Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs?

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Current pharmaceutical design

• Publication date

  2008-02-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/138161208783877820PMID 18336311
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Drug treatments for obesity: orlistat, sibutramine, and rimonabant.

  2007cited by this paper
• Drug treatment of the overweight patient.

  2007cited by this paper
• Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA.

  2007cited by this paper
• Safety of Drug Therapies Used for Weight Loss and Treatment of Obesity

  2006cited by this paper
• Current and novel approaches to the drug therapy of obesity

  2006cited by this paper
• Pharmacotherapy for obesity.

  2006cited by this paper
• Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial.

  2006cited by this paper
• Pharmacologic treatment of obesity.

  2006cited by this paper
• Zonisamide: review of its use in epilepsy therapy.

  2005cited by this paper
• Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.

  2005cited by this paper
• Current and investigational antiobesity agents and obesity therapeutic treatment targets.

  2004cited by this paper
• Zonisamide for weight loss in obese adults: a randomized controlled trial.

  2003cited by this paper
• Zonisamide effective for weight loss in women.

  2003cited by this paper
• Obesity and the Environment: Where Do We Go from Here?

  2003cited by this paper
• Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.

  2003cited by this paper
• A War on Obesity, Not the Obese

  2003cited by this paper
• Carbonic anhydrase inhibitors

  2003cited by this paper
• Carbonic Anhydrase: New Insights for an Ancient Enzyme* 210

  2001cited by this paper
• Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V).

  2001cited by this paper
• Weight loss with sibutramine improves glycaemic control and other metabolic parameters in obese patients with type 2 diabetes mellitus

  2000cited by this paper
• Newer Anticonvulsants

  2000cited by this paper
• Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity. European Orlistat Obesity Study Group.

  2000cited by this paper
• Topiramate reduces energy and fat gains in lean (Fa/?) and obese (fa/fa) Zucker rats.

  2000cited by this paper
• A comparison of topiramate and acetazolamide on seizure duration and paired-pulse inhibition in the dentate gyrus of the rat.

  2000cited by this paper
• Mood stabilization and weight loss with topiramate.

  1999cited by this paper
• Weight control and risk factor reduction in obese subjects treated for 2 years with orlistat: a randomized controlled trial.

  1999cited by this paper
• Role of Orlistat in the Treatment of Obese Patients With Type 2 Diabetes: A 1-year randomized double-blind study

  1998cited by this paper
• Strategies and potential molecular targets for obesity treatment.

  1998cited by this paper
• Sibutramine. A review of its contribution to the management of obesity.

  1998cited by this paper
• Differentiation‐dependent expression of CA V and the role of carbonic anhydrase isozymes in pyruvate carboxylation in adipocytes

  1996cited by this paper
• Role of hepatic carbonic anhydrase in de novo lipogenesis.

  1995cited by this paper
• Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

  1994cited by this paper
• Inhibitory effect of zonisamide on human carbonic anhydrase in vitro.

  1993cited by this paper
• Mitochondrial carbonic anhydrase is involved in rat renal glucose synthesis.

  1989cited by this paper
• Inhibition of mitochondrial carbonic anhydrase and ureagenesis: a discrepancy examined.

  1987cited by this paper

• Structural Advances in Non‐Sulfonamide Carbonic Anhydrase Inhibitors: Insights Into Design, Bioactivity, and Binding Mechanism

  2025cites this paper
• Binding of Sunset Yellow, a food coloring, to human carbonic anhydrase II: Structural and functional insights from a multi-spectroscopic study.

  2025cites this paper
• Synthesis and Enzymatic Evaluation of a Small Library of Substituted Phenylsulfonamido-Alkyl Sulfamates towards Carbonic Anhydrase II

  2024cites this paper
• Multi- and poly-pharmacology of carbonic anhydrase inhibitors.

  2024cites this paper
• Synthesis, molecular docking and molecular dynamics simulations, drug-likeness studies, ADMET prediction and biological evaluation of novel pyrazole-carboxamides bearing sulfonamide moiety as potent carbonic anhydrase inhibitors

  2024cites this paper
• An asiatic acid derived trisulfamate acts as a nanomolar inhibitor of human carbonic anhydrase VA.

  2024cites this paper
• Exploring heterocyclic scaffolds in carbonic anhydrase inhibition: a decade of structural and therapeutic insights

  2024cites this paper
• The synthesis and study of carbonic anhydrase activity of sulfonamide-containing dibenzo[1,4]thiazepines

  2023cites this paper
• Effect of hydrophobic extension of aryl enaminones and pyrazole-linked compounds combined with sulphonamide, sulfaguanidine, or carboxylic acid functionalities on carbonic anhydrase inhibitory potency and selectivity

  2023cites this paper
• Sulfonamide derivatives with benzothiazole scaffold: Synthesis and carbonic anhydrase I–II inhibition properties

  2023cites this paper
• A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation.

  2023cites this paper
• Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhibitors.

  2023cites this paper
• Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities

  2022cites this paper
• Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as “Antidiabesity” Agents Based on Repurposing and Morphing of WB-4101

  2022cites this paper
• The inhibitory effect of boric acid on hypoxia-regulated tumour-associated carbonic anhydrase IX

  2022cites this paper
• The Carbonic Anhydrases in Health and Disease

  2021cites this paper
• The Carbonic Anhydrases: Current and Emerging Therapeutic Targets

  2021cites this paper
• Theoretical study of spodium bonding in the active site of three Zn-proteins and several model systems.

  2021cites this paper
• Emerging role of carbonic anhydrase inhibitors.

  2021cites this paper
• Synthesis of and molecular docking studies of azomethine- tethered sulfonamides as carbonic anhydrase II & 15-lipoxygenase inhibitors

  2021cites this paper
• Synthesis and Human Carbonic Anhydrase I, II, IX, and XII Inhibition Studies of Sulphonamides Incorporating Mono-, Bi- and Tricyclic Imide Moieties

  2021cites this paper
• A Cardioplegic Solution with an Understanding of a Cardiochannelopathy

  2021cites this paper
• Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action

  2020cites this paper
• New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII.

  2020cites this paper
• An update on drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors

  2020cites this paper
• Benzilydene and thiourea derivatives as new classes of carbonic anhydrase inhibitors: an in vitro and molecular docking study

  2020cites this paper
• Human carbonic anhydrases

  2019cites this paper
• α-Carbonic anhydrases

  2019cites this paper
• Carbonic anhydrase inhibitors for the treatment of neuropathic pain and arthritis

  2019cites this paper
• Polypharmacology of carbonic anhydrase inhibitors

  2019influential citation
• Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors.

  2019cites this paper
• Mechanisms of action of carbonic anhydrase inhibitors

  2019cites this paper
• Enhancement of intrinsic fluorescence of human carbonic anhydrase II upon topiramate binding: Some evidence for drug-induced molecular contraction of the protein.

  2018cites this paper
• Unprotected primary sulfonamide group facilitates ring-forming cascade en route to polycyclic [1,4]oxazepine-based carbonic anhydrase inhibitors.

  2018cites this paper
• Synthesis, carbonic anhydrase inhibitory activity and antioxidant activity of some 1,3‐oxazine derivatives

  2018cites this paper
• Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.

  2018cites this paper
• Discovery of thiazolin-4-one-based aromatic sulfamates as a new class of carbonic anhydrase isoforms I, II, IV, and IX inhibitors.

  2018cites this paper
• Carbonic anhydrase inhibition of Schiff base derivative of imino-methyl-naphthalen-2-ol: Synthesis, structure elucidation, molecular docking, dynamic simulation and density functional theory calculations

  2018cites this paper
• Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII.

  2017cites this paper
• Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor

  2017cites this paper
• Bortezomib inhibits mammalian carbonic anhydrases.

  2017cites this paper
• Obesity: Current and potential pharmacotherapeutics and targets

  2017cites this paper
• 13 – Synthesis of Fluorinated Nitrogen-Containing Compounds Through Superelectrophilic Activation in Superacid HF/SbF5∗

  2017cites this paper
• Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action.

  2017cites this paper
• Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides.

  2017cites this paper
• Carbonic anhydrase inhibitory properties of phenolic sulfonamides derived from dopamine related compounds

  2017cites this paper
• Trastorno de atracones en pacientes obesos candidatos a cirugía bariátrica

  2017cites this paper
• Combinatorial Design of Isoform‐Selective N‐Alkylated Benzimidazole‐Based Inhibitors of Carbonic Anhydrases

  2017cites this paper
• MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism

  2017cites this paper
• 4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies.

  2016cites this paper
• In Vivo Evaluation of Selective Carbonic Anhydrase Inhibitors as Potential Anticonvulsant Agents

  2016cites this paper
• Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII.

  2016cites this paper
• Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action

  2016cites this paper
• Carbonic anhydrase activators: Activation of the β-carbonic anhydrase from Malassezia globosa with amines and amino acids.

  2016cites this paper
• Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors

  2016cites this paper
• Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies.

  2016cites this paper
• Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action.

  2016cites this paper
• Fluoxetine, topiramate, and combination of both to stabilize eating behavior before bariatric surgery.

  2016cites this paper
• Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties.

  2016cites this paper
• Synthesis of novel bisindolylmethanes: New carbonic anhydrase II inhibitors, docking, and 3D pharmacophore studies.

  2016cites this paper
• The anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies.

  2016cites this paper
• A Combined Crystallographic and Theoretical Study Explains the Capability of Carboxylic Acids to Adopt Multiple Binding Modes in the Active Site of Carbonic Anhydrases.

  2016cites this paper
• The human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives

  2016cites this paper
• Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.

  2016cites this paper
• Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.

  2016cites this paper
• Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

  2016cites this paper
• The human carbonic anhydrase isoenzymes I and II inhibitory effects of some hydroperoxides, alcohols, and acetates

  2016cites this paper
• Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds.

  2016cites this paper
• Development of 3-(4-aminosulphonyl)-phenyl-2-mercapto-3H-quinazolin-4-ones as inhibitors of carbonic anhydrase isoforms involved in tumorigenesis and glaucoma.

  2016cites this paper
• Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.

  2016cites this paper
• A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents

  2016cites this paper
• A Rational Approach towards the Development of Human Carbonic Anhydrase Inhibitors as Antiepileptic Agent

  2016influential citation
• Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.

  2016cites this paper
• Human Carbonic Anhydrases: Catalytic Properties, Structural Features, and Tissue Distribution

  2015cites this paper
• Bacterial, fungal and protozoan carbonic anhydrases as drug targets

  2015cites this paper
• Inhibiteurs sélectifs d'anhydrase carbonique

  2015cites this paper
• Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.

  2015cites this paper
• Synthesis, biological evaluation, and docking studies of novel thiourea derivatives of bisindolylmethane as carbonic anhydrase II inhibitor.

  2015cites this paper
• Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms.

  2015cites this paper
• Acetylcholinesterase and carbonic anhydrase isoenzymes I and II inhibition profiles of taxifolin

  2015cites this paper
• The zinc coordination pattern in the η-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families.

  2015cites this paper
• Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.

  2015cites this paper
• [New possibilities of monotherapy of symptomatic and cryptogenic partial epilepsy].

  2015cites this paper
• Benzenesulfonamides incorporating bulky aromatic/heterocyclic tails with potent carbonic anhydrase inhibitory activity.

  2015cites this paper
• The Structure, Physiological Role, and Potential Medicinal Applications of Carbonic Anhydrase V

  2015cites this paper
• Synthesis and Carbonic Anhydrase Isoenzymes Inhibitory Effects of Brominated Diphenylmethanone and Its Derivatives

  2014cites this paper
• Capsaicin: A Potent Inhibitor of Carbonic Anhydrase Isoenzymes

  2014cites this paper
• Oxidation of cyanobenzocycloheptatrienes: Synthesis, photooxygenation reaction and carbonic anhydrase isoenzymes inhibition properties of some new benzotropone derivatives.

  2014cites this paper
• Natural products that inhibit carbonic anhydrase.

  2014cites this paper
• Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies

  2014cites this paper
• Proteomic white adipose tissue analysis of obese mice fed with a high-fat diet and treated with oral angiotensin-(1-7).

  2014cites this paper
• Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs

  2014cites this paper
• Complexation of nanoscale enzyme inhibitor with carbonic anhydrase active center: A quantum mechanical approach

  2014cites this paper
• New centrally acting agents for appetite control: from biological mechanisms to clinical efficacy

  2014cites this paper
• Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.

  2014cites this paper
• Clinical utility of phentermine/topiramate (Qsymia™) combination for the treatment of obesity

  2013cites this paper
• Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.

  2013cites this paper
• Clinical utility of phentermine/topiramate (Qsymia™) combination for the treatment of obesity

  2013cites this paper
• Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.

  2013cites this paper
• Zonisamide for weight reduction in obese adults.

  2013cites this paper