Methylation of the androgen receptor minimal promoter silences transcription in human prostate cancer.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Cancer Research

• Publication date

  2000-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10910077
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999cited by this paper
• CpG island methylator phenotype in colorectal cancer.

  1999cited by this paper
• Cancer-epigenetics comes of age

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  1999cited by this paper
• Androgen receptor gene and hormonal therapy failure of prostate cancer.

  1998cited by this paper
• Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

  1998cited by this paper
• Methylation of the androgen receptor promoter CpG island is associated with loss of androgen receptor expression in prostate cancer cells.

  1998influential reference
• Mapping of ER gene CpG island methylation-specific polymerase chain reaction.

  1998cited by this paper
• Alterations in DNA methylation: a fundamental aspect of neoplasia.

  1998cited by this paper
• Loss of heterozygosity on chromosome XP22.2-p22.13 and Xq26.1-q27.1 in human breast carcinomas.

  1998cited by this paper
• Modulation of cytokeratin subtype, EGF receptor, and androgen receptor expression during progression of prostate cancer.

  1998cited by this paper
• The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines.

  1998cited by this paper
• Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome.

  1998cited by this paper
• Mapping Patterns of CpG Island Methylation in Normal and Neoplastic Cells Implicates Both Upstream and Downstream Regions inde Novo Methylation*

  1997cited by this paper
• Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA.

  1997cited by this paper
• Epigenetic variation illustrated by DNA methylation patterns of the fragile-X gene FMR1.

  1997cited by this paper
• Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE).

  1997influential reference
• Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.

  1997cited by this paper
• Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors.

  1997cited by this paper
• Androgen-dependent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor.

  1997cited by this paper
• Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects.

  1997cited by this paper
• Aberrant silencing of the CpG island-containing human O6-methylguanine DNA methyltransferase gene is associated with the loss of nucleosome-like positioning

  1997cited by this paper
• Human prostate tumor growth in athymic mice: inhibition by androgens and stimulation by finasteride.

  1996cited by this paper
• Functional analysis of the human androgen receptor promoter.

  1996influential reference
• Androgenic up-regulation of androgen receptor cDNA expression in androgen-independent prostate cancer cells.

  1996cited by this paper
• Androgen receptor status of lymph node metastases from prostate cancer

  1996cited by this paper
• Clonality of tuberous sclerosis harmatomas shown by non-random X-chromosome inactivation

  1996cited by this paper
• Distant metastases from prostatic carcinoma express androgen receptor protein.

  1995cited by this paper
• Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial

  1995cited by this paper
• Androgen receptor defects: historical, clinical, and molecular perspectives.

  1995cited by this paper
• High sensitivity mapping of methylated cytosines.

  1994cited by this paper
• Progressive increases in the methylation status and heterochromatinization of the myoD CpG island during oncogenic transformation

  1994cited by this paper
• Induction of translation by the 5'-untranslated region of human androgen receptor mRNA.

  1994cited by this paper
• Steroid-growth factor interaction in human prostate cancer. 1. Short-term effects of transforming growth factors on growth of human prostate cancer cells.

  1994cited by this paper
• Transfection of human estrogen receptor (ER) cDNA into ER-negative mammalian cell lines.

  1994cited by this paper
• Detection of Human Androgen Receptor mRNA Expression Abnormalities by Competitive PCR

  1994cited by this paper
• Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.

  1994cited by this paper
• Spl elements protect a CpG island from de novo methylation

  1994cited by this paper
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  1994cited by this paper
• Identification of 3',5'-cyclic adenosine monophosphate response element and other cis-acting elements in the human androgen receptor gene promoter.

  1994influential reference
• Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen.

  1993cited by this paper
• Androgen receptors in endocrine‐therapy‐resistant human prostate cancer

  1991cited by this paper
• CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

  1990cited by this paper
• Androgen receptor gene expression in human prostate carcinoma cell lines.

  1990cited by this paper
• CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

  1989cited by this paper
• CpG islands in vertebrate genomes.

  1987cited by this paper
• Chromosomes: Correlation with Binding Sites for Transcription Factors

  year unknowncited by this paper

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• Lineage plasticity and treatment resistance in prostate cancer: the intersection of genetics, epigenetics, and evolution

  2023cites this paper
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• Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth

  2023cites this paper
• Epigenetics in cancer development, diagnosis and therapy.

  2023cites this paper
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  2022cites this paper
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  2022cites this paper
• DNA Methylation in Genes Associated with the Evolution of Ageing and Disease: A Critical Review.

  2021cites this paper
• Targeting DNMTs to Overcome Enzalutamide Resistance in Prostate Cancer

  2021cites this paper
• Epigenetic reprogramming during prostate cancer progression: A perspective from development.

  2021cites this paper
• The heterogeneity of prostate cancers lacking AR activity will require diverse treatment approaches.

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• A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer

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  2021cites this paper
• Non-CpG methylation-a key epigenetic modification in cancer.

  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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• DNA Methylation Alterations as Biomarkers for Prostate Cancer

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• Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy

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• Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries.

  2015cites this paper
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  2015cites this paper
• DNA methylation as a dynamic regulator of development and disease processes: spotlight on the prostate.

  2015cites this paper
• Targeting the Hedgehog Pathway Components by Using Inhibitors and Epigenetic Modulators

  2015cites this paper
• Promoter hypermethylation as a biomarker in prostate adenocarcinoma.

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• Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver

  2014cites this paper
• The evidence for functional non-CpG methylation in mammalian cells

  2014cites this paper
• Advances in systemic therapies for metastatic castration-resistant prostate cancer.

  2014cites this paper
• Alterations Associated with Androgen Receptor Gene Activation in Salivary Duct Carcinoma of Both Sexes: Potential Therapeutic Ramifications

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• Challenges in overcoming hormonal resistance in prostate cancer

  2014cites this paper
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• TMEFF2 and SARDH cooperate to modulate one‐carbon metabolism and invasion of prostate cancer cells

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• Effect of histone deacetylase and DNA methyltransferase inhibitors on the expression of the androgen receptor gene in androgen-independent prostate cancer cell lines.

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• The E2F1/DNMT1 axis is associated with the development of AR negative castration resistant prostate cancer

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• CpG island hypermethylation frequently silences FILIP1L isoform 2 expression in prostate cancer.

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• The effect of diet-induced insulin resistance on DNA methylation of the androgen receptor promoter in the penile cavernosal smooth muscle of mice.

  2013cites this paper
• DNA methylation in promoter region as biomarkers in prostate cancer.

  2012cites this paper
• Development of a method to measure DNA methylation levels by using methyl CpG-binding protein and luciferase-fused zinc finger protein.

  2012cites this paper
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  2012cites this paper
• Androgen receptor (AR) aberrations in castration-resistant prostate cancer.

  2012cites this paper
• Androgen receptor expression predicts breast cancer survival: the role of genetic and epigenetic events

  2012cites this paper
• Androgens and the masculinisation programming window

  2012cites this paper
• Androgen receptor (AR) expression in prostate cancer and progression of the tumor: Lessons from cell lines, animal models and human specimens.

  2012cites this paper
• Aberrant DNA Methylation and Prostate Cancer

  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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• Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (review).

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