Recent Advances and the Future of Stem Cell Therapies in Amyotrophic Lateral Sclerosis

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Neurotherapeutics

• Publication date

  2015-03-17

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s13311-015-0339-9PMID 25776222PMCID PMC4404436
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PloS One 2012

  2015cited by this paper
• Analysis of graft survival in a trial of stem cell transplant in ALS

  2014cited by this paper
• Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord

  2014cited by this paper
• Motor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectives

  2014cited by this paper
• Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: a phase I trial, cervical microinjection, and final surgical safety outcomes.

  2014cited by this paper
• Diagnostic timelines and delays in diagnosing amyotrophic lateral sclerosis (ALS)

  2014cited by this paper
• Minorities, men, and unmarried amyotrophic lateral sclerosis patients are more likely to die in an acute care facility

  2014cited by this paper
• Intraspinal Neural Stem Cell Transplantation in Amyotrophic Lateral Sclerosis: Phase 1 Trial Outcomes

  2014cited by this paper
• Quantifying Disease Progression in Amyotrophic Lateral Sclerosis

  2014cited by this paper
• Patient-Specific Induced Pluripotent Stem Cells for SOD1-Associated Amyotrophic Lateral Sclerosis Pathogenesis Studies

  2014cited by this paper
• Concise Review: Stem Cell Therapies for Amyotrophic Lateral Sclerosis: Recent Advances and Prospects for the Future

  2014cited by this paper
• The changing scene of amyotrophic lateral sclerosis

  2013cited by this paper
• Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model

  2013cited by this paper
• Neural Induction with Neurogenin 1 Enhances the Therapeutic Potential of Mesenchymal Stem Cells in an Amyotrophic Lateral Sclerosis Mouse Model

  2013cited by this paper
• 25 years of neuroimaging in amyotrophic lateral sclerosis

  2013cited by this paper
• Bone Marrow Transplantation in Hindlimb Muscles of Motoneuron Degenerative Mice Reduces Neuronal Death and Improves Motor Function

  2013cited by this paper
• Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model.

  2013cited by this paper
• A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells.

  2013cited by this paper
• State of play in amyotrophic lateral sclerosis genetics

  2013cited by this paper
• Neural Progenitors Derived From Human Induced Pluripotent Stem Cells Survive and Differentiate Upon Transplantation Into a Rat Model of Amyotrophic Lateral Sclerosis

  2013cited by this paper
• Neurotrophic Bone Marrow Cellular Nests Prevent Spinal Motoneuron Degeneration in Amyotrophic Lateral Sclerosis Patients: A Pilot Safety Study

  2012cited by this paper
• Olfactory Ensheathing Cell Neurorestorotherapy for Amyotrophic Lateral Sclerosis Patients: Benefits from Multiple Transplantations

  2012cited by this paper
• Stem Cell Transplantation in Amyotrophic Lateral Sclerosis Patients: Methodological Approach, Safety, and Feasibility

  2012cited by this paper
• Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

  2012cited by this paper
• Intracerebroventricular Injection of Encapsulated Human Mesenchymal Cells Producing Glucagon-Like Peptide 1 Prolongs Survival in a Mouse Model of ALS

  2012cited by this paper
• Translational stem cell therapy for amyotrophic lateral sclerosis

  2012cited by this paper
• Feasibility, Safety, and Preliminary Proof of Principles of Autologous Neural Stem Cell Treatment Combined with T-Cell Vaccination for ALS Patients

  2012cited by this paper
• Mesenchymal stromal cell transplantation in amyotrophic lateral sclerosis: a long-term safety study.

  2012cited by this paper
• Human Neural Stem Cell Replacement Therapy for Amyotrophic Lateral Sclerosis by Spinal Transplantation

  2012cited by this paper
• Lumbar Intraspinal Injection of Neural Stem Cells in Patients with Amyotrophic Lateral Sclerosis: Results of a Phase I Trial in 12 Patients

  2012cited by this paper
• Intravenous Mesenchymal Stem Cells Improve Survival and Motor Function in Experimental Amyotrophic Lateral Sclerosis

  2012cited by this paper
• Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: a phase I safety trial, technical note, and lumbar safety outcomes.

  2012cited by this paper
• Comparative Effects between Bone Marrow and Mesenchymal Stem Cell Transplantation in GDNF Expression and Motor Function Recovery in a Motorneuron Degenerative Mouse Model

  2012cited by this paper
• Autologous bone marrow-derived stem cells in amyotrophic lateral sclerosis: a pilot study.

  2012cited by this paper
• Stem cell transplantation into the intraventricular space via an Ommaya reservoir in a patient with amyotrophic lateral sclerosis.

  2012cited by this paper
• Intraspinal Injection of Human Umbilical Cord Blood-Derived Cells Is Neuroprotective in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

  2011cited by this paper
• Genetically modified human umbilical cord blood cells expressing vascular endothelial growth factor and fibroblast growth factor 2 differentiate into glial cells after transplantation into amyotrophic lateral sclerosis transgenic mice

  2011cited by this paper
• Human Glial-Restricted Progenitor Transplantation into Cervical Spinal Cord of the SOD1G93A Mouse Model of ALS

  2011cited by this paper
• Erratum: Stem cell technology for the study and treatment of motor neuron diseases, which appeared in the February issue of Regenerative Medicine (Regen. Med. (2011) 6:2 (201-213))

  2011cited by this paper
• Repeated courses of granulocyte colony‐stimulating factor in amyotrophic lateral sclerosis: Clinical and biological results from a prospective multicenter study

  2011cited by this paper
• Defective Neuromuscular Transmission in the SOD1G93A Transgenic Mouse Improves After Administration of Human Umbilical Cord Blood Cells

  2011cited by this paper
• Stem cell technology for the study and treatment of motor neuron diseases.

  2011cited by this paper
• Neuroprotective features of mesenchymal stem cells.

  2011cited by this paper
• Bone marrow mesenchymal stem cells can be mobilized into peripheral blood by G-CSF in vivo and integrate into traumatically injured cerebral tissue

  2011cited by this paper
• Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis.

  2011cited by this paper
• Intracerebroventricular Administration of Human Umbilical Cord Blood Cells Delays Disease Progression in Two Murine Models of Motor Neuron Degeneration

  2011cited by this paper
• Dual transplantation of human neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in SOD1 transgenic rats.

  2011cited by this paper
• Consistent bone marrow-derived cell mobilization following repeated short courses of granulocyte-colony-stimulating factor in patients with amyotrophic lateral sclerosis: results from a multicenter prospective trial.

  2010cited by this paper
• Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis.

  2010cited by this paper
• Characterization of a human fetal spinal cord stem cell line, NSI‐566RSC, and its induction to functional motoneurons

  2010cited by this paper
• Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis

  2010cited by this paper
• Human umbilical cord blood treatment in a mouse model of ALS : optimization of cell dose. PLoS ONE 2008; 3(6): e2494

  2010cited by this paper
• Stem cells and the ALS neurologist

  2010cited by this paper
• No benefits from experimental treatment with olfactory ensheathing cells in patients with ALS

  2010cited by this paper
• Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial.

  2010cited by this paper
• Systemic transplantation of c-kit+ cells exerts a therapeutic effect in a model of amyotrophic lateral sclerosis.

  2010cited by this paper
• Recombinant human granulocyte-colony stimulating factor administration for treating amyotrophic lateral sclerosis: A pilot study

  2010cited by this paper
• Dose-dependent efficacy of ALS-human mesenchymal stem cells transplantation into cisterna magna in SOD1-G93A ALS mice.

  2010cited by this paper
• A surgical technique of spinal cord cell transplantation in amyotrophic lateral sclerosis.

  2010cited by this paper
• Distribution, Differentiation, and Survival of Intravenously Administered Neural Stem Cells in a Rat Model of Amyotrophic Lateral Sclerosis

  2010cited by this paper
• Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

  2009cited by this paper
• SUBCUTANEOUS IGF-1 IS NOT BENEFICIAL IN 2-YEAR ALS TRIAL

  2009cited by this paper
• Neuropathology of Olfactory Ensheathing Cell Transplantation into the Brain of Two Amyotrophic Lateral Sclerosis (ALS) Patients

  2009cited by this paper
• Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients.

  2009cited by this paper
• Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice

  2009cited by this paper
• Preliminary investigation of effect of granulocyte colony stimulating factor on amyotrophic lateral sclerosis

  2009cited by this paper
• Chimerization of astroglial population in the lumbar spinal cord after mesenchymal stem cell transplantation prolongs survival in a rat model of amyotrophic lateral sclerosis

  2009cited by this paper
• Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up.

  2009cited by this paper
• Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis.

  2009cited by this paper
• Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: Differentiation and structural integration into the segmental motor circuitry

  2009cited by this paper
• Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice

  2009cited by this paper
• Transient Recovery in a Rat Model of Familial Amyotrophic Lateral Sclerosis after Transplantation of Motor Neurons Derived from Mouse Embryonic Stem Cells

  2009cited by this paper
• Pilot study of granulocyte colony stimulating factor (G‐CSF)‐mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS)

  2008cited by this paper
• Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis.

  2008cited by this paper
• Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: a controlled pilot study

  2008cited by this paper
• Human umbilical cord blood cells transfected with VEGF and L(1)CAM do not differentiate into neurons but transform into vascular endothelial cells and secrete neuro-trophic factors to support neuro-genesis-a novel approach in stem cell therapy.

  2008cited by this paper
• [Mammalian neural stem cells].

  2008cited by this paper
• A novel cell transplantation protocol and its application to an ALS mouse model.

  2008cited by this paper
• Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

  2008cited by this paper
• Human Umbilical Cord Blood Treatment in a Mouse Model of ALS: Optimization of Cell Dose

  2008cited by this paper
• Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS.

  2008cited by this paper
• Mesenchymal stem cells in health and disease

  2008cited by this paper
• Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

  2008cited by this paper
• Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis

  2008cited by this paper
• Stem cell treatment in Amyotrophic Lateral Sclerosis.

  2008cited by this paper
• Focal Transplantation-based Astrocyte Replacement is Neuroprotective in a Model of Motor Neuron Disease

  2008cited by this paper
• Subcutaneous IGF-1 is not beneficial in 2-year ALS trial

  2008cited by this paper
• Short-term outcome of olfactory ensheathing cells transplantation for treatment of amyotrophic lateral sclerosis.

  2007cited by this paper
• Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

  2007cited by this paper
• Adult Olfactory Bulb Neural Precursor Cell Grafts Provide Temporary Protection From Motor Neuron Degeneration, Improve Motor Function, and Extend Survival in Amyotrophic Lateral Sclerosis Mice

  2007cited by this paper
• GDNF Secreting Human Neural Progenitor Cells Protect Dying Motor Neurons, but Not Their Projection to Muscle, in a Rat Model of Familial ALS

  2007cited by this paper
• Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration.

  2007cited by this paper
• Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

  2007cited by this paper
• Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effects

  2007cited by this paper
• Olfactory ensheathing glia injections in Beijing: Misleading patients with ALS

  2007cited by this paper
• Human mesenchymal stromal cells ameliorate the phenotype of SOD1-G93A ALS mice.

  2007cited by this paper
• Neural stem cells LewisX+ CXCR4+ modify disease progression in an amyotrophic lateral sclerosis model.

  2007cited by this paper
• Amyotrophic lateral sclerosis--are microglia killing motor neurons?

  2006cited by this paper
• Combined Immunosuppressive Agents or CD4 Antibodies Prolong Survival of Human Neural Stem Cell Grafts and Improve Disease Outcomes in Amyotrophic Lateral Sclerosis Transgenic Mice

  2006cited by this paper
• Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia

  2006cited by this paper

• Edaravone mitigates TDP-43 mislocalization in human amyotrophic lateral sclerosis neurons with potential implication of the SIRT1-XBP1 pathway.

  2025cites this paper
• Assessing fetal human neural stem cells tumorigenicity potential in athymic rats with penetrating traumatic brain injury (pTBI).

  2022cites this paper
• Stem-Cell-Based Therapy: The Celestial Weapon against Neurological Disorders

  2022cites this paper
• Case Report: Stem cell therapy in amyotrophic lateral sclerosis

  2021cites this paper
• The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation

  2021cites this paper
• The Role of TLR4 in Neural Stem Cells–Mediated Neurogenesis and Neuroinflammation

  2020cites this paper
• PuraMatrix hydrogel enhances the expression of motor neuron progenitor marker and improves adhesion and proliferation of motor neuron-like cells

  2020cites this paper
• Uses for humanised mouse models in precision medicine for neurodegenerative disease

  2019cites this paper
• Stem cell treatments for amyotrophic lateral sclerosis: a critical overview of early phase trials

  2019influential citation
• Targeted intraspinal injections to assess therapies in rodent models of neurological disorders

  2019cites this paper
• Cell-based therapies for amyotrophic lateral sclerosis/motor neuron disease.

  2019cites this paper
• Emerging understanding of the genotype-phenotype relationship in amyotrophic lateral sclerosis.

  2018cites this paper
• Long‐term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS

  2018cites this paper
• Mapping ALSFRS-R and ALSUI to EQ-5D in Patients with Motor Neuron Disease.

  2018cites this paper
• Stem Cell Therapy for Amyotrophic Lateral Sclerosis – an Overview of Current Clinical Experience

  2018cites this paper
• Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications

  2017cites this paper
• Stem cells for ALS: An overview of possible therapeutic approaches

  2017cites this paper
• Economic Studies in Motor Neurone Disease: A Systematic Methodological Review

  2017cites this paper
• Cell-based therapies for amyotrophic lateral sclerosis/motor neuron disease.

  2016cites this paper
• Intraspinal stem cell transplantation for amyotrophic lateral sclerosis

  2016cites this paper
• Estudo da proliferação, migração e diferenciação dos precursores neurais do sistema nervoso pós-natal de camundongos (Mus musculus)

  2016cites this paper
• Adult Brain Neurogenesis, Neural Stem Cells and Neurogenic Niches

  2016cites this paper
• Clinical Trials of Therapies for Amyotrophic Lateral Sclerosis: One Size Does Not Fit All.

  2015cites this paper
• The Spectrum of Motor Neuron Diseases: From Childhood Spinal Muscular Atrophy to Adult Amyotrophic Lateral Sclerosis

  2015cites this paper