Ketamine in Pain Management

No abstract is available for this paper.

• Publication year

  2013

• Venue

  CNS Neuroscience & Therapeutics

• Publication date

  2013-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/cns.12111PMID 23663314PMCID PMC6493592
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ketamine as an adjuvant to opioids for cancer pain.

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• Novel Animal Models of Acute and Chronic Cancer Pain: A Pivotal Role for PAR2

  2012cited by this paper
• Ketamine as an adjuvant to opioids for cancer pain.

  2012cited by this paper
• Topical amitriptyline, ketamine, and lidocaine in neuropathic pain caused by radiation skin reaction: a pilot study

  2012cited by this paper
• Randomized, double-blind, placebo-controlled study to assess the efficacy and toxicity of subcutaneous ketamine in the management of cancer pain.

  2012cited by this paper
• Effect of Subanesthetic Ketamine on Intrinsic Functional Brain Connectivity: A Placebo-controlled Functional Magnetic Resonance Imaging Study in Healthy Male Volunteers

  2012influential reference
• Ketamine for Pain: An Update of Uses in Palliative Care

  2012cited by this paper
• Ketamine analgesia: a call for better science.

  2012cited by this paper
• Ketamine: A Real-World Experience in Cancer Pain

  2012cited by this paper
• A systematic review of intravenous ketamine for postoperative analgesia

  2011cited by this paper
• A systematic review of ketamine as an analgesic agent in adult burn injuries.

  2011cited by this paper
• Wherefore ketamine?

  2010cited by this paper
• Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials.

  2010cited by this paper
• An observational study on the effect of S(+)‐ketamine on chronic pain versus experimental acute pain in Complex Regional Pain Syndrome type 1 patients

  2010cited by this paper
• Serotonin-Norepinephrine Reuptake Inhibitors for Pain Control: Premise and Promise

  2009cited by this paper
• Opioid Switching and Burst Ketamine to Improve the Opioid Response in Patients With Movement-related Pain Due to Bone Metastases

  2009cited by this paper
• Reduction of allodynia in patients with complex regional pain syndrome: A double‐blind placebo‐controlled trial of topical ketamine

  2009cited by this paper
• Clinical uses of low-dose ketamine in patients undergoing surgery.

  2009cited by this paper
• Pharmacological Aspects and Potential New Clinical Applications of Ketamine: Reevaluation of an Old Drug

  2009cited by this paper
• Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil

  2009cited by this paper
• Ketamine for chronic non‐cancer pain

  2009cited by this paper
• Ketamine and neurotoxicity: clinical perspectives and implications for emergency medicine.

  2009cited by this paper
• Toxicology Profile of N-Methyl-d-aspartate Antagonists Delivered by Intrathecal Infusion in the Canine Model

  2008cited by this paper
• The ketamine enigma

  2008cited by this paper
• Epidural ketamine for postoperative analgesia in the elderly.

  2008cited by this paper
• Something new about ketamine for pediatric anesthesia?

  2008cited by this paper
• Ketamine inhibits tumor necrosis factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation.

  2008cited by this paper
• Epidural ketamine for postoperative analgesia in the elderly

  2007cited by this paper
• Ketamine for prehospital use: new look at an old drug.

  2007cited by this paper
• Low dose ketamine: a therapeutic and research tool to explore N-methyl-D-aspartate (NMDA) receptor-mediated plasticity in pain pathways

  2007cited by this paper
• Imaging Pain Modulation by Subanesthetic S-(+)-Ketamine

  2006cited by this paper
• The effect of ketamine on intraspinal acetylcholine release: involvement of spinal nicotinic receptors.

  2006cited by this paper
• Persistent postsurgical pain: risk factors and prevention.

  2006cited by this paper
• Systemic ketamine inhibits hypersensitivity after surgery via descending inhibitory pathways in rats

  2005cited by this paper
• NMDA antagonists and neuropathic pain--multiple drug targets and multiple uses.

  2005cited by this paper
• Peri‐operative ketamine for acute post‐operative pain: a quantitative and qualitative systematic review (Cochrane review)

  2005cited by this paper
• Breakthrough pain in malignant and non‐malignant diseases: a review of prevalence, characteristics and mechanisms

  2005cited by this paper
• Involvement of Adenosine in the Antiinflammatory Action of Ketamine

  2005cited by this paper
• Pain management in the wilderness and operational setting.

  2005cited by this paper
• Ketamine as Adjuvant Analgesic to Opioids: A Quantitative and Qualitative Systematic Review

  2004cited by this paper
• Ketamine in prehospital care

  2004cited by this paper
• Sigma Receptors and Sigma Ligands: Background to a Pharmacological Enigma

  2004cited by this paper
• An Investigation to Dissociate the Analgesic and Anesthetic Properties of Ketamine Using Functional Magnetic Resonance Imaging

  2004cited by this paper
• Ketamine as adjuvant to opioids for cancer pain. A qualitative systematic review.

  2003cited by this paper
• Ketamine in Chronic Pain Management: An Evidence-Based Review

  2003cited by this paper
• A Single Small Dose of Postoperative Ketamine Provides Rapid and Sustained Improvement in Morphine Analgesia in the Presence of Morphine-Resistant Pain

  2003cited by this paper
• A Qualitative and Quantitative Systematic Review of Preemptive Analgesia for Postoperative Pain Relief: The Role of Timing of Analgesia

  2002cited by this paper
• Mechanisms of Direct Inhibitory Action of Isoflurane on Vascular Smooth Muscle of Mesenteric Resistance Arteries

  2001cited by this paper
• Mechanisms of Direct Inhibitory Action of Ketamine on Vascular Smooth Muscle in Mesenteric Resistance Arteries

  2001cited by this paper
• The semantics of ketamine.

  2001cited by this paper
• Targeting the N-methyl-D-aspartate receptor for chronic pain management. Preclinical animal studies, recent clinical experience and future research directions.

  2000cited by this paper
• The semantics of ketamine.

  2000cited by this paper
• Low-dose ketamine in the management of opioid nonresponsive terminal cancer pain.

  1999cited by this paper
• Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes.

  1999cited by this paper
• Peripheral Analgesic Effects of Ketamine in Acute Inflammatory Pain

  1998cited by this paper
• Ketamine: Teaching an Old Drug New Tricks

  1998cited by this paper
• Adjunctive methods of pain control in burns.

  1997cited by this paper
• Analgesic Efficacy of Low‐dose Ketamine: Somatosensory‐evoked Responses in Relation to Subjective Pain Ratings

  1996cited by this paper
• Ketamine: its mechanism(s) of action and unusual clinical uses.

  1996cited by this paper
• Interaction of the chiral forms of ketamine with opioid, phencyclidine, σ and muscarinic receptors

  1995cited by this paper
• The Effect of N-Methyl-D-aspartate Antagonist (Ketamine) on Single and Repeated Nociceptive Stimuli: A Placebo-Controlled Experimental Human Study

  1995cited by this paper
• Central nervous system effects of subdissociative doses of (S)‐ketamine are related to plasma and brain concentrations measured with positron emission tomography in healthy volunteers

  1995cited by this paper
• Inhibition by Ketamine of Muscarinic Acetylcholine Receptor Function

  1995cited by this paper
• Interaction of the chiral forms of ketamine with opioid, phencyclidine, sigma and muscarinic receptors.

  1995cited by this paper
• Response of chronic neuropathic pain syndromes to ketamine: a preliminary study

  1994cited by this paper
• Use of ketamine in prolonged entrapment.

  1994cited by this paper
• Ketamine inhibition of cytoplasmic calcium signalling in rat pheochromocytoma (PC-12) cells.

  1993cited by this paper
• Management of postoperative pain.

  1993cited by this paper
• Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.

  1992cited by this paper
• Molecular actions of racemic ketamine on human CNS sodium channels.

  1992cited by this paper
• The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn.

  1992cited by this paper
• The local monoaminergic dependency of spinal ketamine.

  1991cited by this paper
• Noncompetitive excitatory amino acid receptor antagonists.

  1990cited by this paper
• Continuous subcutaneous injection of ketamine for cancer pain

  1990cited by this paper
• Evidence of a role for NMDA receptors in pain perception.

  1990influential reference
• Ketamine for Intravenous Regional Anesthesia

  1989cited by this paper
• Comparison of ketamine and pethidine in experimental and postoperative pain

  1989cited by this paper
• Morphine Tolerance Decreases the Analgesic Effects of Ketamine in Mice

  1988cited by this paper
• Taking apart NMDA receptors

  1987cited by this paper
• Properties of the interaction between ketamine and opiate binding sites in vivo and in vitro.

  1987influential reference
• Neurobiology. Taking apart NMDA receptors.

  1987cited by this paper
• Effect of naloxone on loss of consciousness induced by i.v. ketamine.

  1985cited by this paper
• Infusion analgesia for acute war injuries A comparison of pentazocine and ketamine

  1984cited by this paper
• Effect of naloxone on the loss of consciousness induced by i.v. anaesthetic agents in man.

  1984cited by this paper
• Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine.

  1982cited by this paper
• Ketamine inhibits serotonin synthesis and metabolism in vivo.

  1982cited by this paper
• Opiate receptor mediation of ketamine analgesia.

  1982cited by this paper
• Ketamine--its pharmacology and therapeutic uses.

  1982cited by this paper
• Opiate Receptor Mediation of Ketamine Analgesia

  1982cited by this paper
• The interaction of ketamine with the opiate receptor.

  1980cited by this paper
• The management of postoperative pain.

  1975cited by this paper
• The effect of ketamine on nerve conduction in isolated sciatic nerves of the toad.

  1975cited by this paper
• Post‐operative pain relief with ketamine infusion

  1974cited by this paper
• Analgesic Effects of Ketamine Administered in Subdissociative Doses

  1971cited by this paper
• Clinical studies of induction agents. XXXVI: Ketamine.

  1970cited by this paper
• Dissociative Anesthesia: Further Pharmacologic Studies and First Clinical Experience with the Phencyclidine Derivative Cl‐581

  1966cited by this paper
• Pharmacologic effects of CI‐581, a new dissociative anesthetic, in man

  1965cited by this paper
• CLINICAL STUDIES OF INDUCTION AGENTS III: THE RELATIONSHIP BETWEEN DURATION OF ANAESTHESIA AND DOSAGE WITH G.29.505

  1962cited by this paper

• Oral Ketamine as an Analgesic Therapy: Systematic Review of Randomised Clinical Trials

  2025cites this paper
• The Analgesic and Dissociative Properties of Ketamine are Separate and Correspond to Distinct Neural Mechanisms

  2025cites this paper
• Post-surgical pain: evolving drug treatments and challenges

  2025cites this paper
• Therapeutic Applications of Ketamine in Emergency Medicine: Systematic Review

  2025cites this paper
• KETAMINE FOR RAPID CONTROL OF HYPERACTIVE DELIRIUM WITH SEVERE AGITATION. A RETROSPECTIVE COMPARISON STUDY

  2025cites this paper
• ANESTESI KETAMIN PADA TERAPI MANIPULASI ZERO POSITION PADA PASIEN FROZEN SHOULDER

  2025influential citation
• Comparison of Different Formulations of Extended-Release Buprenorphine in Perioperative Pain Management in Common Marmosets (Callithrix jacchus)

  2025cites this paper
• The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery

  2025cites this paper
• Sublingual Ketamine as Breakthrough Analgesia in Patients with Advanced Cancer—A Feasibility Randomised Controlled Repeated Cross-over Trial

  2025cites this paper
• Preliminary pharmacokinetics and in vivo studies indicate analgesic and stress mitigation effects of a novel NMDA receptor modulator

  2025cites this paper
• Molecular pathways of ketamine: A systematic review of immediate and sustained effects on PTSD

  2025cites this paper
• The ketamine chameleon: history, pharmacology, and the contested value of experience

  2025cites this paper
• Emerging Use of Low-Dose Ketamine for Pain Management Beyond the ICU

  2025cites this paper
• Ketamine Infusion for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty: A Prospective Randomized Single-Center Study

  2025cites this paper
• Beyond Anesthesia: Ketamine's Expanding Role in Chronic Pain and Psychiatric Disorders.

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• Antidepressant ketamine via oral gavage impairs fear memory, suppresses 22 kHz ultrasonic vocalizations, lowers GluN2A/B expression, and reduces medial habenula activity in rats.

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• Ketamine Induces Mitochondrial Fission and Dysfunction in Cervical Cancer Cells via RhoA‐Dependent DRP‐1 Activation

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• Managing Chronic Pain: The Ketamine Option

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• Mu Opioid Receptor Activation is Required for NMDA Receptor Antagonist Effects on Stress-induced Maladaptive Behavior.

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• Widespread reductions in cortical thickness following ketamine abuse

  2024cites this paper
• Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case report

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• The Impact of Ketamine on Outcomes in Acute Pain Management: An Umbrella Review

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• The role of ketamine and its enantiomer in managing depression and pain in cancer patients: A narrative review

  2024cites this paper
• Characterization of the temporal profile of the antinociceptive effects of an intravenous bolus of ketamine using the analgesia nociception index in no-anesthetized adult patients

  2024cites this paper
• Effects of Ketamine 0.5 mg/kgBW administration as preemptive analgesia on analgesia duration and the need for Fentanyl following hysterectomy surgery: a randomized controlled trial

  2024influential citation
• Nonopioid Drugs for Postoperative Pain: A Selection Governed by Choices of the Authors of Academic Articles

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• Opioid Administration in the Trauma Bay for Minor Injuries Does Not Improve Disposition

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• Assessing suicide risk in chronic pain management: a narrative review across drug classes

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• Intravenous Ketamine for Cancer Pain: A Single-Center Retrospective Analysis Comparing Fixed-Rate Versus Weight-Based Dosing

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• Attenuation of acute postoperative pain and opioid requirement with the use of magnesium sulfate in patients undergoing limb amputations.

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• Peri‐operative management and analgesic strategy for a patient undergoing quadruple limb amputation

  2024cites this paper
• Transitional Pain Service: An Update

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• Rethinking ketamine as a panacea: adverse effects on oxygenation and postoperative outcomes.

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  2023cites this paper
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• Intravenous S-ketamine’s analgesic efficacy in third molar surgery. A randomized placebo-controlled double-blind clinical trial

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• Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mechanical Allodynia in a Rat Model of Mild Traumatic Brain Injury

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• Intravenous low-dose ketamine in addition to systemic analgesia versus systemic analgesia alone for post-operative pain management in laparotomies:Adouble-blind randomised controlled study

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• Potential ‘anti-cancer’ effects of esketamine on proliferation, apoptosis, migration and invasion in esophageal squamous carcinoma cells

  2023cites this paper
• Pain Management in Patients with Hepatorenal Syndrome: A Literature Review

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• Use of Oral Ketamine in Palliative Care

  2023cites this paper
• Use of Oral Ketamine in Palliative Care

  2023cites this paper
• Combination of fluorescence sensor and artificial intelligence—a new method of quantitative ketamine detection

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• Penggunaan Opioid Free Anesthesia pada Pasien Kehamilan Ektopik Terganggu dengan Hemodinamik Stabil yang Menjalani Operasi Laparotomi

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• Refractory and super-refractory status epilepticus and evidence for the use of ketamine: a scope review

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• Ketamine: Recent evidence and current uses

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• Ketamine as a therapeutic agent for depression and pain: mechanisms and evidence.

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• Analgesic potential of macrodoses and microdoses of classical psychedelics in chronic pain sufferers: a population survey

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• Craving and addictive potential of esketamine as side effects?

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• The Impact of Health Professionals’ Language on Patient Experience: A Case Study

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• Dorsal Column Stimulation and Cannabinoids in the Treatment of Chronic Nociceptive and Neuropathic Pain: a Review of the Clinical and Pre-clinical Data

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• Ketamine in chronic pain: A Delphi survey

  2022cites this paper
• Enhanced Recovery After Surgery: Opioid Sparing Strategies After Discharge: A Review

  2022cites this paper
• Postoperative Pain Management in Enhanced Recovery Pathways

  2022cites this paper
• Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice

  2021cites this paper
• Efficacy of perioperative pharmacological and regional pain interventions in adult spine surgery: a network meta-analysis and systematic review of randomised controlled trials.

  2021cites this paper
• Antisuicidal efficacy of ketamine infusion in suicidal patients of depressive disorder

  2021cites this paper
• Ketamine induces EEG oscillations that may aid anesthetic state but not dissociation monitoring.

  2021cites this paper
• Pain Relief in Short-Lasting Unilateral Neuralgiform Headache with Conjunctival inJection and Tearing Syndrome with Intravenous Ketamine: A Case Report.

  2021cites this paper
• Efficacy and Tolerability of Oral Compared with Sublingual Ketamine Lozenges as Rescue Analgesics in Adults for Acute Pain: The OSKet Trial

  2021cites this paper
• Prise en charge de la fibromyalgie par des perfusions de kétamine : étude observationnelle

  2021cites this paper
• Systematic Review of the Use of Intravenous Ketamine for Fibromyalgia

  2021cites this paper
• Ambulatory Anesthesia for a Case of Idiopathic Bronchiolitis Obliterans.

  2021cites this paper
• Dissociative and analgesic properties of ketamine are independent and unaltered by sevoflurane general anesthesia

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020influential citation
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper