Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Blood

• Publication date

  1999-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V93.12.4406PMID 10361139
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of positive iron status at a cellular level.

  2009influential reference
• The valency state of absorbed iron appearing in the portal blood and ceruloplasmin substitution

  2005cited by this paper
• The Nramp1 protein and its role in resistance to infection and macrophage function.

  1999cited by this paper
• The Iron Transport Protein NRAMP2 Is an Integral Membrane Glycoprotein That Colocalizes with Transferrin in Recycling Endosomes

  1999cited by this paper
• The iron responsive element (IRE) family of mRNA regulators. Regulation of iron transport and uptake compared in animals, plants, and microorganisms.

  1998cited by this paper
• Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans.

  1998cited by this paper
• Recently identified molecular aspects of intestinal iron absorption.

  1998cited by this paper
• The G185R mutation disrupts function of the iron transporter Nramp2.

  1998cited by this paper
• Molecular genetics and control of iron metabolism in hemochromatosis.

  1998cited by this paper
• Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

  1998cited by this paper
• The iron responsive element (IRE) family of mRNA regulators. Regulation of iron transport and uptake compared in animals, plants, and microorganisms.

  1998cited by this paper
• Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections.

  1998cited by this paper
• Adaptive response of iron absorption to anemia, increased erythropoiesis, iron deficiency, and iron loading in beta2-microglobulin knockout mice.

  1998cited by this paper
• Mapping the gene for sex-linked anemia: an inherited defect of intestinal iron absorption in the mouse.

  1998cited by this paper
• Susceptibility to leprosy is linked to the human NRAMP1 gene.

  1998cited by this paper
• Hemochromatosis-related mutation detection.

  1998cited by this paper
• The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms.

  1998cited by this paper
• Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) Impairs Phagosomal Acidification

  1998cited by this paper
• Iron supplementation moderates but does not cure the Belgrade anemia

  1997cited by this paper
• Optimal ratios of biliary glycoprotein isoforms required for inhibition of colonic tumor cell growth.

  1997cited by this paper
• Mechanisms involved in increased iron uptake across rat duodenal brush‐border membrane during hypoxia.

  1997cited by this paper
• Cloning and characterization of a mammalian proton-coupled metal-ion transporter

  1997cited by this paper
• Functional Complementation of the Yeast Divalent Cation Transporter Family SMF by NRAMP2, a Member of the Mammalian Natural Resistance-associated Macrophage Protein Family*

  1997cited by this paper
• Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome

  1997cited by this paper
• Regulation of iron metabolism in eukaryotes.

  1997cited by this paper
• The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells.

  1997cited by this paper
• Activation of NMDA receptors is necessary for the induction of associative long‐term potentiation in area CA1 of the rat hippocampal slice

  1997cited by this paper
• Cell‐specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo

  1997cited by this paper
• Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

  1997cited by this paper
• Characterization of isolated duodenal epithelial cells along a cryptvillus axis in rats fed diets with different iron content

  1997cited by this paper
• Managed care for viruses

  1997cited by this paper
• Expression of the human NRAMP1 gene in professional primary phagocytes: studies in blood cells and in HL‐60 promyelocytic leukemia

  1997cited by this paper
• Characterization of msim, a murine homologue of the Drosophila sim transcription factor.

  1996cited by this paper
• Effects of dietary iron loading with carbonyl iron and of iron depletion on intestinal growth, morphology, and expression of transferrin receptor in the rat

  1996cited by this paper
• Biliary glycoprotein 1 expression during embryogenesis: Correlation with events of epithelial differentiation, mesenchymal‐epithelial interactions, absorption, and myogenesis

  1996cited by this paper
• Iron regulatory proteins 1 and 2

  1996cited by this paper
• Resistance to intracellular infections: comparative genomic analysis of Nramp.

  1996cited by this paper
• Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents.

  1996cited by this paper
• A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.

  1996cited by this paper
• Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.

  1996cited by this paper
• Molecular mechanisms of iron uptake in eukaryotes.

  1996influential reference
• Control of iron absorption

  1996cited by this paper
• Natural resistance to infection with intracellular parasites: molecular genetics identifies Nramp1 as the Bcg/Ity/Lsh locus

  1995cited by this paper
• Membrane topology of P-glycoprotein as determined by epitope insertion: transmembrane organization of the N-terminal domain of mdr3.

  1995cited by this paper
• Identification and characterization of a second mouse Nramp gene.

  1995cited by this paper
• Characteristics of iron binding to solubilized brush border membrane of the rat intestine.

  1995cited by this paper
• The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene

  1995cited by this paper
• Reduction of Fe(III) is required for uptake of nonheme iron by Caco-2 cells.

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Structure and function of IREs, the noncoding mRNA sequences regulating synthesis of ferritin, transferrin receptor and (erythroid) 5-aminolevulinate synthase.

  1994cited by this paper
• Role of redox systems on Fe3+ uptake by transformed human intestinal epithelial (Caco-2) cells.

  1994cited by this paper
• Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms

  1993cited by this paper
• Function of integrin in duodenal mucosal uptake of iron.

  1993cited by this paper
• The expression of mouse biliary glycoprotein, a carcinoembryonic antigen-related gene, is down-regulated in malignant mouse tissues.

  1993cited by this paper
• Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg.

  1993cited by this paper
• Diminished iron acquisition by cells and tissues of Belgrade laboratory rats.

  1992cited by this paper
• Investigation of a role for reduction in ferric iron uptake by mouse duodenum.

  1992cited by this paper
• Changes in Cu,Zn-superoxide dismutase, cytochrome c oxidase, glutathione peroxidase and glutathione transferase activities in copper-deficient mice and rats.

  1991cited by this paper
• Iron uptake by human upper small intestine microvillous membrane vesicles. Indication for a facilitated transport mechanism mediated by a membrane iron-binding protein.

  1990cited by this paper
• Biochemistry of nonheme iron in man. II. Absorption of iron.

  1989cited by this paper
• The effect of Escherichia coli STa enterotoxin and other secretagogues on mucosal surface pH of rat small intestine in vivo

  1988cited by this paper
• Small intestinal regulation of iron absorption in the rat.

  1987cited by this paper
• Iron uptake by rat duodenal microvillous membrane vesicles: evidence for a carrier mediated transport system

  1987cited by this paper
• Fe2+ uptake by mouse intestinal mucosa in vivo and by isolated intestinal brush-border membrane vesicles.

  1986cited by this paper
• Regional specificity of iron uptake by small intestinal brush-border membranes from normal and iron-deficient mice.

  1985cited by this paper
• Iron transport across brush-border membranes from normal and iron-deficient mouse upper small intestine.

  1984cited by this paper
• A model of intestinal iron absorption and plasma iron kinetics: optimal parameter estimates for normal dogs.

  1984cited by this paper
• Identification, developmental regulation, and response to heat shock of two antigenically related forms of a major nuclear envelope protein in Drosophila embryos: application of an improved method for affinity purification of antibodies using polypeptides immobilized on nitrocellulose blots

  1984cited by this paper
• Iron absorption.

  1983cited by this paper
• The kinetics of iron uptake by isolated intestinal cells from normal mice and mice with sex-linked anemia.

  1982cited by this paper
• Characterization of cell lines showing growth control isolated from both the wild type and a leucyl‐tRNA synthetase mutant of chinese hamster ovary cells

  1979cited by this paper
• Genetic defects of iron transport.

  1976cited by this paper
• Uptake of circulating iron by the duodenum of normal mice and mice with altered iron stores, including sex-linked anemia: high resolution radioautographic study.

  1976cited by this paper
• Purification and characterization of (Na+ plus K+ )-ATPase. 3. Purification from the outer medulla of mammalian kidney after selective removal of membrane components by sodium dodecylsulphate.

  1974cited by this paper
• Iron absorption.

  1973cited by this paper
• Defect of Intestinal Mucosal Iron Uptake in Mice with Hereditary Microcytic Anemia

  1972cited by this paper
• Metabolism of copper 67 by the copper-deficient rat.

  1971cited by this paper
• Absorption of iron.

  1970cited by this paper
• Characterization and genetic studies of microcytic anemia in house mouse.

  1970cited by this paper
• THE CONTROL OF IRON ABSORPTION

  1968cited by this paper
• Active transport of iron by intestine: features of the two-step mechanism

  1962cited by this paper
• Natural Resistance to Infection.

  1961cited by this paper
• Absorption of Iron

  1897cited by this paper

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