Calcium dysregulation induces apoptosis-inducing factor release: cross-talk between PARP-1- and calpain-signaling pathways.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Experimental Neurology

• Publication date

  2009-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.expneurol.2009.04.032PMID 19427306PMCID PMC2710414
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondria: the hub of cellular Ca2+ signaling.

  2008cited by this paper
• Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration

  2008cited by this paper
• N Terminus of Calpain 1 Is a Mitochondrial Targeting Sequence*

  2008cited by this paper
• Sequential Activation of Poly(ADP-Ribose) Polymerase 1, Calpains, and Bax Is Essential in Apoptosis-Inducing Factor-Mediated Programmed Necrosis

  2007influential reference
• AIF-Mediated Programmed Necrosis: A Highly Orchestrated Way to Die

  2007cited by this paper
• Critical Role of Calpain I in Mitochondrial Release of Apoptosis-Inducing Factor in Ischemic Neuronal Injury

  2007cited by this paper
• Cell signaling and neuronal death.

  2007cited by this paper
• Role of Na+-K+-Cl- cotransport and Na+/Ca2+ exchange in mitochondrial dysfunction in astrocytes following in vitro ischemia.

  2007cited by this paper
• Ca2+‐dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP‐ribose) polymerase‐1 activation during glutamate excitotoxicity

  2007cited by this paper
• Poly(ADP-ribose) Accumulation and Enhancement of Postischemic Brain Damage in 110-kDa Poly(ADP-ribose) Glycohydrolase Null Mice

  2006cited by this paper
• Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

  2006influential reference
• Molecular insights into mechanisms of the cell death program: role in the progression of neurodegenerative disorders.

  2006cited by this paper
• Poly(ADP-ribose) (PAR) polymer is a death signal

  2006cited by this paper
• Dissociating the dual roles of apoptosis‐inducing factor in maintaining mitochondrial structure and apoptosis

  2006cited by this paper
• Mitochondrial localization of mu-calpain.

  2005cited by this paper
• Calpain I Induces Cleavage and Release of Apoptosis-inducing Factor from Isolated Mitochondria*

  2005influential reference
• Apoptosis-Inducing Factor Triggered by Poly(ADP-Ribose) Polymerase and Bid Mediates Neuronal Cell Death after Oxygen-Glucose Deprivation and Focal Cerebral Ischemia

  2005cited by this paper
• Mitochondrial Nitric Oxide Mediates Decreased Vulnerability of Hippocampal Neurons from Immature Animals to NMDA

  2005cited by this paper
• Determination of peptide substrate specificity for mu-calpain by a peptide library-based approach: the importance of primed side interactions.

  2005cited by this paper
• Mitochondrial localization of μ-calpain

  2005cited by this paper
• Nuclear Translocation of Apoptosis-Inducing Factor after Focal Cerebral Ischemia

  2004cited by this paper
• Apoptosis-Inducing Factor Substitutes for Caspase Executioners in NMDA-Triggered Excitotoxic Neuronal Death

  2004influential reference
• Involvement of apoptosis‐inducing factor in neuronal death after hypoxia‐ischemia in the neonatal rat brain

  2003cited by this paper
• Translocation of Apoptosis-Inducing Factor in Vulnerable Neurons after Transient Cerebral Ischemia and in Neuronal Cultures after Oxygen-Glucose Deprivation

  2003cited by this paper
• Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

  2002cited by this paper
• Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

  2002influential reference
• DNA binding is required for the apoptogenic action of apoptosis inducing factor

  2002cited by this paper
• Caspase-Activated DNase/DNA Fragmentation Factor 40 Mediates Apoptotic DNA Fragmentation in Transient Cerebral Ischemia and in Neuronal Cultures

  2001cited by this paper
• NADH Oxidase Activity of Mitochondrial Apoptosis-inducing Factor*

  2001cited by this paper
• Molecular characterization of mitochondrial apoptosis-inducing factor

  1999influential reference
• Glutamate-induced neuron death requires mitochondrial calcium uptake

  1998cited by this paper
• Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: Involvement of glutamate‐induced nitric oxide in motor neuron toxicity and nonmotor neuron protection

  1998cited by this paper
• Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

  1997cited by this paper
• Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

  1997cited by this paper
• Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice

  1996cited by this paper
• Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

  1991cited by this paper
• Intracellular Ca2+-dependent protease (calpain) and its high-molecular-weight endogenous inhibitor (calpastatin).

  1980cited by this paper

• Protective Effects of TNF-α Neutralizing Antibody on the Neurovascular Unit Through Down-Regulating Calpain/NF-κB Inflammatory Pathway During Ischemic Stroke

  2026cites this paper
• Neuroprotection provided by polyphenols and flavonoids in photoreceptor degenerative diseases

  2025cites this paper
• Podocarpane and cleistanthane diterpenoids from Strophioblachia glandulosa: structural elucidation, anti-hypertrophy activity and network pharmacology.

  2024cites this paper
• Identification and neuroprotective properties of NA‐184, a calpain‐2 inhibitor

  2024cites this paper
• P2X7 receptor: A receptor closely linked with sepsis-associated encephalopathy

  2024cites this paper
• Molecular mechanisms of cell death by parthanatos: More questions than answers

  2024cites this paper
• Antileukemic potential of methylated indolequinone MAC681 through immunogenic necroptosis and PARP1 degradation

  2024cites this paper
• New TIPARP inhibitor rescues mitochondrial function and brain injury in ischemic stroke.

  2024cites this paper
• Elucidating the Therapeutic Utility of Olaparib in Sulfatide-Induced Human Astrocyte Toxicity and Neuroinflammation

  2023cites this paper
• cGMP Signaling in Photoreceptor Degeneration

  2023cites this paper
• Titanium alloys with varying surface micro-area potential differences have antibacterial abilities and a favorable cellular response

  2023cites this paper
• Inherited Retinal Degeneration: Towards the Development of a Combination Therapy Targeting Histone Deacetylase, Poly (ADP-Ribose) Polymerase, and Calpain

  2023cites this paper
• Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: past, present, and future.

  2023cites this paper
• Inhibition of Calpain Attenuates Degeneration of Substantia Nigra Neurons in the Rotenone Rat Model of Parkinson’s Disease

  2022cites this paper
• Inherited Retinal Degeneration: PARP-Dependent Activation of Calpain Requires CNG Channel Activity

  2022cites this paper
• P13BP, a Calpain-2-Mediated Breakdown Product of PTPN13, Is a Novel Blood Biomarker for Traumatic Brain Injury

  2021cites this paper
• Calpain-Mediated Alterations in Astrocytes Before and During Amyloid Chaos in Alzheimer’s Disease

  2021cites this paper
• Microglia Stimulation by Protein Extract of Injured Rat Spinal Cord. A Novel In vitro Model for Studying Activated Microglia

  2021cites this paper
• The role of cGMP-signalling and calcium-signalling in photoreceptor cell death: perspectives for therapy development

  2021cites this paper
• CPCGI Reduces Gray and White Matter Injury by Upregulating Nrf2 Signaling and Suppressing Calpain Overactivation in a Rat Model of Controlled Cortical Impact

  2020cites this paper
• Calpain-2 as a therapeutic target in repeated concussion–induced neuropathy and behavioral impairment

  2020cites this paper
• The Phenomenon of Compensatory Cell Proliferation in Olfactory Epithelium in Fish Caused by Prolonged Exposure to Natural Odorants

  2020cites this paper
• The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective.

  2020cites this paper
• NDT_A_266136 1929..1941

  2020cites this paper
• Fucosterol exerts protection against amyloid β-induced neurotoxicity, reduces intracellular levels of amyloid β and enhances the mRNA expression of neuroglobin in amyloid β-induced SH-SY5Y cells.

  2019cites this paper
• Aging Neurovascular Unit and Potential Role of DNA Damage and Repair in Combating Vascular and Neurodegenerative Disorders

  2019cites this paper
• Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration

  2019cites this paper
• Mitochondrial inner membrane protein (mitofilin) knockdown induces cell death by apoptosis via an AIF-PARP-dependent mechanism and cell cycle arrest.

  2018cites this paper
• Classification and Molecular Aspects of Neurotraumatic Diseases: Similarities and Differences With Neurodegenerative and Neuropsychiatric Diseases

  2018cites this paper
• Preconditioning against ischemic injury of the central nervous system in aortic surgery : an experimental study in a porcine model with remote ischemic preconditioning and diazoxide

  2018cites this paper
• Neuronal Cell Death.

  2018cites this paper
• Calpain and JNK pathways participate in isoflurane - induced nucleus translocation of apoptosis-inducing factor in the brain of neonatal rats.

  2018cites this paper
• Necroptosis in Cerebral Ischemia

  2018cites this paper
• Protective Effects of Calpain Inhibition on Neurovascular Unit Injury through Downregulating Nuclear Factor-κB-related Inflammation during Traumatic Brain Injury in Mice

  2017cites this paper
• Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery.

  2017cites this paper
• Protective Functions of PJ34, a Poly(ADP-ribose) Polymerase Inhibitor, Are Related to Down-Regulation of Calpain and Nuclear Factor-κB in a Mouse Model of Traumatic Brain Injury.

  2017cites this paper
• Identification of potential inhibitors of PARP-1, a regulator of caspase-independent cell death pathway, from Withania somnifera phytochemicals for combating neurotoxicity: A structure-based in-silico study

  2017cites this paper
• Cognitive Deficits after Cerebral Ischemia and Underlying Dysfunctional Plasticity: Potential Targets for Recovery of Cognition

  2017cites this paper
• Poly(adenosine diphosphate-ribose) polymerase as therapeutic target: lessons learned from its inhibitors

  2017cites this paper
• Chapter 5 – N-Methyl-N-Nitrosourea Animal Models for Retinitis Pigmentosa

  2017cites this paper
• Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury.

  2016cites this paper
• Stem cell treatment after ischemic stroke alters the expression of dna damage signaling molecules

  2016cites this paper
• Protective effects of PARP inhibitor, PJ34, is related to down-regulation of calpain and NF-κB in a mouse model of TBI.

  2016cites this paper
• Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?

  2016cites this paper
• Endoplasmic reticulum pathology and stress response in neurons precede programmed necrosis after neonatal hypoxia‐ischemia

  2016cites this paper
• Apoptosis-inducing factor and calpain upregulation in glutamate-induced injury of rat spiral ganglion neurons

  2015cites this paper
• The Role of Excitotoxic Programmed Necrosis in Acute Brain Injury

  2015cites this paper
• HOX/PBX interaction as a therapeutic target in acute myeloid leukaemia

  2015cites this paper
• The assessment of an in-vitro model for evaluating the role of PARP in ethanol-mediated hepatotoxicity

  2015cites this paper
• Protection of the brain following cerebral ischemia through the attenuation of PARP-1-induced neurovascular unit damage in rats.

  2015cites this paper
• Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression

  2015cites this paper
• Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury.

  2015cites this paper
• Evaluation of Neuroprotective Interventions in Different Pde 6 a Mutant Animal Models for Retinitis Pigmentosa

  2015cites this paper
• Cyclosporine A increases hair follicle growth by suppressing apoptosis‐inducing factor nuclear translocation: a new mechanism

  2015cites this paper
• PARP1-mediated necrosis is dependent on parallel JNK and Ca2+/calpain pathways

  2014cites this paper
• Inflammation and Oxidative Stress in Neurological Disorders

  2014cites this paper
• Melatonin’s Protection against Methamphetamine Toxicity in Neuroblastoma Cells

  2014cites this paper
• Effect of Exercise on Oxidative Stress in Neurological Disorders

  2014cites this paper
• Calpains and cancer: friends or enemies?

  2014cites this paper
• Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts.

  2014cites this paper
• N -Methyl- N -Nitrosourea Animal Models for Retinitis Pigmentosa

  2013cites this paper
• Gene delivery with viral vectors for cerebrovascular diseases.

  2013cites this paper
• CAPNS1 Regulates USP1 Stability and Maintenance of Genome Integrity

  2013cites this paper
• Inhibitory Peptide of Mitochondrial μ-Calpain Protects against Photoreceptor Degeneration in Rhodopsin Transgenic S334ter and P23H Rats

  2013cites this paper
• Poly(ADP-ribose) signaling in cell death.

  2013cites this paper
• Mitochondrial Calpains: Who, What, Where, When and Why?

  2013cites this paper
• Roles of poly(ADP-ribose) glycohydrolase in DNA damage and apoptosis.

  2013cites this paper
• Mitochondrial dysfunction is involved in P2X7 receptor‐mediated neuronal cell death

  2012cites this paper
• Effect of early acute high concentrations of iodide exposure on mitochondrial superoxide production in FRTL cells.

  2012cites this paper
• Ameliorated Effects of Verapamil on Hepatotoxicity Induced by Ethanol and Carbon Tetrachloride

  2012cites this paper
• S04-4Mitochondrial involvement in cell death

  2012cites this paper
• Poly (ADP-ribose) polymerase plays an important role in intermittent hypoxia-induced cell death in rat cerebellar granule cells

  2012cites this paper
• Regulation of neural stem cell proliferation and differentiation by apoptosis-relevant factors

  2012cites this paper
• The Role of PARP1 in cGMP Mediated Photoreceptor Degeneration

  2012influential citation
• Angiogenin inhibits nuclear translocation of apoptosis inducing factor in a Bcl‐2‐dependent manner

  2012cites this paper
• Intravitreal injection or topical eye-drop application of a μ-calpain C2L domain peptide protects against photoreceptor cell death in Royal College of Surgeons' rats, a model of retinitis pigmentosa.

  2012cites this paper
• Elevated skeletal muscle apoptotic signaling following glutathione depletion

  2011cites this paper
• Gaining notoriety through translocation: a case of the apoptosis-inducing factor (AIF) in poly (ADP-ribose) polymerase (PARP)-1-dependent neuronal death

  2011cites this paper
• Homeostatic NMDA receptor down‐regulation via brain derived neurotrophic factor and nitric oxide‐dependent signalling in cortical but not in hippocampal neurons

  2011cites this paper
• Ca²+-induced release of mitochondrial m-calpain from outer membrane with binding of calpain small subunit and Grp75.

  2011cites this paper
• Mechanistic Insight into DNA Damage and Repair in Ischemic Stroke: Exploiting the Base Excision Repair Pathway as a Model of Neuroprotection

  2011cites this paper
• Simultaneous cell death and upregulation of poly(ADP-ribose) polymerase-1 expression in early postnatal mouse retina.

  2011cites this paper
• The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes.

  2011cites this paper
• Homeostatic responses compensate for activity perturbations in the CNS both at a synaptic as well as cellular level

  2011cites this paper
• Dipeptidyl Peptidases as Survival Factors in Ewing Sarcoma Family of Tumors

  2011cites this paper
• Review: Animal models of N-Methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials.

  2011cites this paper
• Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation

  2011cites this paper
• The calpain system and cancer

  2011cites this paper
• Free-Radical Scavenger Edaravone Treatment Confers Neuroprotection Against Traumatic Brain Injury in Rats

  2011cites this paper
• A rat model of oligomeric forms of beta-amyloid (Aß) peptide: neuronal loss, synaptic alteration, astrogliosis, and calcium-binding proteins activation in vivo

  2011cites this paper
• Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: evidence in Parkinson's disease patients.

  2011cites this paper
• Calpain and PARP Activation during Photoreceptor Cell Death in P23H and S334ter Rhodopsin Mutant Rats

  2011cites this paper
• The protective effect of melatonin on methamphetamine‐induced calpain‐dependent death pathway in human neuroblastoma SH‐SY5Y cultured cells

  2010cites this paper
• Mitochondrial calpain system: an overview.

  2010cites this paper
• Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms.

  2010cites this paper
• Photoreceptor rescue and toxicity induced by different calpain inhibitors

  2010cites this paper
• Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment

  2010cites this paper
• PARP1 Gene Knock-Out Increases Resistance to Retinal Degeneration without Affecting Retinal Function

  2010cites this paper
• Multifaceted deaths orchestrated by mitochondria in neurones.

  2010cites this paper
• PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

  2010influential citation