Endothelial Cell–Derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Hearts Through Stimulation of Endothelial-to-Mesenchymal Transition

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Circulation

• Publication date

  2010-06-08

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1161/CIRCULATIONAHA.110.938217PMID 20497976
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
• Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition.

  2008cited by this paper
• Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options.

  2008cited by this paper
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• Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1.

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• Endothelin antagonism normalizes VEGF signaling and cardiac function in STZ-induced diabetic rat hearts.

  2007cited by this paper
• Unrecognized glycometabolic disturbance as measured by hemoglobin A1c is associated with a poor outcome after acute myocardial infarction.

  2007cited by this paper
• Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

  2007cited by this paper
• Endothelin Receptor Antagonists in Cancer Therapy

  2007cited by this paper
• Diabetic cardiomyopathy revisited.

  2007cited by this paper
• Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts.

  2007cited by this paper
• Chronic endothelin‐A receptor antagonism is as protective as angiotensin converting enzyme inhibition against cardiac dysfunction in diabetic rats

  2007cited by this paper
• High glucose alters cardiomyocyte contacts and inhibits myofibrillar formation.

  2006cited by this paper
• Endothelin-1 Is Required During Epithelial to Mesenchymal Transition in Ovarian Cancer Progression

  2006cited by this paper
• Diabetic cardiomyopathy: the search for a unifying hypothesis.

  2006cited by this paper
• Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress.

  2006cited by this paper
• Endothelins: Regulators of Extracellular Matrix Protein Production in Diabetes

  2006cited by this paper
• [Cellular and molecular mechanisms of fibrosis].

  2006cited by this paper
• Endothelin receptor antagonists for pulmonary arterial hypertension.

  2005cited by this paper
• Real-Time PCR

  2005cited by this paper
• Endothelin receptor antagonists in pulmonary arterial hypertension.

  2004cited by this paper
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  2004cited by this paper
• The relationship between glycemic control and plasma vascular endothelial growth factor and endothelin-1 concentration in diabetic patients.

  2004cited by this paper
• Heart valve development: endothelial cell signaling and differentiation.

  2004cited by this paper
• Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes.

  2004cited by this paper
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  2003cited by this paper
• Elevated plasma endothelin-1 levels in diabetes mellitus.

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Diabetes-induced myocardial structural changes: role of endothelin-1 and its receptors.

  2000cited by this paper
• Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.

  2000cited by this paper
• Effect of diabetes mellitus on formation of coronary collateral vessels.

  1999cited by this paper
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  1997cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Collagen remodelling in myocardia of patients with diabetes.

  1993cited by this paper
• Factors associated with reactive and reparative fibrosis of the myocardium.

  1992cited by this paper
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  1988cited by this paper
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  1987cited by this paper
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  1972cited by this paper

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  2025cites this paper
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  2025cites this paper
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  2021cites this paper
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