SPARC regulates TGF‐beta1‐dependent signaling in primary glomerular mesangial cells

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Cellular Biochemistry

• Publication date

  2004-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jcb.20008PMID 15034927
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system.

  2003cited by this paper
• SPARC regulates cell cycle progression in mesangial cells via its inhibition of IGF‐dependent signaling

  2003influential reference
• Fibroblast growth factor receptor‐1 mediates the inhibition of endothelial cell proliferation and the promotion of skeletal myoblast differentiation by SPARC: A role for protein kinase A

  2003cited by this paper
• TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation

  2001cited by this paper
• SPARC and the kidney glomerulus: matricellular proteins exhibit diverse functions under normal and pathological conditions.

  2001cited by this paper
• c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells.

  2001cited by this paper
• Regulation of Smad signaling by protein kinase C

  2001cited by this paper
• Cross-talk between the p42/p44 MAP Kinase and Smad Pathways in Transforming Growth Factor β1-induced Furin Gene Transactivation*

  2001cited by this paper
• Expression and purification of recombinant human SPARC produced by baculovirus.

  2000cited by this paper
• TGF-beta receptor expression and binding in rat mesangial cells: modulation by glucose and cyclic mechanical strain.

  1999cited by this paper
• SPARC, a Matricellular Glycoprotein with Important Biological Functions

  1999cited by this paper
• Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation.

  1999cited by this paper
• Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3.

  1999cited by this paper
• ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-β Signaling*

  1999cited by this paper
• Differential regulation of transforming growth factor receptors by angiotensin II and transforming growth factor-β1 in vascular smooth muscle

  1999cited by this paper
• Smads bind directly to the Jun family of AP-1 transcription factors.

  1999cited by this paper
• SPARC Regulates the Expression of Collagen Type I and Transforming Growth Factor-β1 in Mesangial Cells*

  1999influential reference
• SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation‐dependent pathway

  1998cited by this paper
• TGF-beta signal transduction.

  1998cited by this paper
• Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members.

  1998cited by this paper
• SPARC (BM-40, Osteonectin) Inhibits the Mitogenic Effect of Vascular Endothelial Growth Factor on Microvascular Endothelial Cells*

  1998cited by this paper
• Crystal structure and mapping by site‐directed mutagenesis of the collagen‐binding epitope of an activated form of BM‐40/SPARC/osteonectin

  1998cited by this paper
• Renal expression of transforming growth factor-beta inducible gene-h3 (beta ig-h3) in normal and diabetic rats.

  1998cited by this paper
• Renal expression of transforming growth factor-β inducible gene-h3 (βig-h3) in normal and diabetic rats1

  1998cited by this paper
• Overexpression of stromelysin-3, BM-40/SPARC, and MET genes in human esophageal carcinoma: implications for prognosis.

  1998cited by this paper
• Regulation of human mesangial cell collagen expression by transforming growth factor-β1.

  1998cited by this paper
• Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity.

  1997cited by this paper
• TGF-beta signalling from cell membrane to nucleus through SMAD proteins.

  1997influential reference
• SPARC is expressed by mesangial cells in experimental mesangial proliferative nephritis and inhibits platelet-derived-growth-factor-medicated mesangial cell proliferation in vitro.

  1996influential reference
• Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.

  1996cited by this paper
• Expression of biologically active human SPARC in Escherichia coli.

  1996cited by this paper
• Transforming growth factor-beta controls cell-matrix interaction of microvascular dermal endothelial cells by downregulation of integrin expression.

  1996cited by this paper
• Expression of transforming growth factor-beta isoforms in human glomerular diseases.

  1996cited by this paper
• Expression of transforming growth factor-β isoforms in human glomerular diseases

  1996cited by this paper
• The biology of SPARC, a protein that modulates cell‐matrix interactions

  1994cited by this paper
• TGF‐β1 induces the expression of type I collagen and SPARC, and enhances contraction of collagen gels, by fibroblasts from young and aged donors

  1994cited by this paper
• Visceral glomerular epithelial cells can proliferate in vivo and synthesize platelet-derived growth factor B-chain.

  1993influential reference
• SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway

  1993influential reference
• The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors.

  1992influential reference
• Regulation of mesangial cell proliferation.

  1991cited by this paper
• The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells.

  1991cited by this paper

• Micro-proteomics reveals distinct protein profiles and SPARC/FGF2/CDH1 regulation of human Sertoli cells between Sertoli cell-only syndrome and normal men

  2025cites this paper
• The contribution of amphibian macrophage subsets to scarless regeneration of skin wounds

  2025cites this paper
• Regulatory Mechanisms of SPARC Overexpression in Melanoma Progression

  2025cites this paper
• Modulating the blood-brain barrier in CNS disorders: A review of the therapeutic implications of secreted protein acidic and rich in cysteine (SPARC).

  2024cites this paper
• HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

  2024cites this paper
• Exploring the roles of SPARC as a proinflammatory factor and its potential as a novel therapeutic target against cardiovascular disease.

  2024cites this paper
• Omics Overview of the SPARC Gene in Mesothelioma

  2023cites this paper
• SPARC Is Highly Expressed in Young Skin and Promotes Extracellular Matrix Integrity in Fibroblasts via the TGF-β Signaling Pathway

  2023cites this paper
• Identification of ORM1, vWF, SPARC, and PPBP as immune-related proteins involved in immune thrombocytopenia by quantitative LC-MS/MS

  2023cites this paper
• Cell-type-specific alternative polyadenylation promotes oncogenic gene expression in non-small cell lung cancer progression

  2023cites this paper
• The role of SPARC (secreted protein acidic and rich in cysteine) in the pathogenesis of obesity, type 2 diabetes, and non-alcoholic fatty liver disease

  2022cites this paper
• MiR-211-5p Inhibits the Biological Behaviors of Colorectal Cancer via SPARC-Related Growth Factor Pathways

  2022cites this paper
• SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension

  2022cites this paper
• SPARC knockdown attenuated TGF-β1-induced fibrotic effects through Smad2/3 pathways in human pterygium fibroblasts.

  2021cites this paper
• Identification of the growth factor–binding sequence in the extracellular matrix protein MAGP-1

  2020cites this paper
• Osteonectin regulates the extracellular matrix mineralization of osteoblasts through P38 signaling pathway

  2020influential citation
• Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases

  2020cites this paper
• Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation

  2020cites this paper
• Fibronectin acts as a molecular switch to determine SPARC function in pancreatic cancer.

  2020cites this paper
• Identification of coordinately regulated microRNA-gene networks that differ in baboons discordant for LDL-cholesterol

  2019cites this paper
• Interaction of Nerve Growth Factor β with Adiponectin and SPARC Oppositely Modulates its Biological Activity

  2019influential citation
• Mechanisms of therapy-resistance modulated by GRP78, SPARC and HSP47 in colorectal cancer

  2019influential citation
• Secreted modular calcium-binding proteins in pathophysiological processes and embryonic development

  2019cites this paper
• Collagen Signaling in Cancer

  2019cites this paper
• Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies

  2019cites this paper
• Characterization of Proteins Released by Osteoblasts That Promote Expansion of Hematopoietic Progenitors

  2018cites this paper
• SPARC acts as a mediator of TGF‐&bgr;1 in promoting epithelial‐to‐mesenchymal transition in A549 and H1299 lung cancer cells

  2018cites this paper
• The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease

  2017influential citation
• Improving anti-EGFR therapy in HNSCC by targeting the growth factor receptor co-activation network

  2017cites this paper
• SPARC expression in gastric cancer predicts poor prognosis: Results from a clinical cohort, pooled analysis and GSEA assay

  2016cites this paper
• The matricellular protein CCN1 enhances TGF‐β1/SMAD3‐dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury

  2016cites this paper
• The role of inflammation and SPARC (secreted protein acidic and rich in cysteine) in colorectal tumourigenesis

  2016cites this paper
• SPARC Inhibits VEGF-mediated VEGFR2 Activation and Downstream Signaling

  2015cites this paper
• An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases

  2015cites this paper
• Searching for new mechanisms of myocardial fibrosis with diagnostic and/or therapeutic potential

  2015cites this paper
• Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis.

  2015cites this paper
• Secreted Protein Acidic and Rich in Cysteine in Ocular Tissue

  2015cites this paper
• Retinal Glia Promote Dorsal Root Ganglion Axon Regeneration

  2015cites this paper
• Novel Role for Matricellular Proteins in the Regulation of Islet (cid:2) Cell Survival THE OF SPARC ON PROLIFERATION, AND SIGNALING

  2014cites this paper
• Myocardial Extracellular Matrix An Ever-Changing and Diverse Entity

  2014cites this paper
• Novel Role for Matricellular Proteins in the Regulation of Islet β Cell Survival

  2014cites this paper
• Myocardial Extracellular Matrix: An Ever-Changing and Diverse Entity

  2014cites this paper
• Tumour-stroma interactions in pancreatic ductal adenocarcinoma: rationale and current evidence for new therapeutic strategies.

  2014cites this paper
• SPARC in Tumor Pathophysiology and as a Potential Therapeutic Target.

  2014cites this paper
• Artificial extracellular matrix composed of collagen I and highly sulfated hyaluronan interferes with TGFβ(1) signaling and prevents TGFβ(1)-induced myofibroblast differentiation.

  2013cites this paper
• Secreted protein acidic and rich in cysteine (SPARC) is upregulated by transforming growth factor (TGF)-β and is required for TGF-β-induced hydrogen peroxide production in fibroblasts

  2013cites this paper
• SPARC Regulates Microgliosis and Functional Recovery following Cortical Ischemia

  2013cites this paper
• Stromal expression of SPARC in pancreatic adenocarcinoma

  2013cites this paper
• Evolution and Function of SPARC and Tenascins: Matricellular Counter-Adhesive Glycoproteins with Pleiotropic Effects on Angiogenesis and Tissue Fibrosis

  2013cites this paper
• Lack of the Matricellular Protein SPARC (Secreted Protein, Acidic and Rich in Cysteine) Attenuates Liver Fibrogenesis in Mice

  2013cites this paper
• Autocrine control of glioma cells adhesion and migration through IRE1&agr;-mediated cleavage of SPARC mRNA

  2012cites this paper
• SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT

  2012cites this paper
• Losartan Slows Pancreatic Tumor Progression and Extends Survival of SPARC-Null Mice by Abrogating Aberrant TGFβ Activation

  2012cites this paper
• Integrin β4 Regulates SPARC Protein to Promote Invasion*

  2012cites this paper
• Matricellular proteins in cardiac adaptation and disease.

  2012cites this paper
• A critical review of the molecular pathophysiology of lenalidomide sensitivity in 5q − myelodysplastic syndromes

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• Role of Matricellular Proteins in Cardiac Allograft Fibrosis

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• Analysis of Integrin α6β4 Function in Breast Carcinoma: A Dissertation

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• The roles of secreted protein acidic and rich in cystiene (Sparc) in intestinal inflammation, healing and fibrosis

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• Novel Biological Insights and Therapeutic Approaches in High-Risk Acute Myeloid Leukemia

  2012influential citation
• Regulation of Pericyte Behavior by Secreted Protein Acidic and Rich in Cysteine

  2011cites this paper
• SPARC is expressed in scars of the Tenon’s capsule and mediates scarring properties of human Tenon’s fibroblasts in vitro

  2011cites this paper
• The regulatory function of SPARC in vascular biology

  2011cites this paper
• The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling

  2011cites this paper
• SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity

  2011influential citation
• Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors.

  2011cites this paper
• SPARC oppositely regulates inflammation and fibrosis in bleomycin-induced lung damage.

  2011cites this paper
• Change of MAX Interactor 1 Expression in an Anti-Thy1 Nephritis Model and its Effect on Mesangial Cell Proliferation

  2011cites this paper
• Attenuation of Expression of Extracellular Matrix Genes with siRNAs to SPARC and CTGF in Skin Fibroblasts of CTGF Transgenic Mice

  2011cites this paper
• Modulation of matrix remodeling by SPARC in neoplastic progression.

  2010cites this paper
• Matricellular proteins and inflammatory cells: a task force to promote or defeat cancer?

  2010cites this paper
• The function of SPARC in tumor cell biology: SPARC as a modulator of cell-extracellular matrix interaction

  2010cites this paper
• Proteomic analysis in mammary glands of rat offspring exposed in utero to bisphenol A.

  2010cites this paper
• Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis

  2010cites this paper
• Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma

  2010cites this paper
• Anti-SPARC oligopeptide inhibits laser-induced CNV in mice.

  2010cites this paper
• Attenuation of fibrosis in vitro and in vivo with SPARC siRNA

  2010cites this paper
• Large scale analysis of transcription factor TTF-1/NKX2.1 target genes in GnRH secreting cell line GT1-7.

  2010cites this paper
• The role of SPARC in extracellular matrix assembly

  2009cites this paper
• Combination of microarray profiling and protein-protein interaction databases delineates the minimal discriminators as a metastasis network for esophageal squamous cell carcinoma.

  2009cites this paper
• SPARC: a matricellular regulator of tumorigenesis

  2009influential citation
• Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation

  2009cites this paper
• Differences in gene expression profiles from asbestos-treated SPARC-null and wild-type mouse lungs.

  2009cites this paper
• Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction

  2009cites this paper
• SPARC is expressed by macroglia and microglia in the developing and mature nervous system

  2008cites this paper
• Studies of anemia in the myelodysplastic syndromes

  2008cites this paper
• The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase.

  2008influential citation
• The Integrative Studies of Genetic and Environmental Factors in Systemic Sclerosis

  2008cites this paper
• Matricellular proteins at the crossroad of inflammation and cancer.

  2008cites this paper
• The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host

  2008cites this paper
• The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host

  2008cites this paper
• Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q− syndrome patients

  2007cites this paper
• An in vitro model of posterior capsular opacity: SPARC and TGF-beta2 minimize epithelial-to-mesenchymal transition in lens epithelium.

  2007cites this paper
• Identification of secreted proteins during skeletal muscle development.

  2007cites this paper
• SPARC enhances tumor stroma formation and prevents fibroblast activation

  2007cites this paper
• Growth factor binding to the pericellular matrix and its importance in tissue engineering.

  2007cites this paper
• Matricellular proteins : essential modulators of cardiac remodeling

  2007cites this paper
• Increased Notch 1 expression and attenuated stimulatory G protein coupling to adenylyl cyclase in osteonectin-null osteoblasts.

  2007cites this paper
• SPARC from Olfactory Ensheathing Cells Stimulates Schwann Cells to Promote Neurite Outgrowth and Enhances Spinal Cord Repair

  2007cites this paper
• Effects of hyaluronan and SPARC on fibroproliferative events assessed in an in vitro bladder acellular matrix model.

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