Do we really need tranexamic acid in total hip arthroplasty? A meta-analysis of nineteen randomized controlled trials

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Archives of Orthopaedic and Trauma Surgery

• Publication date

  2013-04-25

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s00402-013-1761-2PMID 23615973
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

  2014cited by this paper
• Are Antifibrinolytics Helpful in Decreasing Blood Loss and Transfusions During Spinal Fusion Surgery in Children With Cerebral Palsy Scoliosis?

  2012cited by this paper
• Effect of tranexamic acid on the hidden blood loss after total hip arthroplasty

  2012influential reference
• Tranexamic acid for reduction of blood loss during total hip arthroplasty.

  2012influential reference
• Tranexamic Acid

  2012cited by this paper
• Efficacy of tranexamic acid on blood loss after primary cementless total hip replacement with rivaroxaban thromboprophylaxis: A case-control study in 70 patients.

  2012influential reference
• Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement.

  2011cited by this paper
• Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray

  2011influential reference
• The use of tranexamic acid to reduce blood loss in primary cementless total hip arthroplasty

  2011cited by this paper
• Cell salvage for minimising perioperative allogeneic blood transfusion.

  2010cited by this paper
• The effect of tranexamic acid on reducing blood loss in cementless total hip arthroplasty under epidural anesthesia.

  2010influential reference
• Cell salvage for minimising perioperative allogeneic blood transfusion.

  2010cited by this paper
• Effects of Tranexamic Acid on Blood Loss during Total Hip Arthroplasty

  2010influential reference
• Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement

  2009cited by this paper
• Perioperative management of anemia: Limits of blood transfusion and alternatives to it

  2009cited by this paper
• Perioperative blood conservation

  2009cited by this paper
• The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement.

  2009influential reference
• Strategies for blood management in orthopaedic and trauma surgery.

  2008cited by this paper
• Moving towards evidence-based healthcare for musculoskeletal injuries: featuring the work of the Cochrane Bone, Joint and Muscle Trauma Group

  2007cited by this paper
• Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030.

  2007cited by this paper
• Reduction of Blood Loss with Tranexamic Acid in Primary Total Hip Replacement Surgery

  2007influential reference
• Tranexamic acid reduces blood loss in cemented hip arthroplasty: A randomized, double-blind study of 39 patients with osteoarthritis

  2005influential reference
• Tranexamic acid in total hip arthroplasty saves blood and money

  2005influential reference
• Tranexamic acid reduces blood loss after cementless total hip arthroplasty—prospective randomized study in 40 cases

  2004influential reference
• Hidden blood loss following hip and knee arthroplasty. Correct management of blood loss should take hidden loss into account.

  2004cited by this paper
• Stability analysis of craniovertebral junction fixation techniques.

  2004cited by this paper
• Bone bleeding during total hip arthroplasty after administration of tranexamic acid.

  2004influential reference
• Tranexamic acid reduces the need for allogenic red blood cell transfusions in patients undergoing total hip replacement

  2004influential reference
• Tranexamic acid reduces blood loss and blood transfusions in primary total hip arthroplastyA prospective randomized double-blind study in 40 patients

  2003cited by this paper
• Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis.

  2002cited by this paper
• Quantifying heterogeneity in a meta‐analysis

  2002cited by this paper
• Blood conservation with tranexamic acid in total hip arthroplasty: A randomized, double-blind study in 40 primary operations

  2001influential reference
• Pre-operative autologous donation for minimising perioperative allogeneic blood transfusion.

  2001cited by this paper
• Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty

  2000influential reference
• Reduction of blood loss using tranexamic acid in total knee and hip arthroplasties

  2000influential reference
• Tranexamic Acid Reduces Blood Loss in Total Hip Replacement Surgery

  2000influential reference

• Risk-stratified perioperative tranexamic acid utilization for total hip and knee arthroplasty: Analysis of trends of the past decade.

  2026cites this paper
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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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• Tranexamic Acid Reduces the Amount of Blood Transfused in Revision Total Hip Arthroplasty for Vancouver B2/B3 Periprosthetic Femur Fractures.

  2024cites this paper
• Local Versus Systemic Tranexamic Acid in Total Hip Arthroplasty in Young Adults

  2023cites this paper
• The effect of triple-dose-intravenous tranexamic acid on blood loss in patients undergoing total hip arthroplasty without affecting blood coagulopathy: A prospective thromboelastographic analysis

  2023cites this paper
• Effectiveness of Primary Total Hip Arthroplasty Combined with Intra-articular and Intravenous Tranexamic Acid: A Retrospective Analysis of Number of Doses and Dose Strength

  2022cites this paper
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  2022cites this paper
• Safety and Efficacy of Topical Administration of Tranexamic Acid in High-Risk Patients Undergoing Posterior Lumbar Interbody Fusion Surgery.

  2021cites this paper
• The Clinical Significance of Full Blood Count Day 1 Post-op After Total Joint Arthroplasty

  2021cites this paper
• Perioperative strategies to reduce transfusion rates in one-stage bilateral total hip arthroplasty via direct anterior approach.

  2021cites this paper
• No Difference in Blood Loss and Risk of Transfusion Between Patients Treated with One or Two Doses of Intravenous Tranexamic Acid After Simultaneous Bilateral TKA

  2021cites this paper
• The role of tranexamic acid in decreasing intraoperative and postoperative blood loss in patients undergoing total hip replacement

  2021cites this paper
• Tranexamic acid usage in hip fracture surgery: a meta-analysis and meta-regression analysis of current practice

  2021cites this paper
• Tranexamic acid does not affect intraoperative blood loss or in-hospital outcomes after acetabular fracture surgery

  2021cites this paper
• The efficacy and safety of tranexamic acid in the treatment of intertrochanteric fracture: an updated meta-analysis of 11 randomized controlled trials

  2020cites this paper
• In the Era of Tranexamic Acid, are Type and Screens for Primary Total Joint Arthroplasty Obsolete?

  2020cites this paper
• Does perioperative use of tranexamic acid in hip fracture patients increase the risk of venous thromboembolism and reduce the need for postoperative transfusions?

  2020cites this paper
• Enhanced Recovery After Surgery (ERAS): The Changing Practice

  2020cites this paper
• Efficacy of the Combined Administration of Systemic and Intra-Articular Tranexamic Acid in Total Hip Arthroplasty Secondary to Femoral Neck Fracture: A Retrospective Study

  2020cites this paper
• Rapid Recovery in Total Joint Arthroplasty: Contemporary Strategies

  2020cites this paper
• Comparison of oral versus intravenous tranexamic acid in total knee and hip arthroplasty

  2020cites this paper
• Anesthesia in the Orthopedic Patient

  2020cites this paper
• OPTIMIZATION AND VALIDATION OF AN ANALYTICAL METHOD FOR TRANEXAMIC ACID IN WHITENING CREAMS BY RP-HPLC WITH PRECOLUMN DERIVATIZATION

  2020cites this paper
• Clinical trial on the effect of tranexamic acid on bleeding and fibrinolysis in primary hip and knee replacement.

  2019cites this paper
• Re-evaluation of the efficacy of tranexamic acid in reducing blood loss in percutaneous nephrolithotomy: a randomized clinical trial.

  2019cites this paper
• Evidence Review Conducted for the Agency for Healthcare Research and Quality Safety Program for Improving Surgical Care and Recovery: Focus on Anesthesiology for Total Hip Arthroplasty

  2019cites this paper
• Clinical trial on the effect of tranexamic acid on bleeding and fibrinolysis in primary hip and knee replacement

  2019cites this paper
• Comparative efficacy and safety of different hemostatic methods in total hip arthroplasty: a network meta-analysis

  2019cites this paper
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  2019cites this paper
• [Evaluation of Efficacy of Systemic Administration of Tranexamic Acid (Exacyl) in Total Hip and Knee Arthroplasty - Prospective Cohort Study].

  2019cites this paper
• A randomized, double‐blind, placebo‐controlled trial on the efficacy of tranexamic acid combined with rivaroxaban thromboprophylaxis in reducing blood loss after primary cementless total hip arthroplasty

  2019cites this paper
• Tranexamic Acid Reduces Postoperative Blood Loss in Distal Femoral Osteotomy

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• Perioperative intravenous tranexamic acid reduces blood transfusion in primary cementless total hip arthroplasty

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  2019cites this paper
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  2019cites this paper
• Tranexamic acid use in high-risk blood transfusion patients undergoing total hip replacement: a randomised controlled trial

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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• Intravenous tranexamic acid use in revision total joint arthroplasty: a meta-analysis

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  2018cites this paper
• Tranexamic acid use during total hip arthroplasty

  2018cites this paper
• When Should Complete Blood Count Tests Be Performed in Primary Total Hip Arthroplasty Patients?

  2018cites this paper
• Total Hip Arthroplasty in the Outpatient Setting: What You Need to Know (Part 1).

  2018cites this paper
• intravenous tranexamic acid use in revision total joint arthroplasty: a meta-analysis

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• Topical fibrin sealant versus intravenous tranexamic acid in reducing blood loss during total joint arthroplasty : a systematic review and meta-analysis

  2018cites this paper
• Matched cohort study of topical tranexamic acid in cementless primary total hip replacement

  2018cites this paper
• Topical Tranexamic Acid Reduces Postoperative Blood Loss in Primary Total Hip and Knee Arthroplasty

  2018cites this paper
• Tranexamic Acid results in Less Blood Loss in Total Joint Arthroplasty: A Retrospective Study

  2018cites this paper
• Transfusion rates with intravenous tranexamic acid in total hip arthroplasty performed using the direct anterior approach

  2018cites this paper
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  2018cites this paper
• Intra-Articular Tranexamic Acid Injection During the Hip Hemi-Arthroplasty in Elderly Patients: A Retrospective Study

  2018cites this paper
• Perioperative Tranexamic Acid Treatment and Risk of Cardiovascular Events or Death After Total Hip Arthroplasty: A Population-Based Cohort Study from National Danish Databases

  2018cites this paper
• O uso do ácido tranexâmico em pacientes submetidos a artroplastia total primária do quadril: uma avaliação do seu impacto em diferentes protocolos de administração

  2017cites this paper
• Relative efficacy of tranexamic acid and preoperative anemia treatment for reducing transfusions in total joint arthroplasty

  2017cites this paper
• Tranexamic acid versus fibrin sealant in primary total hip replacement: a comparative study

  2017cites this paper
• Process Improvement Project Using Tranexamic Acid Is Cost-Effective in Reducing Blood Loss and Transfusions After Total Hip and Total Knee Arthroplasty.

  2017cites this paper
• Comparison of oral versus intravenous application of tranexamic acid in total knee and hip arthroplasty: A systematic review and meta-analysis.

  2017cites this paper
• Acute Coronary Artery Thrombus After Tranexamic Acid During Total Shoulder Arthroplasty in a Patient With Coronary Stents: A Case Report.

  2017cites this paper
• Low Risk of Thromboembolic Events After Routine Administration of Tranexamic Acid in Hip and Knee Arthroplasty.

  2017cites this paper
• Efficiency of Tranexamic Acid in Management of Surgical Orthopedic Bleeding in Patients with Haemophilia

  2017cites this paper
• Oral and Intravenous Tranexamic Acid Are Equivalent at Reducing Blood Loss Following Total Hip Arthroplasty: A Randomized Controlled Trial

  2017cites this paper
• The efficacy and safety of epinephrine for postoperative bleeding in total joint arthroplasty

  2017influential citation
• Combined intravenous, topical and oral tranexamic acid administration in total knee replacement: Evaluation of safety in patients with previous thromboembolism and effect on hemoglobin level and transfusion rate.

  2017cites this paper
• The effect of intravenous tranexamic acid on blood loss and early post‐operative pain in total shoulder arthroplasty

  2017cites this paper
• Tranexamic acid decreases blood loss in shoulder arthroplasty

  2017cites this paper
• The use of tranexamic acid in patients submitted to primary total hip arthroplasty: an evaluation of its impact in different administration protocols

  2017cites this paper
• Tranexamic Acid Prophylaxis in Hip and Knee Joint Replacement.

  2017cites this paper
• Comparison of tranexamic acid pharmacokinetics after intra-articular and intravenous administration in rabbits.

  2017cites this paper
• Impact of Tranexamic Acid in Total Knee and Total Hip Replacement

  2017cites this paper
• Tranexamic Acid and Major Spine Surgery: Trends and Controversies

  2017cites this paper
• Application of Tranexamic Acid in Total Hip Arthroplasty : Current Evidences

  2017cites this paper
• Blood-Sparing Efficacy of Oral Tranexamic Acid in Primary Total Hip Arthroplasty.

  2017cites this paper
• Acute Coronary Artery Thrombus After Tranexamic Acid During Total Shoulder Arthroplasty in a Patient With Coronary Stents: A Case Report.

  2017cites this paper
• Tranexamic Acid Use in the Total Hip and Total Knee Arthroplasty Population at an Academic Medical Center: a Retrospective Review of Postoperative Outcomes

  2017cites this paper
• Military use of tranexamic acid in combat trauma: Does it matter?

  2017cites this paper
• Impact of Tranexamic Acid on Blood Loss and Need for Blood Transfusions in Total Knee and Total Hip Arthroplasty.

  2017cites this paper
• Additional Tools to Prevent Blood Loss in Total Joint Arthroplasty

  2017cites this paper
• Effect of tranexamic acid administration on bleeding in primary total hip arthroplasty.

  2017cites this paper
• Effects of two different tranexamic acid administration methods on perioperative blood loss in total hip arthroplasty: study protocol for a prospective, open-label, randomized, controlled clinical trial

  2017cites this paper
• Military use of TXA in combat trauma: Does it matter?

  2017cites this paper
• Tranexamic acid combined with iron pathway may significantly decrease the postoperative rate of transfusion after elective total hip and knee replacement

  2017cites this paper
• Effect of tranexamic acid administration on bleeding in primary total hip arthroplasty.

  2017cites this paper
• Enhanced recovery after surgery for primary hip and knee arthroplasty: a review of the evidence.

  2016cites this paper
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  2016cites this paper
• Tranexamic Acid Compared with Placebo for Reducing Total Blood Loss in Hip Replacement Surgery: A Randomized Clinical Trial

  2016cites this paper
• Efficacy of 2 grammes of intravenous transexamic acid in the reduction of post-surgical bleeding after total hip and knee replacement.

  2016cites this paper
• [Balance of hemostasis and anticoagulation therapy techniques for hip arthroplasty].

  2016cites this paper
• Topical Tranexamic Acid Reduces Postoperative Blood Loss in Patients Undergoing Primary Total Hip Arthroplasty with the Drain-Clamping

  2016cites this paper
• Perioperative blood loss in total hip and knee arthroplasty: Outcomes associated with intravenous tranexamic acid use in an academic medical center

  2016cites this paper
• Comparison of efficacy and safety of topical versus intravenous tranexamic acid in total hip arthroplasty

  2016cites this paper
• Combined intravenous and topical tranexamic acid versus intravenous use alone in primary total knee and hip arthroplasty: A meta-analysis of randomized controlled trials.

  2016cites this paper
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  2016cites this paper