Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region

Human HSCs appear first in the embryonic dorsal aorta, and only later in the yolk sac, liver, and placenta; a single human AGM region HSC can generate at least 300 daughter HSCs that are retransplantable into secondary recipient mice.

• Publication year

  2011

• Venue

  Journal of Experimental Medicine

• Publication date

  2011-11-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20111688PMID 22042975PMCID 3256972
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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