Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Biochemical Journal

• Publication date

  1999-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1042/BJ3440427PMID 10567225PMCID PMC1220660
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Regulation of eIF-4E BP1 Phosphorylation by mTOR*

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• Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms.

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• Molecular mechanisms for the control of translation by insulin.

  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
• 4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

  1996cited by this paper
• Regulation of Both Glycogen Synthase and PHAS-I by Insulin in Rat Skeletal Muscle Involves Mitogen-activated Protein Kinase-independent and Rapamycin-sensitive Pathways (*)

  1996cited by this paper
• Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

  1996cited by this paper
• Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation.

  1996cited by this paper
• Mechanism of activation of protein kinase B by insulin and IGF‐1.

  1996cited by this paper
• Control of the Translational Regulators PHAS-I and PHAS-II by Insulin and cAMP in 3T3-L1 Adipocytes*

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  1996cited by this paper
• A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells.

  1996cited by this paper
• Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells (*)

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• Control of PHAS-I by Insulin in 3T3-L1 Adipocytes

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• Selective inhibition of p70 S6 kinase activation by phosphatidylinositol 3-kinase inhibitors.

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• Received

  1868cited by this paper

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