Efflux pump proteins in antifungal resistance

It is now well-known that the enhanced expression of ATP binding cassette (ABC) and major facilitator superfamily (MFS) proteins contribute to the development of tolerance to antifungals in yeasts. For example, the azole resistant clinical isolates of the opportunistic human fungal pathogen Candida albicans show an overexpression of Cdr1p and/or CaMdr1p belonging to ABC and MFS superfamilies, respectively. Hence, azole resistant isolates display reduced accumulation of therapeutic drug due to its rapid extrusion and that facilitates its survival. Considering the importance of major antifungal transporters, the focus of recent research has been to understand the structure and function of these proteins to design inhibitors/modulators to block the pump protein activity so that the drug already in use could again sensitize resistant yeast cells. The review focuses on the structure and function of ABC and MFS transporters of Candida to highlight the recent advancement in the field.

• Publication year

  2014

• Venue

  Frontiers in Pharmacology

• Publication date

  2014-08-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fphar.2014.00202PMID 25221515PMCID 4148622
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• ATP Binding Cassetteトランスポーターの構造薬理学

  2014cited by this paper
• Characterization of CD8+ T-Cell Responses in the Peripheral Blood and Skin Injection Sites of Melanoma Patients Treated with mRNA Electroporated Autologous Dendritic Cells (TriMixDC-MEL)

  2013cited by this paper
• Insight into Pleiotropic Drug Resistance ATP-binding Cassette Pump Drug Transport through Mutagenesis of Cdr1p Transmembrane Domains*

  2013influential reference
• Yeast ATP-binding cassette transporters conferring multidrug resistance.

  2012influential reference
• Alanine scanning of all cysteines and construction of a functional cysteine-less Cdr1p, a multidrug ABC transporter of Candida albicans.

  2012cited by this paper
• The Transmission Interface of the Saccharomyces cerevisiae Multidrug Transporter Pdr5: Val-656 Located in Intracellular Loop 2 Plays a Major Role in Drug Resistance

  2012influential reference
• A Mutation in Intracellular Loop 4 Affects the Drug-Efflux Activity of the Yeast Multidrug Resistance ABC Transporter Pdr5p

  2012cited by this paper
• A key structural domain of the Candida albicans Mdr1 protein.

  2012cited by this paper
• Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a d‐octapeptide derivative inhibitor

  2012cited by this paper
• The multidrug transporter Pdr5: a molecular diode?

  2011cited by this paper
• Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicans

  2011cited by this paper
• Current perspectives on echinocandin class drugs.

  2011cited by this paper
• Employing Information Theoretic Measures and Mutagenesis to Identify Residues Critical for Drug-Proton Antiport Function in Mdr1p of Candida albicans

  2010cited by this paper
• Intragenic Suppressing Mutations Correct the Folding and Intracellular Traffic of Misfolded Mutants of Yor1p, a Eukaryotic Drug Transporter*

  2010cited by this paper
• Fungal echinocandin resistance

  2010cited by this paper
• Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable.

  2010cited by this paper
• Functional Role of the Intracellular Loop Linking Transmembrane Domains 6 and 7 of the Human Dipeptide Transporter hPEPT1

  2010cited by this paper
• Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.

  2010influential reference
• The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.

  2010cited by this paper
• Fungal PDR transporters: Phylogeny, topology, motifs and function.

  2010influential reference
• The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport.

  2009cited by this paper
• Efflux-Mediated Antifungal Drug Resistance

  2009influential reference
• A novel catalytic mechanism for ATP hydrolysis employed by the N-terminal nucleotide-binding domain of Cdr1p, a multidrug ABC transporter of Candida albicans.

  2008cited by this paper
• Mapping of Interdomain Interfaces Required for the Functional Architecture of Yor1p, a Eukaryotic ATP-binding Cassette (ABC) Transporter*

  2008cited by this paper
• MFS transportome of the human pathogenic yeast Candida albicans

  2008cited by this paper
• Mutations Define Cross-talk between the N-terminal Nucleotide-binding Domain and Transmembrane Helix-2 of the Yeast Multidrug Transporter Pdr5

  2008influential reference
• Sorting Signals within the Saccharomyces cerevisiae Sporulation-Specific Dityrosine Transporter, Dtr1p, C Terminus Promote Golgi-to-Prospore Membrane Transport

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• Structure and Function Analysis of CaMdr1p, a Major Facilitator Superfamily Antifungal Efflux Transporter Protein of Candida albicans: Identification of Amino Acid Residues Critical for Drug/H+ Transport

  2007cited by this paper
• Plant ATP-binding cassette transporters.

  2007influential reference
• Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem

  2007influential reference
• Characterization of Cdr1p, a major multidrug efflux protein of Candida albicans: purified protein is amenable to intrinsic fluorescence analysis.

  2006cited by this paper
• Conserved Asp327 of walker B motif in the N-terminal nucleotide binding domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysis.

  2006cited by this paper
• Chimeras of the ABC drug transporter Cdr1p reveal functional indispensability of transmembrane domains and nucleotide-binding domains, but transmembrane segment 12 is replaceable with the corresponding homologous region of the non-drug transporter Cdr3p.

  2006cited by this paper
• Complete Inventory of ABC Proteins in Human Pathogenic Yeast, Candida albicans

  2005influential reference
• Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: identification of amino acid residues critical for drug efflux.

  2005cited by this paper
• A Human-Curated Annotation of the Candida albicans Genome

  2005cited by this paper
• Changing patterns and trends in systemic fungal infections.

  2005cited by this paper
• TCDB: the Transporter Classification Database for membrane transport protein analyses and information

  2005cited by this paper
• Functional characterization of N-terminal nucleotide binding domain (NBD-1) of a major ABC drug transporter Cdr1p of Candida albicans: uncommon but conserved Trp326 of Walker B is important for ATP binding.

  2005cited by this paper
• Multidrug resistance in yeast Candida.

  2005cited by this paper
• Cytoplasmic Domains

  2005cited by this paper
• The ATP switch model for ABC transporters

  2004cited by this paper
• Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex.

  2004cited by this paper
• ABC multidrug transporter Cdr1p of Candida albicans has divergent nucleotide-binding domains which display functional asymmetry.

  2004cited by this paper
• Purification and characterization of the N-terminal nucleotide binding domain of an ABC drug transporter of Candida albicans: uncommon cysteine 193 of Walker A is critical for ATP hydrolysis.

  2003cited by this paper
• Functional Characterization of Candida albicans ABC Transporter Cdr1p

  2003cited by this paper
• ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators

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• Functional analysis of a vacuolar ABC transporter in wild‐type Candida albicans reveals its involvement in virulence

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  2002cited by this paper
• Drug resistance in yeasts--an emerging scenario.

  2002cited by this paper
• Specificity of drug transport mediated by CaMDR1: a major facilitator of Candida albicans

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• Specificity of drug transport mediated byCaMDR1: A major facilitator ofCandida albicans

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  2000cited by this paper
• A Ste6p/P‐glycoprotein homologue from the asexual yeast Candida albicans transports the a‐factor mating pheromone in Saccharomyces cerevisiae

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• Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter.

  1998cited by this paper
• Characterisation of human steroid hormone transport mediated by Cdr1p, a multidrug transporter of Candida albicans, belonging to the ATP binding cassette super family.

  1998influential reference
• ATPase and Multidrug Transport Activities of the Overexpressed Yeast ABC Protein Yor1p*

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• Expression of CDR1, a multidrug resistance gene of Candida albicans: transcriptional activation by heat shock, drugs and human steroid hormones.

  1998influential reference
• A fourth gene from the Candida albicans CDR family of ABC transporters.

  1998influential reference
• Disruption studies of a Candida albicans gene, ELF1: a member of the ATP-binding cassette family.

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• Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activation

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  1997influential reference
• Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.

  1997influential reference
• Proton-dependent multidrug efflux systems

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• The ATP Binding Cassette Transporters Pdr5 and Snq2 of Saccharomyces cerevisiae Can Mediate Transport of Steroids in Vivo*

  1996cited by this paper
• Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

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• Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene

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• Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes--an analysis.

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• A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport.

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• Isolation and sequence analysis of the gene for translation elongation factor 3 from Candida albicans.

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• Families and superfamilies of transport proteins common to prokaryotes and eukaryotes

  1991cited by this paper
• Steroid binding protein(s) in yeasts.

  1985cited by this paper
• Ketoconazole binds to the intracellular corticosteroid-binding protein in Candida albicans.

  1983cited by this paper
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  1980cited by this paper

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