Ceramide synthases at the centre of sphingolipid metabolism and biology.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Biochemical Journal

• Publication date

  2012-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1042/BJ20111626PMID 22248339PMCID PMC3689921
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Loss of ceramide synthase 3 causes lethal skin barrier disruption.

  2012cited by this paper
• Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death.

  2012cited by this paper
• Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

  2011cited by this paper
• A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

  2011cited by this paper
• Ceramide Synthase-dependent Ceramide Generation and Programmed Cell Death

  2011cited by this paper
• Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism[S]

  2011cited by this paper
• Novel Pathway of Ceramide Production in Mitochondria

  2011cited by this paper
• Visualization of ceramide channels by transmission electron microscopy.

  2011cited by this paper
• Ceramide channels and their role in mitochondria-mediated apoptosis.

  2010cited by this paper
• Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane

  2010cited by this paper
• A Critical Role for Ceramide Synthase 2 in Liver Homeostasis

  2010cited by this paper
• The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during Apoptosis*

  2010cited by this paper
• A Critical Role for Ceramide Synthase 2 in Liver Homeostasis

  2010cited by this paper
• Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.

  2010cited by this paper
• Antiapoptotic roles of ceramide‐synthase‐6‐generated C16‐ceramide via selective regulation of the ATF6/ CHOP arm of ER‐stress‐response pathways

  2010cited by this paper
• Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing.

  2010cited by this paper
• Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.

  2010cited by this paper
• Adult Ceramide Synthase 2 (CERS2)-deficient Mice Exhibit Myelin Sheath Defects, Cerebellar Degeneration, and Hepatocarcinomas*

  2009cited by this paper
• Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue.

  2009cited by this paper
• Neuronal ceroid lipofuscinoses.

  2009cited by this paper
• Potentiation of Cannabinoid-Induced Cytotoxicity in Mantle Cell Lymphoma through Modulation of Ceramide Metabolism

  2009cited by this paper
• AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells

  2009cited by this paper
• Ceramide biosynthesis in keratinocyte and its role in skin function.

  2009cited by this paper
• Ceramide synthases and ceramide levels are increased in breast cancer tissue.

  2009cited by this paper
• De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma.

  2009cited by this paper
• Ceramide synthase 1 is regulated by proteasomal mediated turnover.

  2009cited by this paper
• FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells*

  2009cited by this paper
• Sphingosine Kinase Isoforms Regulate Oxaliplatin Sensitivity of Human Colon Cancer Cells through Ceramide Accumulation and Akt Activation*

  2009cited by this paper
• Infrastructure for the life sciences: design and implementation of the UniProt website

  2009cited by this paper
• Ceramide Synthesis Is Modulated by the Sphingosine Analog FTY720 via a Mixture of Uncompetitive and Noncompetitive Inhibition in an Acyl-CoA Chain Length-de pend ent Manner*

  2009cited by this paper
• Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

  2009cited by this paper
• The Universal Protein Resource (UniProt) in 2010

  2009cited by this paper
• Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response.

  2009cited by this paper
• Male Germ Cells Require Polyenoic Sphingolipids with Complex Glycosylation for Completion of Meiosis

  2008cited by this paper
• Ceramide Generated by Sphingomyelin Hydrolysis and the Salvage Pathway Is Involved in Hypoxia/Reoxygenation-induced Bax Redistribution to Mitochondria in NT-2 Cells*

  2008cited by this paper
• Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2

  2008cited by this paper
• TRAIL receptor-targeted therapeutics: resistance mechanisms and strategies to avoid them.

  2008cited by this paper
• Characterization of Ceramide Synthase 2

  2008cited by this paper
• Principles of bioactive lipid signalling: lessons from sphingolipids

  2008cited by this paper
• CLN3p Impacts Galactosylceramide Transport, Raft Morphology, and Lipid Content

  2008cited by this paper
• De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.

  2008cited by this paper
• Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels*

  2008cited by this paper
• Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells

  2008cited by this paper
• Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer

  2008cited by this paper
• A New Functional Motif in Hox Domain-containing Ceramide Synthases

  2007cited by this paper
• Mechanisms of ceramide‐mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1

  2007cited by this paper
• Alterations of Ceramide/Sphingosine 1-Phosphate Rheostat Involved in the Regulation of Resistance to Imatinib-induced Apoptosis in K562 Human Chronic Myeloid Leukemia Cells*

  2007cited by this paper
• Kinetic characterization of mammalian ceramide synthases: Determination of K m values towards sphinganine

  2007cited by this paper
• (Dihydro)ceramide Synthase 1–Regulated Sensitivity to Cisplatin Is Associated with the Activation of p38 Mitogen-Activated Protein Kinase and Is Abrogated by Sphingosine Kinase 1

  2007cited by this paper
• Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites.

  2007cited by this paper
• mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review).

  2007cited by this paper
• Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis.

  2007cited by this paper
• Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

  2007cited by this paper
• The CLN9 Protein, a Regulator of Dihydroceramide Synthase*

  2006cited by this paper
• Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations.

  2006cited by this paper
• Protein Kinase C-induced Activation of a Ceramide/Protein Phosphatase 1 Pathway Leading to Dephosphorylation of p38 MAPK*

  2006cited by this paper
• LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity.

  2006cited by this paper
• Necessary Role for the Lag1p Motif in (Dihydro)ceramide Synthase Activity*

  2006cited by this paper
• Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice

  2005cited by this paper
• LASS6, an additional member of the longevity assurance gene family.

  2005cited by this paper
• Selective Inhibition of Juxtanuclear Translocation of Protein Kinase C βII by a Negative Feedback Mechanism Involving Ceramide Formed from the Salvage Pathway*

  2005cited by this paper
• ATM regulates target switching to escalating doses of radiation in the intestines

  2005cited by this paper
• Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.

  2005cited by this paper
• Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging

  2005cited by this paper
• Down-regulation of ATM Protein Sensitizes Human Prostate Cancer Cells to Radiation-induced Apoptosis*

  2005cited by this paper
• LASS5 Is a Bona Fide Dihydroceramide Synthase That Selectively Utilizes Palmitoyl-CoA as Acyl Donor*

  2005cited by this paper
• Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 in Human Head and Neck Squamous Cell Carcinomas*

  2004cited by this paper
• Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?

  2004cited by this paper
• De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes.

  2003cited by this paper
• P‐glycoprotein (ABCB1) but not multidrug resistance‐associated protein 1 (ABCC1) is induced by doxorubicin in primary cultures of rat astrocytes

  2003cited by this paper
• Two Mammalian Longevity Assurance Gene (LAG1) Family Members, trh1 and trh4, Regulate Dihydroceramide Synthesis Using Different Fatty Acyl-CoA Donors*

  2003cited by this paper
• Role of the ceramide-signaling pathways in ionizing radiation-induced apoptosis

  2003cited by this paper
• Human Homologues of LAG1 Reconstitute Acyl-CoA-dependent Ceramide Synthesis in Yeast*

  2003cited by this paper
• Ceramide Signaling in Fenretinide-induced Endothelial Cell Apoptosis*

  2002cited by this paper
• Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?

  2002cited by this paper
• Upstream of Growth and Differentiation Factor 1 (uog1), a Mammalian Homolog of the Yeast Longevity Assurance Gene 1 (LAG1), RegulatesN-Stearoyl-sphinganine (C18-(Dihydro)ceramide) Synthesis in a Fumonisin B1-independent Manner in Mammalian Cells*

  2002cited by this paper
• Ceramide Channels Increase the Permeability of the Mitochondrial Outer Membrane to Small Proteins*

  2002cited by this paper
• TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?

  2002cited by this paper
• Protein kinase Cδ amplifies ceramide formation via mitochondrial signaling in prostate cancer cells

  2002cited by this paper
• Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells.

  2002cited by this paper
• Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures.

  2001cited by this paper
• N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.

  2001cited by this paper
• C26‐CoA‐dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p

  2001cited by this paper
• Induction of Apoptosis through B-cell Receptor Cross-linking Occurs via de Novo Generated C16-Ceramide and Involves Mitochondria*

  2001cited by this paper
• Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death.

  2001cited by this paper
• Comparison of the metabolism of L-erythro- and L-threo-sphinganines and ceramides in cultured cells and in subcellular fractions.

  2001cited by this paper
• Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells

  2001cited by this paper
• Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae.

  2001cited by this paper
• Ceramide generation by two distinct pathways in tumor necrosis factor α‐induced cell death

  2001cited by this paper
• Dual video microscopic imaging of membrane potential and cytosolic calcium of immunoidentified embryonic rat cortical cells.

  2000cited by this paper
• Isolation and characterization of novel inhibitors of sphingolipid synthesis: australifungin, viridiofungins, rustmicin, and khafrefungin.

  2000cited by this paper
• Involvement of protein kinase C-regulated ceramide generation in inostamycin-induced apoptosis.

  2000cited by this paper
• The Lipids C2- and C16-Ceramide Form Large Stable Channels

  2000cited by this paper
• Changes in ceramide and sphingomyelin following fludarabine treatment of human chronic B-cell leukemia cells.

  2000cited by this paper
• Serine Palmitoyltransferase Regulates de NovoCeramide Generation during Etoposide-induced Apoptosis*

  2000cited by this paper
• Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase.

  1999cited by this paper
• A Role for Neutral Sphingomyelinase-mediated Ceramide Production in T Cell Receptor–induced Apoptosis and Mitogen-activated Protein Kinase–mediated Signal Transduction

  1999cited by this paper
• Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins.

  1999cited by this paper
• Involvement of Protein Kinase C-β and Ceramide in Tumor Necrosis Factor-α-induced but Not Fas-induced Apoptosis of Human Myeloid Leukemia Cells*

  1999cited by this paper
• Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae.

  1999cited by this paper

• Multi-omic insight into the molecular mechanism of cuproptosis-related genes in the pathogenesis of Parkinson’s disease

  2026cites this paper
• Targeting ceramide metabolism to restore hypoxia-induced apoptosis in p53-deficient colon cancer cells

  2026cites this paper
• An integrative approach to studying sphingolipid metabolism reveals p53 as a master regulator of the pathway.

  2026cites this paper
• Migrasome as a novel organelle: Biogenesis, physiological functions, and therapeutic potential

  2026cites this paper
• Selenium Reprograms the Proteome of Milk Fat Globule Membrane in Yak Colostrum.

  2026cites this paper
• Fungal Sphingolipids: Biosynthesis Pathways, Structural Features and Biological Functions.

  2026cites this paper
• Latilactobacillus sakei CNTA 173 Reduces Fat Mass by Modulating Sphingolipid Metabolism in Diet-Induced Obese Wistar Rats

  2025cites this paper
• Sphingolipid metabolism and signaling in plant stress responses and crop improvement.

  2025cites this paper
• A Distinguishable Peripheral Blood and Conjunctival Transcriptome and Gut Microbiome in Sjögren's Disease: A Pilot Study

  2025cites this paper
• CerS2 is a druggable target in triple-negative breast cancer

  2025cites this paper
• Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants

  2025cites this paper
• Melatonin reverses lenvatinib resistance in HCC by regulating the ATF4-NRF1 pathway mediated by ceramide synthase 6.

  2025cites this paper
• Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection

  2025cites this paper
• Ceramide signaling in immunity: a molecular perspective

  2025cites this paper
• Metabolomics Analysis Uncovers Distinct Profiles of Liver Post-Transplant Patients by Immunosuppression Regimen

  2025cites this paper
• Evaluation of the Sphingolipidomic Profile in Women with Anorexia Nervosa: Relationships with Parameters Related to Body Composition, Cardiovascular Function, Glucometabolic Homeostasis, and Lipoprotein Metabolism

  2025cites this paper
• Uncoupling of nutrient sensing and cell size control by specific defects in ceramide structure

  2025cites this paper
• The Disruptions of Sphingolipid and Sterol Metabolism in the Short Fiber of Ligon-Lintless-1 Mutant Revealed Obesity Impeded Cotton Fiber Elongation and Secondary Cell Wall Deposition

  2025cites this paper
• Plasma Membrane Epichaperome–Lipid Interface: Regulating Dynamics and Trafficking

  2025cites this paper
• Modulation of ceramides through nutrition: a new target in obesity and insulin resistance (Narrative Review).

  2025cites this paper
• Mitochondria-Associated Membrane Dysfunction in Neurodegeneration and Its Effects on Lipid Metabolism, Calcium Signaling, and Cell Fate

  2025cites this paper
• Ceramides may Play a Central Role in the Pathogenesis of Alzheimer’s Disease: a Review of Evidence and Horizons for Discovery

  2025cites this paper
• LC‐MS and High‐Throughput Data Processing Solutions for Lipid Metabolic Tracing Using Bioorthogonal Click Chemistry

  2025cites this paper
• Rapamycin induced autophagy enhances lipid breakdown and ameliorates lipotoxicity in Atlantic salmon cells.

  2025cites this paper
• Bayesian‐optimized deep learning for identifying essential genes of mitophagy and fostering therapies to combat drug resistance in human cancers

  2025cites this paper
• Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer

  2025cites this paper
• The SGLT2 Inhibitor Dapagliflozin Disrupts the Cell Cycle at High Concentrations Without Altering Glycosphingolipid (De Novo)Biosynthesis

  2025cites this paper
• Autophagy activation by the Becn1F121A mutation reprograms neuroinflammation and promotes neurological recovery after spinal cord injury

  2025cites this paper
• Biomarkers of Fumonisin Exposure in Pigs Fed the Maximum Recommended Level in Europe

  2025cites this paper
• Migrasome: a novel insight into unraveling physiological and pathological function

  2025cites this paper
• Ceramide Synthase 2 Promotes Cardiac Very-Long-Chain Dihydroceramide Accumulation and Is Linked to Arrhythmias and Heart Failure in Humans

  2025cites this paper
• Untargeted metabolomic profiling of serum and urine in kidney cancer: a non-invasive approach for biomarker discovery

  2025cites this paper
• Metabolism of sphingolipids in a rat spinal cord stenosis model

  2025cites this paper
• Fasting the mitochondria to prevent neurodegeneration: the role of ceramides

  2025cites this paper
• Synthesis, function, and therapeutic potential of glycosphingolipids

  2025cites this paper
• Development of Human Skin Equivalents with Inducible Ceramide Depletion for In Vitro Modeling of Lipid Impairment

  2025cites this paper
• Individual lipid alterations at the origin of neuronal Ceramide Synthase defects

  2025cites this paper
• Rôle des sphingolipides dans l’insulinorésistance

  2025cites this paper
• Reducing fumonisin contamination in Brazilian maize: The impact of Codex standards and regulatory frameworks.

  2024cites this paper
• The role of sphingolipid rheostat in the adult-type diffuse glioma pathogenesis

  2024cites this paper
• Optical control of sphingolipid biosynthesis using photoswitchable sphingosines

  2024cites this paper
• The Drug Transporter P-Glycoprotein and Its Impact on Ceramide Metabolism—An Unconventional Ally in Cancer Treatment

  2024cites this paper
• Targeting Oligodendrocyte Dynamics and Remyelination: Emerging Therapies and Personalized Approaches in Multiple Sclerosis Management.

  2024cites this paper
• Dysregulation of sphingolipid metabolism in liver fibrosis

  2024cites this paper
• Phosphatidic acid is involved in regulation of autophagy in neurons in vitro and in vivo

  2024cites this paper
• Bioactive lipids in the skin barrier mediate its functionality in health and disease.

  2024cites this paper
• Glycosphingolipids: from metabolism to chemoenzymatic total synthesis.

  2024cites this paper
• A combination of metabolomics and microbiome analyses reveal the modulation of lipid metabolism effect of Nannochloropsis gaditana polysaccharides on alcohol-induced dyslipidemia in mice

  2024cites this paper
• Enzymes of sphingolipid metabolism as transducers of metabolic inputs.

  2024cites this paper
• Metabolomic and sphingolipidomic profiling of human hepatoma cells exposed to widely used pharmaceuticals.

  2024cites this paper
• The Combination of Oolonghomobisflavan B and Diallyl Disulfide Induces Apoptotic Cell Death via 67-kDa Laminin Receptor/Cyclic Guanosine Monophosphate in Acute Myeloid Leukemia Cells

  2024cites this paper
• Lack of Ceramide Synthase 5 Protects Retinal Ganglion Cells from Ocular Hypertensive Injury.

  2024cites this paper
• The impacts of dietary sphingomyelin supplementation on metabolic parameters of healthy adults: a systematic review and meta-analysis of randomized controlled trials

  2024cites this paper
• Downregulation of CerS4 Instead of CerS2 in Liver Effectively Alleviates Hepatic Insulin Resistance in HFD Male Mice.

  2024cites this paper
• Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency

  2024cites this paper
• Alterations in urinary ceramides, sphingoid bases, and their phosphates among patients with kidney disease

  2024cites this paper
• Ceramide Synthase HYL-2 is Required for Neural Preconditioning to Anoxia in Caenorhabditis elegans .

  2024cites this paper
• Glycosphingolipids in congenital disorders of glycosylation (CDG).

  2024cites this paper
• Mysterious sphingolipids: metabolic interrelationships at the center of pathophysiology

  2024cites this paper
• LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells

  2024cites this paper
• Loss of ceramide synthase 5 inhibits the development of experimentally induced aortic valve stenosis

  2024cites this paper
• Sphingolipids: Less Enigmatic but Still Many Questions about the Role(s) of Ceramide in the Synthesis/Function of the Ganglioside Class of Glycosphingolipids

  2024cites this paper
• Sphingolipid Signaling and Complement Activation in Glioblastoma: A Promising Avenue for Therapeutic Intervention

  2024cites this paper
• Metabolic dysfunctions in pearl oysters following recurrent marine heatwaves.

  2024cites this paper
• Fumonisin Distorts the Cellular Membrane Lipid Profile: A Mechanistic Insight.

  2024cites this paper
• Seasonal Changes in Serum Metabolites in Multiple Sclerosis Relapse

  2023cites this paper
• Ceramide concentrations in liver, plasma, and very low-density lipoproteins of humans with severe obesity.

  2023cites this paper
• Ceramide Synthase 1 Inhibits Brain Metastasis of Non-Small Cell Lung Cancer by Interacting with USP14 and Downregulating the PI3K/AKT/mTOR Signaling Pathway

  2023cites this paper
• Role of ceramides in diabetic foot ulcers (Review)

  2023cites this paper
• The natural occurrence, toxicity mechanisms and management strategies of Fumonisin B1：A review.

  2023cites this paper
• Hepatic triglyceride content is intricately associated with numerous metabolites and biochemical pathways

  2023cites this paper
• The Implication of Sphingolipids in Viral Infections

  2023cites this paper
• The Ying and Yang of Ganglioside Function in Cancer

  2023cites this paper
• Alkaline ceramidase 1–mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation

  2023cites this paper
• Drug Targeting of Acyltransferases in the Triacylglyceride and 1-O-AcylCeramide Biosynthetic Pathways

  2023influential citation
• Sphingolipid-Based Synergistic Interactions to Enhance Chemosensitivity in Lung Cancer Cells

  2023cites this paper
• Barrier abnormalities in type 1 diabetes mellitus: the roles of inflammation and ceramide metabolism.

  2023cites this paper
• Associations of plasma sphingolipids with measures of insulin sensitivity, β-cell function, and incident diabetes in Japanese Americans.

  2023cites this paper
• The anti‐cancer effect of epigallocatechin‐3‐ O‐gallate against multiple myeloma cells is potentiated by 5,7‐dimethoxyflavone

  2023cites this paper
• Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation

  2023cites this paper
• Structure of the yeast ceramide synthase

  2023cites this paper
• Review of Eukaryote Cellular Membrane Lipid Composition, with Special Attention to the Fatty Acids

  2023cites this paper
• A Novel HSPB1S139F Mouse Model of Charcot-Marie-Tooth Disease.

  2023cites this paper
• Structure and mechanism of a eukaryotic ceramide synthase complex

  2023cites this paper
• Ceramide compensation by ceramide synthases preserves retinal function and structure in a retinal dystrophy mouse model

  2023cites this paper
• Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy.

  2023cites this paper
• Emerging roles and therapeutic potentials of sphingolipids in pathophysiology --emphasis on fatty acyl heterogeneity.

  2023cites this paper
• The Role of Ceramide in Inherited Retinal Disease Pathology.

  2023cites this paper
• Targeted sphingolipidomics indicates increased C22-C24:16 ratios of virtually all assayed classes in liver, kidney, and plasma of fumonisin-fed chickens.

  2023influential citation
• The role of BCL2L13 in Glioblastoma: Turning a need into a target.

  2023cites this paper
• The therapeutic potential of sphingolipids for cardiovascular diseases

  2023cites this paper
• Tea tree oil, a vibrant source of neuroprotection via neuroinflammation inhibition: a critical insight into repurposing Melaleuca alternifolia by unfolding its characteristics

  2023cites this paper
• Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis

  2023cites this paper
• Ceramide’s Role and Biosynthesis: A Brief Review

  2023cites this paper
• The endocannabinoid system, a new gatekeeper in the pharmacology of human hepatocellular carcinoma.

  2023cites this paper
• A novel homozygous splice site variant in CERS3 causes autosomal recessive congenital ichthyosis

  2023cites this paper
• Detection of Bacterial Neutral Ceramidase in Diabetic Foot Ulcers with an Optimized Substrate and Chemoenzymatic Probes.

  2023cites this paper
• Ceramide analog C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway

  2023influential citation
• Circulating Sphingolipids and Glucose Homeostasis: An Update

  2023influential citation
• Emerging Roles of Ceramide in Cardiovascular Diseases

  2022cites this paper