Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions

R. Shi,A. Proteau,M. Villarroya,I. Moukadiri,Linhua Zhang,J. Trempe,A. Matte,M. Armengod,M. Cygler

Published 2010 in PLoS Biology

ABSTRACT

Crystal structures reveal how distinct sites on the cysteine desulfurase IscS bind two different sulfur-acceptor proteins, IscU and TusA, to transfer sulfur atoms for iron-sulfur cluster biosynthesis and tRNA thiolation.

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