Quantitative Analysis of the Relationship between Intra- Axonal Neurofilament Compaction and Impaired Axonal Transport following Diffuse Traumatic Brain Injury

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Neurotrauma

• Publication date

  2005-10-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1089/neu.2005.22.1066PMID 16238484
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Protein accumulation in traumatic brain injury

  2007cited by this paper
• A Significant Increase in Both Basal and Maximal Calcineurin Activity following Fluid Percussion Injury in the Rat

  2005cited by this paper
• Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: more than a focal brain injury.

  2005cited by this paper
• Early detection of axonal injury after human head trauma using immunocytochemistry for β-amyloid precursor protein

  2004cited by this paper
• Markers of axonal injury in post mortem human brain

  2004cited by this paper
• Axonal microtubules: a computer-linked quantitative analysis

  2004influential reference
• Traumatic Axonal Injury

  2004cited by this paper
• Traumatic Axonal Injury Results in Biphasic Calpain Activation and Retrograde Transport Impairment in Mice

  2003cited by this paper
• Simple Morphometry of Axonal Swellings Cannot Be Used in Isolation for Dating Lesions after Traumatic Brain Injury

  2002influential reference
• Caspase-3-Mediated Cleavage of Amyloid Precursor Protein and Formation of Amyloid β Peptide in Traumatic Axonal Injury

  2002cited by this paper
• Incidence of axonal injury in human brain tissue

  2002cited by this paper
• Traumatic Axonal Injury Induces Calcium Influx Modulated by Tetrodotoxin-Sensitive Sodium Channels

  2001cited by this paper
• The immunophilin ligand FK506 attenuates the axonal damage associated with rapid rewarming following posttraumatic hypothermia.

  2001influential reference
• Intra-axonal neurofilament compaction does not evoke local axonal swelling in all traumatically injured axons.

  2001influential reference
• The Immunophilin Ligand FK506 Attenuates Axonal Injury in an Impact-Acceleration Model of Traumatic Brain Injury

  2001cited by this paper
• Antibodies to the C-terminus of the β-amyloid precursor protein (APP): a site specific marker for the detection of traumatic axonal injury

  2000influential reference
• Cytochrome c Release and Caspase Activation in Traumatic Axonal Injury

  2000cited by this paper
• The neuropathology of the vegetative state after an acute brain insult.

  2000cited by this paper
• Light and confocal microscopic studies of evolutionary changes in neurofilament proteins following cortical impact injury in the rat.

  2000cited by this paper
• Behavioral Efficacy of Posttraumatic Calpain Inhibition is Not Accompanied by Reduced Spectrin Proteolysis, Cortical Lesion, or Apoptosis

  2000cited by this paper
• Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury.

  1999cited by this paper
• Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig.

  1999cited by this paper
• Moderate posttraumatic hypothermia decreases early calpain-mediated proteolysis and concomitant cytoskeletal compromise in traumatic axonal injury.

  1999influential reference
• Evolution of neurofilament subtype accumulation in axons following diffuse brain injury in the pig.

  1999cited by this paper
• The role of calpain-mediated spectrin proteolysis in traumatically induced axonal injury.

  1999influential reference
• Postinjury Cyclosporin A Administration Limits Axonal Damage and Disconnection in Traumatic Brain Injury

  1999influential reference
• An Intrathecal Bolus of Cyclosporin a before Injury Preserves Mitochondrial Integrity and Attenuates Axonal Disruption in Traumatic Brain Injury

  1999cited by this paper
• Correlation of survival time with size of axonal swellings in diffuse axonal injury

  1999influential reference
• Intra-axonal overloading of calcium ion in rat diffuse axonal injury and therapeutic effect of calcium antagonist.

  1999cited by this paper
• Posttraumatic hypothermia in the treatment of axonal damage in an animal model of traumatic axonal injury.

  1998cited by this paper
• Alteration of the neurofilament sidearm and its relation to neurofilament compaction occurring with traumatic axonal injury.

  1998cited by this paper
• The Neuronal Cytoskeleton Is at Risk After Mild and Moderate Brain Injury

  1998cited by this paper
• Loss of Axonal Microtubules and Neurofilaments after Stretch-Injury to Guinea Pig Optic Nerve Fibers

  1997influential reference
• Temporal and Regional Patterns of Axonal Damage following Traumatic Brain Injury: A Beta‐amyloid Precursor Protein Immunocytochemical Study in Rats

  1997influential reference
• Impact Acceleration Injury in the Rat: Evidence for Focal Axolemmal Change and Related Neurofilament Sidearm Alteration

  1997influential reference
• A Mechanistic Analysis of Nondisruptive Axonal Injury: A Review

  1997influential reference
• Traumatically induced axonal damage: evidence for enduring changes in axolemmal permeability with associated cytoskeletal change.

  1996cited by this paper
• Is beta-APP a marker of axonal damage in short-surviving head injury?

  1996cited by this paper
• Is β-APP a marker of axonal damage in short-surviving head injury?

  1996cited by this paper
• Characterization of a distinct set of intra-axonal ultrastructural changes associated with traumatically induced alteration in axolemmal permeability.

  1996cited by this paper
• Cytochemical evidence for redistribution of membrane pump calcium-ATPase and ecto-Ca-ATPase activity, and calcium influx in myelinated nerve fibres of the optic nerve after stretch injury

  1995cited by this paper
• A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics.

  1994cited by this paper
• Increased numbers of βAPP‐immunoreactive neurones in the entorhinal cortex after head injury

  1994cited by this paper
• Increased numbers of beta APP-immunoreactive neurones in the entorhinal cortex after head injury.

  1994cited by this paper
• A new model of diffuse brain injury in rats. Part II: Morphological characterization.

  1994cited by this paper
• Traumatically Induced Altered Membrane Permeability: Its Relationship to Traumatically Induced Reactive Axonal Change

  1994cited by this paper
• Staining of amyloid precursor protein to study axonal damage in mild head injury.

  1994cited by this paper
• Microwave antigen retrieval of beta-amyloid precursor protein immunoreactivity.

  1994cited by this paper
• Stalning af amyloid percursor protein to study axonal damage in mild head Injury

  1994cited by this paper
• Microwave antigen retrieval of β-amyloid precursor protein immunoreactivity

  1994cited by this paper
• Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury.

  1993cited by this paper
• The Use of Antibodies Targeted Against the Neurofilament Subunits for the Detection of Diffuse Axonal Injury in Humans

  1993influential reference
• Pathobiology of traumatically induced axonal injury in animals and man.

  1993cited by this paper
• Ultrastructural localization of amyloid β/A4 protein precursor in the normal rat brain

  1993influential reference
• β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury

  1993cited by this paper
• Actin and neurofilament binding domain of brain spectrin beta subunit.

  1992cited by this paper
• Actin and neurofilament binding domain of brain spectrin β subunit

  1992cited by this paper
• Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons.

  1992influential reference
• Traumatically Induced Reactive Change as Visualized Through the Use of Monoclonal Antibodies Targeted to Neurofilament Subunits

  1992cited by this paper
• Axonal response to traumatic brain injury: reactive axonal change, deafferentation, and neuroplasticity.

  1992cited by this paper
• Rapid appearance of beta-amyloid precursor protein immunoreactivity in damaged axons and reactive glial cells in rat brain following needle stab injury.

  1991cited by this paper
• Focal axonal injury: the early axonal response to stretch

  1991cited by this paper
• Rapid appearance of β-amyloid precursor protein immunoreactivity in damaged axons and reactive glial cells in rat brain following needle stab injury

  1991cited by this paper
• Regional variation in the abundance of axonal cytoskeletal proteins

  1991influential reference
• Phosphorylation‐Dependent epitopes on neurofilament proteins and neurofilament densities differ in axons in the corticospinal and primary sensory dorsal column tracts in the rat spinal cord

  1990influential reference
• Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

  1990cited by this paper
• Protein changes during anterograde-to-retrograde conversion of axonally transported vesicles.

  1989cited by this paper
• Neurofilaments are spaced randomly in the radial dimension of axons

  1988cited by this paper
• Fate of reactive axonal swellings induced by head injury.

  1988cited by this paper
• Expression of the Alzheimer amyloid precursor gene transcripts in the human brain.

  1988cited by this paper
• Inhibition of proteolysis blocks anterograde-retrograde conversion of axonally transported vesicles.

  1988cited by this paper
• Fate of reactive axonal swellings induced by head injury.

  1985cited by this paper
• A quantitative study of microtubules in motor and sensory axons.

  1984influential reference
• NEUROPATHOLOGICAL CHANGES IN THE WHITE MATTER FOLLOWING HEAD INJURY

  1967cited by this paper
• Shear injuries of the brain.

  1967cited by this paper
• SHEARING OF NERVE FIBRES AS A CAUSE OF BRAIN DAMAGE DUE TO HEAD INJURY: A Pathological Study of Twenty Cases

  1961cited by this paper
• DIFFUSE DEGENERATION OF THE CEREBRAL WHITE MATTER IN SEVERE DEMENTIA FOLLOWING HEAD INJURY

  1956cited by this paper

• Worsened axonal injury and gliosis following diffuse brain injury in male and female mice with neurofilament light gene deletion.

  2025cites this paper
• Evolution of Axonal Injury in the Closed Head Impact Model of Engineered Rotational Acceleration in Adult Ferrets

  2025cites this paper
• Large-scale modeling of axonal dynamic responses via deep learning

  2025cites this paper
• Immunohistochemical labeling of ongoing axonal degeneration 10 days following cervical contusion spinal cord injury in the rat

  2025cites this paper
• Imaging a concussion and the ensuing immune response at the blood–brain barrier

  2025cites this paper
• Integrative Diagnostic and Prognostic Paradigms in Diffuse Axonal Injury: Insights from Clinical, Histopathological, Biomolecular, Radiological, and AI-Based Perspectives

  2025cites this paper
• Molecular biomarkers of diffuse axonal injury: recent advances and future perspectives

  2024cites this paper
• The neuropathological basis of elevated serum neurofilament light following experimental concussion

  2024cites this paper
• The evolving pathophysiology of TBI and the advantages of temporally-guided combination therapies.

  2024cites this paper
• Traumatic axonal injury: Clinic, forensic and biomechanics perspectives.

  2024cites this paper
• A computational pipeline towards large-scale and multiscale modeling of traumatic axonal injury

  2024cites this paper
• p17/C18-ceramide–mediated mitophagy is an endogenous neuroprotective response in preclinical and clinical brain injury

  2024cites this paper
• Sex Differences in Axonal Dynamic Responses Under Realistic Tension Using Finite Element Models

  2023cites this paper
• Identifying the Phenotypes of Diffuse Axonal Injury Following Traumatic Brain Injury

  2023cites this paper
• Characterization of Traumatic Brain Injury in a Gyrencephalic Ferret Model Using the Novel Closed Head Injury Model of Engineered Rotational Acceleration (CHIMERA)

  2023cites this paper
• The role of the microbiota–gut–brain axis in long‐term neurodegenerative processes following traumatic brain injury

  2022cites this paper
• Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury

  2022cites this paper
• Intranasally applied human olfactory mucosa neural progenitor cells migrate to damaged brain regions

  2022cites this paper
• Translocator Protein Ligand PIGA1138 Reduces Disease Symptoms and Severity in Experimental Autoimmune Encephalomyelitis Model of Primary Progressive Multiple Sclerosis

  2022cites this paper
• Traumatic Brain Injury in Alpine Winter Sports: Comparison of Two Case Series from a Swiss Trauma Center 30 Years Apart

  2022cites this paper
• Metformin Reduces Repeat Mild Concussive Injury Pathophysiology

  2021cites this paper
• Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures

  2021cites this paper
• Basic brain neuroscience and pathophysiology

  2021cites this paper
• Investigation of Behavioural and Neuropathological Alterations Caused by Repetitive Mild Traumatic Brain Injury in a Rodent Model

  2020cites this paper
• Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study

  2020cites this paper
• Longitudinal optical imaging technique to visualize progressive axonal damage after brain injury in mice reveals responses to different minocycline treatments

  2020cites this paper
• Long-term cognitive impairment without diffuse axonal injury following repetitive mild traumatic brain injury in rats.

  2020cites this paper
• Long-term persistence of cognitive impairment following repetitive mild traumatic brain injury in rats is not associated with common histopathological or molecular biomarkers

  2019cites this paper
• Sarm1 deletion reduces axon damage, demyelination, and white matter atrophy after experimental traumatic brain injury.

  2019cites this paper
• CLARITY reveals a more protracted temporal course of axon swelling and disconnection than previously described following traumatic brain injury

  2018cites this paper
• Histology of Brain Trauma and Hypoxia-Ischemia

  2018cites this paper
• Utilizing a Structural Mechanics Approach to Assess the Primary Effects of Injury Loads Onto the Axon and Its Components

  2018cites this paper
• Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports

  2017cites this paper
• Application of FTIR spectroscopy for traumatic axonal injury: a possible tool for estimating injury interval

  2017cites this paper
• Neuronal Injury and Glial Changes Are Hallmarks of Open Field Blast Exposure in Swine Frontal Lobe

  2017cites this paper
• Extent of impaired axoplasmic transport and neurofilament compaction in traumatically injured axon at various strains and strain rates

  2017cites this paper
• A Novel Closed-Head Model of Mild Traumatic Brain Injury Using Focal Primary Overpressure Blast to the Cranium in Mice

  2016cites this paper
• Delayed Hypoxemia Following Traumatic Brain Injury Exacerbates White Matter Injury

  2016cites this paper
• A Conceptual Overview of Axonopathy in Infants and Children with Allegedly Inflicted Head Trauma

  2016cites this paper
• Memory Disruption Following Traumatic Brain Injury

  2016cites this paper
• Traumatic brain injuries

  2016cites this paper
• Understanding the Brain Injury Mechanisms of Primary Blast Exposure

  2016cites this paper
• Ultrastructure of Diaschisis Lesions after Traumatic Brain Injury

  2016cites this paper
• Pathophysiology of Traumatic Brain Injury.

  2016cites this paper
• The effect of traumatic brain injury in experimental models of Alzheimer’s disease

  2016cites this paper
• The axon as a physical structure in health and acute trauma.

  2016cites this paper
• Neural Circuitry Deficits Associated With Dysfunctional Myelin

  2015cites this paper
• Transplantation of human oligodendrocyte progenitor cells in an animal model of diffuse traumatic axonal injury: survival and differentiation

  2015cites this paper
• SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury

  2015cites this paper
• Calcium signaling is implicated in the diffuse axonal injury of brain stem.

  2015cites this paper
• Experimental subarachnoid haemorrhage results in multifocal axonal injury.

  2015cites this paper
• Dissecting the mechanical behavior of neuronal microcompartments by combining magnetic tweezers and protein micropatterns

  2015cites this paper
• A novel closed-body model of spinal cord injury caused by high-pressure air blasts produces extensive axonal injury and motor impairments.

  2015influential citation
• Cerebrolysin improves cognitive performance in rats after mild traumatic brain injury.

  2015cites this paper
• The Relationship Between Axonal Injury, Biomarker Expression And Mechanical Response In A Rodent Head Impact Acceleration Model

  2015cites this paper
• TRAUMATIC BRAIN INJURY MECHANISMS IN THE GOTTINGEN MINIPIG IN RESPONSE TO TWO UNIQUE INPUT MODES

  2015cites this paper
• Prevention of Blast-Related Injuries

  2015cites this paper
• A Role for Focal Adhesions and Extracellular Matrix in Traumatic Axonal Injury

  2014cites this paper
• Neuropathology in sensory, but not motor, brainstem nuclei of the rat whisker circuit after diffuse brain injury

  2014cites this paper
• Osteopontin Expression During the Acute Immune Response Mediates Reactive Synaptogenesis and Adaptive Outcome

  2013cites this paper
• Award Number: W81XWH-12-2-0038 TITLE: Prevention of Blast-Related Injuries PRINCIPAL INVESTIGATOR: Albert I. King CONTRACTING ORGANIZATION: Wayne State University

  2013cites this paper
• Therapy Development for Diffuse Axonal Injury

  2013cites this paper
• Preventing Flow-Metabolism Uncoupling Acutely Reduces Axonal Injury after Traumatic Brain Injury

  2012cites this paper
• Traumatic brain injury in the neonate, child and adolescent human: An overview of pathology

  2012cites this paper
• Characterisation of the effect of knockout of the amyloid precursor protein on outcome following mild traumatic brain injury.

  2012cites this paper
• Unmyelinated Axons Show Selective Rostrocaudal Pathology in the Corpus Callosum After Traumatic Brain Injury

  2012cites this paper
• Temporal assessment of traumatic axonal injury in the rat corpus callosum and optic chiasm.

  2012cites this paper
• Impaired axoplasmic transport is the dominant injury induced by an impact acceleration injury device: an analysis of traumatic axonal injury in pyramidal tract and corpus callosum of rats.

  2012influential citation
• Temporal profiles of axonal injury following impact acceleration traumatic brain injury in rats—a comparative study with diffusion tensor imaging and morphological analysis

  2012influential citation
• Neuropathology of Traumatic Brain Injury

  2011cites this paper
• Traumatic brain injury with particular reference to diffuse traumatic axonal injury subpopulations

  2011cites this paper
• Comparison of progression of diffuse axonal injury with histology and diffusion tensor imaging

  2011cites this paper
• The Association Between Traumatic Brain Injury and Alzheimer's Disease: Mouse Models and Potential Mechanisms

  2011influential citation
• Traumatic white matter injury and toxic leukoencephalopathies

  2011cites this paper
• A Mouse Model of Blast Injury to Brain: Initial Pathological, Neuropathological, and Behavioral Characterization

  2011cites this paper
• Quantitative Relationship between Axonal Injury and Mechanical Response in a Rodent Head Impact Acceleration Model

  2011cites this paper
• Quantitative evaluation of microscopic injury with diffusion tensor imaging in a rat model of diffuse axonal injury

  2011cites this paper
• Concussive Brain Trauma in the Mouse Results in Acute Cognitive Deficits and Sustained Impairment of Axonal Function

  2011cites this paper
• A Possible Role for Integrin Signaling in Diffuse Axonal Injury

  2011cites this paper
• Controlled Cortical Impact Traumatic Brain Injury in 3xTg-AD Mice Causes Acute Intra-Axonal Amyloid-β Accumulation and Independently Accelerates the Development of Tau Abnormalities

  2011cites this paper
• The involvement of Na+, K+-ATPase activity and free radical generation in the susceptibility to pentylenetetrazol-induced seizures after experimental traumatic brain injury.

  2011cites this paper
• Proteolysis of Submembrane Cytoskeletal Proteins Ankyrin‐G and αII‐Spectrin Following Diffuse Brain Injury: A Role in White Matter Vulnerability at Nodes of Ranvier

  2010cites this paper
• A Novel PARP Inhibitor L-2286 in a Rat Model of Impact Acceleration Head Injury: An Immunohistochemical and Behavioral Study

  2010influential citation
• Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury

  2010cites this paper
• A New Rat Model for Diffuse Axonal Injury Using a Combination of Linear Acceleration and Angular Acceleration

  2010influential citation
• Post-Traumatic Hypoxia Exacerbates Brain Tissue Damage: Analysis of Axonal Injury and Glial Responses

  2010influential citation
• Experience-Dependent Plasticity and Vision Restoration in Rats after Optic Nerve Crush

  2010cites this paper
• The Adverse Pial Arteriolar and Axonal Consequences of Traumatic Brain Injury Complicated by Hypoxia and Their Therapeutic Modulation with Hypothermia in Rat

  2010cites this paper
• Impaired axonal transport and neurofilament compaction occur in separate populations of injured axons following diffuse brain injury in the immature rat.

  2009cites this paper
• Marmarou Weight Drop Injury Model

  2009cites this paper
• Axonal Damage due to Traumatic Brain Injury

  2009cites this paper
• Impaired migration signaling in the hippocampus following prenatal hypoxia.

  2009cites this paper
• Na+,K+-ATPase activity impairment after experimental traumatic brain injury: relationship to spatial learning deficits and oxidative stress.

  2008cites this paper
• Mild traumatic brain injury to the infant mouse causes robust white matter axonal degeneration which precedes apoptotic death of cortical and thalamic neurons.

  2008cites this paper
• Posttraumatic administration of pituitary adenylate cyclase activating polypeptide in central fluid percussion injury in rats

  2008influential citation
• Histological and functional outcomes after traumatic brain injury in mice null for the erythropoietin receptor in the central nervous system.

  2008influential citation
• Cellular and subcellular change evoked by diffuse traumatic brain injury: a complex web of change extending far beyond focal damage.

  2007influential citation
• Electroencephalogram, circulation, and lung function after high-velocity behind armor blunt trauma.

  2007cites this paper
• Cyclosporin‐A treatment attenuates delayed cytoskeletal alterations and secondary axotomy following mild axonal stretch injury

  2007cites this paper
• Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury.

  2007influential citation