Structural features of angiotensin-I converting enzyme catalytic sites: conformational studies in solution, homology models and comparison with other zinc metallopeptidases.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Current Topics in Medicinal Chemistry

• Publication date

  2004-01-31

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.2174/1568026043451294PMID 14965309
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Crystal structure of Drosophila angiotensin I‐converting enzyme bound to captopril and lisinopril 1

  2003cited by this paper
• Crystal structure of the human angiotensin-converting enzyme–lisinopril complex

  2003cited by this paper
• Zinc binding in peptide models of angiotensin‐I converting enzyme active sites studied through 1H‐NMR and chemical shift perturbation mapping

  2003cited by this paper
• Structural biology of metal-binding sequences.

  2002cited by this paper
• Selectivity in heavy metal- binding to peptides and proteins.

  2002cited by this paper
• Mapping protein-protein interactions in solution by NMR spectroscopy.

  2002influential reference
• A theoretical study of the mechanism for peptide hydrolysis by thermolysin

  2002influential reference
• Crystal structure of a novel carboxypeptidase from the hyperthermophilic archaeon Pyrococcus furiosus.

  2002cited by this paper
• Crystal structure of human leukotriene A4 hydrolase, a bifunctional enzyme in inflammation

  2001influential reference
• Angiotensin converting enzymes from human urine of mild hypertensive untreated patients resemble the N-terminal fragment of human angiotensin I-converting enzyme.

  2001cited by this paper
• RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis.

  2001cited by this paper
• Structure of neurolysin reveals a deep channel that limits substrate access

  2001influential reference
• Angiotensin I-converting Enzyme Transition State Stabilization by His1089

  2001cited by this paper
• Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences.

  2001cited by this paper
• Structure of a new 'aspzincin' metalloendopeptidase from Grifola frondosa: implications for the catalytic mechanism and substrate specificity based on several different crystal forms.

  2001influential reference
• A quick solution: ab initio structure determination of a 19 kDa metalloproteinase using ACORN.

  2001cited by this paper
• Crystal structure of the anthrax lethal factor

  2001influential reference
• Arg1098 Is Critical for the Chloride Dependence of Human Angiotensin I-converting Enzyme C-domain Catalytic Activity*

  2001cited by this paper
• A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 2: affinities of ACE inhibitors.

  2000cited by this paper
• Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.

  2000influential reference
• Sequences and topology

  2000cited by this paper
• Mapping the active site of angiotensin-converting enzyme by transferred NOE spectroscopy.

  2000cited by this paper
• The Structure of the Metal-Binding Motif GMTCAAC Is Similar in an 18-Residue Linear Peptide and the Mercury Binding Protein MerP

  2000cited by this paper
• Peptidase specificity characterization of C- and N-terminal catalytic sites of angiotensin I-converting enzyme.

  2000cited by this paper
• NPS@: network protein sequence analysis.

  2000cited by this paper
• Kinin-degrading pathways in the human heart.

  2000influential reference
• Comparative protein structure modeling of genes and genomes.

  2000cited by this paper
• A rapid screening system to determine drug affinities for the intestinal dipeptide transporter 1: system characterisation.

  2000cited by this paper
• Crystal structure of the hydrogenase maturating endopeptidase HYBD from Escherichia coli.

  1999cited by this paper
• Potentiation of Bradykinin Actions by ACE Inhibitors.

  1999cited by this paper
• The Zn-peptidase superfamily: functional convergence after evolutionary divergence.

  1999cited by this paper
• N-domain selectivity of angiotensin I-converting enzyme as assessed by structure-function studies of its highly selective substrate, N-acetyl-seryl-aspartyl-lysyl-proline.

  1999cited by this paper
• Design of angiotensin converting enzyme inhibitors

  1999influential reference
• RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites.

  1999cited by this paper
• N-domain-specific substrate and C-domain inhibitors of angiotensin-converting enzyme: angiotensin-(1-7) and keto-ACE.

  1998cited by this paper
• The crystal structure of the Leishmania major surface proteinase leishmanolysin (gp63).

  1998influential reference
• Carboxypeptidase A: native, zinc-removed and mercury-replaced forms.

  1998cited by this paper
• Crystal structure of botulinum neurotoxin type A and implications for toxicity

  1998influential reference
• Structures of Cys319 variants and acetohydroxamate-inhibited Klebsiella aerogenes urease.

  1997cited by this paper
• Torsion angle dynamics for NMR structure calculation with the new program DYANA.

  1997influential reference
• A simple method to quantitatively measure polypeptide JHNHα coupling constants from TOCSY or NOESY spectra

  1997cited by this paper
• Structure of the zinc endoprotease from Streptomyces caespitosus.

  1997influential reference
• The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.

  1997cited by this paper
• The renin-angiotensin system and vascular function. The role of angiotensin II, angiotensin-converting enzyme, and alternative conversion of angiotensin I.

  1997influential reference
• Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy.

  1997cited by this paper
• Analysis of main chain torsion angles in proteins: prediction of NMR coupling constants for native and random coil conformations.

  1996cited by this paper
• The endopeptidase activity and the activation by Cl- of angiotensin-converting enzyme is evolutionarily conserved: purification and properties of an an angiotensin-converting enzyme from the housefly, Musca domestica.

  1996cited by this paper
• MOLMOL: a program for display and analysis of macromolecular structures.

  1996cited by this paper
• GOR method for predicting protein secondary structure from amino acid sequence.

  1996cited by this paper
• Recent Advances in Zinc Enzymology.

  1996cited by this paper
• Matrilysin-inhibitor complexes: common themes among metalloproteases.

  1996cited by this paper
• ‘Random coil’ 1H chemical shifts obtained as a function of temperature and trifluoroethanol concentration for the peptide series GGXGG

  1995cited by this paper
• Structural analysis of zinc substitutions in the active site of thermolysin

  1995influential reference
• Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed beta-propeller.

  1995cited by this paper
• Structural features of a superfamily of zinc-endopeptidases: the metzincins.

  1995influential reference
• Identification of two active site residues in human angiotensin I-converting enzyme.

  1994influential reference
• Crystal structure of Aeromonas proteolytica aminopeptidase: a prototypical member of the co-catalytic zinc enzyme family.

  1994cited by this paper
• Metalloproteinase superfamilies and drug design.

  1994cited by this paper
• The renin-angiotensin system.

  1994cited by this paper
• 1.56 Å structure of mature truncated human fibroblast collagenase

  1994cited by this paper
• Families of zinc metalloproteases

  1994influential reference
• Crystal structure of the 50 kDa metallo protease from Serratia marcescens.

  1994cited by this paper
• Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coli: a new type of proteolytic enzyme.

  1993cited by this paper
• Evolutionary families of peptidases.

  1993cited by this paper
• Mutations in two specific residues of testicular angiotensin-converting enzyme change its catalytic properties.

  1993cited by this paper
• Alpha helix propensity of amino acids.

  1993cited by this paper
• First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases.

  1993influential reference
• Structural analysis of Serratia protease

  1993cited by this paper
• New perspective on zinc biochemistry: cocatalytic sites in multi-zinc enzymes.

  1993influential reference
• Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides.

  1993cited by this paper
• Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc‐binding environments (HEXXHXXGXXH and Met‐turn) and topologies and should be grouped into a common family, the ‘metzincins’

  1993influential reference
• The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy.

  1992cited by this paper
• Families of metalloendopeptidases and their relationships

  1992cited by this paper
• The functional role of tyrosine-200 in human testis angiotensin-converting enzyme.

  1992cited by this paper
• Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases

  1992influential reference
• [Renin-angiotensin system].

  1992influential reference
• Primary structure of carboxypeptidase T: Delineation of functionally relevant features in Zn-carboxypeptidase family

  1992cited by this paper
• The two homologous domains of human angiotensin I-converting enzyme are both catalytically active.

  1991cited by this paper
• Relationship between nuclear magnetic resonance chemical shift and protein secondary structure.

  1991cited by this paper
• Efficient computation of three-dimensional protein structures in solution from nuclear magnetic resonance data using the program DIANA and the supporting programs CALIBA, HABAS and GLOMSA.

  1991influential reference
• Angiotensin-converting enzyme: zinc- and inhibitor-binding stoichiometries of the somatic and testis isozymes.

  1991cited by this paper
• Molecular structure of leucine aminopeptidase at 2.7-A resolution.

  1990cited by this paper
• A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis.

  1990cited by this paper
• Active-site zinc ligands and activated H2O of zinc enzymes.

  1990influential reference
• Angiotensin converting enzyme inhibition and its impact on cardiovascular disease.

  1990influential reference
• Zinc coordination, function, and structure of zinc enzymes and other proteins.

  1990influential reference
• A unique signature identifies a family of zinc‐dependent metallopeptidases

  1989cited by this paper
• Angiotensin-converting enzyme: new concepts concerning its biological role.

  1989influential reference
• Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues.

  1989cited by this paper
• Short and long spacer sequences and other structural features of zinc binding sites in zinc enzymes

  1989cited by this paper
• Darstellung geschützter peptid-fragmente unter einsatz substituierter triphenylmethyl-harze

  1989cited by this paper
• Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.

  1988cited by this paper
• Structural basis of the action of thermolysin and related zinc peptidases

  1988cited by this paper
• Catalysis of angiotensin I hydrolysis by human angiotensin-converting enzyme: effect of chloride and pH.

  1988cited by this paper
• Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.

  1988influential reference
• Further developments of protein secondary structure prediction using information theory. New parameters and consideration of residue pairs.

  1987cited by this paper
• Mechanism of carboxypeptidase A: hydration of a ketonic substrate analogue.

  1987cited by this paper
• Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond.

  1987cited by this paper
• Synthesis of N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline (lisinopril).

  1985cited by this paper
• Preliminary X-ray studies on Serratia protease.

  1985cited by this paper

• Screening of Angiotensin-I Converting Enzyme (ACE) Inhibitory Peptides from Thermolytic Hydrolysate of Arthrospira platensis

  2025cites this paper
• Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation

  2024cites this paper
• Angiotensin-converting enzyme: a well-known stranger. Part I

  2023cites this paper
• Unraveling the Phytochemistry, Traditional Uses, and Biological and Pharmacological Activities of Thymus algeriensis Boiss. & Reut

  2022cites this paper
• Molecular insights into the interaction of angiotensin I-converting enzyme (ACE) inhibitors and HEXXH motif.

  2021cites this paper
• Citrullyl-Hydroxyprolyl-Proline (ChPP): An Artificially Synthesized Tripeptide as Potent ACE Inhibitor

  2020cites this paper
• Evaluation of new antihypertensive drugs designed in silico using Thermolysin as a target

  2020cites this paper
• Review on druggable targets of key age‐associated properties regulated by therapeutic agents

  2020cites this paper
• Trace Element Zinc, a Nature’s Gift to Fight Unprecedented Global Pandemic COVID-19

  2020cites this paper
• Marine Organisms as Potential Sources of Bioactive Peptides that Inhibit the Activity of Angiotensin I-Converting Enzyme: A Review

  2019cites this paper
• Modelling and Computational Sequence Analysis of a Bacteriocin Isolated from Bacillus licheniformis strain BTHT8

  2018cites this paper
• Chemistry and pharmacology of Angiotensin-converting enzyme inhibitors.

  2015cites this paper
• The effects of micelles of differently charged surfactants on the equilibrium between (Z)- and (E)-diastereomers of five ACE inhibitors in aqueous media

  2015cites this paper
• Anthrax lethal factor inhibitors as potential countermeasure of the infection.

  2014cites this paper
• Coffee components and cardiovascular risk: beneficial and detrimental effects

  2014cites this paper
• Captopril and Lisinopril Only Inhibit Matrix Metalloproteinase‐2 (MMP‐2) Activity at Millimolar Concentrations

  2014cites this paper
• How to design a potent, specific, and stable angiotensin-converting enzyme inhibitor.

  2014cites this paper
• A Modern Understanding of the Traditional and Nontraditional Biological Functions of Angiotensin-Converting Enzyme

  2013cites this paper
• Inhibition of anthrax lethal factor by curcumin and chemically modified curcumin derivatives

  2013cites this paper
• Elimination of angiotensin: Converting enzime inhibitors by peritoneal dialisate

  2011cites this paper
• Antihypertensive Properties of Flavonoid-Rich Apple Peel Extract, Selected Flavonoids and Metabolites In Vitro

  2011cites this paper
• Purification and biophysical characterization of the core protease domain of anthrax lethal factor.

  2010cites this paper
• Synthetic Peptides as Structural Maquettes of Angiotensin-I Converting Enzyme Catalytic Sites

  2010cites this paper
• Determinants for Psychrophilic and Thermophilic Features of Metallopeptidases of the M4 Family

  2009cites this paper
• Polymorphismen des Angiotensin-Converting-Enzym-Gens beeinflussen depressive Störungen und kardiovaskuläre Erkrankungen

  2009cites this paper
• Folding in solution of the C‐catalytic protein fragment of angiotensin‐converting enzyme

  2009cites this paper
• Insights into the anthrax lethal factor–substrate interaction and selectivity using docking and molecular dynamics simulations

  2009cites this paper
• Determination of the structure of lipid vesicle-bound angiotensin II and angiotensin I.

  2008cites this paper
• ΕΛΛΗΝΙΚΗ ΔΗΜΟΚΡΑΤΙΑ

  2008cites this paper
• Low molecular weight inhibitors of the protease anthrax lethal factor.

  2008cites this paper
• Novel Enzyme Technology for Food Applications

  2007cites this paper
• Enzymatic production of bioactive peptides from milk and whey proteins.

  2007cites this paper
• The Structure of Testis Angiotensin-Converting Enzyme ( tACE-g 13 ) in Complex with the Inhibitor RXPA 380 ITAI CHITAPI

  2007cites this paper
• The Structure of Testis Angiotensin-Converting Enzyme (tACE-g13) in Complex with the Inhibitor RXPA380

  2006cites this paper
• Solid‐phase synthesis and conformational properties of angiotensin converting enzyme catalytic‐site peptides: The basis for a structural study on the enzyme–substrate interaction

  2004cites this paper