Simultaneous targeting of telomeres and telomerase as a cancer therapeutic approach.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Cancer Research

• Publication date

  2003-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 12566299
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Quantitative Assay of Telomerase Activity

  2001cited by this paper
• Expression of telomerase inhibits hydroxyl radical‐induced apoptosis in normal telomerase negative human lung fibroblasts

  2001cited by this paper
• In vitro and in vivo antitumor activity of the novel trinuclear platinum complex BBR 3464 in neuroblastoma

  2001cited by this paper
• Hydroxyl radical‐induced apoptosis in human tumor cells is associated with telomere shortening but not telomerase inhibition and caspase activation

  2001cited by this paper
• Telomere Amount and Length Assay

  2001cited by this paper
• Late apoptotic effects of taxanes on K562 erythroleukemia cells: apoptosis is delayed upstream of caspase-3 activation.

  2000cited by this paper
• Role of telomerase in cell senescence and oncogenesis.

  2000cited by this paper
• Fibroblast growth factors: an epigenetic mechanism of broad spectrum resistance to anticancer drugs.

  2000cited by this paper
• Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells.

  2000cited by this paper
• Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

  1999cited by this paper
• Telomerase enzyme activity and RNA expression in adriamycin-resistant human breast carcinoma MCF-7 cells.

  1999cited by this paper
• Inhibition of telomerase limits the growth of human cancer cells

  1999cited by this paper
• Cell-killing by paclitaxel in a metastatic murine melanoma cell line is mediated by extensive telomere erosion with no decrease in telomerase activity.

  1999cited by this paper
• Resistance to apoptosis in human cells conferred by telomerase function and telomere stability

  1999cited by this paper
• Anti-apoptotic Role of Telomerase in Pheochromocytoma Cells*

  1999cited by this paper
• Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death.

  1999cited by this paper
• Pharmacodynamics of immediate and delayed effects of paclitaxel: role of slow apoptosis and intracellular drug retention.

  1998cited by this paper
• Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by 3'-azido-3'-deoxythymidine.

  1998cited by this paper
• Telomere maintenance is dependent on activities required for end repair of double-strand breaks.

  1998cited by this paper
• Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation

  1998cited by this paper
• Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis

  1998cited by this paper
• Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry

  1998cited by this paper
• Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins.

  1998cited by this paper
• Taxanes propagate apoptosis via two cell populations with distinctive cytological and molecular traits.

  1998cited by this paper
• Potent growth inhibitory activity of zidovudine on cultured human breast cancer cells and rat mammary tumors.

  1997cited by this paper
• Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

  1997cited by this paper
• Pharmacodynamics of taxol in human head and neck tumors.

  1996cited by this paper
• Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

  1996cited by this paper
• Mitochondrial toxicity of antiviral drugs

  1995cited by this paper
• The RNA component of human telomerase

  1995cited by this paper
• Telomeres: Beginning to Understand the End

  1995cited by this paper
• Taxol®: science and applications.

  1995cited by this paper
• Decreased Thymidine Kinase Levels in Peripheral Blood Cells from HIV-Seropositive Individuals: Implications for Zidovudine Metabolism

  1995cited by this paper
• Activation of telomerase in a human tumor.

  1994cited by this paper
• Activation of telomerase in a human tumor.

  1994cited by this paper
• Inhibition of human immunodeficiency virus type 1 integrase by 3'-azido-3'-deoxythymidylate.

  1994cited by this paper
• Specific association of human telomerase activity with immortal cells and cancer.

  1994cited by this paper
• Preferential incorporation of 3′‐azido‐2′,3′‐dideoxythymidine into telomeric DNA and Z‐DNA—containing regions of chinese hamster ovary cells

  1993cited by this paper

• Recent Progress and Potential of G4 Ligands in Cancer Immunotherapy

  2025cites this paper
• Neoadjuvant Chemotherapy Shortens the cfDNA Telomere Length in Breast Cancer Patients

  2024cites this paper
• Human adenovirus DNA polymerase is evolutionarily and functionally associated with human telomerase reverse transcriptase based on in silico molecular characterization that implicate abacavir and zidovudine

  2023cites this paper
• Targeting telomeres: advances in telomere maintenance mechanism-specific cancer therapies

  2022cites this paper
• Construction of Molecular Subtype and Prognosis Prediction Model of Osteosarcoma Based on Aging-Related Genes

  2022cites this paper
• A scalable and reproducible preparation for the antitumor protein TLC, a human-derived telomerase inhibitor.

  2021cites this paper
• Azidothymidine (AZT) Inhibits Proliferation of Human Ovarian Cancer Cells by Regulating Cell Cycle Progression

  2020cites this paper
• Long repeating (TTAGGG)n single-stranded DNA self-condenses into compact beaded filaments stabilized by G-quadruplex formation

  2018cites this paper
• A role of LINE-1 in telomere regulation.

  2018cites this paper
• Telomerase Inhibitor: Promising Target Therapy for Cancer

  2018cites this paper
• Catalytic assembly of DNA nanostructures on a nanoporous gold array as 3D architectures for label-free telomerase activity sensing.

  2017cites this paper
• Telomerase and drug resistance in cancer

  2017cites this paper
• Silencing of hTERT blocks growth and migration of anaplastic thyroid cancer cells.

  2017cites this paper
• TELOMERASE ANTISENSE AND TELOMERASE INHIBITORS CROSS-REFERENCE TO RELATED APPLICATIONS

  2017cites this paper
• Cytotoxic platinum coordination compounds. DNA binding agents

  2017cites this paper
• Effect of chemotherapeutic drugs on telomere length and telomerase activity

  2017cites this paper
• Gene silencing effect of SiRNA-magnetic modified with biodegradable copolymer nanoparticles on hTERT gene expression in lung cancer cell line

  2016cites this paper
• Telomere Instability Induced by Anticancer Drugs in Mammalian Cells

  2016cites this paper
• shRNA-armed conditionally replicative adenoviruses: a promising approach for cancer therapy

  2016cites this paper
• Comparison between Platinum-Azidothymidine and Azidothymidine Effects on Bcl-2 and Telomerase Gene Expression in Rats with Hepatocellular Carcinoma

  2015cites this paper
• Modulation of telomerase activity in fish muscle by biological and environmental factors.

  2015cites this paper
• Role of diallyl disulfide-mediated cleavage of c-Myc and Sp-1 in the regulation of telomerase activity in human lymphoma cell line U937.

  2015cites this paper
• Boldine, a natural aporphine alkaloid, inhibits telomerase at non-toxic concentrations.

  2015cites this paper
• Novel trisubstituted acridines as human telomeric quadruplex binding ligands.

  2014cites this paper
• Telomerase modulation in therapeutic approach.

  2014cites this paper
• Adenoviral vectors for prodrug activation-based gene therapy for cancer.

  2014cites this paper
• Effects of Treatment with Platinum Azidothymidine and Azidothymidine on Telomerase Activity and Bcl-2 Concentration in Hepatocellular Carcinoma- Induced Rats

  2014cites this paper
• Pharmacodynamics of Telomerase Inhibition and Telomere Shortening by Noncytotoxic Suramin

  2014cites this paper
• Telomerase downregulation induces proapoptotic genes expression and initializes breast cancer cells apoptosis followed by DNA fragmentation in a cell type dependent manner

  2013cites this paper
• Treatments for the Proliferation of Cancer Cells Consequences of Telomerase Inhibition and Combination

  2013cites this paper
• Potent growth-inhibitory effect of a dual cancer-specific oncolytic adenovirus expressing apoptin on prostate carcinoma.

  2013cites this paper
• Telomeres, Telomerase, and DNA Damage Response in Cancer Therapy

  2013cites this paper
• siRNA-mediated inhibition of hTERC enhances radiosensitivity of cervical cancer.

  2012cites this paper
• Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA.

  2012cites this paper
• Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway. 1

  2012cites this paper
• Telomere and Microtubule Targeting in Treatment-Sensitive and Treatment-Resistant Human Prostate Cancer Cells

  2012cites this paper
• Holistic Molecular Approaches for Anticancer Therapy

  2012cites this paper
• Knockdown of apoptosis-inducing factor disrupts function of respiratory complex I.

  2012cites this paper
• Anticancer Therapy Targeting Telomeres and Telomerase

  2012cites this paper
• Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway.

  2012cites this paper
• Dual E 1 A oncolytic adenovirus : targeting tumor heterogeneity with two independent cancer-specific promoter elements , DF 3 / MUC 1 and hTERT

  2011cites this paper
• Strategies for tumor-directed delivery of siRNA

  2011cites this paper
• (S)-stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor.

  2011cites this paper
• Interferon alfa and antiretroviral agents: a treatment option for adult T-cell leukemia/lymphoma.

  2011cites this paper
• Therapeutic Approaches to the Mature T‐Cell Lymphoproliferative Leukemias

  2011cites this paper
• ADVANCES IN BREAST CANCER THERAPY AND CHEMOPREVENTION: CURRENT STRATEGIES AND NOVEL TARGETS

  2011cites this paper
• Synergic effect of 3′-azido-3′-deoxythymidine and arsenic trioxide in suppressing hepatoma cells

  2011cites this paper
• Azidothymidine treatment of hepatocellular carcinoma in rats: an in vivo study of telomerase inhibition.

  2011cites this paper
• The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances taxol-induced cell death in breast cancer

  2010cites this paper
• Dual E1A Oncolytic Adenovirus: Targeting Tumor Heterogeneity With Two Independent Cancer-specific Promoter Elements, DF3/MUC1 and hTERT

  2010cites this paper
• RNA interference-mediated hTERT inhibition enhances TRAIL-induced apoptosis in resistant hepatocellular carcinoma cells.

  2010cites this paper
• Xenotropic murine leukemia virus-related virus is susceptible to AZT.

  2010cites this paper
• Telomerase Activity and Telomere Length in Human Tumor Cells with Acquired Resistance to Anticancer Agents

  2009cites this paper
• G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo.

  2009cites this paper
• Combined Telomerase Inhibition and Immunotherapy in the Prevention and Treatment of Mammary Carcinomas

  2009cites this paper
• The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel

  2009cites this paper
• Cutaneous Melanoma and Telomerase

  2009cites this paper
• siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells

  2009cites this paper
• Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis

  2009cites this paper
• Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model.

  2009cites this paper
• hTERT-promoter driven oncolytic adenovirus with E1B-19 kDa and E1B-55 kDa gene deletions

  2008cites this paper
• Consequences of Telomerase Inhibition by BIBR1532 on Proliferation and Chemosensitivity of Chondrosarcoma Cell Lines

  2008cites this paper
• TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules.

  2008cites this paper
• Human Telomerase Reverse Transcriptase Promoter-Driven Oncolytic Adenovirus with E1B-19 kDa and E1B-55 kDa Gene Deletions

  2008cites this paper
• Treatment of adult T‐cell leukemia/lymphoma: past, present, and future

  2008cites this paper
• INVESTIGATIONS OF THE TELOMERASE TEMPLATE ANTAGONIST GRN163L AND IMPLICATIONS FOR AUGMENTING BREAST CANCER THERAPY

  2008cites this paper
• Die Wechselwirkung antitumoraler Metallkomplexe mit DNA

  2007cites this paper
• Distinct Mitotic Segregation Errors Mediate Chromosomal Instability in Aggressive Urothelial Cancers

  2007cites this paper
• Radiosensitization effect of zidovudine on human malignant glioma cells.

  2007cites this paper
• Mechanisms of genotoxicity of nucleoside reverse transcriptase inhibitors

  2007cites this paper
• Anticancer therapy targeting telomeres and telomerase : current status.

  2007cites this paper
• Mechanism of acridine-based telomerase inhibition and telomere shortening.

  2007cites this paper
• Telomerase antisense inhibition for the proliferation of endometrial cancer in vitro and in vivo

  2006cites this paper
• Telomerase inhibition in cancer therapeutics: molecular-based approaches.

  2006cites this paper
• Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line.

  2006cites this paper
• Telomerase regulation of myofibroblast differentiation.

  2006cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 119 Activity and Regulation of Telomerase in Malignant Cells

  2006cites this paper
• Neomycin-capped aromatic platforms: quadruplex DNA recognition and telomerase inhibition.

  2006cites this paper
• Telomeres and telomerase in oncogenesis

  2006influential citation
• Efficient inhibition of human telomerase activity by antisense oligonucleotides sensitizes cancer cells to radiotherapy

  2006cites this paper
• Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs.

  2005cites this paper
• The importance of the telomere and telomerase system in hematological malignancies

  2005cites this paper
• Telomerase inhibition and cancer: might platinum based drugs have a future as anti-telomerase pharmacological approach?

  2005cites this paper
• Inhibitory effect of human telomerase antisense oligodeoxyribonucleotides on the growth of gastric cancer cell lines in variant tumor pathological subtype.

  2005cites this paper
• Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma

  2005cites this paper
• The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

  2005cites this paper
• Telomerase as a therapeutic target in cancer

  2005cites this paper
• Drugs targeting mitochondrial functions to control tumor cell growth.

  2005cites this paper
• Modulation de transcriptase inverse codee par line-1

  2005cites this paper
• Telomerase: a potential therapeutic target for cancer

  2005cites this paper
• Targeting telomerase by antisense-based approaches: perspectives for new anti-cancer therapies.

  2005cites this paper
• Expression of POT1 is Associated with Tumor Stage and Telomere Length in Gastric Carcinoma

  2004cites this paper
• Secular trends in cardiovascular disease mortality, incidence, and case fatality rates in adults in the United States.

  2004cites this paper
• Azidothymidine Induces Apoptosis and Inhibits Cell Growth and Telomerase Activity of Human Parathyroid Cancer Cells in Culture

  2004cites this paper
• Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma.

  2004cites this paper
• Telomeres, telomerase, and apoptosis.

  2004cites this paper
• Telomere length measurement by fluorescence in situ hybridization and flow cytometry.

  2004cites this paper
• Telomere maintenance in clinical medicine.

  2004cites this paper
• Telomere function and the radiosensitivity of squamous carcinoma of the head and neck

  2004cites this paper
• Antitumour effects of antiretroviral therapy

  2004cites this paper