Arginylation-dependent regulation of a proteolytic product of talin is essential for cell–cell adhesion

A proteolytic fragment of talin is regulated by arginylation and promotes cadherin-dependent cell–cell adhesion.

• Publication year

  2012

• Venue

  Journal of Cell Biology

• Publication date

  2012-06-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201112129PMID 22665520PMCID 3373405
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Spatiotemporal constraints on the force-dependent growth of focal adhesions.

  2011cited by this paper
• The arginylation-dependent association of calreticulin with stress granules is regulated by calcium.

  2010cited by this paper
• Spatial organization of adhesion: force‐dependent regulation and function in tissue morphogenesis

  2010cited by this paper
• Planar polarized actomyosin contractile flows control epithelial junction remodelling

  2010cited by this paper
• Nanoscale architecture of integrin-based cell adhesions

  2010cited by this paper
• Arginylation-Dependent Neural Crest Cell Migration Is Essential for Mouse Development

  2010cited by this paper
• Differential Arginylation of Actin Isoforms Is Regulated by Coding Sequence–Dependent Degradation

  2010cited by this paper
• N-cadherin/p120 Catenin Association at Cell-Cell Contacts Occurs in Cholesterol-rich Membrane Domains and Is Required for RhoA Activation and Myogenesis*

  2009cited by this paper
• Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases.

  2009cited by this paper
• Initial activation of EpCAM cleavage via cell-to-cell contact

  2009cited by this paper
• Life after proteolysis

  2009cited by this paper
• Stretching Single Talin Rod Molecules Activates Vinculin Binding

  2009cited by this paper
• Knockdown of m‐calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity

  2009cited by this paper
• Arginyltransferase regulates alpha cardiac actin function, myofibril formation and contractility during heart development

  2008cited by this paper
• How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism

  2008cited by this paper
• A two-tiered mechanism for stabilization and immobilization of E-cadherin

  2008cited by this paper
• Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (Review)

  2008cited by this paper
• Arginyltransferase regulates alpha cardiac actin function, myofibril formation and contractility during heart development

  2008cited by this paper
• Studies of focal adhesion assembly.

  2008cited by this paper
• Global Analysis of Posttranslational Protein Arginylation

  2007cited by this paper
• Structure and mechanics of integrin-based cell adhesion.

  2007cited by this paper
• Arginylation of beta-actin regulates actin cytoskeleton and cell motility.

  2006cited by this paper
• Arginylation of ß-Actin Regulates Actin Cytoskeleton and Cell Motility

  2006cited by this paper
• Ubiquitous Calpains Promote Caspase-12 and JNK Activation during Endoplasmic Reticulum Stress-induced Apoptosis*

  2006cited by this paper
• Deconstructing the cadherin-catenin-actin complex.

  2005cited by this paper
• Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophila

  2005cited by this paper
• Phosphorylation of AML1/RUNX1 Regulates Its Degradation and Nuclear Matrix Association

  2005cited by this paper
• Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.

  2005cited by this paper
• Genetic, biochemical and structural approaches to talin function.

  2005cited by this paper
• Talin: an emerging focal point of adhesion dynamics.

  2004cited by this paper
• Isoform specific function of calpain 2 in regulating membrane protrusion.

  2004influential reference
• Calpain-mediated proteolysis of talin regulates adhesion dynamics

  2004cited by this paper
• Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

  2004cited by this paper
• Presenilin 1 and Cadherins: Stabilization of Cell-Cell Adhesion and Proteolysis-Dependent Regulation of Transcription

  2004cited by this paper
• Selective Activation Induced Cleavage of the NR2B Subunit by Calpain

  2003cited by this paper
• Cell adhesion in development: a complex signaling network.

  2003cited by this paper
• The Sla2p talin domain plays a role in endocytosis in Saccharomyces cerevisiae.

  2003cited by this paper
• An Essential Role of N-Terminal Arginylation in Cardiovascular Development

  2002cited by this paper
• RGS4 Is Arginylated and Degraded by the N-end Rule Pathway in Vitro *

  2000cited by this paper
• N-Cadherin: Structure, Function and Importance in the Formation of New Intercalated Disc-Like Cell Contacts in Cardiomyocytes

  2000cited by this paper
• The Cytoskeleton and Related Proteins in the Human Failing Heart

  2000cited by this paper
• c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.

  2000cited by this paper
• The N‐end rule pathway of protein degradation

  1997cited by this paper
• Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain

  1994cited by this paper
• An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.

  1987cited by this paper
• Localization of talin in skeletal and cardiac muscles

  1986cited by this paper
• Identification of two proteins (actin-binding protein and P235) that are hydrolyzed by endogenous Ca2+-dependent protease during platelet aggregation.

  1985cited by this paper

• Arginylation of ⍺-tubulin at E77 regulates microtubule dynamics via MAP1S.

  2025cites this paper
• Targeting human arginyltransferase and post-translational protein arginylation: a pharmacophore-based multilayer screening and molecular dynamics approach to discover novel inhibitors with therapeutic promise

  2025cites this paper
• Arginyltransferase 1 modulates p62-driven autophagy via mTORC1/AMPk signaling

  2024cites this paper
• Long range juxtacrine signalling through cadherin for collective cell orientation.

  2024cites this paper
• Structural analysis of human ATE1 isoforms and their interactions with Arg-tRNAArg

  2023cites this paper
• Protein Arginylation: Milestones of Discovery.

  2023cites this paper
• Understanding the Interplay between Cell Force and Cell Adhesion Processes

  2023cites this paper
• Arginylation Regulates Cytoskeleton Organization and Cell Division and Affects Mitochondria in Fission Yeast

  2022cites this paper
• The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells.

  2022cites this paper
• Arginine-grafted porcine pericardium by copolymerization to improve the cytocompatibility, hemocompatibility and anti-calcification properties of bioprosthetic heart valve materials.

  2022cites this paper
• Functional Interplay between Arginyl-tRNA Synthetases and Arginyltransferase

  2022cites this paper
• The mechanical cell – the role of force dependencies in synchronising protein interaction networks

  2022cites this paper
• Fourier Multiplexed Fluorescence Lifetime Imaging.

  2021cites this paper
• Manipulation of Focal Adhesion Signaling by Pathogenic Microbes

  2021cites this paper
• Ablation of arginyl‐tRNA‐protein transferase in oligodendrocytes impairs central nervous system myelination

  2021cites this paper
• α2β1 integrins spatially restrict Cdc42 activity to stabilise adherens junctions

  2021cites this paper
• Effects of Arginine and Its Deprivation on Human Glioblastoma Physiology and Signaling.

  2020cites this paper
• A new mechanism of fibronectin fibril assembly revealed by live imaging and super-resolution microscopy

  2020cites this paper
• Crosstalk between Cell Adhesion Complexes in Regulation of Mechanotransduction

  2020cites this paper
• Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo

  2020cites this paper
• Regulation of Mitochondrial Respiratory Chain Complex Levels, Organization, and Function by Arginyltransferase 1

  2020cites this paper
• Heat stress induced arginylation of HuR promotes alternative polyadenylation of Hsp70.3 by regulating HuR stability and RNA binding

  2020cites this paper
• Arginylation regulates adipogenesis by regulating expression of PPARγ at transcript and protein level.

  2019cites this paper
• Ate1-mediated posttranslational arginylation affects substrate adhesion and cell migration in Dictyostelium discoideum

  2019cites this paper
• Adhesions Assemble!—Autoinhibition as a Major Regulatory Mechanism of Integrin-Mediated Adhesion

  2019cites this paper
• A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency.

  2018cites this paper
• The tale of two talins – two isoforms to fine‐tune integrin signalling

  2018cites this paper
• Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis

  2018cites this paper
• Talin as a mechanosensitive signaling hub

  2018cites this paper
• Posttranscriptional and Posttranslational Regulation of Actin

  2018cites this paper
• Talin1 Methylation Is Required for Neutrophil Infiltration and Lipopolysaccharide-Induced Lethality

  2018cites this paper
• Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development

  2017cites this paper
• Nanoscale mechanobiology of cell adhesions.

  2017cites this paper
• Reversion of epithelial-mesenchymal transition by a novel agent DZ-50 via IGF binding protein-3 in prostate cancer cells

  2017cites this paper
• Interplay between microtubule organization and cell adhesions during epithelial morphogenesis

  2016cites this paper
• Regulation of Intracellular Structural Tension by Talin in the Axon Growth and Regeneration

  2016cites this paper
• Post‐translational protein arginylation in the normal nervous system and in neurodegeneration

  2016influential citation
• Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response

  2016cites this paper
• Post-translational modification-regulated leukocyte adhesion and migration

  2016cites this paper
• Protein arginylation regulates cellular stress response by stabilizing HSP70 and HSP40 transcripts

  2016cites this paper
• Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays*

  2016cites this paper
• Calreticulin and Arginylated Calreticulin Have Different Susceptibilities to Proteasomal Degradation*

  2015cites this paper
• Jack of all trades: functional modularity in the adherens junction.

  2015cites this paper
• Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase

  2015cites this paper
• The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

  2015cites this paper
• Talin determines the nanoscale architecture of focal adhesions

  2015cites this paper
• Arginyltransferase ATE1 suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers

  2015influential citation
• Protein Arginylation: Over 50 Years of Discovery.

  2015cites this paper
• Arginyltransferase ATE1 catalyzes midchain arginylation of proteins at side chain carboxylates in vivo.

  2014cites this paper
• Protein Arginylation, a Global Biological Regulator that Targets Actin Cytoskeleton and the Muscle

  2014cites this paper
• Inhibition of Arginyltransferase 1 Induces Transcriptional Activity of Myocardin-related Transcription Factor A (MRTF-A) and Promotes Directional Migration*

  2014cites this paper
• Arginine deprivation affects glioblastoma cell adhesion, invasiveness and actin cytoskeleton organization by impairment of β-actin arginylation

  2014cites this paper
• Talin Dependent Mechanosensitivity of Cell Focal Adhesions

  2014cites this paper
• Talins and kindlins: partners in integrin-mediated adhesion

  2013cites this paper
• Cell adhesion: Cell–cell contacts with talin

  2012cites this paper
• Spatial segregation between cell-cell and cell-matrix adhesions.

  2012cites this paper
• Talin is cut out for intercellular adhesion

  2012cites this paper
• hubs regulate a multitude of cellular processes including cytoskeletal dynamics

  year unknowncites this paper