Substitutions at the Putative Receptor-Binding Site of an Encephalitic Flavivirus Alter Virulence and Host Cell Tropism and Reveal a Role for Glycosaminoglycans in Entry

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Virology

• Publication date

  2000-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.74.19.8867-8875.2000PMID 10982329PMCID PMC102081
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Functions of cell surface heparan sulfate proteoglycans.

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• Analysis of the steps involved in Dengue virus entry into host cells.

  1999cited by this paper
• A Putative Host Cell Receptor for Tick-Borne Encephalitis Virus Identified by Anti-Idiotypic Antibodies and Virus Affinoblotting

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• Mutagenesis of the RGD motif in the yellow fever virus 17D envelope protein.

  1999cited by this paper
• Mapping of Functional Elements in the Stem-Anchor Region of Tick-Borne Encephalitis Virus Envelope Protein E

  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Characterization of monoclonal antibody-escape mutants of tick-borne encephalitis virus with reduced neuroinvasiveness in mice.

  1997cited by this paper
• Identification of two surface proteins from C6/36 cells that bind dengue type 4 virus

  1997cited by this paper
• A 65-kDa trypsin-sensible membrane cell protein as a possible receptor for dengue virus in cultured neuroblastoma cells.

  1997cited by this paper
• Tissue culture adaptation of foot-and-mouth disease virus selects viruses that bind to heparin and are attenuated in cattle

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• Microbial adherence to and invasion through proteoglycans

  1997cited by this paper
• A putative cellular receptor for dengue viruses

  1997cited by this paper
• Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate

  1997influential reference
• Construction of infectious cDNA clones for dengue 2 virus: strain 16681 and its attenuated vaccine derivative, strain PDK-53.

  1997cited by this paper
• Arginine-glycine-aspartic acid-specific binding by foot-and-mouth disease viruses to the purified integrin alpha(v)beta3 in vitro

  1997cited by this paper
• Infectious cDNA clones of tick-borne encephalitis virus European subtype prototypic strain Neudoerfl and high virulence strain Hypr.

  1997influential reference
• The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution

  1995cited by this paper
• Completion of Kunjin virus RNA sequence and recovery of an infectious RNA transcribed from stably cloned full-length cDNA

  1994cited by this paper
• Entry of Coxsackievirus A9 into Host Cells: Specific Interactions with αvβ3 Integrin, the Vitronectin Receptor

  1994cited by this paper
• Entry of coxsackievirus A9 into host cells: specific interactions with alpha v beta 3 integrin, the vitronectin receptor.

  1994cited by this paper
• Infectious Japanese encephalitis virus RNA can be synthesized from in vitro-ligated cDNA templates

  1992cited by this paper
• Infectious RNA transcribed from stably cloned full-length cDNA of dengue type 4 virus.

  1991cited by this paper
• Flavivirus genome organization, expression, and replication.

  1990cited by this paper
• Host cell selection of Murray Valley encephalitis virus variants altered at an RGD sequence in the envelope protein and in mouse virulence.

  1990influential reference
• A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model

  1990cited by this paper
• Transcription of infectious yellow fever RNA from full-length cDNA templates produced by in vitro ligation.

  1989influential reference
• Murray Valley encephalitis virus field strains from Australia and Papua New Guinea: studies on the sequence of the major envelope protein gene and virulence for mice.

  1988cited by this paper
• Nucleotide sequence of dengue 2 RNA and comparison of the encoded proteins with those of other flaviviruses.

  1988cited by this paper
• Nucleotide and complete amino acid sequences of Kunjin virus: definitive gene order and characteristics of the virus-specified proteins.

  1988cited by this paper
• Sequence of the structural proteins of tick-borne encephalitis virus (western subtype) and comparative analysis with other flaviviruses.

  1988influential reference
• Genotypic and phenotypic studies on natural isolates and laboratory-derived variants of flaviviruses

  1987cited by this paper
• Partial nucleotide sequence of St. Louis encephalitis virus RNA: structural proteins, NS1, ns2a, and ns2b.

  1987cited by this paper
• New perspectives in cell adhesion: RGD and integrins.

  1987cited by this paper
• The nucleotide sequence of dengue type 4 virus: analysis of genes coding for nonstructural proteins.

  1987cited by this paper
• Sequence of the dengue-1 virus genome in the region encoding the three structural proteins and the major nonstructural protein NS1.

  1987cited by this paper
• Partial nucleotide sequence of the Japanese encephalitis virus genome.

  1987cited by this paper
• Comparison of the virulent Asibi strain of yellow fever virus with the 17D vaccine strain derived from it.

  1987cited by this paper
• The effect of pH on the early interaction of West Nile virus with P388D1 cells.

  1986cited by this paper
• The uncoating and infectivity of the flavivirus West Nile on interaction with cells: effects of pH and ammonium chloride.

  1986cited by this paper
• Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution.

  1985influential reference
• Sequence analysis of the viral core protein and the membrane-associated proteins V1 and NV2 of the flavivirus West Nile virus and of the genome sequence for these proteins.

  1985cited by this paper
• Variation in virulence for mice and rhesus monkeys among St. Louis encephalitis virus strains of different origin.

  1980cited by this paper
• MURRAY VALLEY ENCEPHALITIS: ISOLATION AND CHARACTERIZATION OF THE ÆTIOLOGICAL AGENT

  1952cited by this paper
• Murray Valley encephalitis isolation and characterization of the aetiological agent.

  1952influential reference

• Naturally occurring mutations in envelope mediate virulence of Usutu virus

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• Emerging Arthropod-Borne Viruses Hijack the Host Cell Cytoskeleton During Neuroinvasion

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• Evolutionary dynamics of heparan sulfate utilization by SARS-CoV-2

  2025cites this paper
• Peptides developed against receptor binding sites of the E glycoprotein neutralize tick-borne encephalitis virus

  2025cites this paper
• Arboviruses: Transmission and Host Resistance.

  2024cites this paper
• The mutation of Japanese encephalitis virus envelope protein residue 389 attenuates viral neuroinvasiveness

  2024cites this paper
• Chapter 2b: The molecular and antigenic structure of TBEV

  2023cites this paper
• Novel approaches for the rapid development of rationally designed arbovirus vaccines

  2023cites this paper
• Charge-changing point mutations in the E protein of tick-borne encephalitis virus

  2023cites this paper
• Glycosaminoglycan binding by arboviruses: a cautionary tale.

  2022cites this paper
• Novel Flavivirus Attenuation Markers Identified in the Envelope Protein of Alfuy Virus

  2021influential citation
• The importance of viral and cellular factors on flavivirus entry.

  2021cites this paper
• Murray Valley Encephalitis Virus

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• How Antibodies Recognize Pathogenic Viruses: Structural Correlates of Antibody Neutralization of HIV-1, SARS-CoV-2, and Zika

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• Development of peptides targeting receptor binding site of the envelope glycoprotein to contain the West Nile virus infection

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• The Present and Future of Yellow Fever Vaccines

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• Structure of Usutu virus SAAR-1776 displays fusion loop asymmetry

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• The key amino acids of E protein involved in early flavivirus infection: viral entry

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• Substitutions at Loop Regions of TMUV E Protein Domain III Differentially Impair Viral Entry and Assembly

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• Prohibitin 1/2 mediates Dengue-3 entry into human neuroblastoma (SH-SY5Y) and microglia (CHME-3) cells

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• Mapping the diverse structural landscape of the flavivirus antibody repertoire.

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• Structural Basis of Zika Virus Specific Neutralization in Subsequent Flavivirus Infections

  2020cites this paper
• Chapter 2b: The molecular antigenic structure of the TBEV

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• Substantial Attenuation of Virulence of Tembusu Virus Strain PS Is Determined by an Arginine at Residue 304 of the Envelope Protein

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• Early Events in Japanese Encephalitis Virus Infection: Viral Entry

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• Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis

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• Molecular basis of antibody‐mediated neutralization and protection against flavivirus

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