Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2005-02-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/PNAS.0409856102PMID 15699325PMCID PMC548980
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Kinase Mitogen-activated Protein Kinase Tpl-2/mek/extracellular Signal-regulated Lipopolysaccharide Activation of the Supplemental Material

  2004cited by this paper
• IkappaB kinase is an essential component of the Tpl2 signaling pathway.

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• IκB Kinase Is an Essential Component of the Tpl2 Signaling Pathway

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• Phosphorylation of Threonine 290 in the Activation Loop of Tpl2/Cot Is Necessary but Not Sufficient for Kinase Activity*

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• Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40

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  2003cited by this paper
• NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase.

  2003cited by this paper
• NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity.

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• NF-κB1 p105 Negatively Regulates TPL-2 MEK Kinase Activity

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  1999cited by this paper
• TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105.

  1999cited by this paper
• The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases.

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  1998cited by this paper
• The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines.

  1998cited by this paper
• Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation.

  1997cited by this paper
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  1996cited by this paper
• Activation of MEK‐1 and SEK‐1 by Tpl‐2 proto‐oncoprotein, a novel MAP kinase kinase kinase.

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  1994cited by this paper
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