The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Genes & Development

• Publication date

  1997-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/GAD.11.11.1409PMID 9192869
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality.

  1997cited by this paper
• Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse

  1997cited by this paper
• A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation.

  1996cited by this paper
• Localization and developmental changes in the neuron-specific cyclin-dependent kinase 5 activator (p35nck5a) in the rat brain.

  1996cited by this paper
• Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.

  1996cited by this paper
• The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

  1996cited by this paper
• The Xenopus laevis homologue to the neuronal cyclin-dependent kinase (cdk5) is expressed in embryos by gastrulation.

  1995cited by this paper
• An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator (*)

  1995cited by this paper
• Use of an oocyte expression assay to reconstitute inductive signaling.

  1995cited by this paper
• The identification of two novel ligands of the FGF receptor by a yeast screening method and their activity in Xenopus development.

  1995cited by this paper
• Wiring diagrams: regulatory circuits and the control of skeletal myogenesis.

  1994cited by this paper
• p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

  1994cited by this paper
• Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain

  1994cited by this paper
• Ventral expression of GATA-1 and GATA-2 in the Xenopus embryo defines induction of hematopoietic mesoderm.

  1994cited by this paper
• Myogenesis in Xenopus laevis.

  1994cited by this paper
• Inducing factors in Xenopus early embryos.

  1994cited by this paper
• A brain-specific activator of cyclin-dependent kinase 5

  1994cited by this paper
• Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.

  1994cited by this paper
• E2F and its developmental regulation in Xenopus laevis

  1994cited by this paper
• Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos.

  1993cited by this paper
• Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.

  1993cited by this paper
• cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization.

  1993cited by this paper
• Distinct roles for cyclin-dependent kinases in cell cycle control.

  1993cited by this paper
• Expression of a novel FGF in the Xenopus embryo. A new candidate inducing factor for mesoderm formation and anteroposterior specification.

  1992cited by this paper
• Purification and characterization of a novel proline-directed protein kinase from bovine brain.

  1992cited by this paper
• A family of human cdc2‐related protein kinases.

  1992cited by this paper
• Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development.

  1992cited by this paper
• Ubiquitous MyoD transcription at the midblastula transition precedes induction-dependent MyoD expression in presumptive mesoderm of X. laevis.

  1991cited by this paper
• In situ hybridization: an improved whole-mount method for Xenopus embryos.

  1991cited by this paper
• Cephalic expression and molecular characterization of Xenopus En-2.

  1991cited by this paper
• Assays for gene function in developing Xenopus embryos.

  1991cited by this paper
• Xenopus Myf-5 marks early muscle cells and can activate muscle genes ectopically in early embryos.

  1991cited by this paper
• Cell cycle extracts.

  1991cited by this paper
• Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction.

  1991cited by this paper
• The Xenopus MyoD gene: an unlocalised maternal mRNA predates lineage-restricted expression in the early embryo.

  1990cited by this paper
• Activation of muscle genes without myogenesis by ectopic expression of MyoD in frog embryo cells

  1990cited by this paper
• MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus embryos.

  1989cited by this paper
• Regional expression, pattern and timing of convergence and extension during gastrulation of Xenopus laevis.

  1988cited by this paper
• Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos.

  1988cited by this paper
• Fate map for the 32-cell stage of Xenopus laevis.

  1987cited by this paper
• Biochemical specificity of Xenopus notochord.

  1985cited by this paper
• Two subpopulations of differentiated chondrocytes identified with a monoclonal antibody to keratan sulfate

  1985cited by this paper
• Monoclonal antibodies identify blastemal cells derived from dedifferentiating limb regeneration.

  1984cited by this paper
• A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription.

  1982cited by this paper
• Somitogenesis in amphibian embryos. I. Experimental evidence for an interaction between two temporal factors in the specification of somite pattern.

  1979cited by this paper
• Myogenesis in the trunk and leg during development of the tadpole of Xenopus laevis (Daudin 1802).

  1975cited by this paper
• The formation of somites in Xenopus.

  1969cited by this paper

• Cyclin-dependent protein kinases and cell cycle regulation in biology and disease

  2025cites this paper
• Alzheimer's disease‐related brain insulin resistance and the prospective therapeutic impact of metformin

  2023cites this paper
• XBP1u Is Involved in C2C12 Myoblast Differentiation via Accelerated Proteasomal Degradation of Id3

  2022cites this paper
• From structural resilience to cell specification — Intermediate filaments as regulators of cell fate

  2020cites this paper
• Histological, immunohistochemical and transcriptomic characterization of human tracheoesophageal fistulas

  2020cites this paper
• A kinase of many talents: non-neuronal functions of CDK5 in development and disease

  2020cites this paper
• IRE1-XBP1 Pathway of the Unfolded Protein Response Is Required during Early Differentiation of C2C12 Myoblasts

  2019cites this paper
• Nestin contributes to skeletal muscle homeostasis and regeneration

  2017cites this paper
• Implications physiopathologiques de la Nestine lors du remodelage pulmonaire et cardiaque à la suite de l’infarctus du myocarde, du diabète et de l’hypertension pulmonaire

  2016cites this paper
• Herpes Simplex Virus 1 Upregulates p35, Alters CDK-5 Localization, and Stimulates CDK-5 Kinase Activity during Acute Infection in Neurons

  2015cites this paper
• Implication des cellules Nestin+ dans le remodelage vasculaire en conditions pathologiques

  2015cites this paper
• Interplay Between Viral and Cellular Factors Determines the Fate of Herpes Simplex Virus type I Infection

  2014cites this paper
• Cytoskeleton and Adhesion in Myogenesis

  2014cites this paper
• p39, the Primary Activator for Cyclin-dependent Kinase 5 (Cdk5) in Oligodendroglia, Is Essential for Oligodendroglia Differentiation and Myelin Repair*

  2013cites this paper
• Going out of the brain: non-nervous system physiological and pathological functions of Cdk5.

  2012cites this paper
• Expression and regulation of cold shock proteins in inflammatory kidney and liver diseases

  2012cites this paper
• Cyclin-Dependent Kinase 5–Mediated Hyperphosphorylation of Sirtuin-1 Contributes to the Development of Endothelial Senescence and Atherosclerosis

  2012cites this paper
• Cdk5 Levels Oscillate during the Neuronal Cell Cycle

  2012cites this paper
• Cdk 5 Levels Oscillate during the Neuronal Protein Synthesis and Degradation :

  2012cites this paper
• Neuronal Cell Cycle Regulation of Cdk5 in Alzheimer's Disease

  2012cites this paper
• Mapping the function of the NS3 protein of African horsesickness virus using RNAi and yeast two-hybrid analyses

  2011cites this paper
• Nestin as a regulator of Cdk5 in differentiating myoblasts

  2011cites this paper
• Insights into intermediate filament regulation from development to ageing

  2011cites this paper
• Nestin as a regulator of Cdk 5 in differentiating myoblasts

  2011cites this paper
• Running title : PKC REGULATES MYOGENESIS

  2010influential citation
• Protein Kinase Cζ Regulates Cdk5/p25 Signaling during Myogenesis

  2010cites this paper
• Cyclin Dependent Kinase 5 in Endothelial Cell Migration

  2010cites this paper
• Dynamic interplay between the intermediate filament protein nestin and Cyclin-dependent kinase 5

  2010cites this paper
• CDK5 is present in sea urchin and starfish eggs and embryos and can interact with p35, cyclin E and cyclin B3

  2010influential citation
• Zebrafish Rohon-Beard Neuron Development: Cdk5 in the Midst

  2009cites this paper
• Normal levels of p27Xic1 are necessary for somite segmentation and determining pronephric organ size

  2009cites this paper
• Cyclin-Dependent Kinase 5 and Insulin Secretion

  2008cites this paper
• Cdk5 and the non-catalytic arrest of the neuronal cell cycle

  2008cites this paper
• An Unusual Member of the Cdk Family: Cdk5

  2008cites this paper
• Presymptomatic biochemical changes in hindlimb muscle of G93A human Cu/Zn superoxide dismutase 1 transgenic mouse model of amyotrophic lateral sclerosis.

  2008cites this paper
• Cardiac differentiation in Xenopus requires the cyclin-dependent kinase inhibitor, p27Xic1

  2008cites this paper
• Cdk5 phosphorylates PLD2 to mediate EGF-dependent insulin secretion.

  2008cites this paper
• Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cycline‐dependent kinase 5 complexes

  2008cites this paper
• Providing cellular signposts – Post‐translational modifications of intermediate filaments

  2008cites this paper
• Enterovirus 71 triggering of neuronal apoptosis through activation of Abl‐Cdk5 signalling

  2007cites this paper
• ODF1 Phosphorylation by Cdk5/p35 Enhances ODF1-OIP1 Interaction

  2007cites this paper
• Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5.

  2007influential citation
• Cyclin-dependent kinase inhibitors from natural sources: recent advances and future prospects for cancer treatment

  2006cites this paper
• The BAR Domain Proteins: Molding Membranes in Fission, Fusion, and Phagy

  2006cites this paper
• Cyclin‐dependent kinase 5 influences Rohon‐Beard neuron survival in zebrafish

  2006cites this paper
• Extraneuronal roles of cyclin‐dependent kinase 5

  2006cites this paper
• Reconstructing the Regulatory Kinase Pathways of Myogenesis from Phosphopeptide Data*S

  2006cites this paper
• A nestin scaffold links Cdk5/p35 signaling to oxidant‐induced cell death

  2006cites this paper
• p53, Apaf-1, caspase-3, and -9 are dispensable for Cdk5 activation during cell death

  2006cites this paper
• Therapeutic potential of CDK5 inhibitors to promote corneal epithelial wound healing

  2005cites this paper
• Molecular mechanisms regulating exocytosis : Studies of insulin secretion and neurotransmitter release

  2005cites this paper
• Expression and localization of cyclin-dependent kinase 5 in apoptotic human glioma cells 1

  2005cites this paper
• Cdk5/p35 expression in the mouse ovary.

  2004cites this paper
• Cdk5 regulates activation and localization of Src during corneal epithelial wound closure

  2004cites this paper
• Cellular Senescence Requires CDK5 Repression of Rac1 Activity

  2004cites this paper
• G1/S phase cyclin-dependent kinase overexpression perturbs early development and delays tissue-specific differentiation in Xenopus

  2004cites this paper
• L6 myoblast differentiation is modulated by Cdk5 via the PI3K–AKT–p70S6K signaling pathway

  2004cites this paper
• Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity.

  2004cites this paper
• Identification of Xenopus cyclin-dependent kinase inhibitors, p16Xic2 and p17Xic3.

  2004cites this paper
• CYCLIN DEPENDENT KINASE 5 ( CDK 5 ) IN DEVELOPING OVARIAN FOLICLES , OOCYTES AND EMBRYOS OF MOUSE CYKLIN DEPENDENTNÍ KINÁZA 5 ( CDK 5 ) VE

  2004cites this paper
• Differential expression of presenilin-alpha and -beta (PSalpha and PSbeta) in Xenopus laevis: embryonic phosphorylation of PSalpha.

  2003cites this paper
• Cdk5 Regulates the Organization of Nestin and Its Association with p35

  2003cites this paper
• The Neuronal Cyclin-dependent Kinase 5 Activator p35Nck5a and Cdk5 Activity in Monocytic Cells

  2003cites this paper
• Differential expression of presenilin-α and -β (PSα and PSβ) in Xenopus laevis: embryonic phosphorylation of PSα

  2003cites this paper
• Cdk7 Functions as a Cdk5 Activating Kinase in Brain

  2003cites this paper
• Effect of Protein Phosphorylation on Neurite Outgrowth in Cultured Embryonic Xenopus Spinal Neurons

  2003cites this paper
• Phosphorylation of the Head Domain of Neurofilament Protein (NF-M)

  2003cites this paper
• Cyclin‐dependent kinase 5 (cdk5) activation requires interaction with three domains of p35

  2002cites this paper
• CDK5 regulates cell adhesion and migration in corneal epithelial cells.

  2002cites this paper
• Modulating cell cycle: current applications and prospects for future drug development.

  2002cites this paper
• Cdk5 regulates cell-matrix and cell-cell adhesion in lens epithelial cells.

  2002cites this paper
• Induction of Cdk5 activity in rat skeletal muscle after nerve injury

  2002cites this paper
• CDK 5 Regulates Cell Adhesion and Migration in Corneal Epithelial Cells

  2002cites this paper
• Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase Pathway*

  2002cites this paper
• The role of Rho GTPases and associated kinases in regulating neurite outgrowth.

  2002cites this paper
• Cycling at the interface between neurodevelopment and neurodegeneration

  2002cites this paper
• The IGF pathway regulates head formation by inhibiting Wnt signaling in Xenopus.

  2002cites this paper
• Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction

  2001cites this paper
• Amphiphysin 1 Binds the Cyclin-dependent Kinase (cdk) 5 Regulatory Subunit p35 and Is Phosphorylated by cdk5 and cdc2*

  2001cites this paper
• Mitotic Reorganization of the Intermediate Filament Protein Nestin Involves Phosphorylation by cdc2 Kinase*

  2001cites this paper
• The role of the Cdk5--p35 kinase in neuronal development.

  2001cites this paper
• Cdk5 on the brain.

  2001cites this paper
• Neuronal Cyclin-Dependent Kinase 5 Activity Is Critical for Survival

  2001cites this paper
• Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock.

  2001cites this paper
• A decade of CDK5

  2001cites this paper
• Expression of a Y-box protein, YB2/RYB-a, precedes protamine 2 expression during spermatogenesis in rodents.

  2001cites this paper
• Expression and localization of cyclin-dependent kinase 5 in apoptotic human glioma cells.

  2001cites this paper
• Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism.

  2001cites this paper
• The protein kinase Cdk5

  2001cites this paper
• The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology.

  2001cites this paper
• Regulation of muscle regulatory factors by DNA‐binding, interacting proteins, and post‐transcriptional modifications

  2000cites this paper
• Neurofilament protein synthesis and phosphorylation

  2000cites this paper
• Cell cycle arrest induced by ectopic expression of p27 is not sufficient to promote oligodendrocyte differentiation

  2000cites this paper
• Cyclin-dependent kinase-5 (CDK5) and amyotrophic lateral sclerosis

  2000cites this paper
• Ser67-phosphorylated inhibitor 1 is a potent protein phosphatase 1 inhibitor.

  2000cites this paper
• p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton.

  2000cites this paper
• Specific association of increased cyclin‐dependent kinase 5 expression with monocytic lineage of differentiation of human leukemia HL60 cells

  2000cites this paper
• The role of the p35/cdk5 kinase in cortical development.

  2000cites this paper
• Mouse Brain Development

  2000cites this paper
• ATP-site directed inhibitors of cyclin-dependent kinases.

  1999cites this paper