Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  AJP - Renal Physiology

• Publication date

  2000-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPRENAL.2000.278.5.F726PMID 10807584
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997influential reference
• Cytochrome c: can't live with it--can't live without it.

  1997cited by this paper
• Oxidant mechanisms in toxic acute renal failure.

  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996influential reference
• Role of apoptosis in development of the ascending thin limb of the loop of Henle in rat kidney.

  1996cited by this paper
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  1995influential reference
• Cisplatin generates superoxide anion by interaction with DNA in a cell-free system.

  1994cited by this paper
• Cisplatin nephrotoxicity.

  1994cited by this paper
• Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1991cited by this paper
• Mitochondrial injury: an early event in cisplatin toxicity to renal proximal tubules.

  1990cited by this paper
• Induction of haem oxygenase as a defence against oxidative stress.

  1990cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Cisplatin nephrotoxicity.

  1986cited by this paper
• Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin toxicity.

  1986cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper

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