Translation of myelin basic protein mRNA in oligodendrocytes is regulated by integrin activation and hnRNP-K

α6β1-integrin interacts with hnRNP-K, an mRNA-binding protein, during oligodendrocyte differentiation to promote translation of MBP mRNA and myelin synthesis.

• Publication year

  2011

• Venue

  Journal of Cell Biology

• Publication date

  2011-03-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201007014PMID 21357748PMCID 3051817
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interaction forces and adhesion of supported myelin lipid bilayers modulated by myelin basic protein

  2009cited by this paper
• Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons

  2009influential reference
• An Integrin–Contactin Complex Regulates CNS Myelination by Differential Fyn Phosphorylation

  2009influential reference
• Integrin-mediated axoglial interactions initiate myelination in the central nervous system

  2009cited by this paper
• Laminin Alters Fyn Regulatory Mechanisms and Promotes Oligodendrocyte Development

  2009cited by this paper
• β1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth

  2009cited by this paper
• A crucial role for hnRNP K in axon development in Xenopus laevis

  2008cited by this paper
• Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2–dependent RNA granules

  2008cited by this paper
• In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences.

  2008cited by this paper
• The Microtubule-Associated Protein Tumor Overexpressed Gene/Cytoskeleton-Associated Protein 5 Is Necessary for Myelin Basic Protein Expression in Oligodendrocytes

  2007cited by this paper
• Contrasting effects of mitogenic growth factors on myelination in neuron–oligodendrocyte co‐cultures

  2007cited by this paper
• Rho Regulates Membrane Transport in the Endocytic Pathway to Control Plasma Membrane Specialization in Oligodendroglial Cells

  2007cited by this paper
• Immunoprecipitation of mRNA-protein complexes

  2006cited by this paper
• Dominant‐negative β1 integrin mice have region‐specific myelin defects accompanied by alterations in MAPK activity

  2006cited by this paper
• The DICE-binding activity of KH domain 3 of hnRNP K is affected by c-Src-mediated tyrosine phosphorylation.

  2006cited by this paper
• Heterogeneous nuclear ribonucleoprotein (hnRNP) E1 binds to hnRNP A2 and inhibits translation of A2 response element mRNAs.

  2006cited by this paper
• Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites

  2006cited by this paper
• Myelin basic protein: a multifunctional protein

  2006cited by this paper
• Dynamic regulation of integrin activation by intracellular and extracellular signals controls oligodendrocyte morphology

  2005cited by this paper
• Spatial regulation of β-actin translation by Src-dependent phosphorylation of ZBP1

  2005cited by this paper
• RNA-Binding Proteins Heterogeneous Nuclear Ribonucleoprotein A1, E1, and K Are Involved in Post-Transcriptional Control of Collagen I and III Synthesis

  2004influential reference
• Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development

  2004cited by this paper
• Beta1-integrin orients epithelial polarity via Rac1 and laminin.

  2004cited by this paper
• RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers.

  2004cited by this paper
• Signaling from Integrins to Fyn to Rho Family GTPases Regulates Morphologic Differentiation of Oligodendrocytes

  2004cited by this paper
• hnRNP K: One protein multiple processes

  2004cited by this paper
• BDNF induces translocation of initiation factor 4E to mRNA granules: Evidence for a role of synaptic microfilaments and integrins

  2003cited by this paper
• Integrin-linked kinase is required for laminin-2–induced oligodendrocyte cell spreading and CNS myelination

  2003cited by this paper
• CNS integrins switch growth factor signalling to promote target-dependent survival

  2002cited by this paper
• Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis.

  2002cited by this paper
• c-Src-Mediated Phosphorylation of hnRNP K Drives Translational Activation of Specifically Silenced mRNAs

  2002cited by this paper
• Integrins: bidirectional, allosteric signaling machines.

  2002cited by this paper
• Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta.

  2001cited by this paper
• Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining.

  2001cited by this paper
• Optimized RNA Targets of Two Closely Related Triple KH Domain Proteins, Heterogeneous Nuclear Ribonucleoprotein K and αCP-2KL, Suggest Distinct Modes of RNA Recognition*

  2001cited by this paper
• Severe Hypomyelination of the Murine CNS in the Absence of Myelin-Associated Glycoprotein and Fyn Tyrosine Kinase

  2000cited by this paper
• Integrins mediate a neuronal survival signal for oligodendrocytes.

  1999cited by this paper
• Mutational Analysis of a Heterogeneous Nuclear Ribonucleoprotein A2 Response Element for RNA Trafficking*

  1999cited by this paper
• Laminin-2/integrin interactions enhance myelin membrane formation by oligodendrocytes.

  1999cited by this paper
• The Cis-Acting RNA Trafficking Signal from Myelin Basic Protein mRNA and Its Cognate Trans-Acting Ligand Hnrnp A2 Enhance CaP-Dependent Translation

  1999influential reference
• Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions

  1998cited by this paper
• hnRNP A2 selectively binds the cytoplasmic transport sequence of myelin basic protein mRNA.

  1998cited by this paper
• Transport and Localization Elements in Myelin Basic Protein mRNA

  1997cited by this paper
• mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end.

  1997cited by this paper
• Molecular cloning of Fyn‐associated molecules in the mouse central nervous system

  1997influential reference
• Breaking the Integrin Hinge

  1996cited by this paper
• Lines of Murine Oligodendroglial Precursor Cells Immortalized by an Activated neu Tyrosine Kinase Show Distinct Degrees of Interaction with Axons In Vitro and In Vivo

  1995cited by this paper
• Initial events of myelination involve Fyn tyrosine kinase signalling

  1994cited by this paper
• A developmental analysis of oligodendroglial integrins in primary cells: changes in alpha v-associated beta subunits during differentiation.

  1994cited by this paper
• Transport and localization of exogenous myelin basic protein mRNA microinjected into oligodendrocytes

  1993cited by this paper
• Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

  1980cited by this paper
• Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

  1979cited by this paper

• CellSP enables module discovery and visualization for subcellular spatial transcriptomics data

  2025cites this paper
• Brain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U

  2025cites this paper
• Impacts of hnRNP A1 Splicing Inhibition on the Brain Remyelination Proteome

  2025cites this paper
• CellSP: Module discovery and visualization for subcellular spatial transcriptomics data

  2025cites this paper
• Structure of myelin in the central nervous system and another possible driving force for its formation—myelin compaction

  2025cites this paper
• Guardian of myelin and neural Integrity: foxo1a through slc7a11 mitigating oxidative damage in myelin

  2025cites this paper
• Diverse functions of DEAD‐box proteins in oligodendrocyte development, differentiation, and homeostasis

  2024cites this paper
• Heterogeneous nuclear ribonucleoprotein K promotes cap-independent translation initiation of retroviral mRNAs

  2024cites this paper
• Ninjurin 2, a Cell Adhesion Molecule and a Target of p53, Modulates Wild-Type p53 in Growth Suppression and Mutant p53 in Growth Promotion

  2024cites this paper
• Ambient sound stimulation tunes axonal conduction velocity by regulating radial growth of myelin on an individual, axon-by-axon basis

  2024cites this paper
• Gene expression profiles of endothelium, microglia and oligodendrocytes in hippocampus of post-stroke depression rat at single cell resolution

  2024cites this paper
• Myelination by signaling through Arf guanine nucleotide exchange factor

  2024cites this paper
• HnRNPK is involved in stress-induced depression-like behavior via ERK-BDNF pathway in mice.

  2023cites this paper
• Activated leukocyte cell adhesion molecule on human oligodendrocytes mediates CD4 T cell adhesion.

  2023cites this paper
• The Roles of hnRNP Family in the Brain and Brain-Related Disorders

  2023cites this paper
• The bone transcription factor Osterix controls extracellular matrix- and node of Ranvier-related gene expression in oligodendrocytes.

  2023cites this paper
• Mutant HTT does not affect glial development but impairs myelination in the early disease stage

  2023cites this paper
• HnRNP Pathologies in Frontotemporal Lobar Degeneration

  2023cites this paper
• A zebrafish model of combined saposin deficiency identifies acid sphingomyelinase as a potential therapeutic target

  2023cites this paper
• Development of myelin in fetal and postnatal neocortex of the pig, the European wild boar Sus scrofa

  2023cites this paper
• Effects of ECM proteins (laminin, fibronectin, and type IV collagen) on the biological behavior of Schwann cells and their roles in the process of remyelination after peripheral nerve injury

  2023cites this paper
• Myelin basic protein recovery during PKU mice lifespan and the potential role of microRNAs on its regulation.

  2023cites this paper
• Single-cell RNA-based phenotyping reveals a pivotal role of thyroid hormone receptor alpha for hypothalamic development

  2023cites this paper
• Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways

  2022cites this paper
• RNA-Binding Proteins as Epigenetic Regulators of Brain Functions and Their Involvement in Neurodegeneration

  2022cites this paper
• Chronic oligodendrocyte injury in central nervous system pathologies

  2022cites this paper
• Mitochondrial uncoupling protein 2 is regulated through heterogeneous nuclear ribonucleoprotein K in lead exposure models.

  2021cites this paper
• Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes

  2021cites this paper
• RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons

  2021cites this paper
• CHPG enhances BDNF and myelination in cuprizone‐treated mice through astrocytic metabotropic glutamate receptor 5

  2021cites this paper
• A glimpse on the architecture of hnRNP C1/C2 interaction network in cultured oligodendrocytes.

  2021cites this paper
• HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing

  2021cites this paper
• The Integrin Signaling Network Promotes Axon Regeneration via the Src–Ephexin–RhoA GTPase Signaling Axis

  2021cites this paper
• Ryanodine receptor- and sodium-calcium exchanger-mediated spontaneous calcium activity in immature oligodendrocytes in cultures.

  2020cites this paper
• Ginseng Gintonin Attenuates Lead-Induced Rat Cerebellar Impairments during Gestation and Lactation

  2020cites this paper
• A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells

  2020cites this paper
• Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration

  2020cites this paper
• Cell Adhesion Molecules and Protein Synthesis Regulation in Neurons

  2020cites this paper
• RNA-binding proteins balance brain function in health and disease.

  2020cites this paper
• The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis

  2020cites this paper
• Pushing myelination – developmental regulation of myosin expression drives oligodendrocyte morphological differentiation

  2020cites this paper
• Unraveling The Beta Cell Translatome: Elucidation Of An Erk/hnrnpk/jund Axis

  2019cites this paper
• Myelin in the Central Nervous System: Structure, Function, and Pathology.

  2019cites this paper
• Aβ oligomers promote oligodendrocyte differentiation and maturation via integrin β1 and Fyn kinase signaling

  2019cites this paper
• Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?

  2019cites this paper
• Role of heterogeneous nuclear ribonucleoprotein K in tumor development

  2019cites this paper
• A Fyn - specific biosensor reveals localized, pulsatile kinase activity and spatially regulated signaling crosstalk

  2019cites this paper
• A compartmentalized neuron-oligodendrocyte co-culture device for myelin research: design, fabrication and functionality testing

  2019cites this paper
• α2 isoform of Na+,K+-ATPase via Na+,Ca2+ exchanger modulates myelin basic protein synthesis in oligodendrocyte lineage cells in vitro.

  2018cites this paper
• Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes

  2018cites this paper
• Myelin is remodeled cell-autonomously by oligodendroglial macroautophagy

  2018cites this paper
• Jmy regulates oligodendrocyte differentiation via modulation of actin cytoskeleton dynamics

  2018cites this paper
• The 3’UTRs of Myelin Basic Protein mRNAs Regulate Transport, Local Translation and Sensitivity to Neuronal Activity in Zebrafish

  2018cites this paper
• Biogenesis and maintenance of cytoplasmic domains in myelin of the central nervous system

  2017cites this paper
• Conditional knockout of TOG results in CNS hypomyelination

  2017influential citation
• The logistics of myelin biogenesis in the central nervous system

  2017cites this paper
• The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons

  2017cites this paper
• Conductive polymer nanofibers as a platform for both stimulating and measuring differentiation in oligodendrocyte progenitor cells

  2017cites this paper
• Compartmentalized Signaling in Neurons: From Cell Biology to Neuroscience.

  2017cites this paper
• Endoplasmic reticulum stress signalling in myelination

  2017cites this paper
• Investigation of oligodendroglial pathology in amyotrophic lateral sclerosis

  2017cites this paper
• The Altered Roles of Glia in Neurodevelopmental Disorders

  2017cites this paper
• On the cause of multiple sclerosis: molecular mechanisms regulating myelin biogenesis

  2016cites this paper
• Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin

  2016cites this paper
• University of Groningen On the cause of multiple sclerosis

  2016cites this paper
• Association between chronic stress-induced structural abnormalities in Ranvier nodes and reduced oligodendrocyte activity in major depression

  2016cites this paper
• The transcriptome of mouse central nervous system myelin

  2016cites this paper
• Altered Translational Control of Fragile X Mental Retardation Protein on Myelin Proteins in Neuropsychiatric Disorders

  2016cites this paper
• On the cause of multiple sclerosis

  2016cites this paper
• ntracellular ion signaling influences myelin basic protein synthesis in ligodendrocyte precursor cells

  2016cites this paper
• Intracellular ion signaling influences myelin basic protein synthesis in oligodendrocyte precursor cells.

  2016cites this paper
• Functional organization of an Mbp enhancer exposes striking transcriptional regulatory diversity within myelinating glia

  2016cites this paper
• Oligodendrocytes: Myelination and Axonal Support.

  2015cites this paper
• Downregulation of the microtubule associated protein Tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes

  2015cites this paper
• Translational Control of Myelin Basic Protein Expression by ERK2 MAP Kinase Regulates Timely Remyelination in the Adult Brain

  2015cites this paper
• Axo-Glia Interaction Preceding CNS Myelination Is Regulated by Bidirectional Eph-Ephrin Signaling

  2015cites this paper
• The oligodendrocyte "processosome": novel regulators of differentiation and myelination

  2015influential citation
• Oligodendroglial Argonaute protein Ago2 associates with molecules of the Mbp mRNA localization machinery and is a downstream target of Fyn kinase

  2015cites this paper
• The extracellular matrix compartment of neural stem and glial progenitor cells

  2015cites this paper
• Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination.

  2015cites this paper
• Sulfatide‐mediated control of extracellular matrix‐dependent oligodendrocyte maturation

  2014cites this paper
• Transport and translation of MBP mRNA is regulated differently by distinct hnRNP proteins

  2014influential citation
• Regulation of the neural stem cell compartment by extracellular matrix constituents.

  2014cites this paper
• Axon-glia interaction and membrane traffic in myelin formation

  2014cites this paper
• Myelination at a glance

  2014cites this paper
• Functional implications of demyelination and the molecular control of remyelination in the adult mouse.

  2014cites this paper
• Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue.

  2014cites this paper
• Transcriptional Expression of Myelin Basic Protein in Oligodendrocytes Depends on Functional Syntaxin 4: a Potential Correlation with Autocrine Signaling

  2014cites this paper
• Mechanisms underlying the CNS myelination: A molecular and morphological analysis of the wrapping process

  2014cites this paper
• Conformational Transitions of an Intrinsically-Disordered Protein: Effects of Environment and Binding Partners on Myelin Basic Protein

  2014cites this paper
• The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1

  2014cites this paper
• New insights into co-transcriptional sorting of mRNA for cytoplasmic transport during development.

  2014cites this paper
• Post-transcriptional Regulation of Myelin Basic Protein Expression

  2014cites this paper
• Myelin architecture: zippering membranes tightly together

  2014cites this paper
• Modulation of subventricular zone oligodendrogenesis: a role for hemopressin?

  2014cites this paper
• Identification in the rat brain of a set of nuclear proteins interacting with H1° mRNA.

  2013cites this paper
• Myelin Proteome Analysis: Methods and Implications for the Myelin Cytoskeleton

  2013cites this paper
• Molecular mechanisms of lipid-rich myelin membrane sheet formation

  2013cites this paper
• Making myelin basic protein -from mRNA transport to localized translation

  2013cites this paper
• The role of QKI-5 in CG4 oligodendrocyte differentiation

  2013cites this paper