OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Cell

• Publication date

  1995-02-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0092-8674(95)90500-6PMID 7859290
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Proline-rich activator CTF1 targets the TFIIB assembly step during transcriptional activation.

  1994cited by this paper
• Octamer factors exert a dual effect on the IL-2 and IL-4 promoters.

  1994cited by this paper
• Differential transactivation potential of Oct1 and Oct2 is determined by additional B cell‐specific activities.

  1994cited by this paper
• Targeted disruption of the Oct‐2 locus in a B cell provides genetic evidence for two distinct cell type‐specific pathways of octamer element‐mediated gene activation.

  1993cited by this paper
• Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation

  1993cited by this paper
• Coactivators and TAFs: a new class of eukaryotic transcription factors that connect activators to the basal machinery.

  1993cited by this paper
• Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival.

  1993cited by this paper
• The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein.

  1993cited by this paper
• The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1

  1993cited by this paper
• A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain.

  1992cited by this paper
• A simple and highly efficient procedure for rescuing autonomous plasmids from yeast.

  1992cited by this paper
• Recognition of the surface of a homeo domain protein.

  1992cited by this paper
• Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity

  1992cited by this paper
• A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors.

  1992cited by this paper
• Octamania: the POU factors in murine development.

  1991cited by this paper
• Functional differences between yeast and human TFIID are localized to the highly conserved region.

  1991cited by this paper
• Complex pattern of immunoglobulin mu gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities.

  1991cited by this paper
• Multiple Oct2 isoforms are generated by alternative splicing

  1991cited by this paper
• The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein

  1991cited by this paper
• POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter.

  1991cited by this paper
• Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40.

  1991cited by this paper
• Immunoglobulin gene transcription.

  1991cited by this paper
• Expression and activity of the POU transcription factor SCIP.

  1990cited by this paper
• Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters

  1990cited by this paper
• The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes

  1990cited by this paper
• Extinction of an immunoglobulin κ promoter in cell hybrids is mediated by the octamer motif and correlates with suppression of Oct-2 expression

  1990cited by this paper
• Transcription factor Oct‐2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non‐lymphoid (HeLa) cells.

  1990cited by this paper
• Oct‐4: a germline‐specific transcription factor mapping to the mouse t‐complex.

  1990cited by this paper
• A wide variety of DNA sequences can functionally replace a yeast TATA element for transcriptional activation.

  1990cited by this paper
• A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells.

  1990cited by this paper
• Oct‐6: a POU transcription factor expressed in embryonal stem cells and in the developing brain.

  1990cited by this paper
• High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

  1989cited by this paper
• Functional distinctions between yeast TATA elements

  1989cited by this paper
• Eukaryotic expression vectors for the analysis of mutant proteins.

  1989cited by this paper
• A novel genetic system to detect protein–protein interactions

  1989cited by this paper
• The octamer‐binding proteins form multi‐protein‐‐DNA complexes with the HSV alpha TIF regulatory protein.

  1989cited by this paper
• Purified octamer binding transcription factors stimulate RNA polymerase III--mediated transcription of the 7SK RNA gene.

  1989cited by this paper
• The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain.

  1989cited by this paper
• The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

  1988cited by this paper
• The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.

  1988cited by this paper
• Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element.

  1988cited by this paper
• The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

  1988cited by this paper
• Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements.

  1988cited by this paper
• Octamer-binding proteins from B or HeLa cells stimulate transcription of the immunoglobulin heavy-chain promoter in vitro.

  1988cited by this paper
• A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells

  1988cited by this paper
• Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation.

  1988cited by this paper
• A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins.

  1988cited by this paper
• Saturation mutagenesis of a yeast his3 "TATA element": genetic evidence for a specific TATA-binding protein.

  1988cited by this paper
• The conserved decanucleotide from the immunoglobulin heavy chain promoter induces a very high transcriptional activity in B‐cells when introduced into an heterologous promoter.

  1987cited by this paper
• Cell type‐specificity elements of the immunoglobulin heavy chain gene enhancer.

  1987cited by this paper
• Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an immunoglobulin promoter in vitro.

  1987cited by this paper
• An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

  1987cited by this paper
• A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

  1986cited by this paper
• Cell-type-specific transcription of an immunoglobulin kappa light chain gene in vitro.

  1986cited by this paper
• Transcription cell type specificity is conferred by an immunoglobulin VH gene promoter that includes a functional consensus sequence.

  1985cited by this paper
• Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

  1984cited by this paper

• OCT‐2 Is Associated With Pro‐Metastatic Epigenomic Properties of Triple‐Negative Breast Cancer Cells

  2025cites this paper
• OCA-B/Pou2af1 Expression in Mouse T Cells Promotes PD-1 Blockade-Induced Autoimmunity but is Dispensable for Anti-Tumor Immunity

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• Transcriptomic Analysis Reveals Sixteen Potential Genes Associated with the Successful Differentiation of Antibody-Secreting Cells through the Utilization of Unfolded Protein Response Mechanisms in Robust Responders to the Influenza Vaccine

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• Bob1 maintains T follicular helper cells for long-term humoral immunity

  2024cites this paper
• The Role of the Transcriptional Coactivator BOB.1/OBF.1 in Adaptive Immunity.

  2024cites this paper
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  2023cites this paper
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  2022cites this paper
• POU2AF2/C11orf53 functions as a coactivator of POU2F3 by maintaining chromatin accessibility and enhancer activity

  2022cites this paper
• CD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis

  2022cites this paper
• Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component

  2022cites this paper
• OCA‐B does not act as a transcriptional coactivator in T cells

  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• OBF1 and Oct factors control the germinal center transcriptional program.

  2021cites this paper
• Compartments and Connections Within the Germinal Center

  2021cites this paper
• BOB.1/OBF.1 is required during B‐cell ontogeny for B‐cell differentiation and germinal center function

  2021cites this paper
• Transcriptional regulator BOB.1: Molecular mechanisms and emerging role in chronic inflammation and autoimmunity.

  2021cites this paper
• Loss of OcaB Prevents Age-Induced Fat Accretion and Insulin Resistance by Altering B-Lymphocyte Transition and Promoting Energy Expenditure

  2018cites this paper
• The Transcriptional Regulation of Germinal Center Formation

  2018cites this paper
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  2016cites this paper
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  2016cites this paper
• Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2

  2016cites this paper
• Oct2 and Bob1 are sensitive and specific markers in lineage determination of B cell lymphomas with no expression of conventional B cell markers

  2016cites this paper
• Regulatory roles of Oct proteins in the mammary gland.

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015influential citation
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  2015cites this paper
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