Blockade of B7-H1 on Macrophages Suppresses CD4+ T Cell Proliferation by Augmenting IFN-γ-Induced Nitric Oxide Production1

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Immunology

• Publication date

  2005-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.175.3.1586PMID 16034097
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Psoriasis genomics: analysis of proinflammatory (type 1) gene expression in large plaque (Western) and small plaque (Asian) psoriasis vulgaris

  2004cited by this paper
• Experimental autoimmune encephalomyelitis in mice with a targeted deletion of the inducible nitric oxide synthase gene: increased T-helper 1 response.

  2004cited by this paper
• SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation1

  2004cited by this paper
• PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells.

  2004cited by this paper
• Preferential contribution of B7‐H1 to programmed death‐1‐mediated regulation of hapten‐specific allergic inflammatory responses

  2003cited by this paper
• The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

  2003cited by this paper
• Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

  2002cited by this paper
• The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses.

  2002cited by this paper
• The B7–CD28 superfamily

  2002cited by this paper
• Expression of Programmed Death 1 Ligands by Murine T Cells and APC1

  2002cited by this paper
• Prevention of T cell–driven complement activation and inflammation by tryptophan catabolism during pregnancy

  2001cited by this paper
• Double-Stranded Ribonucleic Acid (RNA) Induces β-Cell Fas Messenger RNA Expression and Increases Cytokine-Induced β-Cell Apoptosis.

  2001cited by this paper
• B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function.

  2001cited by this paper
• Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice.

  2001cited by this paper
• Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis.

  2001cited by this paper
• PD-1: an inhibitory immunoreceptor involved in peripheral tolerance.

  2001cited by this paper
• PD-L2 is a second ligand for PD-1 and inhibits T cell activation

  2001cited by this paper
• B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

  2001cited by this paper
• Macrophage-derived nitric oxide inhibits the proliferation of activated T helper cells and is induced during antigenic stimulation of resting T cells.

  2000cited by this paper
• Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

  2000cited by this paper
• Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.

  1999cited by this paper
• CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells.

  1999cited by this paper
• Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis: a review.

  1999cited by this paper
• Inhibition of  T Cell Proliferation by Macrophage Tryptophan Catabolism

  1999cited by this paper
• Nitric oxide suppresses human T lymphocyte proliferation through IFN-gamma-dependent and IFN-gamma-independent induction of apoptosis.

  1999cited by this paper
• Nitric Oxide Suppresses Human T Lymphocyte Proliferation Through IFN-γ-Dependent and IFN-γ-Independent Induction of Apoptosis

  1999cited by this paper
• B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

  1999cited by this paper
• Nitric oxide inhibits the proliferation of T-helper 1 and 2 lymphocytes without reduction in cytokine secretion.

  1999cited by this paper
• Double-stranded RNA Inhibits β-Cell Function and Induces Islet Damage by Stimulating β-Cell Production of Nitric Oxide*

  1999cited by this paper
• Nitric oxide in the local host reaction to total hip replacement.

  1998cited by this paper
• This information is current as Gene NOS 2 Exacerbated in Mice Lacking the Experimental Autoimmune Encephalomyelitis Is

  1998cited by this paper
• Prevention of allogeneic fetal rejection by tryptophan catabolism.

  1998cited by this paper
• Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway.

  1998cited by this paper
• Inhibition of inducible nitric oxide synthase intensifies injury and functional deterioration in autoimmune interstitial nephritis.

  1997cited by this paper
• Nitric oxide and macrophage function.

  1997cited by this paper
• Activation-induced expression of human programmed death-1 gene in T-lymphocytes.

  1997cited by this paper
• Elevated nitric oxide production in rheumatoid arthritis. Detection using the fasting urinary nitrate:creatinine ratio.

  1996cited by this paper
• Regulation of T‐cell activation in the lung: alveolar macrophages induce reversible T‐cell anergy in vitro associated with inhibition of interleukin‐2 receptor signal transduction

  1996cited by this paper
• Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.

  1996cited by this paper
• CD40‐mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus

  1996cited by this paper
• Alveolar macrophages from humans and rodents selectively inhibit T-cell proliferation but permit T-cell activation and cytokine secretion.

  1995cited by this paper
• Altered immune responses in mice lacking inducible nitric oxide synthase

  1995cited by this paper
• Suppression of T-cell activation by pulmonary alveolar macrophages: dissociation of effects on TcR, IL-2R expression, and proliferation.

  1994influential reference
• Nitric oxide and arthritis.

  1993cited by this paper
• Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

  1992cited by this paper
• Nitric oxide mediates suppression of T cell responses in murine Trypanosoma brucei infection

  1992cited by this paper
• Suppression of lymphocyte proliferation through the nitric oxide synthesizing pathway.

  1991cited by this paper
• Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase.

  1991cited by this paper
• Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway.

  1991cited by this paper
• Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.

  1991cited by this paper
• Essential contribution of macrophages to islet cell destruction in vivo and in vitro.

  1990cited by this paper
• Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages

  1990cited by this paper
• Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism

  1990cited by this paper
• Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism.

  1990cited by this paper
• Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine.

  1990cited by this paper
• Alveolar macrophages. VI. Regulation of alveolar macrophage-mediated suppression of lymphocyte proliferation by a putative T cell.

  1981cited by this paper

• Targeting highly attenuated IL-18 to PD-1 for enhanced anti-tumor activity

  2025cites this paper
• Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy

  2025cites this paper
• ANV600 is a novel PD-1 targeted IL-2Rβγ agonist that selectively expands tumor antigen-specific T cells and potentiates PD-1 checkpoint inhibitor therapy

  2025influential citation
• Machine Learning-Directed Conversion of Glioblastoma Cells to Dendritic Cell-like Antigen-Presenting Cells as Cancer Immunotherapy.

  2024cites this paper
• T Cell Resistance: On the Mechanisms of T Cell Non-activation

  2024cites this paper
• Predictive Biomarkers and Resistance Mechanisms of Checkpoint Inhibitors in Malignant Solid Tumors

  2024cites this paper
• Effects of a bioengineered allogeneic cellular construct on burn‐related macrophage phenotype

  2024cites this paper
• Programmed death-ligand 1 (PD-L1) expression in cervical intraepithelial neoplasia and cervical squamous cell carcinoma of HIV-infected and non-infected patients

  2023cites this paper
• Revisiting PD-1/PD-L pathway in T and B cell response: Beyond immunosuppression.

  2022cites this paper
• Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS)

  2022cites this paper
• Using a degradable three-layer sandwich-type coating to prevent titanium implant infection with the combined efficient bactericidal ability and fast immune remodeling property.

  2022cites this paper
• Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS)

  2022cites this paper
• Associations of PD-L1, PD-L2, and HLA class I expression with responses to immunotherapy in patients with advanced sarcoma: post hoc analysis of a phase 1/2 trial

  2021cites this paper
• Depleting Tumor Cells Expressing Immune Checkpoint Ligands—A New Approach to Combat Cancer

  2021cites this paper
• Non‐neoplastic inflammatory pseudotumor of the lung after immunotherapy for melanoma: A diagnostic pitfall on fine needle aspiration biopsy of lung

  2021cites this paper
• Enhanced Immunogenicity of Engineered HER2 Antigens Potentiates Antitumor Immune Responses

  2020cites this paper
• PD-1 Specific ‘Blocking’ Antibodies That Deplete PD-1+ T Cells Present An Inconvenient Variable In Pre-clinical Immunotherapy Experiments

  2020cites this paper
• Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions

  2020cites this paper
• Natural Killer T-Cell Agonist α-Galactosylceramide and PD-1 Blockade Synergize to Reduce Tumor Development in a Preclinical Model of Colon Cancer

  2020cites this paper
• Radiotherapy, Temozolomide, and Antiprogrammed Cell Death Protein 1 Treatments Modulate the Immune Microenvironment in Experimental High-Grade Glioma.

  2020cites this paper
• The expression of C-MYC in gastric adenocarcinoma is associated with PD-L1 and FOXP3 expression: C-MYC overexpression is a good prognostic factor.

  2019cites this paper
• PD‐L2+ wound zone macrophage‐like cells display M1/M2‐mixed activation and restrain the effector Th1 responses

  2019cites this paper
• Depletion of PD-1-positive cells ameliorates autoimmune disease

  2019cites this paper
• Quantification of the anti-murine PD-1 monoclonal antibody RMP1-14 in BALB/c mouse plasma by liquid chromatography-tandem mass spectrometry and application to a pharmacokinetic study

  2019cites this paper
• Stromal PD‐1/PD‐L1 Expression Predicts Outcome in Colon Cancer Patients

  2019cites this paper
• Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

  2019cites this paper
• T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

  2018cites this paper
• TSR-033, a Novel Therapeutic Antibody Targeting LAG-3, Enhances T-Cell Function and the Activity of PD-1 Blockade In Vitro and In Vivo

  2018cites this paper
• High macrophage PD-L1 expression not responsible for T cell suppression.

  2017cites this paper
• Checkpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract

  2017cites this paper
• Treatment with a programmed cell death-1-specific antibody has little effect on afatinib- and naphthalene-induced acute pneumonitis in mice.

  2017cites this paper
• Epigenetic regulation of immune checkpoints: another target for cancer immunotherapy?

  2017cites this paper
• PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?

  2017cites this paper
• PD-L1 Expression Is Associated with FOXP3+ Regulatory T-Cell Infiltration of Soft Tissue Sarcoma and Poor Patient Prognosis

  2017cites this paper
• Vaccination establishes clonal relatives of germinal center T cells in the blood of humans

  2017cites this paper
• Treatment with anti-programmed cell death 1 (PD-1) antibody restored postoperative CD8+ T cell dysfunction by surgical stress.

  2017cites this paper
• Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

  2017cites this paper
• Anti-KIT Monoclonal Antibody Treatment Enhances the Antitumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression

  2017influential citation
• PD-1/PD-Ls: A New Target for Regulating Immunopathogenesis in Central Nervous System Disorders.

  2017cites this paper
• Physiologic Doses of Bilirubin Contribute to Tolerance of Islet Transplants by Suppressing the Innate Immune Response

  2017cites this paper
• An Anti-Programmed Death-1 Antibody (αPD-1) Fusion Protein That Self-Assembles into a Multivalent and Functional αPD-1 Nanoparticle.

  2017cites this paper
• Expression of PD-1/PD-L1 and PD-L2 in peripheral T-cells from non-small cell lung cancer patients

  2017cites this paper
• Differential contribution of three immune checkpoint (VISTA, CTLA-4, PD-1) pathways to antitumor responses against squamous cell carcinoma.

  2016cites this paper
• TCRVγ9 γδ T Cell Response to IL-33: A CD4 T Cell–Dependent Mechanism

  2016cites this paper
• PD-L1 expression in human cancers and its association with clinical outcomes

  2016cites this paper
• The Role of Immune Modulatory MicroRNAs in Tumors

  2016cites this paper
• Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma

  2016cites this paper
• PD-1 function in apoptosis of T lymphocytes in canine visceral leishmaniasis.

  2016cites this paper
• OGR1/GPR68 Modulates the Severity of Experimental Autoimmune Encephalomyelitis and Regulates Nitric Oxide Production by Macrophages

  2016cites this paper
• PD-L1 expression in human cancers and its association with clinical outcomes

  2016cites this paper
• Immunomodulatory effect of peritumorally administered interferon-beta on melanoma through tumor-associated macrophages

  2015cites this paper
• Differential control of CD4+ T‐cell subsets by the PD‐1/PD‐L1 axis in a mouse model of allergic asthma

  2015cites this paper
• Combination immunotherapy with 4-1BB activation and PD-1 blockade enhances antitumor efficacy in a mouse model of subcutaneous tumor.

  2015cites this paper
• FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis.

  2015cites this paper
• Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway

  2015cites this paper
• Regulation of Anti-Tumor Immune Responses

  2015cites this paper
• VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors

  2015influential citation
• Fc g Rs Modulate the Anti-t umor Activity of Antibodies Targeting the PD-1 / PD-L 1 Axis Graphical Abstract Highlights

  2015cites this paper
• CANCER IMMUNOTHERAPY BASED ON THE BLOCKADE OF IMMUNE CHECKPOINTS

  2015cites this paper
• Using a PD-1-Blocking scFv Along with a Chimeric Antigen Receptor to Prevent T Cell Inhibition in the Tumor Microenvironment

  2014cites this paper
• Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation

  2014cites this paper
• Agonistic Anti-CD40 Enhances the CD8+ T Cell Response during Vesicular Stomatitis Virus Infection

  2014cites this paper
• Local tumour ablative therapies: opportunities for maximising immune engagement and activation.

  2014influential citation
• The Curative Outcome of Radioimmunotherapy in a Mouse Breast Cancer Model Relies on mTOR Signaling

  2014cites this paper
• B7-H1 and B7-H4 expression in colorectal carcinoma: correlation with tumor FOXP3(+) regulatory T-cell infiltration.

  2014cites this paper
• Role of the Programmed Death-1 (PD-1) pathway in regulation of Theiler's murine encephalomyelitis virus-induced demyelinating disease.

  2014cites this paper
• T Lymphocytes as Tools in Diagnostics and Immunotoxicology

  2014cites this paper
• On the role of co-inhibitory molecules in dendritic cell: T helper cell coculture assays aimed to detect chemical-induced contact allergy.

  2014cites this paper
• The complex and central role of interferon‐γ in graft‐versus‐host disease and graft‐versus‐tumor activity

  2014cites this paper
• Inflammatory cells of immunosuppressive phenotypes in oral lichen planus have a proinflammatory pattern of expression and are associated with clinical parameters

  2013cites this paper
• A Potential New Pathway for PD-L1 Costimulation of the CD8-T Cell Response to Listeria monocytogenes Infection

  2013cites this paper
• Expression of selected regulatory molecules on the CD83+ monocyte-derived dendritic cells generated from patients with laryngeal cancer and their clinical significance

  2013cites this paper
• Biliary obstruction results in PD‐1‐dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils

  2013cites this paper
• Th2 Cell-Intrinsic Hypo-Responsiveness Determines Susceptibility to Helminth Infection

  2013cites this paper
• Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells

  2013cites this paper
• Two sides to every proinflammatory coin: new insights into the role of dendritic cells in the regulation of T-cell driven autoimmune myocarditis.

  2013cites this paper
• Different roles of PD-L1 and FasL in immunomodulation mediated by human placenta-derived mesenchymal stem cells.

  2013cites this paper
• The risks of targeting co-inhibitory pathways to modulate pathogen-directed T cell responses

  2013cites this paper
• Analysis of Innate and Adaptive Immune Responses to Listeria Monocytogenes Infection

  2013cites this paper
• Insights from Infections Inhibitory Receptors on Lymphocytes

  2013cites this paper
• The effects of adiposity and type II diabetes on the immune response to influenza virus in adults

  2013cites this paper
• Listeria monocytogenes following Mediated T Cell Stimulation − Death Ligand-1 Is Essential for Programmed γ Innate IFN -

  2012cites this paper
• Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo

  2012cites this paper
• CD4+ Type II NKT Cells Mediate ICOS and Programmed Death-1–Dependent Regulation of Type 1 Diabetes

  2012cites this paper
• Inhibitory Receptors on Lymphocytes: Insights from Infections

  2012cites this paper
• Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies.

  2012cites this paper
• PD-1 Regulates T Cell Proliferation in a Tissue and Subset-Specific Manner During Normal Mouse Pregnancy

  2012cites this paper
• Inducible Chemokines γ IFN-PD-1 Blockade Enhances T-cell Migration to Tumors by Elevating

  2012cites this paper
• Regulation of Type 1 DiabetesDependent - Programmed Death-1 and Type II NKT Cells Mediate ICOS + CD4

  2012cites this paper
• [The assessment of selected molecules belonging to B7 family on the mature dendritic cells in laryngeal cancer patients].

  2012cites this paper
• Studying the role of the immune system on the antitumor activity of a Hedgehog inhibitor against murine osteosarcoma

  2012cites this paper
• PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines.

  2012cites this paper
• Microenvironment and Immunology PD-1 Blockade Enhances T-cell Migration to Tumors by Elevating IFN-g Inducible Chemokines

  2012cites this paper
• Lentivector based gene transfer for immunotherapy – application of integration deficient vectors and PDL1knockdown as tools to manipulate immune responses

  2012cites this paper
• PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production

  2012cites this paper
• CD28 ligation increases macrophage suppression of T-cell proliferation

  2012cites this paper
• Déviation de l’auto-immunité chez la souris NOD invalidée pour la voie ICOS/ICOSL

  2012cites this paper
• Contribution of PD-L1 to oncogenesis of lymphoma and its RNAi-based targeting therapy

  2012cites this paper
• Ocena ekspresji wybranych molekuł z rodziny B7 na powierzchni dojrzałych komórek dendrytycznych u chorych na raka krtani

  2012cites this paper
• Innate IFN-γ Is Essential for Programmed Death Ligand-1–Mediated T Cell Stimulation following Listeria monocytogenes Infection

  2012cites this paper