Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cancer Research

• Publication date

  2010-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-10-1169PMID 20651255PMCID PMC2936697
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Oncogene].

  2019cited by this paper
• Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: clinical potential of neonatal Nav1.5 in breast cancer.

  2009influential reference
• Discovery and Scoring of Protein Interaction Subnetworks Discriminative of Late Stage Human Colon Cancer*S

  2009cited by this paper
• Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells*

  2009cited by this paper
• Regulation of Podosome Formation in Macrophages by a Splice Variant of the Sodium Channel SCN8A*

  2009influential reference
• A Factor Graph Nested Effects Model To Identify Networks from Genetic Perturbations

  2009cited by this paper
• Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?

  2009cited by this paper
• Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling

  2009cited by this paper
• Anesthetic Technique for Radical Prostatectomy Surgery Affects Cancer Recurrence: A Retrospective Analysis

  2008cited by this paper
• Functional Voltage-Gated Sodium Channels Are Expressed in Human Intestinal Epithelial Cells

  2008cited by this paper
• Activation of Gαi3 triggers cell migration via regulation of GIV

  2008cited by this paper
• The ADAMs: signalling scissors in the tumour microenvironment

  2008cited by this paper
• Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases

  2008cited by this paper
• Insig2 is associated with colon tumorigenesis and inhibits Bax‐mediated apoptosis

  2008cited by this paper
• IFN-Induced Transmembrane Protein 1 Promotes Invasion at Early Stage of Head and Neck Cancer Progression

  2008cited by this paper
• The tumorigenicity diversification in human embryonic kidney 293 cell line cultured in vitro.

  2008cited by this paper
• Gating pore current in an inherited ion channelopathy

  2007cited by this paper
• The Role of PP2A A Subunits in Tumor Suppression

  2007cited by this paper
• Differential gene expression in skeletal muscle cells after membrane depolarization

  2007cited by this paper
• Nested effects models for high-dimensional phenotyping screens

  2007cited by this paper
• Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines.

  2007cited by this paper
• The Genomic Landscapes of Human Breast and Colorectal Cancers

  2007influential reference
• A multidimensional analysis of genes mutated in breast and colorectal cancers.

  2007cited by this paper
• The Consensus Coding Sequences of Human Breast and Colorectal Cancers

  2006cited by this paper
• Identification of the IFITM family as a new molecular marker in human colorectal tumors.

  2006cited by this paper
• From molecule to malady

  2006cited by this paper
• Cardiac Sodium Channel Nav1.5 Is Regulated by a Multiprotein Complex Composed of Syntrophins and Dystrophin

  2006cited by this paper
• Activity‐dependent regulation of voltage‐gated Na+ channel expression in Mat‐LyLu rat prostate cancer cell line

  2006cited by this paper
• Voltage-gated sodium channels: new targets in cancer therapy?

  2006cited by this paper
• Iterative microarray and RNA interference-based interrogation of the SRC-induced invasive phenotype.

  2005cited by this paper
• The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells.

  2005cited by this paper
• Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12

  2005cited by this paper
• Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis

  2005influential reference
• Neuronal characteristics of small-cell lung cancer

  2005cited by this paper
• Ion Channels and Cancer

  2005cited by this paper
• Osteopontin regulates multiple functions contributing to human colon cancer development and progression

  2004cited by this paper
• Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons.

  2004cited by this paper
• ADAM 12 Cleaves Extracellular Matrix Proteins and Correlates with Cancer Status and Stage*

  2004cited by this paper
• Downregulation of Matrix Metalloproteinases and Collagens and Suppression of Cardiac Fibrosis by Inhibition of the Proteasome

  2004cited by this paper
• Sodium Channel β1 Subunits Promote Neurite Outgrowth in Cerebellar Granule Neurons*

  2004cited by this paper
• Automated Selection of DAB-labeled Tissue for Immunohistochemical Quantification

  2003cited by this paper
• Identification of Src transformation fingerprint in human colon cancer

  2002cited by this paper
• Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis.

  2002cited by this paper
• Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1/MAP kinase pathway, resulting in phosphorylation of c-myc in human small cell lung carcinoma cells and pulmonary neuroendocrine cells

  2001cited by this paper
• Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms.

  2000cited by this paper
• Low frequency of alterations of the α (PPP2R1A) and β (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms

  2000cited by this paper
• Expression and functional analysis of voltage-activated Na+ channels in human prostate cancer cell lines and their contribution to invasion in vitro.

  1997cited by this paper
• Effect of cell polarization and differentiation on entry of Listeria monocytogenes into the enterocyte-like Caco-2 cell line

  1996cited by this paper
• Regulation of somatostatin gene expression by veratridine-induced depolarization in cultured fetal cerebrocortical cells.

  1996cited by this paper
• Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth.

  1994cited by this paper
• Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.

  1992cited by this paper
• Intracellular concentration of sodium and other elements as related to mitogenesis and oncogenesis in vivo.

  1980cited by this paper
• Classification of human colorectal adenocarcinoma cell lines.

  1976cited by this paper
• A quantitative description of membrane current and its application to conduction and excitation in nerve

  1952cited by this paper

• Exploring Neonatal NaV1.5 Voltage-Gated Sodium Channel as a Therapeutic Target in Cancer

  2026cites this paper
• Ancestral intronic splicing regulatory elements in the SCNα gene family

  2026cites this paper
• Local anesthetics, regional anesthesia and cancer biology: Part 1

  2025cites this paper
• Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

  2025cites this paper
• Voltage-Gated sodium channel Nav1.6 mediates glioblastoma proliferation and migration via Na+/H+ Exchanger-1 and inhibits apoptosis through ERK-AKT pathway

  2025cites this paper
• Inflammatory Co-Regulation of Voltage-Gated Sodium Channels and Na,K-ATPase in Metastatic Breast Cancer

  2025cites this paper
• Explainable deep learning for identifying cancer driver genes based on the Cancer Dependency Map

  2025influential citation
• D-DARTS: an alternative method for NaV1.5 affinity molecules identification based on dual-drug affinity responsive target stability.

  2025cites this paper
• The potential of dibenzazepine carboxamides in cancer therapy

  2025cites this paper
• The local anesthetic, lidocaine, suppresses the growth of colon cancer SW480 cells by decreasing the voltage-gated sodium channel subunit Nav1.5

  2025influential citation
• Ion channel mutations and cancer

  2025cites this paper
• Voltage-Gated Sodium Channel, as an Ion Channel in Therapeutics: A Bibliometric Analysis of Global Trends (1984–2023)

  2025cites this paper
• A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis

  2024cites this paper
• Overexpression of SCN5A overcomes ABC transporter-mediated multidrug resistance in acute myeloid leukemia through promoting apoptosis

  2024cites this paper
• Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley.

  2024cites this paper
• Effects of NaV1.5 and Rac1 on the Epithelial-Mesenchymal Transition in Breast Cancer

  2024cites this paper
• The Problem of Diagnosing Prostate Cancer—The Promise of Ion Channels as Novel Biomarkers of Disease!

  2024cites this paper
• Modulating voltage-gated sodium channels to enhance differentiation and sensitize glioblastoma cells to chemotherapy

  2024cites this paper
• Molecular subtyping and the construction of a predictive model of colorectal cancer based on ion channel genes

  2024cites this paper
• Disrupting Na+ ion homeostasis and Na+/K+ ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo

  2024cites this paper
• Comprehensive characterization of long QT syndrome‐associated genes in cancer and development of a robust prognosis model

  2024cites this paper
• Therapeutic targeting of voltage-gated sodium channel NaV1.7 for cancer metastasis

  2024cites this paper
• NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness

  2023cites this paper
• Voltage-gated sodium channels, sodium transport and progression of solid tumours.

  2023cites this paper
• FSCN1 has a potential indication for the prognosis and regulates the migration of HNSCC

  2023cites this paper
• Tetracaine downregulates matrix metalloproteinase activity and inhibits invasiveness of strongly metastatic MDA-MB-231 human breast cancer cells.

  2023cites this paper
• Voltage-gated sodium channels in cancer and their specific inhibitors.

  2023cites this paper
• NALCN is a potential biomarker and therapeutic target in human cancers

  2023cites this paper
• Voltage-Gated Sodium Channel NaV1.7 Inhibitors with Potent Anticancer Activities in Medullary Thyroid Cancer Cells

  2023cites this paper
• Antiproliferative, Antioxidant, Chemopreventive and Antiangiogenic Potential of Chromatographic Fractions from Anemonia sulcata with and without Its Symbiont Symbiodinium in Colorectal Cancer Therapy

  2023cites this paper
• Voltage-gated sodium channel activity mediates sea urchin larval skeletal patterning through spatial regulation of Wnt5 expression

  2023cites this paper
• The role of initial sodium and globulin values in the prognosis prediction of patients diagnosed with colon cancer

  2023cites this paper
• FSCN1 is critical for HNSCC

  2023cites this paper
• Inactivation of epithelial sodium ion channel molecules serves as effective diagnostic biomarkers in clear cell renal cell carcinoma

  2023cites this paper
• Voltage-gated sodium channels: from roles and mechanisms in the metastatic cell behavior to clinical potential as therapeutic targets

  2023influential citation
• News and views on ion channels in cancer: is cancer a channelopathy?

  2023cites this paper
• Invasion and Metastasis Suppression by Anti-Neonatal Nav1.5 Antibodies in Breast Cancer

  2022cites this paper
• Comprehensive Analysis to Identify the Encoded Gens of Sodium Channels as a Prognostic Biomarker in Hepatocellular Carcinoma

  2022cites this paper
• Ion Transporting Proteins and Cancer: Progress and Perspectives.

  2022cites this paper
• The NALCN channel regulates metastasis and nonmalignant cell dissemination

  2022cites this paper
• Expression of neuronal Na+ leak channel, NALCN, provides for persistent invasion of metastasizing cancer cells

  2022cites this paper
• From HDAC to Voltage-Gated Ion Channels: What’s Next? The Long Road of Antiepileptic Drugs Repositioning in Cancer

  2022influential citation
• Cancer as a Channelopathy—Appreciation of Complimentary Pathways Provides a Different Perspective for Developing Treatments

  2022cites this paper
• Discovering the Triad between Nav1.5, Breast Cancer, and the Immune System: A Fundamental Review and Future Perspectives

  2022cites this paper
• Sodium channels and the ionic microenvironment of breast tumours

  2022cites this paper
• Novel immunotherapeutic approaches to cancer: Voltage-gated sodium channel expression in immune cells and tumors

  2022cites this paper
• Effects of Intravenous Infusion of Lidocaine on Short-Term Outcomes and Survival in Patients Undergoing Surgery for Ovarian Cancer: A Retrospective Propensity Score Matching Study

  2022cites this paper
• Nav1.6 promotes the progression of human follicular thyroid carcinoma cells via JAK-STAT signaling pathway.

  2022cites this paper
• Differential expression analysis of genes and long non-coding RNAs associated with KRAS mutation in colorectal cancer cells

  2022cites this paper
• Voltage-Gated Sodium Channel NaV1.5 Controls NHE−1−Dependent Invasive Properties in Colon Cancer Cells

  2022cites this paper
• Targeted Osmotic Lysis: A Novel Approach to Targeted Cancer Therapies

  2022cites this paper
• nNav1.5 expression is associated with glutamate level in breast cancer cells

  2022cites this paper
• The distinguishing electrical properties of cancer cells.

  2022cites this paper
• Anti-invasive effects of minoxidil on human breast cancer cells: combination with ranolazine

  2022cites this paper
• The SCN5A Gene Is a Predictor of Phenotype Severity in Brugada Syndrome: A Comprehensive Literature Review

  2022cites this paper
• Bioelectric Dysregulation in Cancer Initiation, Promotion, and Progression

  2022cites this paper
• SCN5A promotes the growth and lung metastasis of triple-negative breast cancer through EF2-kinase signaling.

  2022cites this paper
• Impact of Local Anesthetics on Cancer Behavior and Outcome during the Perioperative Period: A Review

  2022cites this paper
• Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment

  2021cites this paper
• Sodium ion channels as potential therapeutic targets for cancer metastasis.

  2021cites this paper
• Brugada Syndrome: Warning of a Systemic Condition?

  2021cites this paper
• Knockdown of rno_circRNA_009194 Improves Outcomes in Traumatic Brain Injury Rats through Inhibiting Voltage-Gated Sodium Channel Nav1.3

  2021cites this paper
• Influence of nNav1.5 on MHC class I expression in breast cancer

  2021cites this paper
• Bioelectrical approaches to cancer as a problem of the scaling of the cellular self.

  2021cites this paper
• Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation

  2021cites this paper
• Neonatal Nav1.5 Protein Expression in Human Colorectal Cancer: Immunohistochemical Characterization and Clinical Evaluation

  2021cites this paper
• Positive Impact of Intraoperative Epidural Ropivacaine Infusion on Oncologic Outcomes in Pancreatic Cancer Patients Undergoing Pancreatectomy: A Retrospective Cohort Study

  2021cites this paper
• Novel mechanisms of epithelial ion transport: insights from the cryptonephridial system of lepidopteran larvae.

  2021cites this paper
• The sodium/D-dimer ratio predicts the effect of first-line chemotherapy and prognosis in patients with advanced gastric cancer.

  2021cites this paper
• Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers

  2021cites this paper
• Evaluating the Use of Genetics in Brugada Syndrome Risk Stratification

  2021cites this paper
• Voltage-gated calcium channels regulate K+ transport in the Malpighian tubules of the larval cabbage looper, Trichoplusia ni.

  2021cites this paper
• Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment

  2021cites this paper
• Neonatal NaV1.5 channels: pharmacological distinctiveness of a cancer‐related voltage‐gated sodium channel splice variant

  2021influential citation
• Voltage-gated sodium channel Nav1.5 promotes tumor progression and enhances chemosensitivity to 5-fluorouracil in colorectal cancer.

  2020cites this paper
• Sodium to globulin ratio as a prognostic factor for patients with advanced gastric cancer

  2020cites this paper
• Lidocaine inhibits the metastatic potential of ovarian cancer by blocking NaV1.5‐mediated EMT and FAK/Paxillin signaling pathway

  2020cites this paper
• Impact of anesthesia methods on perioperative systemic inflammation and long-term outcomes in patients undergoing surgery for hepatocellular carcinoma: a propensity score-matched analysis

  2020cites this paper
• Breast cancer therapy affects the expression of antineonatal Nav1.5 antibodies in the serum of patients with breast cancer

  2020cites this paper
• Chronic neural activity recorded within breast tumors

  2020cites this paper
• Integrated Analysis of Distant Metastasis-Associated Genes and Potential Drugs in Colon Adenocarcinoma

  2020cites this paper
• Anesthesia Options and the Recurrence of Cancer: What We Know so Far?

  2020cites this paper
• Malignant assignment of neuronal Na+ leak channel, NALCN: governor of Ca2+ oscillations-encoded invadopodogenesis

  2020cites this paper
• Rock inhibition promotes NaV1.5 sodium channel-dependent SW620 colon cancer cell invasiveness

  2020cites this paper
• Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases.

  2020cites this paper
• Knockdown of Nav1.5 inhibits cell proliferation, migration and invasion via Wnt/β-catenin signaling pathway in oral squamous cell carcinoma.

  2020cites this paper
• Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance

  2020cites this paper
• The effect of intra-abdominal local anaesthetics following major gyneacological surgery

  2020cites this paper
• How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer.

  2020cites this paper
• Hyponatremia and Cancer Progression: Possible Association with Sodium-Transporting Proteins

  2020cites this paper
• Migration, invasion, invadopodia, and the inversion of the pH gradient

  2020cites this paper
• Voltage gated sodium channels

  2020cites this paper
• Human Breast Cancer Cells Demonstrate Electrical Excitability

  2020cites this paper
• Inhibitory Effect of Eslicarbazepine Acetate and S-Licarbazepine on Nav1.5 Channels

  2020cites this paper
• pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology

  2020cites this paper
• Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate

  2019cites this paper
• In Vivo Evidence for Voltage-Gated Sodium Channel Expression in Carcinomas and Potentiation of Metastasis

  2019influential citation
• Role of ion channels in gastrointestinal cancer

  2019cites this paper
• Malpighian tubules of caterpillars: blending RNAseq and physiology to reveal regional functional diversity and novel epithelial ion transport control mechanisms

  2019cites this paper
• Voltage‐dependent activation of Rac1 by Nav1.5 channels promotes cell migration

  2019cites this paper