Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Neuron

• Publication date

  2004-04-22

• Fields of study

  Biology, Medicine, Chemistry, Psychology

• Identifiers
  DOI 10.1016/S0896-6273(04)00159-XPMID 15091342PMCID PMC3619420
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Forebrain astroglial plasticity is induced following withdrawal from repeated cocaine administration

  2003cited by this paper
• A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats

  2003cited by this paper
• Accessory proteins for G protein-signaling systems: activators of G protein signaling and other nonreceptor proteins influencing the activation state of G proteins.

  2003cited by this paper
• Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse

  2003cited by this paper
• Dopamine Enhances EPSCs in Layer II–III Pyramidal Neurons in Rat Prefrontal Cortex

  2003cited by this paper
• RGS9 modulates dopamine signaling in the basal ganglia.

  2003cited by this paper
• GABA Transmission in the Nucleus Accumbens Is Altered after Withdrawal from Repeated Cocaine

  2003cited by this paper
• Prefrontal Glutamate Release into the Core of the Nucleus Accumbens Mediates Cocaine-Induced Reinstatement of Drug-Seeking Behavior

  2003cited by this paper
• Manipulation of dopamine d1-like receptor activation in the rat medial prefrontal cortex alters stress- and cocaine-induced reinstatement of conditioned place preference behavior.

  2003cited by this paper
• Decreased Cocaine Self-Administration in Kir3 Potassium Channel Subunit Knockout Mice

  2003cited by this paper
• Intra-accumbens pertussis toxin sensitizes rats to the locomotor activating effects of a single cocaine challenge.

  2003cited by this paper
• Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex.

  2002cited by this paper
• The computational role of dopamine D1 receptors in working memory

  2002cited by this paper
• Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration

  2002cited by this paper
• Expression Analysis and Subcellular Distribution of the Two G-protein Regulators AGS3 and LGN Indicate Distinct Functionality

  2002cited by this paper
• Repeated cocaine administration alters the electrophysiological properties of prefrontal cortical neurons.

  2002cited by this paper
• Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review

  2002cited by this paper
• Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens

  2002cited by this paper
• Neural Systems and Cue-Induced Cocaine Craving

  2002cited by this paper
• Novel antisense and peptide nucleic acid strategies for controlling gene expression.

  2002cited by this paper
• Pertussis Toxin-insensitive Activation of the Heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein Activator*

  2002cited by this paper
• Abused drugs modulate RGS4 mRNA levels in rat brain: comparison between acute drug treatment and a drug challenge after chronic treatment.

  2002cited by this paper
• Identification of Structural Features in the G-protein Regulatory Motif Required for Regulation of Heterotrimeric G-proteins*

  2002cited by this paper
• Psychomotor Stimulant Addiction: A Neural Systems Perspective

  2002cited by this paper
• Modulation of Group II Metabotropic Glutamate Receptor Signaling by Chronic Cocaine

  2002cited by this paper
• The Circuitry Mediating Cocaine-Induced Reinstatement of Drug-Seeking Behavior

  2001cited by this paper
• Molecular basis of long-term plasticity underlying addiction

  2001cited by this paper
• DeltaFosB: a sustained molecular switch for addiction.

  2001cited by this paper
• Molecular basis of long-term plasticity underlying addiction

  2001cited by this paper
• Selective Interaction of AGS3 with G-proteins and the Influence of AGS3 on the Activation State of G-proteins*

  2001cited by this paper
• ΔFosB: A sustained molecular switch for addiction

  2001cited by this paper
• Alterations in behaviour and glutamate transmission following presentation of stimuli previously associated with cocaine exposure

  2001cited by this paper
• Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5

  2001cited by this paper
• cAMP-Dependent Protein Kinase Inhibits mGluR2 Coupling to G-Proteins by Direct Receptor Phosphorylation

  2000cited by this paper
• Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein βγ subunits

  2000cited by this paper
• The regulator of G protein signaling family.

  2000cited by this paper
• Ventral tegmental area afferents to the prefrontal cortex maintain membrane potential 'up' states in pyramidal neurons via D(1) dopamine receptors.

  2000cited by this paper
• Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein beta gamma subunits.

  2000cited by this paper
• GABA(B) receptors: altered coupling to G-proteins in rats sensitized to amphetamine.

  2000cited by this paper
• Stabilization of the GDP-bound Conformation of Giα by a Peptide Derived from the G-protein Regulatory Motif of AGS3*

  2000cited by this paper
• Dendritic asymmetry cannot account for directional responses of neurons in visual cortex

  1999cited by this paper
• The expression of cocaine sensitization is not prevented by MK-801 or ibotenic acid lesions of the medial prefrontal cortex.

  1999cited by this paper
• In vivo protein transduction: delivery of a biologically active protein into the mouse.

  1999cited by this paper
• Receptor-independent Activators of Heterotrimeric G-protein Signaling Pathways*

  1999cited by this paper
• Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli

  1999cited by this paper
• RGS mRNA Expression in Rat Striatum

  1999cited by this paper
• Functional heterogeneity of the rat medial prefrontal cortex: effects of discrete subarea‐specific lesions on drug‐induced conditioned place preference and behavioural sensitization

  1999cited by this paper
• Both glutamate receptor antagonists and prefrontal cortex lesions prevent induction of cocaine sensitization and associated neuroadaptations

  1999cited by this paper
• Impairment of social and moral behavior related to early damage in human prefrontal cortex

  1999cited by this paper
• How do we predict the consequences of our actions? A functional imaging study.

  1998cited by this paper
• Ibotenic acid lesions of the dorsal prefrontal cortex disrupt the expression of behavioral sensitization to cocaine.

  1997cited by this paper
• Chronic Cocaine Enhances γ-Aminobutyric Acid and Glutamate Release by Altering Presynaptic and not Postsynaptic γ-Aminobutyric AcidB Receptors within the Rat Dorsolateral Septal Nucleus

  1997cited by this paper
• Chronic cocaine enhances gamma-aminobutyric acid and glutamate release by altering presynaptic and not postsynaptic gamma-aminobutyric acidB receptors within the rat dorsolateral septal nucleus.

  1997cited by this paper
• Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization

  1996cited by this paper
• The persistence of behavioral sensitization to cocaine parallels enhanced inhibition of nucleus accumbens neurons

  1995cited by this paper
• Cocaine increases extraneuronal levels of aspartate and glutamate in the nucleus accumbens.

  1995cited by this paper
• Regulation of G-protein activation by mastoparans and other cationic peptides.

  1994cited by this paper
• Issues in searching molecular sequence databases

  1994cited by this paper
• Inactivation of Gi and G(o) proteins in nucleus accumbens reduces both cocaine and heroin reinforcement

  1994cited by this paper
• A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components

  1993cited by this paper
• Robustness of G protein changes in cocaine sensitization shown with immunoblotting

  1993cited by this paper
• Analysis of messy data

  1992cited by this paper
• Sensitization to psychostimulants and stress after injection of pertussis toxin into the A10 dopamine region.

  1991cited by this paper
• Chronic Cocaine Treatment Decreases Levels of the G Protein Subunits Giα and Goα in Discrete Regions of Rat Brain

  1990cited by this paper
• Chronic cocaine treatment decreases levels of the G protein subunits Gi alpha and Go alpha in discrete regions of rat brain.

  1990cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper

• Carbonic anhydrase 4 disruption and pharmacological inhibition reduce synaptic and behavioral adaptations following oxycodone withdrawal

  2025cites this paper
• Combined administration of cocaine and alcohol alters the expression of brain peptide/protein profiles in rats: a MALDI imaging mass spectrometry approach.

  2025cites this paper
• Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens

  2025cites this paper
• Emerging modes of regulation of neuromodulatory G protein-coupled receptors.

  2024cites this paper
• Isradipine, an L-type calcium channel blocker, attenuates cocaine effects in mice by reducing central glutamate release.

  2024cites this paper
• GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity

  2023cites this paper
• Future perspectives of emerging novel drug targets and immunotherapies to control drug addiction.

  2023cites this paper
• Astrocytes: Role in pathogenesis and effect of commonly misused drugs in the HIV infected brain

  2023cites this paper
• Biomolecular Condensates defined by Receptor Independent Activator of G protein Signaling: Properties and Regulation

  2023cites this paper
• Regulation of Cocaine-related Behaviors by Estrogen and Progesterone.

  2022cites this paper
• Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors.

  2021cites this paper
• Neuropathology of Drug Abuse

  2021cites this paper
• ∆9-Tetrahydrocannabinol Self-Administration Induces Cell-Type Specific Adaptations and cFOS Expression in the Nucleus Accumbens Core

  2021cites this paper
• Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats

  2021cites this paper
• Novelty preferences and cocaine-associated cues influence regions associated with the salience network in juvenile female rats.

  2021cites this paper
• The Opioid-Addicted Tetrapartite Synapse.

  2020cites this paper
• Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction

  2020cites this paper
• Psychostimulants

  2020cites this paper
• Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D2 Dopamine Receptor (D2-R) Isoforms

  2020cites this paper
• Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters.

  2020cites this paper
• Basic Substance Characteristics and Neuropathological Findings in Drug Abusers

  2020cites this paper
• Intersection of two key signal integrators in the cell: activator of G-protein signaling 3 and dishevelled-2

  2020cites this paper
• Neural Circuit Plasticity in Addiction

  2019cites this paper
• Adenosine A2a Receptor Subpopulation and Dopamine D4 Receptor Effects on Psychostimulant-Induced Behavior

  2019cites this paper
• Mechanisms Regulating Compulsive Drug Behaviors

  2019cites this paper
• The Neuroscience of Drug Reward and Addiction.

  2019cites this paper
• Neuronal scaffolding protein spinophilin is integral for cocaine-induced behavioral sensitization and ERK1/2 activation

  2019cites this paper
• Neurobiological theories of addiction

  2019cites this paper
• MEASURING GLUTAMATE AND OXYGEN IN BRAIN REWARD CIRCUITS IN ANIMAL MODELS OF COCAINE ABUSE AND DECISION-MAKING

  2019cites this paper
• From Synapse to Function: A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction

  2018cites this paper
• Role of G-proteins and phosphorylation in the distribution of AGS3 to cell puncta

  2018cites this paper
• Metaplasticity at the addicted tetrapartite synapse: A common denominator of drug induced adaptations and potential treatment target for addiction

  2018cites this paper
• Molecular Windows into the Human Brain for Psychiatric Disorders

  2018cites this paper
• Effects of repeated cocaine administration on dopamine D1 receptor modulation of mesocorticolimbic GABA and glutamate transmission.

  2018cites this paper
• Opioid and Psychostimulant Plasticity: Targeting Overlap in Nucleus Accumbens Glutamate Signaling.

  2018cites this paper
• Interference of norepinephrine transporter trafficking motif attenuates amphetamine‐induced locomotor hyperactivity and conditioned place preference

  2018cites this paper
• N-Acetylcysteine reduces cocaine-cue attentional bias and differentially alters cocaine self-administration based on dosing order.

  2017cites this paper
• Chapter Seven – The Neuropathology of Drug Abuse

  2017cites this paper
• The Behavioral Effects of Chronic Sugar and/or Caffeine Consumption in Adult and Adolescent Rats

  2017cites this paper
• The Spindle Orientation Machinery Beyond Mitosis: When Cell Specialization Demands Polarization.

  2017cites this paper
• Open Access book

  2017cites this paper
• Epigenetics: a link between addiction and social environment

  2017cites this paper
• au Identification of a Deubiquitinating Enzyme as a Novel AGS 3-Interacting Protein

  2017cites this paper
• 1 Metabotropic Receptors for Glutamate and GABA

  2017cites this paper
• Regulation of Chemokine Signal Integration by Activator of G-Protein Signaling 4 (AGS4)

  2017cites this paper
• Evidence of a Role for G Protein Signaling Modulator 3 in Cell Division

  2016cites this paper
• The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

  2016cites this paper
• The role of adenylyl cyclase in the medial prefrontal cortex in cocaine-induced behavioral sensitization in rats.

  2016cites this paper
• Post‐cocaine changes in regulator of G‐protein signaling (RGS) proteins in the dorsal striatum: Relevance for cocaine‐seeking and protein kinase C‐mediated phosphorylation

  2016cites this paper
• Corticostriatal circuitry in regulating diseases characterized by intrusive thinking

  2016cites this paper
• The good and bad news about glutamate in drug addiction

  2016cites this paper
• Signals from the Fourth Dimension Regulate Drug Relapse.

  2016cites this paper
• Ibudilast attenuates expression of behavioral sensitization to cocaine in male and female rats.

  2016cites this paper
• Activator of G-Protein Signaling 3–Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection

  2016cites this paper
• Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

  2015cites this paper
• Overexpression of activator of G-protein signaling 3 decreases the proliferation of esophageal squamous cell carcinoma.

  2015cites this paper
• Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking.

  2015cites this paper
• Evaluación del rol de la vía canónica de Wnt en la adicción a cocaína

  2015cites this paper
• Chronic cocaine disrupts mesocortical learning mechanisms.

  2015cites this paper
• Direct Coupling of a Seven-Transmembrane-Span Receptor to a Gαi G-Protein Regulatory Motif Complex

  2015cites this paper
• Activators of G Protein Signaling Exhibit Broad Functionality and Define a Distinct Core Signaling Triad

  2014cites this paper
• Rapid, transient synaptic plasticity in addiction.

  2014cites this paper
• Principles of Epigenome Evolution

  2014cites this paper
• Dysregulation of Dopamine and Glutamate Release in the Prefrontal Cortex and Nucleus Accumbens Following Methamphetamine Self-Administration and During Reinstatement in Rats

  2014cites this paper
• Signaling 3 ( AGS 3 ) Leukocytes Lacking Activator of G Protein Defective Chemokine Signal Integration in Signal Transduction :

  2014cites this paper
• Synergistic Regulation of Glutamatergic Transmission by Serotonin and Norepinephrine Reuptake Inhibitors in Prefrontal Cortical Neurons*

  2014cites this paper
• Defective Chemokine Signal Integration in Leukocytes Lacking Activator of G Protein Signaling 3 (AGS3)*

  2014cites this paper
• Recent approaches for studying the role of glia.

  2014cites this paper
• Development of inhibitors of heterotrimeric Gαi subunits.

  2014cites this paper
• Epigenetics and early life origins of chronic noncommunicable diseases.

  2013cites this paper
• The role of DNA methylation in the development of cocaine-induced behavioural sensitisation

  2013influential citation
• Novel Modulation of Adenylyl Cyclase Type 2

  2013influential citation
• Attenuation of methamphetamine seeking by the mGluR2/3 agonist LY379268 in rats with histories of restricted and escalated self-administration.

  2013cites this paper
• Translocation of Activator of G-protein Signaling 3 to the Golgi Apparatus in Response to Receptor Activation and Its Effect on the trans-Golgi Network*

  2013cites this paper
• Group I metabotropic glutamate receptors in the medial prefrontal cortex: Role in mesocorticolimbic glutamate release in cocaine sensitization

  2013cites this paper
• Reduction of Group II Metabotropic Glutamate Receptors during Development of Benzodiazepine Dependence

  2013cites this paper
• Fine-tuning of GPCR signals by intracellular G protein modulators.

  2013cites this paper
• Repeated cocaine exposure increases fast-spiking interneuron excitability in the rat medial prefrontal cortex.

  2013cites this paper
• Prefrontal synaptic markers of cocaine addiction-like behavior in rats

  2013cites this paper
• Differential Effects of AGS3 Expression on D2L Dopamine Receptor-Mediated Adenylyl Cyclase Signaling

  2013cites this paper
• The Role of Trait Impulsivity and Novelty-Seeking as Predisposing Factors to the Acquisition and Reinstatement of MDMA Self-Administration

  2013cites this paper
• Examination of a role for metabotropic glutamate receptor 5 in the medial prefrontal cortex in cocaine sensitization in rats

  2012cites this paper
• Metabotropic Receptors for Glutamate and GABA

  2012cites this paper
• Regulation of the G-protein Regulatory-Gαi Signaling Complex by Nonreceptor Guanine Nucleotide Exchange Factors*

  2012cites this paper
• The importance of the adenosine A(2A) receptor-dopamine D(2) receptor interaction in drug addiction.

  2012cites this paper
• Neuroplasticity in the Mesolimbic System Induced by Sexual Experience and Subsequent Reward Abstinence

  2012cites this paper
• Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system

  2012cites this paper
• Oscillatory power and synchrony in the rat forebrain are altered by a sensitizing regime of D-amphetamine.

  2012cites this paper
• Neuronal Functions of Activators of G Protein Signaling

  2012cites this paper
• Role of Prefrontal Cortex Dopamine and Noradrenaline Circuitry in Addiction

  2012cites this paper
• Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction

  2012influential citation
• Histone post-translational modifications in the nuclei of striatal D1 and D2 neurons : development of a novel method of study and effects of cocaine

  2012cites this paper
• Estudio funcional del receptor dopaminérgico D2 en el sistema nervioso central mediante el uso de ratones mutantes inducibles

  2012cites this paper
• From Linkage to GWAS: A Multifaceted Exploration of the Genetic Risk for Alcohol Dependence

  2012cites this paper
• Molecular and Contextual Markers of Hepatitis C Virus and Drug Abuse

  2012cites this paper
• Neuroadaptation in Nicotine Addiction: Update on the Sensitization-Homeostasis Model

  2012cites this paper
• Rhes: A GTP-Binding Protein Integral to Striatal Physiology and Pathology

  2012cites this paper
• fMRI response in the medial prefrontal cortex predicts cocaine but not sucrose self-administration history

  2012cites this paper
• Group II activators of G‐protein signalling and proteins containing a G‐protein regulatory motif

  2012cites this paper
• Opioid Receptor Signal Transduction Mechanisms

  2011cites this paper