ATM is down-regulated by N-Myc–regulated microRNA-421

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2010-01-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.0907763107PMID 20080624PMCID PMC2824372
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MicroRNAs: Target Recognition and Regulatory Functions

  2009cited by this paper
• Identification of the human mature B cell miRNome.

  2009cited by this paper
• Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death

  2009cited by this paper
• Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.

  2009cited by this paper
• Nonaminoglycoside compounds induce readthrough of nonsense mutations

  2009cited by this paper
• Functional and computational assessment of missense variants in the ataxia‐telangiectasia mutated (ATM) gene: mutations with increased cancer risk

  2009cited by this paper
• MicroRNA target site polymorphisms and human disease.

  2008cited by this paper
• Small non-coding RNAs in animal development

  2008cited by this paper
• Germinal centres: role in B-cell physiology and malignancy

  2008cited by this paper
• Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

  2008cited by this paper
• Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

  2008cited by this paper
• MicroRNA expression in lymphocyte development and malignancy

  2008cited by this paper
• ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

  2007cited by this paper
• Integration of Transforming Growth Factor β and RAS Signaling Silences a RAB5 Guanine Nucleotide Exchange Factor and Enhances Growth Factor-Directed Cell Migration

  2007cited by this paper
• N-MYC Regulates Focal Adhesion Kinase Expression in Human Neuroblastoma*

  2007cited by this paper
• Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR

  2007cited by this paper
• Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

  2007influential reference
• Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

  2006cited by this paper
• Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

  2006cited by this paper
• Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity.

  2006cited by this paper
• MicroRNA-cancer connection: the beginning of a new tale.

  2006cited by this paper
• DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

  2005cited by this paper
• Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

  2005cited by this paper
• Combinatorial microRNA target predictions

  2005cited by this paper
• Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.

  2004cited by this paper
• Cell-cycle checkpoints and cancer

  2004cited by this paper
• MicroRNAs: small RNAs with a big role in gene regulation

  2004cited by this paper
• Neuroblastoma: biological insights into a clinical enigma

  2003cited by this paper
• ATM is a target for positive regulation by E2F-1

  2003cited by this paper
• DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

  2003cited by this paper
• ATM and related protein kinases: safeguarding genome integrity

  2003cited by this paper
• Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line

  2002cited by this paper
• The DNA damage response: putting checkpoints in perspective

  2000cited by this paper
• Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system.

  1998cited by this paper
• Diversity of ATM gene mutations detected in patients with ataxia‐telangiectasia

  1997cited by this paper
• A single ataxia telangiectasia gene with a product similar to PI-3 kinase.

  1995cited by this paper
• Localization of an ataxia-telangiectasia gene to chromosome 11q22–23

  1988cited by this paper
• Breast and other cancers in families with ataxia-telangiectasia.

  1987cited by this paper
• Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas.

  1985cited by this paper
• Radioresistant DNA synthesis: an intrinsic feature of ataxia telangiectasia.

  1981cited by this paper
• Mutagenicity and cytotoxicity of haloethanes as studied in the CHO/HGPRT system.

  1981cited by this paper
• Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells.

  1980cited by this paper

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  2025cites this paper
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  2025cites this paper
• The emerging role of miRNAs in biological aging and age-related diseases

  2025cites this paper
• Mapping the non-coding RNA landscape in ataxia telangiectasia: a scoping review of ATM dependent miRNA and lncRNA dysregulation

  2025cites this paper
• Adaptive Significance of Non-coding RNAs: Insights from Cancer Biology

  2025cites this paper
• miR-103a regulates DNA repair capacity in human astrocytes under oxidative stress through direct OGG1 targeting

  2025cites this paper
• Expression of miRNAs Associated With Embryo Development and DNA Damage Response in Porcine Embryos

  2025cites this paper
• Poly (ADP-ribose) polymerase inhibitor sensitized DNA damage caused by an alkylating pyrrole-imidazole polyamide targeting MYCN in neuroblastoma cells.

  2024cites this paper
• A multi-omics approach for biomarker discovery in neuroblastoma: a network-based framework

  2024cites this paper
• Association of MiRNA and Bone Tumors: Future Therapeutic Inroads.

  2024cites this paper
• Adult Pulmonary Blastoma: A Case Report with Spectrum of Rare Manifestations

  2024cites this paper
• Clinical and genetic spectrum of Ataxia Telangiectasia Tunisian patients: Bioinformatic analysis unveil mechanisms of ATM variants pathogenicity.

  2024cites this paper
• Drugs targeting microRNAs that regulate DNA damage sensing and repair mechanisms: A computational drug discovery approach

  2024cites this paper
• Unraveling Therapeutic Opportunities and the Diagnostic Potential of microRNAs for Human Lung Cancer

  2023cites this paper
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  2023cites this paper
• Application of nano‐radiosensitizers in combination cancer therapy

  2023cites this paper
• Epigenetic Dysregulation in MYCN-Amplified Neuroblastoma

  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• Antitumor and radiosensitizing effects of Anagallis arvensis hydromethanolic extract on breast cancer cells through upregulating FOXO3, Let-7, and mir-421 Expression

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• MicroRNAs and the DNA damage response: How is cell fate determined?

  2021cites this paper
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  2021cites this paper
• Home and Away: The Role of Non-Coding RNA in Intracellular and Intercellular DNA Damage Response

  2021cites this paper
• Aging and Protein Kinases.

  2021cites this paper
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  2021cites this paper
• The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements

  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Peptide Hormone Regulation of DNA Damage Responses.

  2020cites this paper
• MicroRNA deregulation and cancer and medicinal plants as microRNA regulator

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Crosstalk between oncogenic MYC and noncoding RNAs in cancer.

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• MicroRNA dysregulation interplay with childhood abdominal tumors

  2019cites this paper
• miR-222 enhances radiosensitivity of cancer cells by inhibiting the expression of CD47.

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• MicroRNA-mediated redox regulation modulates therapy resistance in cancer cells: clinical perspectives

  2019cites this paper
• N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway

  2019cites this paper
• MicroRNA-421 promotes inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis by targeting SPRY1.

  2019cites this paper
• Upregulation of the APE1 and H2AX genes and miRNAs involved in DNA damage response and repair in gastric cancer

  2019cites this paper
• miR-211 facilitates platinum chemosensitivity by blocking the DNA damage response (DDR) in ovarian cancer

  2019cites this paper
• Pharmacological boost of DNA damage response and repair by enhanced biogenesis of DNA damage response RNAs

  2019cites this paper
• Mechanism for IL-15–Driven B Cell Chronic Lymphocytic Leukemia Cycling: Roles for AKT and STAT5 in Modulating Cyclin D2 and DNA Damage Response Proteins

  2019cites this paper
• TAp63 represses transcription of MYCN/NCYM gene and its high levels of expression are associated with favorable outcome in neuroblastoma.

  2019cites this paper
• Regulatory effect of miR-421 on humeral fracture and heterotopic ossification in elderly patients.

  2019cites this paper
• miRNA‐106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation

  2018cites this paper
• EBV‐encoded miRNAs target ATM‐mediated response in nasopharyngeal carcinoma

  2018cites this paper
• MicroRNA-421 inhibits caspase-10 expression and promotes breast cancer progression.

  2018cites this paper
• Inherent and toxicant-provoked reduction in DNA repair capacity: A key mechanism for personalized risk assessment, cancer prevention and intervention, and response to therapy.

  2018cites this paper
• Epigenetic Silencing of miRNA-338-5p and miRNA-421 Drives SPINK1-Positive Prostate Cancer

  2018cites this paper
• miRNAs as potential regulators of mTOR pathway in renal cell carcinoma.

  2018cites this paper
• MicroRNA‐421 suppresses the apoptosis and autophagy of hippocampal neurons in epilepsy mice model by inhibition of the TLR/MYD88 pathway

  2018cites this paper
• Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates

  2018cites this paper
• Mutated Ataxia-Telangiectasia and Its Correlation with the Incidence of Neoplasms : A Literature Review

  2018cites this paper
• Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs

  2018cites this paper
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  2018cites this paper
• The Role of Noncoding RNAs in Genome Stability and Aging

  2018cites this paper
• Cancer RNome: Evolution and Sustenance

  2018cites this paper
• MicroRNAs in DNA Damage Response, Carcinogenesis, and Chemoresistance.

  2017cites this paper
• Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor

  2017cites this paper
• The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents

  2017cites this paper
• Reciprocal antagonistic regulation of N-myc mRNA by miR-17 and the neuronal-specific RNA-binding protein HuD

  2017cites this paper
• Ataxia telangiectasia syndrome: moonlighting ATM

  2017cites this paper
• miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin

  2017cites this paper
• Ability to downregulate the level of cyclin-dependent kinase inhibitor p27Kip1 after DNA damage is retained in chronic lymphocytic leukemia cells with functional ATM/p53 signaling pathway

  2017cites this paper
• c-Fos-dependent miR-22 targets MDC1 and regulates DNA repair in terminally differentiated cells

  2017cites this paper
• Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase

  2017influential citation
• Targeting DNA damage response via miRNAs to enhance radiosensitivity

  2017influential citation
• The emerging role of epigenetic modifiers in repair of DNA damage associated with chronic inflammatory diseases.

  2017cites this paper
• Targeting MicroRNAs in Prostate Cancer Radiotherapy

  2017cites this paper
• Linking loss of sodium-iodide symporter expression to DNA damage.

  2016cites this paper