-133a-5p inhibits androgen receptor (AR)-induced proliferation in prostate cancer cells via targeting FUsed in Sarcoma (FUS) and AR

  2019cites this paper
• Applications of Molecular Testing to Differential Diagnosis

  2019cites this paper
• Cancer-related genes and ALS.

  2019cites this paper
• The current insights into the genetics of amyotrophic lateral sclerosis

  2019cites this paper
• Molecular pathomechanisms of Amyotrophic Lateral Sclerosis caused by FUS mutations

  2019cites this paper
• A unified mechanism for LLPS of ALS/FTLD-causing FUS as well as its modulation by ATP and oligonucleic acids

  2019cites this paper
• Protein Phase Separation: A New Phase in Cell Biology.

  2018cites this paper
• Genomic Applications in Soft Tissue Sarcomas

  2018cites this paper
• Yeast as a Model to Unravel Mechanisms Behind FUS Toxicity in Amyotrophic Lateral Sclerosis

  2018cites this paper
• Phasing in on the cell cycle

  2018cites this paper
• LncRNA XIST accelerates cervical cancer progression via upregulating Fus through competitively binding with miR-200a.

  2018cites this paper
• Structural investigation of SOD1 aggregates in ALS : identification of prion strains using anti-peptide antibodies

  2018cites this paper
• RNA-Binding Proteins in Amyotrophic Lateral Sclerosis

  2018cites this paper
• Transcribing malignancy: transcription-associated genomic instability in cancer

  2018cites this paper
• Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

  2018cites this paper
• Analysis of the synaptic localization of the FUS RNA-binding protein with high- and super-resolution microscopy

  2018cites this paper
• Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats.

  2018cites this paper
• Homogeneous myxoid liposarcomas mimicking cysts on MRI: A challenging diagnosis.

  2018cites this paper
• Pathomechanisms driving phase separation and aggregation of the fused in sarcoma protein in neurodegenerative diseases

  2018cites this paper
• Animal Models for the Study of Human Neurodegenerative Diseases

  2017cites this paper
• TDP-43 and FUS in Amyotrophic Lateral Sclerosis: From Animal Models to Disease Mechanisms

  2017cites this paper
• Cytogenetic methods and findings in human solid tumors

  2017cites this paper
• RRM domain of ALS/FTD-causing FUS interacts with membrane: an anchor of membraneless organelles to membranes?

  2017influential citation
• Impact of clinical factors on outcome of leukemia patients with TLS-ERG fusion gene

  2017cites this paper
• Hidden α-helical propensity segments within disordered regions of the transcriptional activator CHOP

  2017cites this paper
• Varied Presentations of Pediatric Lipoblastoma: Case Series and Review of the Literature

  2017cites this paper
• RRM domain of ALS/FTD-causing FUS characteristic of irreversible unfolding spontaneously self-assembles into amyloid fibrils

  2017cites this paper
• Sequestration of PRMT1 and Nd1-L mRNA into ALS-linked FUS mutant R521C-positive aggregates contributes to neurite degeneration upon oxidative stress

  2017cites this paper