Inhibitors of Oxidative ATP Production Cause Transient Vasoconstriction and Block Subsequent Pressor Responses in Rat Lungs

No abstract is available for this paper.

• Publication year

  1981

• Venue

  Circulation Research

• Publication date

  1981-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1161/01.RES.48.3.393PMID 7460212
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vasodilator and constrictor responses to hypoxia in isolated pig lungs.

  1980cited by this paper
• Calcium augments hypoxic vasoconstriction in lungs from high-altitude rats.

  1980cited by this paper
• Calcium, Calcium Translocation, and Specific Calcium Antagonists

  1978cited by this paper
• The Effects of Agents that Bind to Cytochrome P‐450 on Hypoxic Pulmonary Vasoconstriction

  1978cited by this paper
• Relationship between cellular energy production and rates of glucose utilization by lung cells

  1977cited by this paper
• What is a molecular oxygen sensor? What is a transduction process?

  1977cited by this paper
• Evaluation of redox state of isolated perfused rat lung.

  1976cited by this paper
• Stimulation of rat lung metabolism with 2,4-dinitrophenol and phenazine methosulfate.

  1976cited by this paper
• The physiology of the pulmonary circulation and methods of study.

  1976cited by this paper
• Inhibition of Hypoxic Pulmonary Vasoconstriction by Calcium Antagonists in Isolated Rat Lungs

  1976cited by this paper
• Hypoxia on the pulmonary circulation. How and where it acts.

  1976cited by this paper
• Nonsustained pulmonary vasoconstriction during acute hypoxia in anesthetized dogs.

  1975cited by this paper
• Factors in oxygen delivery to tissue.

  1974cited by this paper
• Effect of hypoxia on incorporation of glucose carbons into lipids by isolated rat lung.

  1974cited by this paper
• Phenols: effects on membrane permeability of molluscan neurons.

  1974cited by this paper
• Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension.

  1972cited by this paper
• Physiology of the pulmonary circulation.

  1971cited by this paper
• Effects of 2:4-dinitrophenol on the electrical and mechanical activity of vascular smooth muscle.

  1970cited by this paper
• Control of smooth muscle actomyosin by phosphate and 5′AMP: Possible role in metabolic autoregulation

  1968cited by this paper
• Conditions governing the pressor response to ventilation hypoxia in isolated perfused rat lungs.

  1968cited by this paper
• A Study of the Mechanisms Involved in the Pulmonary Arterial Pressor Response to Hypoxia

  1967cited by this paper
• STATISTICAL METHODS

  1967cited by this paper
• Role of nerve pathways in the hypoxic vasoconstriction of lung.

  1966cited by this paper
• Influence of blood pH on hypoxic pulmonary vasoconstriction.

  1966cited by this paper
• Pulmonary vasoconstriction during histotoxic hypoxia.

  1965cited by this paper
• EFFECT OF ALVEOLAR HYPOXIA ON PULMONARY VASCULAR RESISTANCE.

  1964cited by this paper
• CHAPTER 29 – Cations and Anions: Inhibitions and Interactions in Metabolism and in Enzyme Activity

  1963cited by this paper
• PULMONARY VASOCONSTRICTION IN RESPONSE TO PRECAPILLARY HYPOXEMIA.

  1963cited by this paper
• [Hypoxia & pulmonary circulation].

  1958cited by this paper
• Pulmonary vasomotor responses of isolated perfused cat lungs to anoxia

  1952cited by this paper
• The physiology of the pulmonary circulation.

  1951cited by this paper
• Organic correlation and allometry.

  1950cited by this paper

• Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function

  2025cites this paper
• Sorbitol enhances chilling tolerance in post-harvest lemon basil by modulating antioxidant defense system, mitochondrial stability and ATP levels

  2025cites this paper
• Hypoxic Pulmonary Vasoconstriction: An Important Component of the Homeostatic Oxygen Sensing System.

  2024cites this paper
• Acute oxygen sensing by vascular smooth muscle cells

  2023cites this paper
• The role of mitochondrial reactive oxygen species in oxygen sensing in the pulmonary vasculature – use of novel genetic tools

  2021cites this paper
• Effects of respiratory rate on venous-to-arterial CO2 tension difference in septic shock patients undergoing volume mechanical ventilation

  2020cites this paper
• Mitochondrial bioenergetics and pulmonary dysfunction: Current progress and future directions.

  2020cites this paper
• Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction.

  2019cites this paper
• Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia

  2018cites this paper
• Effects of human relaxin-2 (serelaxin) on hypoxic pulmonary vasoconstriction during acute hypoxia in a sheep model

  2018cites this paper
• Sensors and signals: the role of reactive oxygen species in hypoxic pulmonary vasoconstriction

  2018cites this paper
• Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine

  2017cites this paper
• NADPH Oxidase 4 is Not Involved in Hypoxia-Induced Pulmonary Hypertension

  2016cites this paper
• Mitochondrial Impairment in Cerebrovascular Endothelial Cells is Involved in the Correlation between Body Temperature and Stroke Severity.

  2016cites this paper
• A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus

  2015cites this paper
• Mechanisms of hypoxic pulmonary vasoconstriction.

  2015cites this paper
• Oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction

  2015cites this paper
• Pulmonary Vascular Physiology and Pathophysiology

  2014cites this paper
• Mitochondria : a multimodal hub of hypoxia tolerance 1

  2014cites this paper
• Mitochondria: a multimodal hub of hypoxia tolerance1

  2014cites this paper
• Mitochondria in vascular health and disease.

  2013cites this paper
• Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation.

  2013cites this paper
• Hypoxic pulmonary vasoconstriction.

  2012influential citation
• Hydrogen sulfide mediates hypoxic vasoconstriction through a production of mitochondrial ROS in trout gills.

  2012cites this paper
• A Redox-Based 02 Sensor in RatPulmonary Vasculature

  2011cites this paper
• Mitochondrial Reactive Oxygen Species and Redox State in Pulmonary Vascular O2 Sensing

  2011cites this paper
• Investigation of the Mechanisms of Excitation and Contraction in Rat Pulmonary and Systemic Resistance Arteries

  2010cites this paper
• Interactions between calcium and reactive oxygen species in pulmonary arterial smooth muscle responses to hypoxia.

  2010cites this paper
• Hypoxia-induced changes in pulmonary and systemic vascular resistance: where is the O2 sensor?

  2010cites this paper
• Role of NADPH oxidases and KDR channels in the pathophysiology of hypoxia induced pulmonary hypertension

  2009cites this paper
• Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer.

  2008influential citation
• Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms

  2008cites this paper
• Chapter 5 A Mitochondria-AOS-Kv Channel Axis in Health and Disease; New Insights and Therapeutic Targets for Vascular Disease and Cancer

  2008cites this paper
• Oxidant and Redox Signaling in Vascular Oxygen Sensing: Implications for Systemic and Pulmonary Hypertension

  2008cites this paper
• Potassium channel diversity in the pulmonary arteries and pulmonary veins: implications for regulation of the pulmonary vasculature in health and during pulmonary hypertension.

  2007cites this paper
• An investigation of NAADP-dependent Ca²⁺ signalling mechanisms in arterial smooth muscle

  2007cites this paper
• Anoxia-induced changes in reactive oxygen species and cyclic nucleotides in the painted turtle

  2007cites this paper
• Ascites susceptibility as affected by dietary lysine to energy ratios in interaction with broiler genotypes Einfluss des Gehaltes an Lysin im Futter in Relation zum Energiegehalt auf die Aszites- Anfälligkeit in Abhängigkeit vom Broilergenotyp

  2007cites this paper
• Ascites susceptibility as affected by dietary lysine to energy ratios in interaction with broiler genotypes

  2007cites this paper
• Oxygen sensors in hypoxic pulmonary vasoconstriction.

  2006cites this paper
• An anesthesiologist's guide to hypoxic pulmonary vasoconstriction: implications for managing single-lung anesthesia and atelectasis

  2006cites this paper
• AMP‐activated protein kinase and the regulation of Ca2+ signalling in O2‐sensing cells

  2006cites this paper
• The arterial chemoreceptors

  2006cites this paper
• AMP‐activated protein kinase underpins hypoxic pulmonary vasoconstriction and carotid body excitation by hypoxia in mammals

  2006cites this paper
• Does AMP-activated protein kinase couple inhibition of mitochondrial oxidative phosphorylation by hypoxia to pulmonary artery constriction?

  2006cites this paper
• Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH.

  2005cites this paper
• Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing.

  2005cites this paper
• One hundred years of research in the pathogenesis of pulmonary hypertension.

  2005cites this paper
• Does AMP-activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Calcium Signaling in O2-sensing Cells?*

  2005cites this paper
• Hypoxic Pulmonary Vasoconstriction

  2004influential citation
• Hypoxic pulmonary vasoconstriction: redox regulation of O2-sensitive K+ channels by a mitochondrial O2-sensor in resistance artery smooth muscle cells.

  2004cites this paper
• Calcium, mitochondria and oxygen sensing in the pulmonary circulation.

  2004cites this paper
• Mechanisms for hypoxia detection in O2-sensitive cells.

  2004cites this paper
• Hypoxic Regulation of K + Channel Expression and Function in Pulmonary Artery Smooth Muscle Cells

  2004cites this paper
• Regulation of O2-Sensitive K+ Channels by a Mitochondrial Redox Sensor: Implications for Hypoxic Pulmonary Vasoconstriction

  2004cites this paper
• Haematological characteristics predicting susceptibility for ascites. 1. High carbon dioxide tensions in juvenile chickens

  2003cites this paper
• Mitochondria as Vascular Oxygen Sensors: The Redox Hypothesis of Vascular O2 Sensing

  2003cites this paper
• Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs.

  2003cites this paper
• Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature.

  2003cites this paper
• Metabolic inhibition with cyanide induces calcium release in pulmonary artery myocytes and Xenopus oocytes.

  2003cites this paper
• The regulation of pulmonary vascular tone.

  2003cites this paper
• Ion channels in pulmonary arterial hypertension.

  2002cites this paper
• Mitochondrial Reactive Oxygen Species Trigger Calcium Increases During Hypoxia in Pulmonary Arterial Myocytes

  2002cites this paper
• O(2) sensing in hypoxic pulmonary vasoconstriction: the mitochondrial door re-opens.

  2002cites this paper
• Metabolic inhibition with cyanide induces intracellular calcium release in pulmonary artery myocytes and Xenopus oocytes

  2002cites this paper
• Hypoxic pulmonary vasoconstriction: cyclic adenosine diphosphate-ribose, smooth muscle Ca(2+) stores and the endothelium.

  2002cites this paper
• Hypoxia, energy state and pulmonary vasomotor tone.

  2002cites this paper
• Role of oxidative phosphorylation and ATP release in mediating birth-related pulmonary vasodilation in fetal lambs.

  2002cites this paper
• FCCP depolarizes plasma membrane potential by activating proton and Na+ currents in bovine aortic endothelial cells

  2001cites this paper
• Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K+ channels.

  2001cites this paper
• invited review Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K 1 channels

  2001cites this paper
• Cellular mechanisms of acute hypoxic pulmonary vasoconstriction

  2001cites this paper
• Model for Hypoxic Pulmonary Vasoconstriction Involving Mitochondrial Oxygen Sensing

  2001cites this paper
• Hypoxic pulmonary vasoconstriction: a radical view.

  2001cites this paper
• Hydrogen peroxide--an intracellular signal in the pulmonary circulation: involvement in hypoxic pulmonary vasoconstriction.

  2000cites this paper
• Role of Nitric Oxide in the Regulation of Pulmonary Vascular Tone

  2000cites this paper
• Molecular identification of O2 sensors and O2-sensitive potassium channels in the pulmonary circulation.

  2000cites this paper
• Nitric Oxide in Pulmonary Processes

  2000cites this paper
• O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase.

  1999cites this paper
• Mechanisms of hypoxic vasodilatation of isolated rat mesenteric arteries: a comparison with metabolic inhibition

  1999cites this paper
• Pharmacological Modifications of the Pulmonary Circulation in ALI

  1998cites this paper
• Pulmonary vasoconstriction, oxygen sensing, and the role of ion channels: Thomas A. Neff lecture.

  1998cites this paper
• Cellular and molecular biology of vascular smooth muscle cells in pulmonary hypertension.

  1997cites this paper
• Kv2.1/Kv9.3, a novel ATP‐dependent delayed‐rectifier K+ channel in oxygen‐sensitive pulmonary artery myocytes

  1997cites this paper
• Diversity of response in vascular smooth muscle cells to changes in oxygen tension.

  1997cites this paper
• Pathological changes in metabolism of poultry related to increasing production levels.

  1997cites this paper
• ATP increases Ca(2+)-activated K+ channel activity in isolated rat arterial smooth muscle cells.

  1996cites this paper
• A mitochondrial uncoupler increases KCa currents but decreases KV currents in pulmonary artery myocytes.

  1996cites this paper
• Adenine nucleotides via activation of ATP-sensitive K+ channels modulate hypoxic response in rat pulmonary artery.

  1996cites this paper
• ENDOTHELIUM DERIVED NITRIC OXIDE-DEPENDENT RESPONSE TO HYPOXIA IN PIGLET INTRAPULMONARY ARTERIES. † 2110

  1996cites this paper
• Ascites in chickens : oxygen consumption and requirement related to its occurrence

  1996cites this paper
• The vein utilizes different sources of energy than the artery during pulmonary hypoxic vasoconstriction.

  1996cites this paper
• ATP increases Ca2+-activated K+ channel activity in isolated rat arterial smooth muscle cells

  1996cites this paper
• Inhibition of glycolysis by 2-DG increases [Ca2+]i in pulmonary arterial smooth muscle cells.

  1995cites this paper
• Acute hypoxic pulmonary vasoconstriction: a model of oxygen sensing.

  1995cites this paper
• The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels

  1995cites this paper
• Potential role of NADH oxidoreductase-derived reactive O2 species in calf pulmonary arterial PO2-elicited responses.

  1995cites this paper
• Regulation of pulmonary vascular tone.

  1995cites this paper
• Almitrine and Inhaled Nitric Oxide in Acute Respiratory Failure

  1995cites this paper
• The Effect of Hypoxia on Endothelial Cell Function

  1995cites this paper