Role of amino acid transporters in amino acid sensing.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  American Journal of Clinical Nutrition

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3945/ajcn.113.070086PMID 24284439PMCID PMC3862456
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of amino acid transporters in nutrition

  2013cited by this paper
• Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism.

  2013cited by this paper
• Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

  2013cited by this paper
• An Extended Proteome Map of the Lysosomal Membrane Reveals Novel Potential Transporters*

  2013cited by this paper
• The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb.

  2013cited by this paper
• Nutrient regulation of the mTOR Complex 1 signaling pathway

  2013influential reference
• Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.

  2013cited by this paper
• Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR.

  2013cited by this paper
• Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes

  2012cited by this paper
• Leucine and mTORC1: a complex relationship.

  2012cited by this paper
• Exercise and Amino Acid Anabolic Cell Signaling and the Regulation of Skeletal Muscle Mass

  2012cited by this paper
• Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.

  2012cited by this paper
• Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.

  2012cited by this paper
• Insulin resistance and the metabolism of branched-chain amino acids in humans

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• AMPK and mTOR in cellular energy homeostasis and drug targets.

  2012cited by this paper
• Amino acids and mTORC1: from lysosomes to disease.

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• LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino Acid Homeostasis

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2011influential reference
• Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats.

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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.

  2010cited by this paper
• Role of N‐end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine‐mTOR signaling pathway

  2010cited by this paper
• Amino acid regulation of TOR complex 1.

  2009cited by this paper
• Dietary Guidelines should reflect new understandings about adult protein needs

  2009cited by this paper
• Bidirectional transport of amino acids regulates mTOR and autophagy.

  2009influential reference
• Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes.

  2009cited by this paper
• Regulation of placental amino acid transporter activity by mammalian target of rapamycin.

  2009cited by this paper
• Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling.

  2009cited by this paper
• Regulation of translation initiation in eukaryotes: mechanisms and biological targets.

  2009cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1989cited by this paper

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