Microelectrode array recordings of cultured hippocampal networks reveal a simple model for transcription and protein synthesis‐dependent plasticity

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Physiology

• Publication date

  2005-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1113/jphysiol.2004.077446PMID 15618268PMCID PMC1456059
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Amyloid precursor protein promotes post‐developmental neurite arborization in the Drosophila brain

  2005cited by this paper
• Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors

  2004cited by this paper
• Optical Quantal Analysis Indicates That Long-Term Potentiation at Single Hippocampal Mossy Fiber Synapses Is Expressed through Increased Release Probability, Recruitment of New Release Sites, and Activation of Silent Synapses

  2004cited by this paper
• ‘Deaf, mute and whispering’ silent synapses: their role in synaptic plasticity

  2004cited by this paper
• Single-neuron discharge properties and network activity in dissociated cultures of neocortex.

  2004cited by this paper
• CBP histone acetyltransferase activity is a critical component of memory consolidation.

  2004cited by this paper
• Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.

  2004cited by this paper
• Epileptiform activity in rat hippocampus strengthens excitatory synapses

  2004cited by this paper
• Synaptic activity induces signalling to CREB without increasing global levels of cAMP in hippocampal neurons

  2003cited by this paper
• Proteins interactions implicated in AMPA receptor trafficking: a clear destination and an improving route map.

  2003influential reference
• Synaptic Plasticity and AMPA Receptor Trafficking

  2003influential reference
• Optical quantal analysis reveals a presynaptic component of LTP at hippocampal Schaffer-associational synapses.

  2003cited by this paper
• The molecular basis of CaMKII function in synaptic and behavioural memory

  2002cited by this paper
• Regulation of AMPA receptors during synaptic plasticity.

  2002cited by this paper
• Spontaneous development of synchronous oscillatory activity during maturation of cortical networks in vitro.

  2002cited by this paper
• Correlated Bursts of Activity in the Neonatal Hippocampus in Vivo

  2002cited by this paper
• Ras and Rap control AMPA receptor trafficking during synaptic plasticity.

  2002cited by this paper
• Cortical and subcortical generators of normal and abnormal rhythmicity.

  2002cited by this paper
• Rapid ocular dominance plasticity requires cortical but not geniculate protein synthesis.

  2002cited by this paper
• Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

  2002influential reference
• AMPA receptor trafficking and synaptic plasticity.

  2002cited by this paper
• Regulation of transcription factors by neuronal activity

  2002cited by this paper
• The generation of rhythmic activity in dissociated cultures of rat spinal cord

  2001cited by this paper
• A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication

  2001influential reference
• Dentritic spines : structure, dynamics and regulation

  2001cited by this paper
• Mitogen-activated protein kinase/extracellular signal-regulated kinase induced gene regulation in brain

  2001cited by this paper
• Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

  2001influential reference
• Rapid Increase in Clusters of Presynaptic Proteins at Onset of Long-Lasting Potentiation

  2001cited by this paper
• The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

  2001cited by this paper
• Synaptic reverberation underlying mnemonic persistent activity.

  2001cited by this paper
• Transcriptional regulation by the phosphorylation-dependent factor CREB

  2001cited by this paper
• Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway

  2001cited by this paper
• Extracellular Signal-Regulated Kinase, Synaptic Plasticity, and Memory

  2001cited by this paper
• Synaptic modification by correlated activity: Hebb's postulate revisited.

  2001cited by this paper
• Mitogen-activated protein kinase/extracellular signal-regulated kinase induced gene regulation in brain: a molecular substrate for learning and memory?

  2001cited by this paper
• Spatiotemporal characterization of rhythmic activity in rat spinal cord slice cultures

  2001cited by this paper
• Cell Death and Synaptic Reorganizations Produced by Seizures

  2001cited by this paper
• Synaptic plasticity and dynamic modulation of the postsynaptic membrane

  2000influential reference
• Calcium-regulated protein kinase cascades and their transcription factor targets

  2000cited by this paper
• LTP mechanisms: from silence to four-lane traffic.

  2000influential reference
• Transcription-dependent neuronal plasticity: The nuclear calcium hypothesis.

  2000influential reference
• Postfusional regulation of cleft glutamate concentration during LTP at ‘silent synapses’

  2000cited by this paper
• Synchronous membrane potential fluctuations in neurons of the cat visual cortex.

  1999cited by this paper
• Can molecules explain long-term potentiation?

  1999cited by this paper
• Long-term potentiation--a decade of progress?

  1999cited by this paper
• Synaptic and intrinsic mechanisms shape synchronous oscillations in hippocampal neurons in culture

  1999cited by this paper
• 英国生理学会(The Physiological Society)

  1999cited by this paper
• Reciprocal interactions between CA3 network activity and strength of recurrent collateral synapses

  1999influential reference
• Correlational structure of spontaneous neuronal activity in the developing lateral geniculate nucleus in vivo.

  1999cited by this paper
• Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels.

  1999influential reference
• Synaptic plasticity.

  1998cited by this paper
• Cognitive neuroscience and the study of memory.

  1998influential reference
• Memory consolidation during sleep: a neurophysiological perspective

  1998cited by this paper
• CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.

  1998influential reference
• Ca2+-dependent regulation in neuronal gene expression.

  1997cited by this paper
• Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression

  1997influential reference
• Spontaneous subthreshold membrane potential fluctuations and action potential variability of rat corticostriatal and striatal neurons in vivo.

  1997cited by this paper
• CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression.

  1996cited by this paper
• Mechanisms of long‐lasting hyperpolarizations underlying slow sleep oscillations in cat corticothalamic networks.

  1996cited by this paper
• Spontaneous periodic synchronized bursting during formation of mature patterns of connections in cortical cultures.

  1996cited by this paper
• A protein synthesis-dependent late phase of cerebellar long-term depression.

  1996cited by this paper
• Early functional neural networks in the developing retina

  1995cited by this paper
• N-methyl-D-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons.

  1995cited by this paper
• Requirement of a critical period of transcription for induction of a late phase of LTP.

  1994cited by this paper
• Rhythmic spontaneous activity in the developing avian auditory system

  1994cited by this paper
• Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.

  1993cited by this paper
• Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.

  1993cited by this paper
• A synaptic model of memory: long-term potentiation in the hippocampus

  1993cited by this paper
• A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components

  1993cited by this paper
• Ionic flux contributions to neocortical slow waves and nucleus basalis- mediated activation: whole-cell recordings in vivo

  1993cited by this paper
• Intracellular analysis of relations between the slow (< 1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram

  1993cited by this paper
• The slow (< 1 Hz) oscillation in reticular thalamic and thalamocortical neurons: scenario of sleep rhythm generation in interacting thalamic and neocortical networks

  1993cited by this paper
• Spontaneous synchronous synaptic calcium transients in cultured cortical neurons

  1992cited by this paper
• Synchronous bursts of action potentials in ganglion cells of the developing mammalian retina.

  1991cited by this paper
• Stimulation of protein tyrosine phosphorylation by NMDA receptor activation

  1991cited by this paper
• Two-stage model of memory trace formation: a role for "noisy" brain states.

  1989cited by this paper
• Long-term depression.

  1989cited by this paper
• [Long term depression].

  1989cited by this paper
• Long‐lasting modification of the synaptic properties of rat CA3 hippocampal neurones induced by kainic acid.

  1988cited by this paper
• Spontaneous impulse activity of rat retinal ganglion cells in prenatal life.

  1988cited by this paper
• Long-term potentiation induced by physiologically relevant stimulus patterns.

  1987cited by this paper

• Acute, prolonged, and chronic exposure to organochlorine insecticides evoke differential effects on in vitro neuronal activity and network development.

  2025cites this paper
• THC, CBD and minor cannabinoid CBDV differently modulate hippocampal neurons firing.

  2025cites this paper
• Nuclear calcium signaling in D1 receptor-expressing neurons of the nucleus accumbens regulates molecular, cellular and behavioral adaptations to cocaine.

  2025cites this paper
• Heterosynaptic plasticity: one name for several phenomena

  2024cites this paper
• Anesthetics inhibit phosphorylation of the ribosomal protein S6 in mouse cultured cortical cells and developing brain

  2023cites this paper
• A functional network of highly pure enteric neurons in a dish

  2023cites this paper
• Assaying Chemical Long-Term Potentiation in Human iPSC-Derived Neuronal Networks.

  2023cites this paper
• The microbiota‐gut‐brain axis and epilepsy from a multidisciplinary perspective: Clinical evidence and technological solutions for improvement of in vitro preclinical models

  2022cites this paper
• A flexible and versatile system for multicolor fiber photometry and optogenetic manipulation

  2022cites this paper
• Development of a platform to investigate long-term potentiation in human iPSC-derived neuronal networks

  2022influential citation
• Comparative study between radiofrequency-induced and muscimol-induced inhibition of cultured networks of cortical neuron

  2022cites this paper
• Flexibility of in vitro cortical circuits influences resilience from microtrauma

  2022cites this paper
• Dysregulation of Npas4 and Inhba expression and an altered excitation–inhibition balance are associated with cognitive deficits in DBA/2 mice

  2022cites this paper
• Neuronal activity‐induced SUMOylation of Akt1 by PIAS3 is required for long‐term potentiation of synaptic transmission

  2021cites this paper
• Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABAAR density

  2021cites this paper
• Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction

  2021cites this paper
• Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic

  2021cites this paper
• The Future of Neurotoxicology: A Neuroelectrophysiological Viewpoint

  2021cites this paper
• Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes

  2020influential citation
• A microscopy-based small molecule screen in primary neurons reveals neuroprotective properties of the FDA-approved anti-viral drug Elvitegravir

  2020cites this paper
• Activity-Dependent Remodeling of Synaptic Protein Organization Revealed by High Throughput Analysis of STED Nanoscopy Images

  2020cites this paper
• Activity-Induced SUMOylation of Neuronal Nitric Oxide Synthase Is Associated with Plasticity of Synaptic Transmission and Extracellular Signal-Regulated Kinase 1/2 Signaling

  2020cites this paper
• PLA2 G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment.

  2020cites this paper
• Pre-proof PLA 2 G 4 E , a candidate gene for resilience in Alzheimerś disease and a new target for dementia treatment

  2020cites this paper
• Neurogranin Expression Is Regulated by Synaptic Activity and Promotes Synaptogenesis in Cultured Hippocampal Neurons

  2019cites this paper
• Application of Microelectrode Array Approaches to Neurotoxicity Testing and Screening.

  2019cites this paper
• Activation of nicotinic acetylcholine receptors induces potentiation and synchronization within in vitro hippocampal networks

  2019cites this paper
• The role of the genome in experience-dependent plasticity: Extending the analogy of the genomic action potential

  2019cites this paper
• Unique Features of Network Bursts Emerge From the Complex Interplay of Excitatory and Inhibitory Receptors in Rat Neocortical Networks

  2019cites this paper
• An Optogenetic Study of the Electrophysiological Properties of Hippocampal Neurons in PS1-M146V Transgenic Mice (a model of Alzheimer’s disease)

  2019cites this paper
• In Vitro Screening for Seizure Liability Using Microelectrode Array Technology

  2018cites this paper
• Different Neuronal Activity Patterns Induce Different Gene Expression Programs.

  2018cites this paper
• Pathway sensor-based functional genomics screening identifies modulators of neuronal activity

  2018cites this paper
• Networks of Cultured iPSC-Derived Neurons Reveal the Human Synaptic Activity-Regulated Adaptive Gene Program

  2017cites this paper
• One nuclear calcium transient induced by a single burst of action potentials represents the minimum signal strength in activity-dependent transcription in hippocampal neurons.

  2017cites this paper
• Distinct neuronal activity patterns induce different gene expression programs

  2017cites this paper
• Recurrently connected and localized neuronal communities initiate coordinated spontaneous activity in neuronal networks

  2017cites this paper
• PEDOT:PSS microelectrode arrays for hippocampal cell culture electrophysiological recordings

  2017cites this paper
• Regulation of Lysosomal Adaptation to Nutrient Starvation by Lysosomal TRPML1 and PIKfyve

  2017cites this paper
• MOTOR FUNCTION RESTORATION: THERAPEUTIC APPROACHES TO DENERVATION PATHOLOGIES

  2016cites this paper
• Comparative Analysis of Human and Rodent Brain Primary Neuronal Culture Spontaneous Activity Using Micro‐Electrode Array Technology

  2016cites this paper
• Emerging brain circuits in silico and in vitro

  2016cites this paper
• Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits

  2016cites this paper
• Early Alterations of Hippocampal Neuronal Firing Induced by Abeta42

  2016cites this paper
• A Neuronal Activity-Dependent Dual Function Chromatin-Modifying Complex Regulates Arc Expression1,2,3

  2015cites this paper
• Progress Toward Therapies and Interventions for Neurodevelopmental Disorders

  2015cites this paper
• Calcium Signaling, Excitability, and Synaptic Plasticity Defects in a Mouse Model of Alzheimer's Disease

  2015influential citation
• The Upregulation of NR2A-Containing N-Methyl-d-Aspartate Receptor Function by Tyrosine Phosphorylation of Postsynaptic Density 95 Via Facilitating Src/Proline-Rich Tyrosine Kinase 2 Activation

  2015cites this paper
• Hardware Acceleration of an Image Processing System for Dielectrophoretic Loading of Single Neurons Inside Micro-Wells of Microelectrode Arrays

  2015cites this paper
• Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation

  2015cites this paper
• Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission

  2015cites this paper
• BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A.

  2015cites this paper
• Cambios fenotípicos en proteínas relacionadas con la sinapsis en el prosencéfalo del ratón modelo del síndrome x frágil

  2015cites this paper
• Alterations in Hippocampal Network Activity after In Vitro Traumatic Brain Injury

  2015cites this paper
• cortical networks: models and experimental results Slow oscillating population activity in developing

  2015cites this paper
• The Nuclear Calcium Signaling Target, Activating Transcription Factor 3 (ATF3), Protects against Dendrotoxicity and Facilitates the Recovery of Synaptic Transmission after an Excitotoxic Insult*

  2014cites this paper
• Induced Current Pharmacological Split Stimulation System for Neuronal Networks

  2014influential citation
• Single-Neuron NMDA Receptor Phenotype Influences Neuronal Rewiring and Reintegration following Traumatic Injury

  2014influential citation
• Burst and principal components analyses of MEA data for 16 chemicals describe at least three effects classes.

  2014cites this paper
• Nanotechnologies for the study of the central nervous system.

  2014cites this paper
• Single-NeuronNMDAReceptorPhenotypeInfluences NeuronalRewiringandReintegrationfollowingTraumatic Injury

  2014cites this paper
• Intrinsically Active and Pacemaker Neurons in Pluripotent Stem Cell-Derived Neuronal Populations

  2014cites this paper
• Nuclear Calcium Signaling Induces Expression of the Synaptic Organizers Lrrtm1 and Lrrtm2*

  2014cites this paper
• Automation of network burst analysis in the single neuron resolution based on calcium imaging

  2013cites this paper
• Nuclear Calcium Signaling Regulates Nuclear Export of a Subset of Class IIa Histone Deacetylases following Synaptic Activity*

  2013cites this paper
• The impact of mild traumatic brain injury on neuronal networks and neurobehavior

  2013influential citation
• Calcium responses to synaptically activated bursts of action potentials and their synapse-independent replay in cultured networks of hippocampal neurons.

  2013cites this paper
• Advances in microfluidics-based experimental methods for neuroscience research.

  2013cites this paper
• Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation.

  2012influential citation
• Leptin Counteracts the Hypoxia-Induced Inhibition of Spontaneously Firing Hippocampal Neurons: A Microelectrode Array Study

  2012cites this paper
• The cytochrome c gene proximal enhancer drives activity-dependent reporter gene expression in hippocampal neurons

  2012cites this paper
• A new indirect co-culture set up of mouse hippocampal neurons and cortical astrocytes on microelectrode arrays.

  2012influential citation
• Nuclear Calcium Signaling Controls Methyl-CpG-binding Protein 2 (MeCP2) Phosphorylation on Serine 421 following Synaptic Activity*

  2012cites this paper
• Bursting dynamics and topological structure of in vitro neuronal networks

  2012cites this paper
• Novel modulatory effects of neurosteroids and benzodiazepines on excitatory and inhibitory neurons excitability: a multi-electrode array recording study

  2012cites this paper
• Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study.

  2011cites this paper
• An in vitro and in silico investigation of the role of NMDA receptor subtypes following mechanical injury

  2011cites this paper
• Neuronal Nitric Oxide Contributes to Neuroplasticity-Associated Protein Expression through cGMP, Protein Kinase G, and Extracellular Signal-Regulated Kinase

  2011influential citation
• The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics

  2011cites this paper
• Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro

  2011cites this paper
• Soluble Aβ1-40 Peptide Increases Excitatory Neurotransmission and Induces Epileptiform Activity in Hippocampal Neurons

  2011cites this paper
• Calcium signaling in synapse-to-nucleus communication.

  2011cites this paper
• Experience-Dependent Plasticity Acts via GluR1 and a Novel Neuronal Nitric Oxide Synthase-Dependent Synaptic Mechanism in Adult Cortex

  2011cites this paper
• Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture.

  2011cites this paper
• A Signaling Cascade of Nuclear Calcium-CREB-ATF3 Activated by Synaptic NMDA Receptors Defines a Gene Repression Module That Protects against Extrasynaptic NMDA Receptor-Induced Neuronal Cell Death and Ischemic Brain Damage

  2011cites this paper
• Synaptic and Extrasynaptic NMDA Receptors Differentially Modulate Neuronal Cyclooxygenase-2 Function, Lipid Peroxidation, and Neuroprotection

  2011influential citation
• Nuclear calcium-VEGFD signaling controls maintenance of dendrite arborization necessary for memory formation.

  2011cites this paper
• Slow oscillating population activity in developing cortical networks: models and experimental results.

  2011cites this paper
• Computational Investigation of the Changing Patterns of Subtype Specific NMDA Receptor Activation during Physiological Glutamatergic Neurotransmission

  2011cites this paper
• Canonical Wnt3a Modulates Intracellular Calcium and Enhances Excitatory Neurotransmission in Hippocampal Neurons*

  2010cites this paper
• 2010 Special Issue: Investigating neuronal activity by SPYCODE multi-channel data analyzer

  2010cites this paper
• Nuclear calcium sensors reveal that repetition of trains of synaptic stimuli boosts nuclear calcium signaling in CA1 pyramidal neurons.

  2010cites this paper
• Progressive NKCC1-Dependent Neuronal Chloride Accumulation during Neonatal Seizures

  2010cites this paper
• Microelectrode arrays: a physiologically based neurotoxicity testing platform for the 21st century.

  2010cites this paper
• Synaptic Activity and Nuclear Calcium Signaling Protect Hippocampal Neurons from Death Signal-associated Nuclear Translocation of FoxO3a Induced by Extrasynaptic N-Methyl-d-aspartate Receptors*

  2010cites this paper
• The generation of the synchronized burst in the cultured neuronal networks

  2009cites this paper
• Charakterisierung und Anwendung funktioneller neuronaler Netzwerke generiert aus murinen embryonalen Stammzellen.

  2009influential citation
• Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity

  2009cites this paper
• Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-D-aspartate receptors.

  2009cites this paper
• Alzheimer beta-amyloid blocks epileptiform activity in hippocampal neurons.

  2009influential citation