Impulsive alcohol-related risk-behavior and emotional dysregulation among individuals with a serotonin 2B receptor stop codon

A relatively common stop codon (Q20*) was identified in the serotonin 2B receptor gene (HTR2B) in a Finnish founder population in 2010 and it was associated with impulsivity. Here we examine the phenotype of HTR2B Q20* carriers in a setting comprising 14 heterozygous HTR2B Q20* carriers and 156 healthy controls without the HTR2B Q20*. The tridimensional personality questionnaire, Brown–Goodwin lifetime aggression scale, the Michigan alcoholism screening test and lifetime drinking history were used to measure personality traits, impulsive and aggressive behavior, both while sober and under the influence of alcohol, and alcohol consumption. Regression analyses showed that among the HTR2B Q20* carriers, temperamental traits resembled a passive-dependent personality profile, and the presence of the HTR2B Q20* predicted impulsive and aggressive behaviors particularly under the influence of alcohol. Results present examples of how one gene may contribute to personality structure and behaviors in a founder population and how personality may translate into behavior.

• Publication year

  2015

• Venue

  Translational Psychiatry

• Publication date

  2015-11-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1038/tp.2015.170PMID 26575222PMCID 5068763
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state.

  2015cited by this paper
• Basal insulin secretion, PCL-R and recidivism among impulsive violent alcoholic offenders.

  2015cited by this paper
• Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases.

  2015cited by this paper
• Genetic background of extreme violent behavior

  2014cited by this paper
• Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population

  2014cited by this paper
• The missing heritability of behavior: the search continues.

  2014cited by this paper
• The Neural Basis of Autism: A Review

  2014cited by this paper
• Advancements and challenges in generating accurate animal models of gestational diabetes mellitus.

  2013cited by this paper
• Genetics of impulsive behaviour

  2013cited by this paper
• Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

  2013cited by this paper
• 5-HT2B receptors are required for serotonin-selective antidepressant actions

  2012cited by this paper
• Serotonin 5-HT2B receptors are required for bone-marrow contribution to pulmonary arterial hypertension.

  2012cited by this paper
• Functional genetic variants in the vesicular monoamine transporter 1 (VMAT1) modulate emotion processing

  2012cited by this paper
• Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor

  2011cited by this paper
• Genetics of emotion.

  2011cited by this paper
• DAT1 and COMT Effects on Delay Discounting and Trait Impulsivity in Male Adolescents with Attention Deficit/Hyperactivity Disorder and Healthy Controls

  2010cited by this paper
• A POPULATION-SPECIFIC HTR2B STOP CODON PREDISPOSES TO SEVERE IMPULSIVITY

  2010cited by this paper
• Significant association between the C(−1019)G functional polymorphism of the HTR1A gene and impulsivity

  2010cited by this paper
• HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power--an intermediate phenotype for alcoholism and co-morbid behaviors.

  2009cited by this paper
• Low non-oxidative glucose metabolism and violent offending: an 8-year prospective follow-up study.

  2009cited by this paper
• Genetic approaches to addiction: genes and alcohol.

  2008cited by this paper
• Genetic variation in human NPY expression affects stress response and emotion

  2008cited by this paper
• Serotonin 5-HT2B Receptors Are Required for 3,4-Methylenedioxymethamphetamine-Induced Hyperlocomotion and 5-HT Release In Vivo and In Vitro

  2008cited by this paper
• A Non-Additive Interaction of a Functional MAO-A VNTR and Testosterone Predicts Antisocial Behavior

  2008cited by this paper
• Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls

  2007cited by this paper
• Tridimensional Personality Questionnaire data on alcoholic violent offenders: specific connections to severe impulsive cluster B personality disorders and violent criminality

  2007cited by this paper
• Energy substrate metabolism among habitually violent alcoholic offenders having antisocial personality disorder.

  2007cited by this paper
• Serotonin transport and serotonin transporter‐mediated antidepressant recognition are controlled by 5‐HT2B receptor signaling in serotonergic neuronal cells

  2006cited by this paper
• Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations.

  2005cited by this paper
• Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

  2004cited by this paper
• A psychometrically derived impulsive trait related to a polymorphism in the serotonin transporter gene‐linked polymorphic region (5‐HTTLPR) in a japanese nonclinical population: Assessment by the barratt impulsiveness scale (BIS)

  2003cited by this paper
• A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.

  2002cited by this paper
• Serotonin 2B receptor is required for heart development.

  2000cited by this paper
• Molecular genetics of the Finnish disease heritage.

  1999cited by this paper
• Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations.

  1998cited by this paper
• 5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells.

  1997cited by this paper
• Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

  1996cited by this paper
• Ras Involvement in Signal Transduction by the Serotonin 5-HT2B Receptor (*)

  1996cited by this paper
• Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics

  1995cited by this paper
• Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A.

  1993cited by this paper
• Brain serotonin, type II alcoholism and impulsive violence.

  1993cited by this paper
• [Affective disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association -- diagnostic and statistical manual of mental disorders].

  1993cited by this paper
• A systematic method for clinical description and classification of personality variants: A proposal.

  1987cited by this paper
• A systematic method for clinical description and classification of personality variants. A proposal.

  1987cited by this paper
• Neurogenetic adaptive mechanisms in alcoholism.

  1987cited by this paper
• Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior.

  1983cited by this paper
• Reliability of alcohol use indices. The Lifetime Drinking History and the MAST.

  1982cited by this paper
• Aggression in humans correlates with cerebrospinal fluid amine metabolites.

  1979cited by this paper

• The Role of Alcohol Use Severity in the Link Between Attitude and Microaggression Perpetration Toward Sexually- and Gender-Diverse Individuals

  2025cites this paper
• Revisiting the Role of Serotonin in Attention-Deficit Hyperactivity Disorder: New Insights from Preclinical and Clinical Studies

  2025cites this paper
• Effect of serotonin receptor gene variants on substance use disorders

  2024cites this paper
• Serotonin-2B receptor (5-HT2BR) expression and binding in the brain of ageing APPswe/PS1de9 transgenic mice and in human Alzheimer’s Disease brain tissue

  2024cites this paper
• Serotonin-2B receptor (5-HT2BR) expression and binding in the brain of APPswe/PS1dE9 transgenic mice and in Alzheimer's disease brain tissue.

  2024cites this paper
• 5-HT1A and 5-HT2B receptor interaction and co-clustering regulate serotonergic neuron excitability

  2023cites this paper
• Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia

  2023cites this paper
• 5-HT1A and 5-HT2B receptor interaction and co-clustering regulates serotonergic neuron excitability

  2023cites this paper
• 5-HT 1A and 5-HT 2B receptor interaction and co-clustering regulates serotonergic neuron excitability. 5-HT receptor cross-talks shape 5-HT neuron function

  2022cites this paper
• Neurotransmission-Related Gene Expression in the Frontal Pole (Brodmann Area 10) is Altered in Subjects with Bipolar Disorder and Schizophrenia

  2022cites this paper
• The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference

  2022cites this paper
• The nonlinear association between HbA1c and cognitive impairment in patients with alcohol use disorder

  2022cites this paper
• Impulsivity is affected by cognitive enrichment and links to brain gene expression in red junglefowl chicks

  2021cites this paper
• The Role of 5-HT2B Receptor on Aggression and Drugs of Abuse

  2021cites this paper
• mRNA Levels of MAOA and 5-HT2A Receptor in Patients With Pathological Internet Use: Correlations With Comorbid Symptoms

  2021cites this paper
• Punch-Drunk or Drunken Boxing? The Etiology of Alcohol-Related Physical Violence through Adolescence and Young Adulthood

  2021cites this paper
• The relationship between monoaminergic gene expression, learning, and optimism in red junglefowl chicks

  2020cites this paper
• Improved visual discrimination learning in mice with partial 5-HT2B gene deletion.

  2020cites this paper
• Dietary yeast influences ethanol sedation in Drosophila via serotonergic neuron function

  2020cites this paper
• Serotonin neurobiology in cocaine use disorder

  2020cites this paper
• On alcohol disinhibition and inhibition: The intricate relationship between oxidative stress and behavior

  2020cites this paper
• The role of serotonin in alcohol use and abuse

  2020cites this paper
• A positive association between a polymorphism in the HTR2B gene and cocaine-crack in a French Caribbean population

  2020cites this paper
• Genetic and environmental factors influence Drosophila ethanol sedation

  2019cites this paper
• 2-Aminoindan and its ring-substituted derivatives interact with plasma membrane monoamine transporters and α2-adrenergic receptors

  2019cites this paper
• A positive association between a polymorphism in the HTR2B gene and cocaine-crack in a French Afro-Caribbean population

  2019cites this paper
• A quantitative trait locus on chromosome 1 modulates intermale aggression in mice

  2018cites this paper
• Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response

  2018cites this paper
• Personalized Treatment of Antisocial Personality Disorder with Inherent Impulsivity and Severe Alcoholism: A Brief Review of Relevant Literature

  2018cites this paper
• Societal Acceptance of Crime 8 Rape: Blaming Victims and Excusing the Behavior of the Offender

  2017cites this paper
• Hostility predicts alcohol consumption over a 21-year follow-up in the Gazel cohort.

  2017cites this paper
• Genetic studies of alcohol dependence in the context of the addiction cycle

  2017cites this paper
• A biopsychosocial model of violence when sleepwalking: review and reconceptualisation

  2017cites this paper
• Influence of a HTR2B Stop Codon on Glucagon Homeostasis and Glucose Excursion in Non-Diabetic Men

  2016cites this paper
• The effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males.

  2016cites this paper
• Uxoricide and dismemberment in a case of illicit anabolic steroid use: A case report and literature review

  2016cites this paper
• Health and life hazards related to aggressive behaviour of patients diagnosed with alcohol abstinence syndrome

  2016cites this paper
• Alcohol

  1865cites this paper